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Q05597

- CBIP_SALTY

UniProt

Q05597 - CBIP_SALTY

Protein

Cobyric acid synthase

Gene

cbiP

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH2 groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei332 – 3321NucleophileBy similarity
    Active sitei440 – 4401By similarity

    GO - Molecular functioni

    1. cobalamin-transporting ATPase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cobalamin biosynthetic process Source: UniProtKB-HAMAP
    2. glutamine metabolic process Source: UniProtKB-HAMAP

    Keywords - Biological processi

    Cobalamin biosynthesis

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-13223.
    SENT99287:GCTI-2031-MONOMER.
    UniPathwayiUPA00148.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cobyric acid synthase
    Gene namesi
    Name:cbiP
    Ordered Locus Names:STM2019
    OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
    Taxonomic identifieri99287 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001014: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 506506Cobyric acid synthasePRO_0000141329Add
    BLAST

    Proteomic databases

    PRIDEiQ05597.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi99287.STM2019.

    Structurei

    3D structure databases

    ProteinModelPortaliQ05597.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini251 – 448198GATase cobBQ-typeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CobB/CobQ family. CobQ subfamily.Curated
    Contains 1 GATase cobBQ-type domain.Curated

    Keywords - Domaini

    Glutamine amidotransferase

    Phylogenomic databases

    HOGENOMiHOG000224803.
    KOiK02232.
    OMAiPHIANFD.
    OrthoDBiEOG6M9F07.
    PhylomeDBiQ05597.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    3.40.50.880. 1 hit.
    HAMAPiMF_00028. CobQ.
    InterProiIPR029062. Class_I_gatase-like.
    IPR017929. CobB/CobQ_GATase.
    IPR002586. CobQ/CobB/MinD/ParA_Nub-bd_dom.
    IPR004459. CobQ_synth.
    IPR011698. GATase_3.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01656. CbiA. 1 hit.
    PF07685. GATase_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF52317. SSF52317. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00313. cobQ. 1 hit.
    PROSITEiPS51274. GATASE_COBBQ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q05597-1 [UniParc]FASTAAdd to Basket

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    MTQAVMLQGT ASDVGKSVLA AGLCRIFYQD GLRTAPFKSQ NMALNSGITP    50
    DGKEMGRAQI FQAEAAGITP DVRMNPVLLK PTSDRQAQVV LMGKVATNMD 100
    AVSYHDYKPR LREQILAVYN SLAQEYDVIV LEGAGSPAEI NLRDRDIVNM 150
    GMAEMAQCPV ILVADIDRGG VFAAIYGTLA LLHKQERDRV KGVIINKFRG 200
    DVALLYSGIE QIESLTGVPV LGVMPWLDVD LEDEDGVALQ NDKYRGNAPR 250
    DITIAIVQLP HISNFTDFNA LAAQPDVRIR YIRRPEALTD VDLVILPGSK 300
    NTLSDLAWLR ESGMADAVLQ THRQGVPVMG ICGGYQMLGD TIVDEVESGL 350
    GTQPGLGLLN TITRFAQDKT TTQVNATMSG ELPGWLAAAA GLPVRGYEIH 400
    MGETVLQEGC CTAMTLQKNG CSVADGAVTA DGLAFGTYLH GLFDSDAFTR 450
    AVVNGLRARK GLAPWETTFC YADHKARQFD LLAEAMRQHI DIDKIYTIMQ 500
    QHQEPV 506
    Length:506
    Mass (Da):54,967
    Last modified:June 1, 1994 - v1
    Checksum:i4F7658E1ADB36CE7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L12006 Genomic DNA. Translation: AAA27268.1.
    AE006468 Genomic DNA. Translation: AAL20923.1.
    RefSeqiNP_460964.1. NC_003197.1.

    Genome annotation databases

    EnsemblBacteriaiAAL20923; AAL20923; STM2019.
    GeneIDi1253540.
    KEGGistm:STM2019.
    PATRICi32382621. VBISalEnt20916_2141.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L12006 Genomic DNA. Translation: AAA27268.1 .
    AE006468 Genomic DNA. Translation: AAL20923.1 .
    RefSeqi NP_460964.1. NC_003197.1.

    3D structure databases

    ProteinModelPortali Q05597.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 99287.STM2019.

    Proteomic databases

    PRIDEi Q05597.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL20923 ; AAL20923 ; STM2019 .
    GeneIDi 1253540.
    KEGGi stm:STM2019.
    PATRICi 32382621. VBISalEnt20916_2141.

    Phylogenomic databases

    HOGENOMi HOG000224803.
    KOi K02232.
    OMAi PHIANFD.
    OrthoDBi EOG6M9F07.
    PhylomeDBi Q05597.

    Enzyme and pathway databases

    UniPathwayi UPA00148 .
    BioCyci MetaCyc:MONOMER-13223.
    SENT99287:GCTI-2031-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    3.40.50.880. 1 hit.
    HAMAPi MF_00028. CobQ.
    InterProi IPR029062. Class_I_gatase-like.
    IPR017929. CobB/CobQ_GATase.
    IPR002586. CobQ/CobB/MinD/ParA_Nub-bd_dom.
    IPR004459. CobQ_synth.
    IPR011698. GATase_3.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01656. CbiA. 1 hit.
    PF07685. GATase_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52317. SSF52317. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00313. cobQ. 1 hit.
    PROSITEi PS51274. GATASE_COBBQ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the cobalamin (vitamin B12) biosynthetic genes of Salmonella typhimurium."
      Roth J.R., Lawrence J.G., Rubenfield M., Kieffer-Higgins S., Church G.M.
      J. Bacteriol. 175:3303-3316(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: LT2.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LT2 / SGSC1412 / ATCC 700720.

    Entry informationi

    Entry nameiCBIP_SALTY
    AccessioniPrimary (citable) accession number: Q05597
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3