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Q05586

- NMDZ1_HUMAN

UniProt

Q05586 - NMDZ1_HUMAN

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Protein

Glutamate receptor ionotropic, NMDA 1

Gene

GRIN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei523 – 5231GlycineBy similarity
Binding sitei688 – 6881GlycineBy similarity
Binding sitei732 – 7321GlycineBy similarity

GO - Molecular functioni

  1. calcium channel activity Source: Ensembl
  2. calcium ion binding Source: UniProtKB
  3. calmodulin binding Source: UniProtKB
  4. extracellular-glutamate-gated ion channel activity Source: RefGenome
  5. glutamate binding Source: UniProtKB
  6. glycine binding Source: UniProtKB
  7. neurotransmitter binding Source: BHF-UCL
  8. N-methyl-D-aspartate selective glutamate receptor activity Source: Ensembl
  9. voltage-gated cation channel activity Source: Ensembl

GO - Biological processi

  1. adult locomotory behavior Source: Ensembl
  2. calcium ion homeostasis Source: UniProtKB
  3. calcium ion transmembrane transport Source: GOC
  4. cation transport Source: UniProtKB
  5. cellular calcium ion homeostasis Source: Ensembl
  6. cellular response to manganese ion Source: Ensembl
  7. cerebral cortex development Source: Ensembl
  8. conditioned taste aversion Source: Ensembl
  9. ionotropic glutamate receptor signaling pathway Source: UniProtKB
  10. ion transmembrane transport Source: RefGenome
  11. long-term memory Source: Ensembl
  12. male mating behavior Source: Ensembl
  13. negative regulation of neuron apoptotic process Source: Ensembl
  14. olfactory learning Source: Ensembl
  15. pons maturation Source: Ensembl
  16. positive regulation of apoptotic process Source: Ensembl
  17. positive regulation of excitatory postsynaptic membrane potential Source: BHF-UCL
  18. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  19. prepulse inhibition Source: Ensembl
  20. propylene metabolic process Source: BHF-UCL
  21. protein tetramerization Source: Ensembl
  22. regulation of axonogenesis Source: Ensembl
  23. regulation of dendrite morphogenesis Source: Ensembl
  24. regulation of excitatory postsynaptic membrane potential Source: UniProtKB
  25. regulation of long-term neuronal synaptic plasticity Source: Ensembl
  26. regulation of membrane potential Source: UniProtKB
  27. regulation of respiratory gaseous exchange Source: Ensembl
  28. regulation of synapse assembly Source: Ensembl
  29. respiratory gaseous exchange Source: Ensembl
  30. response to amphetamine Source: Ensembl
  31. response to calcium ion Source: Ensembl
  32. response to ethanol Source: UniProtKB
  33. response to fungicide Source: Ensembl
  34. response to morphine Source: Ensembl
  35. rhythmic process Source: Ensembl
  36. sensory perception of pain Source: Ensembl
  37. social behavior Source: Ensembl
  38. suckling behavior Source: Ensembl
  39. synaptic transmission Source: Reactome
  40. synaptic transmission, glutamatergic Source: RefGenome
  41. visual learning Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Calcium, Magnesium

Enzyme and pathway databases

ReactomeiREACT_20546. Ras activation uopn Ca2+ infux through NMDA receptor.
REACT_20594. Unblocking of NMDA receptor, glutamate binding and activation.
REACT_20642. CREB phosphorylation through the activation of CaMKII.
REACT_228085. EPHB-mediated forward signaling.
SignaLinkiQ05586.

