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Q05585 (MSRE_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Macrophage scavenger receptor types I and II
Alternative name(s):
Macrophage acetylated LDL receptor I and II
CD_antigen=CD204
Gene names
Name:MSR1
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length454 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL).

Subunit structure

Homotrimer.

Subcellular location

Membrane; Single-pass type II membrane protein.

Sequence similarities

Contains 1 collagen-like domain.

Contains 1 SRCR domain.

Ontologies

Keywords
   Biological processEndocytosis
   Cellular componentLDL
Membrane
   Coding sequence diversityAlternative splicing
   DomainCoiled coil
Collagen
Signal-anchor
Transmembrane
Transmembrane helix
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcollagen

Inferred from electronic annotation. Source: UniProtKB-KW

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

low-density lipoprotein particle

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionscavenger receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform I (identifier: Q05585-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform II (identifier: Q05585-2)

The sequence of this isoform differs from the canonical sequence as follows:
     348-354: TPSATVR → RPVQLTP
     355-454: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 454454Macrophage scavenger receptor types I and II
PRO_0000181629

Regions

Topological domain1 – 5050Cytoplasmic Potential
Transmembrane51 – 7323Helical; Signal-anchor for type II membrane protein; Potential
Topological domain74 – 454381Extracellular Potential
Domain273 – 34472Collagen-like
Domain353 – 453101SRCR
Region74 – 10936Spacer Probable
Coiled coil199 – 25658 Potential

Amino acid modifications

Modified residue271Phosphoserine By similarity
Modified residue291Phosphothreonine By similarity
Glycosylation821N-linked (GlcNAc...) Potential
Glycosylation1021N-linked (GlcNAc...) Potential
Glycosylation1431N-linked (GlcNAc...) Potential
Glycosylation1841N-linked (GlcNAc...) Potential
Glycosylation2211N-linked (GlcNAc...) Potential
Glycosylation2491N-linked (GlcNAc...) Potential
Glycosylation2671N-linked (GlcNAc...) Potential
Disulfide bond378 ↔ 442 By similarity
Disulfide bond391 ↔ 452 By similarity
Disulfide bond422 ↔ 432 By similarity

Natural variations

Alternative sequence348 – 3547TPSATVR → RPVQLTP in isoform II.
VSP_006233
Alternative sequence355 – 454100Missing in isoform II.
VSP_006234

Experimental info

Sequence conflict1061H → D in BAA02649. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform I [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 527A79692EA76429

FASTA45449,745
        10         20         30         40         50         60 
MAQWDSFTDQ QEDTDSCSES VKFDARSNTA LLPPNPKNGP PLQEKLKSFK AALIALYLLV 

        70         80         90        100        110        120 
FAVLIPIIAI MAAQLLKWEM KNCTVGSINA NSVSSSLLGR GNDSEHEVRF REVVMEHISK 

       130        140        150        160        170        180 
MEKRIQYISD TEENLVDSEH FQNFSVTTDQ RFADVLLQLS TLVPTVQGHG NAVDEITRSL 

       190        200        210        220        230        240 
ISLNTTLLDL HLYVETLNVK FQENTLKGQE EISKLKERVH NASAEIMSMK EEQVHLEQEI 

       250        260        270        280        290        300 
KREVKVLNNI TNDLRLKDWE HSQTLRNITL IQGPPGPPGE KGDRGPTGES GPPGVPGPVG 

       310        320        330        340        350        360 
PPGLKGDRGS IGFPGSRGYP GQSGKTGRTG YPGPKGQKGE KGSGSILTPS ATVRLVGGRG 

       370        380        390        400        410        420 
PHEGRVEILH NGQWGTVCDD HWELRAGQVV CRSLGYRGVK SVHKKAYFGQ GTGPIWLNEV 

       430        440        450 
PCLGMESSIE ECKIRQWGVR VCSHGEDAGV TCTL

« Hide

Isoform II [UniParc].

Checksum: 76CD415B33285119
Show »

FASTA35438,853

References

[1]"Rabbit aortic smooth muscle cells express inducible macrophage scavenger receptor messenger RNA that is absent from endothelial cells."
Bickel P.E., Freeman M.W.
J. Clin. Invest. 90:1450-1457(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Charged collagen structure mediates the recognition of negatively charged macromolecules by macrophage scavenger receptors."
Doi T., Wada Y., Kodama T., Higashi K.I., Kurihara Y., Miyazaki T., Nakamura H., Uesugi S., Imanishi T., Kawabe Y., Itakura H., Yazaki Y., Matsumoto A.
J. Biol. Chem. 268:2126-2133(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L11693 mRNA. Translation: AAA31402.1.
L11692 mRNA. Translation: AAA31403.1.
D13381 mRNA. Translation: BAA02649.1.
PIRA44407.
I46862.
I46863.
RefSeqNP_001075717.1. NM_001082248.1.
UniGeneOcu.1929.

3D structure databases

ProteinModelPortalQ05585.
ModBaseSearch...

Protein-protein interaction databases

STRING9986.ENSOCUP00000020109.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100009067.

Organism-specific databases

CTD4481.

Phylogenomic databases

eggNOGNOG150350.
HOGENOMHOG000085659.
HOVERGENHBG002473.
OrthoDBEOG4RJG1J.

Family and domain databases

InterProIPR008160. Collagen.
IPR003543. Macro_scav_rcpt.
IPR001190. Srcr_rcpt.
IPR017448. Srcr_rcpt-rel.
[Graphical view]
PfamPF01391. Collagen. 2 hits.
PF03523. Macscav_rec. 1 hit.
PF00530. SRCR. 1 hit.
[Graphical view]
PRINTSPR01408. MACSCAVRCPTR.
PR00258. SPERACTRCPTR.
SMARTSM00202. SR. 1 hit.
[Graphical view]
SUPFAMSSF56487. Srcr_receptor. 1 hit.
PROSITEPS00420. SRCR_1. 1 hit.
PS50287. SRCR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMSRE_RABIT
AccessionPrimary (citable) accession number: Q05585
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 3, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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