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Protein

Urokinase plasminogen activator surface receptor

Gene

PLAUR

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-BTA-162791 Attachment of GPI anchor to uPAR
R-BTA-6798695 Neutrophil degranulation
R-BTA-75205 Dissolution of Fibrin Clot

Names & Taxonomyi

Protein namesi
Recommended name:
Urokinase plasminogen activator surface receptor
Short name:
U-PAR
Short name:
uPAR
Alternative name(s):
CD_antigen: CD87
Gene namesi
Name:PLAUR
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Organism-specific databases

VGNCiVGNC:32976 PLAUR

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000003608621 – ?300Urokinase plasminogen activator surface receptorAdd BLAST280
PropeptideiPRO_0000036087?301 – 330Removed in mature formSequence analysisAdd BLAST30

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi23 ↔ 44By similarity
Disulfide bondi26 ↔ 32By similarity
Glycosylationi28N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi37 ↔ 65By similarity
Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi91 ↔ 96By similarity
Disulfide bondi115 ↔ 142By similarity
Disulfide bondi118 ↔ 125By similarity
Disulfide bondi135 ↔ 164By similarity
Disulfide bondi170 ↔ 187By similarity
Glycosylationi179N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi188 ↔ 193By similarity
Glycosylationi189N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi211 ↔ 239By similarity
Disulfide bondi214 ↔ 222By similarity
Disulfide bondi232 ↔ 258By similarity
Disulfide bondi264 ↔ 282By similarity
Glycosylationi279N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi283 ↔ 288By similarity
Lipidationi300GPI-anchor amidated glycineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ05588
PRIDEiQ05588

Expressioni

Inductioni

By retinoic acid.

Gene expression databases

BgeeiENSBTAG00000013125

Interactioni

Subunit structurei

Monomer (Probable). Interacts (via the UPAR/Ly6 domains) with SRPX2. Interacts with MRC2 (By similarity). Interacts with SORL1 (By similarity).By similarityCurated

GO - Molecular functioni

  • protein domain specific binding Source: Ensembl
  • receptor binding Source: Ensembl
  • zymogen binding Source: AgBase

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017446

Structurei

3D structure databases

ProteinModelPortaliQ05588
SMRiQ05588
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 112UPAR/Ly6 1Add BLAST92
Domaini113 – 208UPAR/Ly6 2Add BLAST96
Domaini209 – 300UPAR/Ly6 3Add BLAST92

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IJ50 Eukaryota
ENOG410Z47S LUCA
GeneTreeiENSGT00510000049144
HOGENOMiHOG000136855
HOVERGENiHBG000245
InParanoidiQ05588
KOiK03985
OMAiVERGCAH
OrthoDBiEOG091G0FQ6
TreeFamiTF338662

Family and domain databases

InterProiView protein in InterPro
IPR018363 CD59_antigen_CS
IPR016054 LY6_UPA_recep-like
IPR033084 U-PAR
PANTHERiPTHR10624:SF6 PTHR10624:SF6, 1 hit
PfamiView protein in Pfam
PF00021 UPAR_LY6, 3 hits
SMARTiView protein in SMART
SM00134 LU, 3 hits
PROSITEiView protein in PROSITE
PS00983 LY6_UPAR, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05588-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQPLLLLLL VYTYIPGSWG LRCLQCENTT SCSVEECTPG QDLCRTTVLS
60 70 80 90 100
VWEGGNEMNV VRKGCTHPDK TNRSMSYRAA DQIITLSETV CRSDLCNKPN
110 120 130 140 150
PGRDATVSRN RYLECASCSS TDLSCERGWD QTMQCLKSRD QCVDVITHRS
160 170 180 190 200
LKENPGDERH IRGCGILPGC PGPTGFHNNH TFHFLRCCNT TKCNAGSVLE
210 220 230 240 250
LQNLPPNGLQ CYSCEGNGAH RCSSEETFLI DCRGPMNQCL EATGTKGLRN
260 270 280 290 300
PSYTIRGCAA PSWCQSLHVA EAFDLTHVNV SCCTGSGCNH PARDDQPGKG
310 320 330
GAPKTSPAHL SFFVSLLLTA RLWGATLLCT
Length:330
Mass (Da):35,989
Last modified:February 1, 1994 - v1
Checksum:i75E8BFAD1CE39C5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L03545 mRNA Translation: AAA30802.1
S70635 mRNA Translation: AAB30120.1
BC134754 mRNA Translation: AAI34755.1
BC142002 mRNA Translation: AAI42003.1
PIRiJN0561
RefSeqiNP_776848.1, NM_174423.3
UniGeneiBt.1942

Genome annotation databases

EnsembliENSBTAT00000017446; ENSBTAP00000017446; ENSBTAG00000013125
GeneIDi281983
KEGGibta:281983

Similar proteinsi

Entry informationi

Entry nameiUPAR_BOVIN
AccessioniPrimary (citable) accession number: Q05588
Secondary accession number(s): A5PJ83
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: March 28, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health