Protein family/group databases

TCDBi1.A.10.1.6. the glutamate-gated ion channel (gic) family of neurotransmitter receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor ionotropic, NMDA 1
Short name:
GluN1
Alternative name(s):
Glutamate [NMDA] receptor subunit zeta-1
N-methyl-D-aspartate receptor subunit NR1
Short name:
NMD-R1
Gene namesi
Name:GRIN1
Synonyms:NMDAR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:4584. GRIN1.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity. Cell junctionsynapsepostsynaptic cell membrane By similarity. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density By similarity
Note: Enriched in postsynaptic plasma membrane and postsynaptic densities.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 559541ExtracellularSequence AnalysisAdd
BLAST
Transmembranei560 – 58021HelicalSequence AnalysisAdd
BLAST
Topological domaini581 – 63656CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei637 – 65721HelicalSequence AnalysisAdd
BLAST
Topological domaini658 – 812155ExtracellularSequence AnalysisAdd
BLAST
Transmembranei813 – 83321HelicalSequence AnalysisAdd
BLAST
Topological domaini834 – 938105CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cell surface Source: BHF-UCL
  3. dendrite Source: UniProtKB
  4. dendrite membrane Source: Ensembl
  5. dendritic spine Source: BHF-UCL
  6. endoplasmic reticulum Source: Ensembl
  7. excitatory synapse Source: BHF-UCL
  8. integral component of plasma membrane Source: UniProtKB
  9. neuronal postsynaptic density Source: Ensembl
  10. neuron projection Source: UniProtKB
  11. N-methyl-D-aspartate selective glutamate receptor complex Source: UniProtKB
  12. plasma membrane Source: Reactome
  13. postsynaptic density Source: UniProtKB
  14. postsynaptic membrane Source: UniProtKB
  15. synapse Source: UniProtKB
  16. synaptic cleft Source: BHF-UCL
  17. synaptic vesicle Source: UniProtKB
  18. terminal bouton Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Involvement in diseasei

Mental retardation, autosomal dominant 8 (MRD8) [MIM:614254]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti560 – 5601S → SS in MRD8; there is near abolition of the activity of the NMDA receptor in Xenopus oocytes; alters the 3-dimensional structure at the receptor's channel pore entrance. 1 Publication
VAR_066597
Natural varianti662 – 6621E → K in MRD8; this mutation produces a significant increase in NMDA receptor-induced calcium currents; excessive calcium influx through NMDA receptor could lead to excitotoxic neuronal cell damage. 1 Publication
VAR_066598

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

MIMi614254. phenotype.
Orphaneti178469. Autosomal dominant non-syndromic intellectual disability.
PharmGKBiPA28978.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 938920Glutamate receptor ionotropic, NMDA 1PRO_0000011587Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi61 – 611N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi79 – 79Interchain
Glycosylationi203 – 2031N-linked (GlcNAc...)Sequence Analysis
Glycosylationi239 – 2391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi276 – 2761N-linked (GlcNAc...)Sequence Analysis
Glycosylationi300 – 3001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi350 – 3501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi368 – 3681N-linked (GlcNAc...)Sequence Analysis
Glycosylationi440 – 4401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi471 – 4711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi491 – 4911N-linked (GlcNAc...)Sequence Analysis
Modified residuei889 – 8891Phosphoserine; by PKC1 Publication
Modified residuei890 – 8901Phosphoserine; by PKC1 Publication
Modified residuei896 – 8961Phosphoserine; by PKC1 Publication
Modified residuei897 – 8971Phosphoserine; by PKC1 Publication

Post-translational modificationi

NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ05586.
PRIDEiQ05586.

PTM databases

PhosphoSiteiQ05586.

Miscellaneous databases

PMAP-CutDBQ5VSF3.

Expressioni

Gene expression databases

BgeeiQ05586.
CleanExiHS_GRIN1.
ExpressionAtlasiQ05586. baseline and differential.
GenevestigatoriQ05586.

Organism-specific databases

HPAiCAB006831.

Interactioni

Subunit structurei

Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B); disulfide-linked. Found in a complex with GRIN2A or GRIN2B, GRIN3A or GRIN3B and PPP2CB. Interacts with DLG4 and MPDZ. Interacts with SNX27 (via PDZ domain); the interaction is required for recycling to the plasma membrane when endocytosed and prevent degradation in lysosomes (By similarity). Interacts with LRFN1 and LRFN2 (By similarity). Interacts with MYZAP.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Dlg3Q629363EBI-8286218,EBI-349596From a different organism.

Protein-protein interaction databases

BioGridi109159. 11 interactions.
IntActiQ05586. 7 interactions.
MINTiMINT-1900224.

