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Protein

Glutamate receptor ionotropic, NMDA 1

Gene

GRIN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei523GlycineBy similarity1
Binding sitei688GlycineBy similarity1
Binding sitei732GlycineBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Calcium, Magnesium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176884-MONOMER.
ReactomeiR-HSA-3928662. EPHB-mediated forward signaling.
R-HSA-438066. Unblocking of NMDA receptor, glutamate binding and activation.
R-HSA-442729. CREB phosphorylation through the activation of CaMKII.
R-HSA-442982. Ras activation uopn Ca2+ infux through NMDA receptor.
R-HSA-5673001. RAF/MAP kinase cascade.
R-HSA-6794361. Interactions of neurexins and neuroligins at synapses.
R-HSA-8849932. SALM protein interactions at the synapses.
SignaLinkiQ05586.

Protein family/group databases

TCDBi1.A.10.1.6. the glutamate-gated ion channel (gic) family of neurotransmitter receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor ionotropic, NMDA 1
Short name:
GluN1
Alternative name(s):
Glutamate [NMDA] receptor subunit zeta-1
N-methyl-D-aspartate receptor subunit NR1
Short name:
NMD-R1
Gene namesi
Name:GRIN1
Synonyms:NMDAR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:4584. GRIN1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 559ExtracellularSequence analysisAdd BLAST541
Transmembranei560 – 580HelicalSequence analysisAdd BLAST21
Topological domaini581 – 636CytoplasmicSequence analysisAdd BLAST56
Transmembranei637 – 657HelicalSequence analysisAdd BLAST21
Topological domaini658 – 812ExtracellularSequence analysisAdd BLAST155
Transmembranei813 – 833HelicalSequence analysisAdd BLAST21
Topological domaini834 – 938CytoplasmicSequence analysisAdd BLAST105

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Involvement in diseasei

Mental retardation, autosomal dominant 8 (MRD8)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
See also OMIM:614254
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_066597560S → SS in MRD8; there is near abolition of the activity of the NMDA receptor in Xenopus oocytes; alters the 3-dimensional structure at the receptor's channel pore entrance. 1 Publication1
Natural variantiVAR_066598662E → K in MRD8; this mutation produces a significant increase in NMDA receptor-induced calcium currents; excessive calcium influx through NMDA receptor could lead to excitotoxic neuronal cell damage. 1 PublicationCorresponds to variant rs387906635dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

DisGeNETi2902.
MalaCardsiGRIN1.
MIMi614254. phenotype.
OpenTargetsiENSG00000176884.
Orphaneti178469. Autosomal dominant non-syndromic intellectual disability.
PharmGKBiPA28978.

Chemistry databases

ChEMBLiCHEMBL2015.
DrugBankiDB00659. Acamprosate.
DB06151. Acetylcysteine.
DB00289. Atomoxetine.
DB00996. Gabapentin.
DB08954. Ifenprodil.
DB06738. Ketobemidone.
DB01043. Memantine.
DB04896. Milnacipran.
DB01173. Orphenadrine.
DB00312. Pentobarbital.
DB00454. Pethidine.
DB01174. Phenobarbital.
DB00418. Secobarbital.
GuidetoPHARMACOLOGYi455.

Polymorphism and mutation databases

BioMutaiGRIN1.
DMDMi548377.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001158719 – 938Glutamate receptor ionotropic, NMDA 1Add BLAST920

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi61N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi79Interchain
Glycosylationi203N-linked (GlcNAc...)Sequence analysis1
Glycosylationi239N-linked (GlcNAc...)Sequence analysis1
Glycosylationi276N-linked (GlcNAc...)Sequence analysis1
Glycosylationi300N-linked (GlcNAc...)Sequence analysis1
Glycosylationi350N-linked (GlcNAc...)Sequence analysis1
Glycosylationi368N-linked (GlcNAc...)Sequence analysis1
Glycosylationi440N-linked (GlcNAc...)Sequence analysis1
Glycosylationi471N-linked (GlcNAc...)Sequence analysis1
Glycosylationi491N-linked (GlcNAc...)Sequence analysis1
Modified residuei889Phosphoserine; by PKC1 Publication1
Modified residuei890Phosphoserine; by PKC1 Publication1
Modified residuei896Phosphoserine; by PKC1 Publication1
Modified residuei897Phosphoserine; by PKC1 Publication1

Post-translational modificationi

NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ05586.
PeptideAtlasiQ05586.
PRIDEiQ05586.

