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Protein

Cbb3-type cytochrome c oxidase subunit FixP

Gene

fixP

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex. FixP subunit is required for transferring electrons from donor cytochrome c via its heme groups to FixO subunit. From there, electrons are shuttled to the catalytic binuclear center of FixN subunit where oxygen reduction takes place. The complex also functions as a proton pump (By similarity).By similarity

Cofactori

heme cBy similarityNote: Binds 2 heme C groups per subunit.By similarity

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.By similarity
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei123 – 1231Heme C 1 (covalent)By similarity
Binding sitei126 – 1261Heme C 1 (covalent)By similarity
Metal bindingi127 – 1271Iron (heme C 1 axial ligand)By similarity
Metal bindingi175 – 1751Iron (heme C 2 axial ligand)By similarity
Binding sitei218 – 2181Heme C 2 (covalent)By similarity
Binding sitei221 – 2211Heme C 2 (covalent)By similarity
Metal bindingi222 – 2221Iron (heme C 2 axial ligand)By similarity
Metal bindingi263 – 2631Iron (heme C 1 axial ligand)By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Hydrogen ion transport, Ion transport, Respiratory chain, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciSMEL266834:GJF6-5670-MONOMER.
UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cbb3-type cytochrome c oxidase subunit FixPBy similarityImported
Short name:
Cbb3-Cox subunit FixPBy similarity
Alternative name(s):
C-type cytochrome FixPBy similarity
Short name:
Cyt c(FixP)By similarity
Cytochrome c oxidase subunit IIIBy similarity
Gene namesi
Name:fixPImported
Synonyms:fixP1Imported
Ordered Locus Names:RA0662
ORF Names:SMa1213
Encoded oniPlasmid pSymA (megaplasmid 1)Imported
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000001976 Componenti: Plasmid pSymA

Subcellular locationi

  • Cell inner membrane Sequence analysisBy similarity; Single-pass membrane protein Sequence analysisBy similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333CytoplasmicSequence analysisBy similarityAdd
BLAST
Transmembranei34 – 5623HelicalSequence analysisAdd
BLAST
Topological domaini57 – 289233PeriplasmicSequence analysisBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Cbb3-type cytochrome c oxidase subunit FixPPRO_0000412300Add
BLAST

Interactioni

Subunit structurei

Component of the cbb3-type cytochrome c oxidase at least composed of FixN, FixO, FixQ and FixP.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ05577.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini110 – 19889Cytochrome c 1PROSITE-ProRule annotationAdd
BLAST
Domaini205 – 28682Cytochrome c 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the CcoP / FixP family.Curated
Contains 2 cytochrome c domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000277941.
KOiK00406.
OMAiAIWLKGE.
OrthoDBiEOG6H4K86.

Family and domain databases

Gene3Di1.10.760.10. 3 hits.
InterProiIPR032858. CcoP_N.
IPR009056. Cyt_c-like_dom.
IPR008168. Cyt_C_IC.
IPR004678. Cyt_c_oxidase_cbb3_su3.
[Graphical view]
PfamiPF13442. Cytochrome_CBB3. 2 hits.
PF14715. FixP_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000006. Cbb3-Cox_fixP. 1 hit.
PRINTSiPR00605. CYTCHROMECIC.
SUPFAMiSSF46626. SSF46626. 3 hits.
TIGRFAMsiTIGR00782. ccoP. 1 hit.
PROSITEiPS51007. CYTC. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05577-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADKHKHVDE VSGVETTGHE WDGIRELNNP MPRWWVYSFY ATIIWAIGYA
60 70 80 90 100
IAYPSWPMLT EATKGMLGYS SRAEVSVELA AAKAAQAGNL EQIASSSVEE
110 120 130 140 150
IIANPQLQQF AVSAGASAFK VNCAQCHGSG AAGGQGFPNL NDDDWLWGGK
160 170 180 190 200
PQEIYQTIAH GVRHAPDGET RVSEMPPFGD MLTPELMQQT AAYVVSLTQA
210 220 230 240 250
PSQPHLVQQG KQVFADNCAS CHGADAKGNR EMGAPNLADA IWLKGEGEQA
260 270 280
VITQMKTPKH GVMPAWLPRL GDDTVKQLAV FVHSLGGGE
Length:289
Mass (Da):31,097
Last modified:November 1, 1996 - v1
Checksum:i46442B50508B4A9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21854 Genomic DNA. Translation: CAA79904.1.
AE006469 Genomic DNA. Translation: AAK65320.1.
PIRiF95344.
S39991.
RefSeqiNP_435908.1. NC_003037.1.
WP_010967641.1. NC_003037.1.

Genome annotation databases

EnsemblBacteriaiAAK65320; AAK65320; SMa1213.
GeneIDi1235698.
KEGGisme:SMa1213.
PATRICi23627806. VBISinMel96828_0682.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21854 Genomic DNA. Translation: CAA79904.1.
AE006469 Genomic DNA. Translation: AAK65320.1.
PIRiF95344.
S39991.
RefSeqiNP_435908.1. NC_003037.1.
WP_010967641.1. NC_003037.1.

3D structure databases

ProteinModelPortaliQ05577.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK65320; AAK65320; SMa1213.
GeneIDi1235698.
KEGGisme:SMa1213.
PATRICi23627806. VBISinMel96828_0682.

Phylogenomic databases

HOGENOMiHOG000277941.
KOiK00406.
OMAiAIWLKGE.
OrthoDBiEOG6H4K86.

Enzyme and pathway databases

UniPathwayiUPA00705.
BioCyciSMEL266834:GJF6-5670-MONOMER.

Family and domain databases

Gene3Di1.10.760.10. 3 hits.
InterProiIPR032858. CcoP_N.
IPR009056. Cyt_c-like_dom.
IPR008168. Cyt_C_IC.
IPR004678. Cyt_c_oxidase_cbb3_su3.
[Graphical view]
PfamiPF13442. Cytochrome_CBB3. 2 hits.
PF14715. FixP_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000006. Cbb3-Cox_fixP. 1 hit.
PRINTSiPR00605. CYTCHROMECIC.
SUPFAMiSSF46626. SSF46626. 3 hits.
TIGRFAMsiTIGR00782. ccoP. 1 hit.
PROSITEiPS51007. CYTC. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Negative autoregulation of the Rhizobium meliloti fixK gene is indirect and requires a newly identified regulator, FixT."
    Foussard M., Garnerone A.-M., Ni F., Soupene E., Boistard P., Batut J.
    Mol. Microbiol. 25:27-37(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: RCR2011 / SU47Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021Imported.
    Plasmid: pSymA (megaplasmid 1)
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.

Entry informationi

Entry nameiFIXP_RHIME
AccessioniPrimary (citable) accession number: Q05577
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: November 1, 1996
Last modified: January 20, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.