Structurei

Secondary structure

1
938
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi600 – 62021Combined sources
Helixi877 – 89216Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HQWX-ray1.90B875-898[»]
2NR1NMR-A599-621[»]
3BYAX-ray1.85B875-898[»]
ProteinModelPortaliQ05586.
SMRiQ05586. Positions 24-833.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ05586.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni516 – 5183Glycine bindingBy similarity

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG282132.
GeneTreeiENSGT00760000119186.
HOVERGENiHBG052638.
InParanoidiQ05586.
KOiK05208.
OMAiWNHVILL.
OrthoDBiEOG79GT5V.
PhylomeDBiQ05586.
TreeFamiTF351405.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR018882. CaM-bd_C0_NMDA_rcpt_NR1.
IPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR028082. Peripla_BP_I.
IPR001638. SBP_bac_3.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF10562. CaM_bdg_C0. 1 hit.
PF00060. Lig_chan. 1 hit.
PF00497. SBP_bac_3. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequences (7)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. Align

Isoform 3 (identifier: Q05586-1) [UniParc]FASTAAdd to Basket

Also known as: Long, NR1-3

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTMRLLTLA LLFSCSVARA ACDPKIVNIG AVLSTRKHEQ MFREAVNQAN
60 70 80 90 100
KRHGSWKIQL NATSVTHKPN AIQMALSVCE DLISSQVYAI LVSHPPTPND
110 120 130 140 150
HFTPTPVSYT AGFYRIPVLG LTTRMSIYSD KSIHLSFLRT VPPYSHQSSV
160 170 180 190 200
WFEMMRVYSW NHIILLVSDD HEGRAAQKRL ETLLEERESK AEKVLQFDPG
210 220 230 240 250
TKNVTALLME AKELEARVII LSASEDDAAT VYRAAAMLNM TGSGYVWLVG
260 270 280 290 300
EREISGNALR YAPDGILGLQ LINGKNESAH ISDAVGVVAQ AVHELLEKEN
310 320 330 340 350
ITDPPRGCVG NTNIWKTGPL FKRVLMSSKY ADGVTGRVEF NEDGDRKFAN
360 370 380 390 400
YSIMNLQNRK LVQVGIYNGT HVIPNDRKII WPGGETEKPR GYQMSTRLKI
410 420 430 440 450
VTIHQEPFVY VKPTLSDGTC KEEFTVNGDP VKKVICTGPN DTSPGSPRHT
460 470 480 490 500
VPQCCYGFCI DLLIKLARTM NFTYEVHLVA DGKFGTQERV NNSNKKEWNG
510 520 530 540 550
MMGELLSGQA DMIVAPLTIN NERAQYIEFS KPFKYQGLTI LVKKEIPRST
560 570 580 590 600
LDSFMQPFQS TLWLLVGLSV HVVAVMLYLL DRFSPFGRFK VNSEEEEEDA
610 620 630 640 650
LTLSSAMWFS WGVLLNSGIG EGAPRSFSAR ILGMVWAGFA MIIVASYTAN
660 670 680 690 700
LAAFLVLDRP EERITGINDP RLRNPSDKFI YATVKQSSVD IYFRRQVELS
710 720 730 740 750
TMYRHMEKHN YESAAEAIQA VRDNKLHAFI WDSAVLEFEA SQKCDLVTTG
760 770 780 790 800
ELFFRSGFGI GMRKDSPWKQ NVSLSILKSH ENGFMEDLDK TWVRYQECDS
810 820 830 840 850
RSNAPATLTF ENMAGVFMLV AGGIVAGIFL IFIEIAYKRH KDARRKQMQL
860 870 880 890 900
AFAAVNVWRK NLQDRKSGRA EPDPKKKATF RAITSTLASS FKRRRSSKDT
910 920 930
STGGGRGALQ NQKDTVLPRR AIEREEGQLQ LCSRHRES
Length:938
Mass (Da):105,373
Last modified:June 1, 1994 - v1
Checksum:iCDF5402769E530AB
GO
Isoform 1 (identifier: Q05586-2) [UniParc]FASTAAdd to Basket

Also known as: Short, NR1-1

The sequence of this isoform differs from the canonical sequence as follows:
     864-885: DRKSGRAEPDPKKKATFRAITS → QYHPTDITGPLNLSDPSVSTVV
     886-938: Missing.