PTM databases

iPTMnetiQ05586.
PhosphoSitePlusiQ05586.

Miscellaneous databases

PMAP-CutDBQ5VSF3.

Expressioni

Gene expression databases

BgeeiENSG00000176884.
CleanExiHS_GRIN1.
ExpressionAtlasiQ05586. baseline and differential.
GenevisibleiQ05586. HS.

Organism-specific databases

HPAiCAB006831.

Interactioni

Subunit structurei

Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B); disulfide-linked. Found in a complex with GRIN2A or GRIN2B, GRIN3A or GRIN3B and PPP2CB. Interacts with DLG4 and MPDZ. Interacts with SNX27 (via PDZ domain); the interaction is required for recycling to the plasma membrane when endocytosed and prevent degradation in lysosomes (By similarity). Interacts with LRFN1 and LRFN2 (By similarity). Interacts with MYZAP.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Dlg3Q629363EBI-8286218,EBI-349596From a different organism.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109159. 11 interactors.
IntActiQ05586. 7 interactors.
MINTiMINT-1900224.
STRINGi9606.ENSP00000360608.

Chemistry databases

BindingDBiQ05586.

Structurei

Secondary structure

1938
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi398 – 402Combined sources5
Turni406 – 408Combined sources3
Beta strandi409 – 413Combined sources5
Beta strandi426 – 428Combined sources3
Beta strandi434 – 441Combined sources8
Beta strandi450 – 457Combined sources8
Helixi458 – 470Combined sources13
Beta strandi474 – 478Combined sources5
Beta strandi487 – 489Combined sources3
Beta strandi496 – 498Combined sources3
Helixi500 – 506Combined sources7
Beta strandi511 – 513Combined sources3
Helixi521 – 524Combined sources4
Beta strandi527 – 529Combined sources3
Beta strandi533 – 543Combined sources11
Helixi600 – 620Combined sources21
Helixi670 – 673Combined sources4
Helixi688 – 695Combined sources8
Helixi697 – 699Combined sources3
Helixi700 – 707Combined sources8
Beta strandi711 – 713Combined sources3
Helixi714 – 722Combined sources9
Beta strandi727 – 732Combined sources6
Helixi733 – 742Combined sources10
Beta strandi746 – 758Combined sources13
Beta strandi761 – 763Combined sources3
Helixi769 – 781Combined sources13
Helixi784 – 792Combined sources9
Helixi805 – 813Combined sources9
Helixi877 – 892Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HQWX-ray1.90B875-898[»]
2NR1NMR-A599-621[»]
3BYAX-ray1.85B875-898[»]
5H8FX-ray1.81B394-544[»]
B663-800[»]
5H8HX-ray2.23B394-544[»]
B663-800[»]
5H8NX-ray2.50B394-544[»]
B663-800[»]
5H8QX-ray1.90B394-544[»]
B663-800[»]
5I2KX-ray2.86B394-544[»]
B684-821[»]
5I2NX-ray2.12B394-544[»]
B684-821[»]
5KCJX-ray2.09B394-544[»]
B663-800[»]
5KDTX-ray2.44B394-544[»]
B684-821[»]
ProteinModelPortaliQ05586.
SMRiQ05586.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ05586.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni516 – 518Glycine bindingBy similarity3

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1053. Eukaryota.
ENOG410XNUR. LUCA.
GeneTreeiENSGT00760000119186.
HOGENOMiHOG000231491.
HOVERGENiHBG052638.
InParanoidiQ05586.
KOiK05208.
OMAiTMSDGTC.
OrthoDBiEOG091G0M5H.
PhylomeDBiQ05586.
TreeFamiTF351405.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR018882. CaM-bd_C0_NMDA_rcpt_NR1.
IPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF10562. CaM_bdg_C0. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequences (7)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 3 (identifier: Q05586-1) [UniParc]FASTAAdd to basket
Also known as: Long, NR1-3

