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Protein

Peroxisome biogenesis factor 10

Gene

PEX10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Somewhat implicated in the biogenesis of peroxisomes.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri286 – 32742RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • ubiquitin-protein transferase activity Source: SGD
  • zinc ion binding Source: InterPro

GO - Biological processi

  • protein import into peroxisome matrix Source: SGD
  • protein polyubiquitination Source: SGD
  • protein ubiquitination Source: SGD
Complete GO annotation...

Keywords - Biological processi

Peroxisome biogenesis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-29835-MONOMER.

Protein family/group databases

TCDBi3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome biogenesis factor 10
Alternative name(s):
Peroxin-10
Peroxisomal biogenesis factor 10
Peroxisome assembly protein 10
Gene namesi
Name:PEX10
Synonyms:PAS4
Ordered Locus Names:YDR265W
ORF Names:D9954.8
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR265W.
SGDiS000002673. PEX10.

Subcellular locationi

GO - Cellular componenti

  • integral component of peroxisomal membrane Source: InterPro
  • peroxisomal importomer complex Source: SGD
  • peroxisomal membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337Peroxisome biogenesis factor 10PRO_0000056381Add
BLAST

Proteomic databases

MaxQBiQ05568.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PEX12Q0437012EBI-13194,EBI-2077297
PEX13P806677EBI-13194,EBI-13206
PEX2P3280014EBI-13194,EBI-13160

Protein-protein interaction databases

BioGridi32321. 66 interactions.
DIPiDIP-7566N.
IntActiQ05568. 16 interactions.
MINTiMINT-737331.

Structurei

3D structure databases

ProteinModelPortaliQ05568.
SMRiQ05568. Positions 260-335.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pex2/pex10/pex12 family.Curated
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri286 – 32742RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00510000048446.
HOGENOMiHOG000180194.
InParanoidiQ05568.
KOiK13346.
OMAiIYLRHYR.
OrthoDBiEOG092C0ORB.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR025654. PEX10.
IPR006845. Pex_N.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PANTHERiPTHR23350. PTHR23350. 1 hit.
PfamiPF04757. Pex2_Pex12. 1 hit.
PF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05568-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNDNKLQKE ALMRLSQLRF PFADAPSIVQ AHQKDEQIQG LLIMKVTELC
60 70 80 90 100
KLIKSQLFVN SYPKELSIFA KLLYLLFTTG RRGRTLGEEY VDLTYTNRKG
110 120 130 140 150
TRLAGRLKMI VFAFAYPLCP YFITKLYKKI MKNNKESKIE DTESVAAFCK
160 170 180 190 200
GLLDFILDVH MTLFYFKGAF YSISKRIFGM RYVFKHILSK NEANFREEGS
210 220 230 240 250
QKYKVLGYIL LAQNVMKWYP VLTSTLGSWI YGRKRTNDSI TRSSVGLQER
260 270 280 290 300
SEHESIEGIP KESQLTHINL SDKNQLPFIP EASRKCILCL MNMSDPSCAP
310 320 330
CGHLFCWSCL MSWCKERPEC PLCRQHCQPQ EILVLRQ
Length:337
Mass (Da):39,099
Last modified:November 1, 1996 - v1
Checksum:i9AF308A8AB2A0E28
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti183 – 1831V → A in AAS56114 (PubMed:17322287).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51030 Genomic DNA. Translation: AAB64453.1.
AY557788 Genomic DNA. Translation: AAS56114.1.
BK006938 Genomic DNA. Translation: DAA12109.1.
PIRiS70125.
RefSeqiNP_010551.1. NM_001180573.1.

Genome annotation databases

EnsemblFungiiYDR265W; YDR265W; YDR265W.
GeneIDi851858.
KEGGisce:YDR265W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51030 Genomic DNA. Translation: AAB64453.1.
AY557788 Genomic DNA. Translation: AAS56114.1.
BK006938 Genomic DNA. Translation: DAA12109.1.
PIRiS70125.
RefSeqiNP_010551.1. NM_001180573.1.

3D structure databases

ProteinModelPortaliQ05568.
SMRiQ05568. Positions 260-335.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32321. 66 interactions.
DIPiDIP-7566N.
IntActiQ05568. 16 interactions.
MINTiMINT-737331.

Protein family/group databases

TCDBi3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Proteomic databases

MaxQBiQ05568.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR265W; YDR265W; YDR265W.
GeneIDi851858.
KEGGisce:YDR265W.

Organism-specific databases

EuPathDBiFungiDB:YDR265W.
SGDiS000002673. PEX10.

Phylogenomic databases

GeneTreeiENSGT00510000048446.
HOGENOMiHOG000180194.
InParanoidiQ05568.
KOiK13346.
OMAiIYLRHYR.
OrthoDBiEOG092C0ORB.

Enzyme and pathway databases

BioCyciYEAST:G3O-29835-MONOMER.

Miscellaneous databases

PROiQ05568.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR025654. PEX10.
IPR006845. Pex_N.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PANTHERiPTHR23350. PTHR23350. 1 hit.
PfamiPF04757. Pex2_Pex12. 1 hit.
PF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPEX10_YEAST
AccessioniPrimary (citable) accession number: Q05568
Secondary accession number(s): D6VSP9, E9P8T2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.