Show »
Length:885
Mass (Da):99,315
Checksum:i28C383037998DA20
GO
Isoform 2 (identifier: Q05586-3) [UniParc]FASTAAdd to Basket

Also known as: Medium, NR1-2

The sequence of this isoform differs from the canonical sequence as follows:
     864-900: Missing.

Show »
Length:901
Mass (Da):101,209
Checksum:iE0C37E8C9F686155
GO
Isoform 4 (identifier: Q05586-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     901-922: STGGGRGALQNQKDTVLPRRAI → QYHPTDITGPLNLSDPSVSTVV
     923-938: Missing.

Show »
Length:922
Mass (Da):103,479
Checksum:iF704AD9A244BD78E
GO
Isoform 5 (identifier: Q05586-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-190: K → KSKKRNYENLDQLSYDNKRGPK

Show »
Length:959
Mass (Da):107,909
Checksum:iC7F52E8535F521EE
GO
Isoform 6 (identifier: Q05586-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-190: K → KSKKRNYENLDQLSYDNKRGPK
     901-922: STGGGRGALQNQKDTVLPRRAI → QYHPTDITGPLNLSDPSVSTVV
     923-938: Missing.

Show »
Length:943
Mass (Da):106,015
Checksum:i20DBA38A2B9E3ED0
GO
Isoform 7 (identifier: Q05586-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-190: K → KSKKRNYENLDQLSYDNKRGPK
     864-938: DRKSGRAEPD...LQLCSRHRES → QYHPTDITGPLNLSDPSVSTVV

Show »
Length:906
Mass (Da):101,851
Checksum:iB275FBD4126F4F15
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti389 – 3891P → S in AAB25917. (PubMed:7681588)Curated
Sequence conflicti488 – 4881E → K in AAB59361. (PubMed:8406025)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti540 – 5401I → M.1 Publication
Corresponds to variant rs3181457 [ dbSNP | Ensembl ].
VAR_049187
Natural varianti560 – 5601S → SS in MRD8; there is near abolition of the activity of the NMDA receptor in Xenopus oocytes; alters the 3-dimensional structure at the receptor's channel pore entrance. 1 Publication
VAR_066597
Natural varianti662 – 6621E → K in MRD8; this mutation produces a significant increase in NMDA receptor-induced calcium currents; excessive calcium influx through NMDA receptor could lead to excitotoxic neuronal cell damage. 1 Publication
VAR_066598
Natural varianti682 – 6821A → S.1 Publication
Corresponds to variant rs1126448 [ dbSNP | Ensembl ].
VAR_069057

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei190 – 1901K → KSKKRNYENLDQLSYDNKRG PK in isoform 5, isoform 6 and isoform 7. 2 PublicationsVSP_011777
Alternative sequencei864 – 93875DRKSG…RHRES → QYHPTDITGPLNLSDPSVST VV in isoform 7. 1 PublicationVSP_045464Add
BLAST
Alternative sequencei864 – 90037Missing in isoform 2. 1 PublicationVSP_000139Add
BLAST
Alternative sequencei864 – 88522DRKSG…RAITS → QYHPTDITGPLNLSDPSVST VV in isoform 1. 2 PublicationsVSP_000137Add
BLAST
Alternative sequencei886 – 93853Missing in isoform 1. 2 PublicationsVSP_000138Add
BLAST
Alternative sequencei901 – 92222STGGG…PRRAI → QYHPTDITGPLNLSDPSVST VV in isoform 4 and isoform 6. 2 PublicationsVSP_011778Add
BLAST
Alternative sequencei923 – 93816Missing in isoform 4 and isoform 6. 2 PublicationsVSP_011779Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13266 mRNA. Translation: AAB59360.1.
L13267 mRNA. Translation: AAA36198.1.
L13268 mRNA. Translation: AAB59361.1.
D13515 mRNA. Translation: BAA02732.1.
L05666 mRNA. Translation: AAA21180.1.
AF015730 mRNA. Translation: AAB67723.1.
AF015731 mRNA. Translation: AAB67724.1.
Z32772 Genomic DNA. No translation available.
Z32773 Genomic DNA. No translation available.
Z32774 Genomic DNA. No translation available.
AL929554 Genomic DNA. Translation: CAH72874.2.
AL929554 Genomic DNA. Translation: CAH72875.2.
AL929554 Genomic DNA. Translation: CAH72876.2.
AL929554 Genomic DNA. Translation: CAH72879.2.
U08106 mRNA. Translation: AAA62111.1.
U08107 mRNA. Translation: AAA62112.1.
S57708 mRNA. Translation: AAB25917.1.
CCDSiCCDS43910.1. [Q05586-2]
CCDS55354.1. [Q05586-6]
CCDS55355.1. [Q05586-7]
CCDS7031.1. [Q05586-1]
CCDS7032.1. [Q05586-3]
PIRiA46612.
A47551.
RefSeqiNP_000823.4. NM_000832.6. [Q05586-2]
NP_001172019.1. NM_001185090.1. [Q05586-6]
NP_001172020.1. NM_001185091.1. [Q05586-7]
NP_015566.1. NM_007327.3. [Q05586-1]
NP_067544.1. NM_021569.3. [Q05586-3]
XP_005266128.1. XM_005266071.1. [Q05586-4]
XP_005266130.1. XM_005266073.2. [Q05586-5]
UniGeneiHs.558334.