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTMRLLTLA LLFSCSVARA ACDPKIVNIG AVLSTRKHEQ MFREAVNQAN
60 70 80 90 100
KRHGSWKIQL NATSVTHKPN AIQMALSVCE DLISSQVYAI LVSHPPTPND
110 120 130 140 150
HFTPTPVSYT AGFYRIPVLG LTTRMSIYSD KSIHLSFLRT VPPYSHQSSV
160 170 180 190 200
WFEMMRVYSW NHIILLVSDD HEGRAAQKRL ETLLEERESK AEKVLQFDPG
210 220 230 240 250
TKNVTALLME AKELEARVII LSASEDDAAT VYRAAAMLNM TGSGYVWLVG
260 270 280 290 300
EREISGNALR YAPDGILGLQ LINGKNESAH ISDAVGVVAQ AVHELLEKEN
310 320 330 340 350
ITDPPRGCVG NTNIWKTGPL FKRVLMSSKY ADGVTGRVEF NEDGDRKFAN
360 370 380 390 400
YSIMNLQNRK LVQVGIYNGT HVIPNDRKII WPGGETEKPR GYQMSTRLKI
410 420 430 440 450
VTIHQEPFVY VKPTLSDGTC KEEFTVNGDP VKKVICTGPN DTSPGSPRHT
460 470 480 490 500
VPQCCYGFCI DLLIKLARTM NFTYEVHLVA DGKFGTQERV NNSNKKEWNG
510 520 530 540 550
MMGELLSGQA DMIVAPLTIN NERAQYIEFS KPFKYQGLTI LVKKEIPRST
560 570 580 590 600
LDSFMQPFQS TLWLLVGLSV HVVAVMLYLL DRFSPFGRFK VNSEEEEEDA
610 620 630 640 650
LTLSSAMWFS WGVLLNSGIG EGAPRSFSAR ILGMVWAGFA MIIVASYTAN
660 670 680 690 700
LAAFLVLDRP EERITGINDP RLRNPSDKFI YATVKQSSVD IYFRRQVELS
710 720 730 740 750
TMYRHMEKHN YESAAEAIQA VRDNKLHAFI WDSAVLEFEA SQKCDLVTTG
760 770 780 790 800
ELFFRSGFGI GMRKDSPWKQ NVSLSILKSH ENGFMEDLDK TWVRYQECDS
810 820 830 840 850
RSNAPATLTF ENMAGVFMLV AGGIVAGIFL IFIEIAYKRH KDARRKQMQL
860 870 880 890 900
AFAAVNVWRK NLQDRKSGRA EPDPKKKATF RAITSTLASS FKRRRSSKDT
910 920 930
STGGGRGALQ NQKDTVLPRR AIEREEGQLQ LCSRHRES
Length:938
Mass (Da):105,373
Last modified:June 1, 1994 - v1
Checksum:iCDF5402769E530AB
GO
Isoform 1 (identifier: Q05586-2) [UniParc]FASTAAdd to basket
Also known as: Short, NR1-1

The sequence of this isoform differs from the canonical sequence as follows:
     864-885: DRKSGRAEPDPKKKATFRAITS → QYHPTDITGPLNLSDPSVSTVV
     886-938: Missing.

Show »
Length:885
Mass (Da):99,315
Checksum:i28C383037998DA20
GO
Isoform 2 (identifier: Q05586-3) [UniParc]FASTAAdd to basket
Also known as: Medium, NR1-2

The sequence of this isoform differs from the canonical sequence as follows:
     864-900: Missing.

Show »
Length:901
Mass (Da):101,209
Checksum:iE0C37E8C9F686155
GO
Isoform 4 (identifier: Q05586-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     901-922: STGGGRGALQNQKDTVLPRRAI → QYHPTDITGPLNLSDPSVSTVV
     923-938: Missing.

