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Protein

Urokinase plasminogen activator surface receptor

Gene

PLAUR

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA.

GO - Molecular functioni

  • urokinase plasminogen activator receptor activity Source: GO_Central
  • zymogen binding Source: AgBase

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-BTA-162791. Attachment of GPI anchor to uPAR.
R-BTA-75205. Dissolution of Fibrin Clot.

Names & Taxonomyi

Protein namesi
Recommended name:
Urokinase plasminogen activator surface receptor
Short name:
U-PAR
Short name:
uPAR
Alternative name(s):
CD_antigen: CD87
Gene namesi
Name:PLAUR
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Subcellular locationi

  • Cell membrane By similarity; Lipid-anchorGPI-anchor By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – ?300280Urokinase plasminogen activator surface receptorPRO_0000036086Add
BLAST
Propeptidei?301 – 33030Removed in mature formSequence analysisPRO_0000036087Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi23 ↔ 44By similarity
Disulfide bondi26 ↔ 32By similarity
Glycosylationi28 – 281N-linked (GlcNAc...)Sequence analysis
Disulfide bondi37 ↔ 65By similarity
Glycosylationi72 – 721N-linked (GlcNAc...)Sequence analysis
Disulfide bondi91 ↔ 96By similarity
Disulfide bondi115 ↔ 142By similarity
Disulfide bondi118 ↔ 125By similarity
Disulfide bondi135 ↔ 164By similarity
Disulfide bondi170 ↔ 187By similarity
Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence analysis
Disulfide bondi188 ↔ 193By similarity
Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence analysis
Disulfide bondi211 ↔ 239By similarity
Disulfide bondi214 ↔ 222By similarity
Disulfide bondi232 ↔ 258By similarity
Disulfide bondi264 ↔ 282By similarity
Glycosylationi279 – 2791N-linked (GlcNAc...)Sequence analysis
Disulfide bondi283 ↔ 288By similarity
Lipidationi300 – 3001GPI-anchor amidated glycineSequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ05588.
PRIDEiQ05588.

Expressioni

Inductioni

By retinoic acid.

Interactioni

Subunit structurei

Monomer (Probable). Interacts (via the UPAR/Ly6 domains) with SRPX2. Interacts with MRC2 (By similarity). Interacts with SORL1 (By similarity).By similarityCurated

GO - Molecular functioni

  • zymogen binding Source: AgBase

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017446.

Structurei

3D structure databases

ProteinModelPortaliQ05588.
SMRiQ05588. Positions 21-291.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 11292UPAR/Ly6 1Add
BLAST
Domaini113 – 20896UPAR/Ly6 2Add
BLAST
Domaini209 – 30092UPAR/Ly6 3Add
BLAST

Sequence similaritiesi

Contains 3 UPAR/Ly6 domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IJ50. Eukaryota.
ENOG410Z47S. LUCA.
GeneTreeiENSGT00510000049144.
HOGENOMiHOG000136855.
HOVERGENiHBG000245.
InParanoidiQ05588.
KOiK03985.
OMAiNRTMSYR.
OrthoDBiEOG7QRQVG.
TreeFamiTF338662.

Family and domain databases

InterProiIPR018363. CD59_antigen_CS.
IPR016054. LY6_UPA_recep-like.
IPR033084. U-PAR.
[Graphical view]
PANTHERiPTHR10624:SF6. PTHR10624:SF6. 1 hit.
PfamiPF00021. UPAR_LY6. 3 hits.
[Graphical view]
SMARTiSM00134. LU. 3 hits.
[Graphical view]
PROSITEiPS00983. LY6_UPAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05588-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQPLLLLLL VYTYIPGSWG LRCLQCENTT SCSVEECTPG QDLCRTTVLS
60 70 80 90 100
VWEGGNEMNV VRKGCTHPDK TNRSMSYRAA DQIITLSETV CRSDLCNKPN
110 120 130 140 150
PGRDATVSRN RYLECASCSS TDLSCERGWD QTMQCLKSRD QCVDVITHRS
160 170 180 190 200
LKENPGDERH IRGCGILPGC PGPTGFHNNH TFHFLRCCNT TKCNAGSVLE
210 220 230 240 250
LQNLPPNGLQ CYSCEGNGAH RCSSEETFLI DCRGPMNQCL EATGTKGLRN
260 270 280 290 300
PSYTIRGCAA PSWCQSLHVA EAFDLTHVNV SCCTGSGCNH PARDDQPGKG
310 320 330
GAPKTSPAHL SFFVSLLLTA RLWGATLLCT
Length:330
Mass (Da):35,989
Last modified:February 1, 1994 - v1
Checksum:i75E8BFAD1CE39C5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L03545 mRNA. Translation: AAA30802.1.
S70635 mRNA. Translation: AAB30120.1.
BC134754 mRNA. Translation: AAI34755.1.
BC142002 mRNA. Translation: AAI42003.1.
PIRiJN0561.
RefSeqiNP_776848.1. NM_174423.3.
UniGeneiBt.1942.

Genome annotation databases

EnsembliENSBTAT00000017446; ENSBTAP00000017446; ENSBTAG00000013125.
GeneIDi281983.
KEGGibta:281983.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L03545 mRNA. Translation: AAA30802.1.
S70635 mRNA. Translation: AAB30120.1.
BC134754 mRNA. Translation: AAI34755.1.
BC142002 mRNA. Translation: AAI42003.1.
PIRiJN0561.
RefSeqiNP_776848.1. NM_174423.3.
UniGeneiBt.1942.

3D structure databases

ProteinModelPortaliQ05588.
SMRiQ05588. Positions 21-291.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017446.

Proteomic databases

PaxDbiQ05588.
PRIDEiQ05588.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000017446; ENSBTAP00000017446; ENSBTAG00000013125.
GeneIDi281983.
KEGGibta:281983.

Organism-specific databases

CTDi5329.

Phylogenomic databases

eggNOGiENOG410IJ50. Eukaryota.
ENOG410Z47S. LUCA.
GeneTreeiENSGT00510000049144.
HOGENOMiHOG000136855.
HOVERGENiHBG000245.
InParanoidiQ05588.
KOiK03985.
OMAiNRTMSYR.
OrthoDBiEOG7QRQVG.
TreeFamiTF338662.

Enzyme and pathway databases

ReactomeiR-BTA-162791. Attachment of GPI anchor to uPAR.
R-BTA-75205. Dissolution of Fibrin Clot.

Family and domain databases

InterProiIPR018363. CD59_antigen_CS.
IPR016054. LY6_UPA_recep-like.
IPR033084. U-PAR.
[Graphical view]
PANTHERiPTHR10624:SF6. PTHR10624:SF6. 1 hit.
PfamiPF00021. UPAR_LY6. 3 hits.
[Graphical view]
SMARTiSM00134. LU. 3 hits.
[Graphical view]
PROSITEiPS00983. LY6_UPAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Bovine urokinase-type plasminogen activator and its receptor: cloning and induction by retinoic acid."
    Kraetzschmar J., Haendler B., Kojima S., Rifkin D.B., Schleuning W.-D.
    Gene 125:177-183(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Aortic endothelium.
  2. "Molecular cloning of cDNA for the bovine urokinase-type plasminogen activator receptor."
    Reuning U., Little S.P., Dixon E.P., Johnstone E.M., Bang N.U.
    Thromb. Res. 72:59-70(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Aortic endothelium.
  3. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Hypothalamus.

Entry informationi

Entry nameiUPAR_BOVIN
AccessioniPrimary (citable) accession number: Q05588
Secondary accession number(s): A5PJ83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: June 8, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.