Genome annotation databases

EnsembliENST00000371546; ENSP00000360601; ENSG00000176884. [Q05586-5]
ENST00000371550; ENSP00000360605; ENSG00000176884. [Q05586-3]
ENST00000371553; ENSP00000360608; ENSG00000176884. [Q05586-6]
ENST00000371559; ENSP00000360614; ENSG00000176884. [Q05586-2]
ENST00000371560; ENSP00000360615; ENSG00000176884. [Q05586-7]
ENST00000371561; ENSP00000360616; ENSG00000176884. [Q05586-1]
GeneIDi2902.
KEGGihsa:2902.
UCSCiuc004clk.3. human. [Q05586-1]
uc004cll.3. human. [Q05586-3]
uc004clm.3. human. [Q05586-2]

Polymorphism databases

DMDMi548377.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

NMDA receptor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13266 mRNA. Translation: AAB59360.1 .
L13267 mRNA. Translation: AAA36198.1 .
L13268 mRNA. Translation: AAB59361.1 .
D13515 mRNA. Translation: BAA02732.1 .
L05666 mRNA. Translation: AAA21180.1 .
AF015730 mRNA. Translation: AAB67723.1 .
AF015731 mRNA. Translation: AAB67724.1 .
Z32772 Genomic DNA. No translation available.
Z32773 Genomic DNA. No translation available.
Z32774 Genomic DNA. No translation available.
AL929554 Genomic DNA. Translation: CAH72874.2 .
AL929554 Genomic DNA. Translation: CAH72875.2 .
AL929554 Genomic DNA. Translation: CAH72876.2 .
AL929554 Genomic DNA. Translation: CAH72879.2 .
U08106 mRNA. Translation: AAA62111.1 .
U08107 mRNA. Translation: AAA62112.1 .
S57708 mRNA. Translation: AAB25917.1 .
CCDSi CCDS43910.1. [Q05586-2 ]
CCDS55354.1. [Q05586-6 ]
CCDS55355.1. [Q05586-7 ]
CCDS7031.1. [Q05586-1 ]
CCDS7032.1. [Q05586-3 ]
PIRi A46612.
A47551.
RefSeqi NP_000823.4. NM_000832.6. [Q05586-2 ]
NP_001172019.1. NM_001185090.1. [Q05586-6 ]
NP_001172020.1. NM_001185091.1. [Q05586-7 ]
NP_015566.1. NM_007327.3. [Q05586-1 ]
NP_067544.1. NM_021569.3. [Q05586-3 ]
XP_005266128.1. XM_005266071.1. [Q05586-4 ]
XP_005266130.1. XM_005266073.2. [Q05586-5 ]
UniGenei Hs.558334.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2HQW X-ray 1.90 B 875-898 [» ]
2NR1 NMR - A 599-621 [» ]
3BYA X-ray 1.85 B 875-898 [» ]
ProteinModelPortali Q05586.
SMRi Q05586. Positions 24-833.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109159. 11 interactions.
IntActi Q05586. 7 interactions.
MINTi MINT-1900224.