Show »
Length:922
Mass (Da):103,479
Checksum:iF704AD9A244BD78E
GO
Isoform 5 (identifier: Q05586-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-190: K → KSKKRNYENLDQLSYDNKRGPK

Show »
Length:959
Mass (Da):107,909
Checksum:iC7F52E8535F521EE
GO
Isoform 6 (identifier: Q05586-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-190: K → KSKKRNYENLDQLSYDNKRGPK
     901-922: STGGGRGALQNQKDTVLPRRAI → QYHPTDITGPLNLSDPSVSTVV
     923-938: Missing.

Show »
Length:943
Mass (Da):106,015
Checksum:i20DBA38A2B9E3ED0
GO
Isoform 7 (identifier: Q05586-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-190: K → KSKKRNYENLDQLSYDNKRGPK
     864-938: DRKSGRAEPD...LQLCSRHRES → QYHPTDITGPLNLSDPSVSTVV

Show »
Length:906
Mass (Da):101,851
Checksum:iB275FBD4126F4F15
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti389P → S in AAB25917 (PubMed:7681588).Curated1
Sequence conflicti488E → K in AAB59361 (PubMed:8406025).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049187540I → M.1 PublicationCorresponds to variant rs3181457dbSNPEnsembl.1
Natural variantiVAR_066597560S → SS in MRD8; there is near abolition of the activity of the NMDA receptor in Xenopus oocytes; alters the 3-dimensional structure at the receptor's channel pore entrance. 1 Publication1
Natural variantiVAR_066598662E → K in MRD8; this mutation produces a significant increase in NMDA receptor-induced calcium currents; excessive calcium influx through NMDA receptor could lead to excitotoxic neuronal cell damage. 1 PublicationCorresponds to variant rs387906635dbSNPEnsembl.1
Natural variantiVAR_069057682A → S.1 PublicationCorresponds to variant rs1126448dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011777190K → KSKKRNYENLDQLSYDNKRG PK in isoform 5, isoform 6 and isoform 7. 2 Publications1
Alternative sequenceiVSP_045464864 – 938DRKSG…RHRES → QYHPTDITGPLNLSDPSVST VV in isoform 7. 1 PublicationAdd BLAST75
Alternative sequenceiVSP_000139864 – 900Missing in isoform 2. 1 PublicationAdd BLAST37
Alternative sequenceiVSP_000137864 – 885DRKSG…RAITS → QYHPTDITGPLNLSDPSVST VV in isoform 1. 2 PublicationsAdd BLAST22
Alternative sequenceiVSP_000138886 – 938Missing in isoform 1. 2 PublicationsAdd BLAST53
Alternative sequenceiVSP_011778901 – 922STGGG…PRRAI → QYHPTDITGPLNLSDPSVST VV in isoform 4 and isoform 6. 2 PublicationsAdd BLAST22
Alternative sequenceiVSP_011779923 – 938Missing in isoform 4 and isoform 6. 2 PublicationsAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13266 mRNA. Translation: AAB59360.1.
L13267 mRNA. Translation: AAA36198.1.
L13268 mRNA. Translation: AAB59361.1.
D13515 mRNA. Translation: BAA02732.1.
L05666 mRNA. Translation: AAA21180.1.
AF015730 mRNA. Translation: AAB67723.1.
AF015731 mRNA. Translation: AAB67724.1.
Z32772 Genomic DNA. No translation available.
Z32773 Genomic DNA. No translation available.
Z32774 Genomic DNA. No translation available.
AL929554 Genomic DNA. Translation: CAH72874.2.
AL929554 Genomic DNA. Translation: CAH72875.2.
AL929554 Genomic DNA. Translation: CAH72876.2.
AL929554 Genomic DNA. Translation: CAH72879.2.
U08106 mRNA. Translation: AAA62111.1.
U08107 mRNA. Translation: AAA62112.1.
S57708 mRNA. Translation: AAB25917.1.
CCDSiCCDS43910.1. [Q05586-2]
CCDS55354.1. [Q05586-6]
CCDS55355.1. [Q05586-7]
CCDS7031.1. [Q05586-1]
CCDS7032.1. [Q05586-3]
PIRiA46612.
A47551.
RefSeqiNP_000823.4. NM_000832.6. [Q05586-2]
NP_001172019.1. NM_001185090.1. [Q05586-6]
NP_001172020.1. NM_001185091.1. [Q05586-7]
NP_015566.1. NM_007327.3. [Q05586-1]
NP_067544.1. NM_021569.3. [Q05586-3]
XP_005266128.1. XM_005266071.3. [Q05586-4]
XP_005266130.1. XM_005266073.4. [Q05586-5]
UniGeneiHs.558334.

