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Protein

Cytosolic iron-sulfur protein assembly protein 1

Gene

CIA1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.UniRule annotation1 Publication

Miscellaneous

Present with 5640 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • iron-sulfur cluster assembly Source: SGD
  • tRNA wobble uridine modification Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-29837-MONOMER
ReactomeiR-SCE-2564818 Cytosolic iron-sulfur cluster assembly (yeast)
R-SCE-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Cytosolic iron-sulfur protein assembly protein 1
Gene namesi
Name:CIA1UniRule annotation
Ordered Locus Names:YDR267C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR267C
SGDiS000002675 CIA1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi127R → E: Impaired in cytosolic Fe/S protein assembly. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002538061 – 330Cytosolic iron-sulfur protein assembly protein 1Add BLAST330

Proteomic databases

MaxQBiQ05583
PaxDbiQ05583
PRIDEiQ05583

Interactioni

Subunit structurei

Interacts with NAR1.UniRule annotation1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi32323, 65 interactors
DIPiDIP-1836N
IntActiQ05583, 73 interactors
MINTiQ05583
STRINGi4932.YDR267C

Structurei

Secondary structure

1330
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 11Combined sources7
Beta strandi17 – 23Combined sources7
Beta strandi26 – 34Combined sources9
Beta strandi36 – 40Combined sources5
Beta strandi42 – 44Combined sources3
Beta strandi47 – 52Combined sources6
Beta strandi61 – 66Combined sources6
Beta strandi70 – 77Combined sources8
Beta strandi82 – 86Combined sources5
Beta strandi98 – 103Combined sources6
Beta strandi110 – 115Combined sources6
Beta strandi121 – 126Combined sources6
Beta strandi131 – 135Combined sources5
Beta strandi144 – 149Combined sources6
Beta strandi156 – 161Combined sources6
Beta strandi163 – 172Combined sources10
Beta strandi177 – 183Combined sources7
Beta strandi186 – 193Combined sources8
Beta strandi200 – 205Combined sources6
Beta strandi208 – 211Combined sources4
Beta strandi213 – 218Combined sources6
Beta strandi223 – 231Combined sources9
Beta strandi237 – 244Combined sources8
Beta strandi253 – 258Combined sources6
Beta strandi264 – 268Combined sources5
Beta strandi273 – 279Combined sources7
Beta strandi282 – 290Combined sources9
Turni292 – 295Combined sources4
Beta strandi298 – 303Combined sources6
Beta strandi312 – 316Combined sources5
Beta strandi319 – 325Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HESX-ray1.70X1-330[»]
ProteinModelPortaliQ05583
SMRiQ05583
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ05583

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati12 – 53WD 1Add BLAST42
Repeati56 – 95WD 2Add BLAST40
Repeati105 – 144WD 3Add BLAST40
Repeati151 – 190WD 4Add BLAST40
Repeati195 – 236WD 5Add BLAST42
Repeati248 – 286WD 6Add BLAST39
Repeati292 – 330WD 7Add BLAST39

Sequence similaritiesi

Belongs to the WD repeat CIA1 family.UniRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

GeneTreeiENSGT00890000139406
HOGENOMiHOG000208901
InParanoidiQ05583
OMAiVWKCVCT
OrthoDBiEOG092C4BLN

Family and domain databases

Gene3Di2.130.10.10, 1 hit
HAMAPiMF_03037 ciao1, 1 hit
InterProiView protein in InterPro
IPR028608 CIAO1/Cia1
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR19920 PTHR19920, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 4 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q05583-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASINLIKSL KLYKEKIWSF DFSQGILATG STDRKIKLVS VKYDDFTLID
60 70 80 90 100
VLDETAHKKA IRSVAWRPHT SLLAAGSFDS TVSIWAKEES ADRTFEMDLL
110 120 130 140 150
AIIEGHENEV KGVAWSNDGY YLATCSRDKS VWIWETDESG EEYECISVLQ
160 170 180 190 200
EHSQDVKHVI WHPSEALLAS SSYDDTVRIW KDYDDDWECV AVLNGHEGTV
210 220 230 240 250
WSSDFDKTEG VFRLCSGSDD STVRVWKYMG DDEDDQQEWV CEAILPDVHK
260 270 280 290 300
RQVYNVAWGF NGLIASVGAD GVLAVYEEVD GEWKVFAKRA LCHGVYEINV
310 320 330
VKWLELNGKT ILATGGDDGI VNFWSLEKAA
Length:330
Mass (Da):37,275
Last modified:November 1, 1996 - v1
Checksum:iB44CCAA3125FD666
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51030 Genomic DNA Translation: AAB64456.1
BK006938 Genomic DNA Translation: DAA12111.1
PIRiS70127
RefSeqiNP_010553.3, NM_001180575.3

Genome annotation databases

EnsemblFungiiYDR267C; YDR267C; YDR267C
GeneIDi851860
KEGGisce:YDR267C

Similar proteinsi

Entry informationi

Entry nameiCIAO1_YEAST
AccessioniPrimary (citable) accession number: Q05583
Secondary accession number(s): D6VSQ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

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