Chemistry

BindingDBi Q05586.
ChEMBLi CHEMBL3038505.
DrugBanki DB00659. Acamprosate.
DB06151. Acetylcysteine.
DB00289. Atomoxetine.
DB00996. Gabapentin.
DB06738. Ketobemidone.
DB01043. Memantine.
DB04896. Milnacipran.
DB01173. Orphenadrine.
DB00312. Pentobarbital.
DB00454. Pethidine.
DB01174. Phenobarbital.
DB00418. Secobarbital.
GuidetoPHARMACOLOGYi 455.

Protein family/group databases

TCDBi 1.A.10.1.6. the glutamate-gated ion channel (gic) family of neurotransmitter receptors.

PTM databases

PhosphoSitei Q05586.

Polymorphism databases

DMDMi 548377.

Proteomic databases

PaxDbi Q05586.
PRIDEi Q05586.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000371546 ; ENSP00000360601 ; ENSG00000176884 . [Q05586-5 ]
ENST00000371550 ; ENSP00000360605 ; ENSG00000176884 . [Q05586-3 ]
ENST00000371553 ; ENSP00000360608 ; ENSG00000176884 . [Q05586-6 ]
ENST00000371559 ; ENSP00000360614 ; ENSG00000176884 . [Q05586-2 ]
ENST00000371560 ; ENSP00000360615 ; ENSG00000176884 . [Q05586-7 ]
ENST00000371561 ; ENSP00000360616 ; ENSG00000176884 . [Q05586-1 ]
GeneIDi 2902.
KEGGi hsa:2902.
UCSCi uc004clk.3. human. [Q05586-1 ]
uc004cll.3. human. [Q05586-3 ]
uc004clm.3. human. [Q05586-2 ]

Organism-specific databases

CTDi 2902.
GeneCardsi GC09P140032.
HGNCi HGNC:4584. GRIN1.
HPAi CAB006831.
MIMi 138249. gene.
614254. phenotype.
neXtProti NX_Q05586.
Orphaneti 178469. Autosomal dominant non-syndromic intellectual disability.
PharmGKBi PA28978.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG282132.
GeneTreei ENSGT00760000119186.
HOVERGENi HBG052638.
InParanoidi Q05586.
KOi K05208.
OMAi WNHVILL.
OrthoDBi EOG79GT5V.
PhylomeDBi Q05586.
TreeFami TF351405.

Enzyme and pathway databases

Reactomei REACT_20546. Ras activation uopn Ca2+ infux through NMDA receptor.
REACT_20594. Unblocking of NMDA receptor, glutamate binding and activation.
REACT_20642. CREB phosphorylation through the activation of CaMKII.
REACT_228085. EPHB-mediated forward signaling.
SignaLinki Q05586.

Miscellaneous databases

ChiTaRSi GRIN1. human.
EvolutionaryTracei Q05586.
GeneWikii GRIN1.
GenomeRNAii 2902.
NextBioi 11487.
PMAP-CutDB Q5VSF3.
PROi Q05586.
SOURCEi Search...

Gene expression databases

Bgeei Q05586.
CleanExi HS_GRIN1.
ExpressionAtlasi Q05586. baseline and differential.
Genevestigatori Q05586.