Genome annotation databases

EnsembliENST00000371546; ENSP00000360601; ENSG00000176884. [Q05586-5]
ENST00000371550; ENSP00000360605; ENSG00000176884. [Q05586-3]
ENST00000371553; ENSP00000360608; ENSG00000176884. [Q05586-6]
ENST00000371559; ENSP00000360614; ENSG00000176884. [Q05586-2]
ENST00000371560; ENSP00000360615; ENSG00000176884. [Q05586-7]
ENST00000371561; ENSP00000360616; ENSG00000176884. [Q05586-1]
GeneIDi2902.
KEGGihsa:2902.
UCSCiuc004clk.4. human. [Q05586-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

NMDA receptor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13266 mRNA. Translation: AAB59360.1.
L13267 mRNA. Translation: AAA36198.1.
L13268 mRNA. Translation: AAB59361.1.
D13515 mRNA. Translation: BAA02732.1.
L05666 mRNA. Translation: AAA21180.1.
AF015730 mRNA. Translation: AAB67723.1.
AF015731 mRNA. Translation: AAB67724.1.
Z32772 Genomic DNA. No translation available.
Z32773 Genomic DNA. No translation available.
Z32774 Genomic DNA. No translation available.
AL929554 Genomic DNA. Translation: CAH72874.2.
AL929554 Genomic DNA. Translation: CAH72875.2.
AL929554 Genomic DNA. Translation: CAH72876.2.
AL929554 Genomic DNA. Translation: CAH72879.2.
U08106 mRNA. Translation: AAA62111.1.
U08107 mRNA. Translation: AAA62112.1.
S57708 mRNA. Translation: AAB25917.1.
CCDSiCCDS43910.1. [Q05586-2]
CCDS55354.1. [Q05586-6]
CCDS55355.1. [Q05586-7]
CCDS7031.1. [Q05586-1]
CCDS7032.1. [Q05586-3]
PIRiA46612.
A47551.
RefSeqiNP_000823.4. NM_000832.6. [Q05586-2]
NP_001172019.1. NM_001185090.1. [Q05586-6]
NP_001172020.1. NM_001185091.1. [Q05586-7]
NP_015566.1. NM_007327.3. [Q05586-1]
NP_067544.1. NM_021569.3. [Q05586-3]
XP_005266128.1. XM_005266071.3. [Q05586-4]
XP_005266130.1. XM_005266073.4. [Q05586-5]
UniGeneiHs.558334.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HQWX-ray1.90B875-898[»]
2NR1NMR-A599-621[»]
3BYAX-ray1.85B875-898[»]
5H8FX-ray1.81B394-544[»]
B663-800[»]
5H8HX-ray2.23B394-544[»]
B663-800[»]
5H8NX-ray2.50B394-544[»]
B663-800[»]
5H8QX-ray1.90B394-544[»]
B663-800[»]
5I2KX-ray2.86B394-544[»]
B684-821[»]
5I2NX-ray2.12B394-544[»]
B684-821[»]
5KCJX-ray2.09B394-544[»]
B663-800[»]
5KDTX-ray2.44B394-544[»]
B684-821[»]
ProteinModelPortaliQ05586.
SMRiQ05586.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109159. 11 interactors.
IntActiQ05586. 7 interactors.
MINTiMINT-1900224.
STRINGi9606.ENSP00000360608.

