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Q05572

- FIXN_RHIME

UniProt

Q05572 - FIXN_RHIME

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Protein

Cytochrome c oxidase subunit 1 homolog, bacteroid

Gene

fixN

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Co I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c or a quinol are transferred to the bimetallic center formed by a high-spin heme and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi117 – 1171Iron (heme B axial ligand)Curated
Metal bindingi266 – 2661Copper BCurated
Metal bindingi316 – 3161Copper BCurated
Metal bindingi317 – 3171Copper BCurated
Metal bindingi404 – 4041Iron (high-spin heme B axial ligand)Curated
Metal bindingi406 – 4061Iron (heme B axial ligand)Curated

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciSMEL266834:GJF6-5673-MONOMER.
UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 homolog, bacteroid (EC:1.9.3.1)
Alternative name(s):
Cytochrome CBB3 subunit 1
Cytochrome c oxidase polypeptide I homolog
Heme B/copper cytochrome c oxidase subunit
Gene namesi
Name:fixN
Ordered Locus Names:RA0665
ORF Names:SMa1220
Encoded oniPlasmid pSymA (megaplasmid 1)0 Publication
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001976: Plasmid pSymA

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane respiratory chain complex IV Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 539539Cytochrome c oxidase subunit 1 homolog, bacteroidPRO_0000183470Add
BLAST

Expressioni

Developmental stagei

Bacteroid (nitrogen-fixing endosymbiont).

Inductioni

By low oxygen levels.

Interactioni

Protein-protein interaction databases

STRINGi266834.SMa1220.

Structurei

3D structure databases

ProteinModelPortaliQ05572.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4 – 2421HelicalSequence AnalysisAdd
BLAST
Transmembranei28 – 4821HelicalSequence AnalysisAdd
BLAST
Transmembranei75 – 9521HelicalSequence AnalysisAdd
BLAST
Transmembranei118 – 13821HelicalSequence AnalysisAdd
BLAST
Transmembranei154 – 17421HelicalSequence AnalysisAdd
BLAST
Transmembranei187 – 20721HelicalSequence AnalysisAdd
BLAST
Transmembranei214 – 23421HelicalSequence AnalysisAdd
BLAST
Transmembranei265 – 28521HelicalSequence AnalysisAdd
BLAST
Transmembranei298 – 31821HelicalSequence AnalysisAdd
BLAST
Transmembranei330 – 35021HelicalSequence AnalysisAdd
BLAST
Transmembranei368 – 38821HelicalSequence AnalysisAdd
BLAST
Transmembranei405 – 42521HelicalSequence AnalysisAdd
BLAST
Transmembranei443 – 46321HelicalSequence AnalysisAdd
BLAST
Transmembranei475 – 49521HelicalSequence AnalysisAdd
BLAST
Transmembranei499 – 51921HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG3278.
HOGENOMiHOG000277908.
KOiK00404.
OMAiEYGIFGR.
OrthoDBiEOG6G7QZX.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR004677. Cyt_c_oxidase_cbb3_su1.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR00780. ccoN. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05572 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKHTVEMVVL SVGAFLALVG AGLAQDRLFG AHMWVLFFAL LAGTLVLMRR
60 70 80 90 100
VDFRPAVAGH PGRRREYFDE VVKYGVVATV FWGVVGFLVG VVVALQLAFP
110 120 130 140 150
ELNVEPWFNF GRVRPLHTSA VIFAFGGNAL IATSFYVVQR TSRARLFGGD
160 170 180 190 200
LGWFVFWGYQ LFIVLAASGY LLGITQSREY AEPEWYVDLW LTIVWVAYLV
210 220 230 240 250
AFLGTIMKRK EPHIYVANWF YLAFIVTIAM LHVVNNLAVP VSFLGSKSYS
260 270 280 290 300
AFSGVQDALT QWWYGHNAVG FFLTAGFLAM MYYFIPKQVN RPVYSYRLSI
310 320 330 340 350
IHFWAIIFMY IWAGPHHLHY TALPDWAQTL GMVFSIMLWM PSWGGMINGL
360 370 380 390 400
MTLSGAWDKI RTDPVVRMMV MAVAFYGMAT FEGPMMSIKT VNSLSHYTDW
410 420 430 440 450
TIGHVHSGAL GWNGLITFGA IYYLVPKLWN RERLYSVRMV NWHFWLATLG
460 470 480 490 500
IVVYAAVMWV AGIQQGLMWR EYDDQGFLVY SFAETVAAMF PYYVMRAAGG
510 520 530
ALFLAGALLM AFNVTMTILG RVRDEEPIFG AAPLPAPAE
Length:539
Mass (Da):60,869
Last modified:February 1, 1996 - v1
Checksum:i6471FBF102719076
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z21854 Genomic DNA. Translation: CAA79901.1.
AE006469 Genomic DNA. Translation: AAK65323.1.
PIRiA95345.
S39988.
RefSeqiNP_435911.1. NC_003037.1.
WP_010967644.1. NC_003037.1.

Genome annotation databases

EnsemblBacteriaiAAK65323; AAK65323; SMa1220.
GeneIDi1235701.
KEGGisme:SMa1220.
PATRICi23627812. VBISinMel96828_0685.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z21854 Genomic DNA. Translation: CAA79901.1 .
AE006469 Genomic DNA. Translation: AAK65323.1 .
PIRi A95345.
S39988.
RefSeqi NP_435911.1. NC_003037.1.
WP_010967644.1. NC_003037.1.

3D structure databases

ProteinModelPortali Q05572.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266834.SMa1220.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK65323 ; AAK65323 ; SMa1220 .
GeneIDi 1235701.
KEGGi sme:SMa1220.
PATRICi 23627812. VBISinMel96828_0685.

Phylogenomic databases

eggNOGi COG3278.
HOGENOMi HOG000277908.
KOi K00404.
OMAi EYGIFGR.
OrthoDBi EOG6G7QZX.

Enzyme and pathway databases

UniPathwayi UPA00705 .
BioCyci SMEL266834:GJF6-5673-MONOMER.

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR004677. Cyt_c_oxidase_cbb3_su1.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
SUPFAMi SSF81442. SSF81442. 1 hit.
TIGRFAMsi TIGR00780. ccoN. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Kahn D., Daveran-Mingot M.-L.
    Submitted (MAR-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: RCR2011 / SU47.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.

Entry informationi

Entry nameiFIXN_RHIME
AccessioniPrimary (citable) accession number: Q05572
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 1, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

This cytochrome oxidase is probably a cbb3-type.

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3