Family and domain databases

InterProi IPR001828. ANF_lig-bd_rcpt.
IPR018882. CaM-bd_C0_NMDA_rcpt_NR1.
IPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR028082. Peripla_BP_I.
IPR001638. SBP_bac_3.
[Graphical view ]
Pfami PF01094. ANF_receptor. 1 hit.
PF10562. CaM_bdg_C0. 1 hit.
PF00060. Lig_chan. 1 hit.
PF00497. SBP_bac_3. 1 hit.
[Graphical view ]
PRINTSi PR00177. NMDARECEPTOR.
SMARTi SM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view ]
SUPFAMi SSF53822. SSF53822. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequence analysis of cDNAs encoding human hippocampus N-methyl-D-aspartate receptor subunits: evidence for alternative RNA splicing."
    Foldes R.L., Rampersad V., Kamboj R.K.
    Gene 131:293-298(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 11-938 (ISOFORM 3), NUCLEOTIDE SEQUENCE [MRNA] OF 300-938 (ISOFORM 2).
    Tissue: Brain.
  2. "Molecular cloning and chromosomal localization of the key subunit of the human N-methyl-D-aspartate receptor."
    Karp S.J., Masu M., Eki T., Ozawa K., Nakanishi S.
    J. Biol. Chem. 268:3728-3733(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  3. "Molecular cloning, functional expression, and pharmacological characterization of an N-methyl-D-aspartate receptor subunit from human brain."
    Planells-Cases R., Sun W., Ferrer-Montiel A.V., Montal M.
    Proc. Natl. Acad. Sci. U.S.A. 90:5057-5061(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  4. "Cloning and structure of the gene encoding the human N-methyl-D-aspartate receptor (NMDAR1)."
    Zimmer M., Fink T.M., Franke Y., Lichter P., Spiess J.
    Gene 159:219-223(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Cloning and localization of exon 5-containing isoforms of the NMDAR1 subunit in human and rat brains."
    Nash N.R., Heilman C.J., Rees H.D., Levey A.I.
    J. Neurochem. 69:485-493(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 6 AND 7), VARIANTS MET-540 AND SER-682.
  6. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "Cloning and sequence analysis of additional splice variants encoding human N-methyl-D-aspartate receptor (hNR1) subunits."
    Foldes R.L., Rampersad V., Kamboj R.K.
    Gene 147:303-304(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 332-922 (ISOFORM 4), NUCLEOTIDE SEQUENCE [MRNA] OF 86-259 (ISOFORM 5).
    Tissue: Cerebellum and Hippocampus.
  8. "Inducible expression of neuronal glutamate receptor channels in the NT2 human cell line."
    Younkin D.P., Tang C.-M., Hardy M., Reddy U.R., Shi Q.-Y., Pleasure S.J., Lee V.M.-Y., Pleasure D.
    Proc. Natl. Acad. Sci. U.S.A. 90:2174-2178(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 364-464 (ISOFORMS 1/2/3).
  9. "Regulation of NMDA receptor phosphorylation by alternative splicing of the C-terminal domain."
    Tingley W.G., Roche K.W., Thompson A.K., Huganir R.L.
    Nature 364:70-73(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION BY PKC.
  10. "Appropriate NR1-NR1 disulfide-linked homodimer formation is requisite for efficient expression of functional, cell surface N-methyl-D-aspartate NR1/NR2 receptors."
    Papadakis M., Hawkins L.M., Stephenson F.A.
    J. Biol. Chem. 279:14703-14712(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERCHAIN DISULFIDE BOND.
  11. "GRINL1A colocalizes with N-methyl D-aspartate receptor NR1 subunit and reduces N-methyl D-aspartate toxicity."
    Roginski R.S., Goubaeva F., Mikami M., Fried-Cassorla E., Nair M.R., Yang J.
    NeuroReport 19:1721-1726(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MYZAP.
  12. "Structures of the M2 channel-lining segments from nicotinic acetylcholine and NMDA receptors by NMR spectroscopy."
    Opella S.J., Marassi F.M., Gesell J.J., Valente A.P., Kim Y., Oblatt-Montal M., Montal M.
    Nat. Struct. Biol. 6:374-379(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 599-621.
  13. Cited for: VARIANTS MRD8 SER-560 INS AND LYS-662, CHARACTERIZATION OF VARIANTS MRD8 SER-560 INS AND LYS-662.

Entry informationi

Entry nameiNMDZ1_HUMAN
AccessioniPrimary (citable) accession number: Q05586
Secondary accession number(s): A6NLK7
, A6NLR1, C9K0X1, P35437, Q12867, Q12868, Q5VSF3, Q5VSF4, Q5VSF5, Q5VSF6, Q5VSF7, Q5VSF8, Q9UPF8, Q9UPF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 26, 2014
This is version 177 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3