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Q05572

- FIXN_RHIME

UniProt

Q05572 - FIXN_RHIME

Protein

Cytochrome c oxidase subunit 1 homolog, bacteroid

Gene

fixN

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Co I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c or a quinol are transferred to the bimetallic center formed by a high-spin heme and copper B.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi117 – 1171Iron (heme B axial ligand)Curated
    Metal bindingi266 – 2661Copper BCurated
    Metal bindingi316 – 3161Copper BCurated
    Metal bindingi317 – 3171Copper BCurated
    Metal bindingi404 – 4041Iron (high-spin heme B axial ligand)Curated
    Metal bindingi406 – 4061Iron (heme B axial ligand)Curated

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciSMEL266834:GJF6-5673-MONOMER.
    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1 homolog, bacteroid (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome CBB3 subunit 1
    Cytochrome c oxidase polypeptide I homolog
    Heme B/copper cytochrome c oxidase subunit
    Gene namesi
    Name:fixN
    Ordered Locus Names:RA0665
    ORF Names:SMa1220
    Encoded oniPlasmid pSymA (megaplasmid 1)0 Publication
    OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
    Taxonomic identifieri266834 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
    ProteomesiUP000001976: Plasmid pSymA

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane respiratory chain complex IV Source: InterPro

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 539539Cytochrome c oxidase subunit 1 homolog, bacteroidPRO_0000183470Add
    BLAST

    Expressioni

    Developmental stagei

    Bacteroid (nitrogen-fixing endosymbiont).

    Inductioni

    By low oxygen levels.

    Interactioni

    Protein-protein interaction databases

    STRINGi266834.SMa1220.

    Structurei

    3D structure databases

    ProteinModelPortaliQ05572.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei4 – 2421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei28 – 4821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei75 – 9521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei118 – 13821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei154 – 17421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei187 – 20721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei214 – 23421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei265 – 28521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei298 – 31821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei330 – 35021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei368 – 38821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei405 – 42521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei443 – 46321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei475 – 49521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei499 – 51921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG3278.
    HOGENOMiHOG000277908.
    KOiK00404.
    OMAiEYGIFGR.
    OrthoDBiEOG6G7QZX.

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    IPR004677. Cyt_c_oxidase_cbb3_su1.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    SUPFAMiSSF81442. SSF81442. 1 hit.
    TIGRFAMsiTIGR00780. ccoN. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q05572-1 [UniParc]FASTAAdd to Basket

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    MKHTVEMVVL SVGAFLALVG AGLAQDRLFG AHMWVLFFAL LAGTLVLMRR    50
    VDFRPAVAGH PGRRREYFDE VVKYGVVATV FWGVVGFLVG VVVALQLAFP 100
    ELNVEPWFNF GRVRPLHTSA VIFAFGGNAL IATSFYVVQR TSRARLFGGD 150
    LGWFVFWGYQ LFIVLAASGY LLGITQSREY AEPEWYVDLW LTIVWVAYLV 200
    AFLGTIMKRK EPHIYVANWF YLAFIVTIAM LHVVNNLAVP VSFLGSKSYS 250
    AFSGVQDALT QWWYGHNAVG FFLTAGFLAM MYYFIPKQVN RPVYSYRLSI 300
    IHFWAIIFMY IWAGPHHLHY TALPDWAQTL GMVFSIMLWM PSWGGMINGL 350
    MTLSGAWDKI RTDPVVRMMV MAVAFYGMAT FEGPMMSIKT VNSLSHYTDW 400
    TIGHVHSGAL GWNGLITFGA IYYLVPKLWN RERLYSVRMV NWHFWLATLG 450
    IVVYAAVMWV AGIQQGLMWR EYDDQGFLVY SFAETVAAMF PYYVMRAAGG 500
    ALFLAGALLM AFNVTMTILG RVRDEEPIFG AAPLPAPAE 539
    Length:539
    Mass (Da):60,869
    Last modified:February 1, 1996 - v1
    Checksum:i6471FBF102719076
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z21854 Genomic DNA. Translation: CAA79901.1.
    AE006469 Genomic DNA. Translation: AAK65323.1.
    PIRiA95345.
    S39988.
    RefSeqiNP_435911.1. NC_003037.1.
    WP_010967644.1. NC_003037.1.

    Genome annotation databases

    EnsemblBacteriaiAAK65323; AAK65323; SMa1220.
    GeneIDi1235701.
    KEGGisme:SMa1220.
    PATRICi23627812. VBISinMel96828_0685.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z21854 Genomic DNA. Translation: CAA79901.1 .
    AE006469 Genomic DNA. Translation: AAK65323.1 .
    PIRi A95345.
    S39988.
    RefSeqi NP_435911.1. NC_003037.1.
    WP_010967644.1. NC_003037.1.

    3D structure databases

    ProteinModelPortali Q05572.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266834.SMa1220.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK65323 ; AAK65323 ; SMa1220 .
    GeneIDi 1235701.
    KEGGi sme:SMa1220.
    PATRICi 23627812. VBISinMel96828_0685.

    Phylogenomic databases

    eggNOGi COG3278.
    HOGENOMi HOG000277908.
    KOi K00404.
    OMAi EYGIFGR.
    OrthoDBi EOG6G7QZX.

    Enzyme and pathway databases

    UniPathwayi UPA00705 .
    BioCyci SMEL266834:GJF6-5673-MONOMER.

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    IPR004677. Cyt_c_oxidase_cbb3_su1.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81442. SSF81442. 1 hit.
    TIGRFAMsi TIGR00780. ccoN. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Kahn D., Daveran-Mingot M.-L.
      Submitted (MAR-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: RCR2011 / SU47.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1021.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1021.

    Entry informationi

    Entry nameiFIXN_RHIME
    AccessioniPrimary (citable) accession number: Q05572
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    This cytochrome oxidase is probably a cbb3-type.

    Keywords - Technical termi

    Complete proteome, Plasmid, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3