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Q055P8 (GCSP_LEPBL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:LBL_0338
OrganismLeptospira borgpetersenii serovar Hardjo-bovis (strain L550) [Complete proteome] [HAMAP]
Taxonomic identifier355276 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira

Protein attributes

Sequence length964 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 964964Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000045588

Amino acid modifications

Modified residue7131N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q055P8 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: 04E09A3DD637E767

FASTA964106,287
        10         20         30         40         50         60 
MNSTLQNRNR TNLERVSTDP LDTFPRRHIG PDSQQVDKML KSLGLSSLEE LVDKAVPAGI 

        70         80         90        100        110        120 
RLKKEPDLPK ASTEHKILQD LKNIASQNQI FRSYIGAGYN ACIIPGVIQR NILENPGWYT 

       130        140        150        160        170        180 
AYTPYQAEIS QGRLEALLNF QTMIIDLTGL EISNASLLDE GTAAAEAMFL AYSIRKNEIA 

       190        200        210        220        230        240 
KKFFVSELCH PQTIDVVVTR ANPLGIEIVI GNHESVELNE DFFGVLLQYP ATDGKIIDYT 

       250        260        270        280        290        300 
SFIQRAHNVG AISTVAADLL ALTLLKSPGE MGADIAVGSS QRFGLPLGFG GPHAGYFATK 

       310        320        330        340        350        360 
DEFKRSMPGR LIGVSKDSQG NPGLRLSLQT REQHIRRDKA TSNICTAQVL LAVISSMYAV 

       370        380        390        400        410        420 
YHGPEGLKDI ATRIHKFTSI LADALKSSGF TISNDTFFDT ITIQAGAKAK DILNRARSER 

       430        440        450        460        470        480 
INLREYKDGR IGIALDETVN SDDIKDLFKI FEVKNTDIEK LFSNSGNISD SFKRSTSYLT 

       490        500        510        520        530        540 
HPVFQSFHTE TKMLRYIRKL ESRDLSLTTS MIPLGSCTMK LNATTEMYPV TWPEFGAIHP 

       550        560        570        580        590        600 
FAPSEQTKGY KIIFEQLEKW LCEITGFAGV SLQPNAGSQG EYAGLLAIRR YHESRKETHR 

       610        620        630        640        650        660 
NVCLIPISAH GTNPASAAMA GFKVVVVSCD QNGNVDLEDL KIKAEEHKND LAALMITYPS 

       670        680        690        700        710        720 
THGVFEESVK EICQIVHSRG GQVYMDGANM NAQVGLTSPG EIGADVCHLN LHKTFCIPHG 

       730        740        750        760        770        780 
GGGPGVGPIG VAKHLVPFLP GHVLVDNTTG NEHGAVSAAP WGSASIVLIS WIYIALMGSE 

       790        800        810        820        830        840 
GLTNATRISI LNANYIAKRL EKAYPVLYKG KNGFVAHECI LDVRPFKKSA EIEVEDVAKR 

       850        860        870        880        890        900 
LIDYGFHAPT MSFPVPGTLM IEPTESESLE ELDRFCEAML LIHQEILDVQ NGTLDKIDNP 

       910        920        930        940        950        960 
LKNSPHTAAM TTSDRWDHLY PKERAAYPAP WSRDHKFWPF VGRVDNVYGD RNLVCSCLPV 


ESYQ 

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References

[1]"Genome reduction in Leptospira borgpetersenii reflects limited transmission potential."
Bulach D.M., Zuerner R.L., Wilson P., Seemann T., McGrath A., Cullen P.A., Davis J., Johnson M., Kuczek E., Alt D.P., Peterson-Burch B., Coppel R.L., Rood J.I., Davies J.K., Adler B.
Proc. Natl. Acad. Sci. U.S.A. 103:14560-14565(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: L550.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000348 Genomic DNA. Translation: ABJ77947.1.
RefSeqYP_796880.1. NC_008508.1.

3D structure databases

ProteinModelPortalQ055P8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING355276.LBL_0338.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ77947; ABJ77947; LBL_0338.
GeneID4408615.
KEGGlbl:LBL_0338.
PATRIC22363872. VBILepBor75619_0415.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAQTMVCDL.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycLBOR355276:GHUQ-338-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_LEPBL
AccessionPrimary (citable) accession number: Q055P8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: February 19, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families