Chemistry databases

BindingDBiQ05586.
ChEMBLiCHEMBL2015.
DrugBankiDB00659. Acamprosate.
DB06151. Acetylcysteine.
DB00289. Atomoxetine.
DB00996. Gabapentin.
DB08954. Ifenprodil.
DB06738. Ketobemidone.
DB01043. Memantine.
DB04896. Milnacipran.
DB01173. Orphenadrine.
DB00312. Pentobarbital.
DB00454. Pethidine.
DB01174. Phenobarbital.
DB00418. Secobarbital.
GuidetoPHARMACOLOGYi455.

Protein family/group databases

TCDBi1.A.10.1.6. the glutamate-gated ion channel (gic) family of neurotransmitter receptors.

PTM databases

iPTMnetiQ05586.
PhosphoSitePlusiQ05586.

Polymorphism and mutation databases

BioMutaiGRIN1.
DMDMi548377.

Proteomic databases

PaxDbiQ05586.
PeptideAtlasiQ05586.
PRIDEiQ05586.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371546; ENSP00000360601; ENSG00000176884. [Q05586-5]
ENST00000371550; ENSP00000360605; ENSG00000176884. [Q05586-3]
ENST00000371553; ENSP00000360608; ENSG00000176884. [Q05586-6]
ENST00000371559; ENSP00000360614; ENSG00000176884. [Q05586-2]
ENST00000371560; ENSP00000360615; ENSG00000176884. [Q05586-7]
ENST00000371561; ENSP00000360616; ENSG00000176884. [Q05586-1]
GeneIDi2902.
KEGGihsa:2902.
UCSCiuc004clk.4. human. [Q05586-1]

Organism-specific databases

CTDi2902.
DisGeNETi2902.
GeneCardsiGRIN1.
HGNCiHGNC:4584. GRIN1.
HPAiCAB006831.
MalaCardsiGRIN1.
MIMi138249. gene.
614254. phenotype.
neXtProtiNX_Q05586.
OpenTargetsiENSG00000176884.
Orphaneti178469. Autosomal dominant non-syndromic intellectual disability.
PharmGKBiPA28978.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1053. Eukaryota.
ENOG410XNUR. LUCA.
GeneTreeiENSGT00760000119186.
HOGENOMiHOG000231491.
HOVERGENiHBG052638.
InParanoidiQ05586.
KOiK05208.
OMAiTMSDGTC.
OrthoDBiEOG091G0M5H.
PhylomeDBiQ05586.
TreeFamiTF351405.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176884-MONOMER.
ReactomeiR-HSA-3928662. EPHB-mediated forward signaling.
R-HSA-438066. Unblocking of NMDA receptor, glutamate binding and activation.
R-HSA-442729. CREB phosphorylation through the activation of CaMKII.
R-HSA-442982. Ras activation uopn Ca2+ infux through NMDA receptor.
R-HSA-5673001. RAF/MAP kinase cascade.
R-HSA-6794361. Interactions of neurexins and neuroligins at synapses.
R-HSA-8849932. SALM protein interactions at the synapses.
SignaLinkiQ05586.

Miscellaneous databases

ChiTaRSiGRIN1. human.
EvolutionaryTraceiQ05586.
GeneWikiiGRIN1.
GenomeRNAii2902.
PMAP-CutDBQ5VSF3.
PROiQ05586.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000176884.
CleanExiHS_GRIN1.
ExpressionAtlasiQ05586. baseline and differential.
GenevisibleiQ05586. HS.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR018882. CaM-bd_C0_NMDA_rcpt_NR1.
IPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF10562. CaM_bdg_C0. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNMDZ1_HUMAN
AccessioniPrimary (citable) accession number: Q05586
Secondary accession number(s): A6NLK7
, A6NLR1, C9K0X1, P35437, Q12867, Q12868, Q5VSF3, Q5VSF4, Q5VSF5, Q5VSF6, Q5VSF7, Q5VSF8, Q9UPF8, Q9UPF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 30, 2016
This is version 199 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.