SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q05556

- CP2AB_RABIT

UniProt

Q05556 - CP2AB_RABIT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Cytochrome P450 2A11
Gene
CYP2A11
Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the oxygenation of a variety of substrates, including ethanol and procarcinogens such as N-nitrosodiethylamine and phenacetin. Has no or little activity as a coumarin 7-hydroxylase and in the formation of androstenedione from testosterone.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi439 – 4391Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2A11 (EC:1.14.14.1)
Alternative name(s):
CYPIIA11
Cytochrome P450-IIA11
Gene namesi
Name:CYP2A11
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi62 – 632RD → SE: No effect. Almost as active as CYP2A10 in coumarin hydroxylation and approximately half as active as CYP2A10 in androstenedione formation; when associated with L-104; V-117 and S-120.
Mutagenesisi104 – 1041Q → L: No effect. Almost as active as CYP2A10 in coumarin hydroxylation and approximately half as active as CYP2A10 in androstenedione formation; when associated with 62-SE-63; V-117 and S-120. 1 Publication
Mutagenesisi117 – 1171A → V: No effect. Almost as active as CYP2A10 in coumarin hydroxylation and approximately half as active as CYP2A10 in androstenedione formation; when associated with 62-SE-63; L-104 and S-120. 1 Publication
Mutagenesisi120 – 1201T → S: No effect. Almost as active as CYP2A10 in coumarin hydroxylation and approximately half as active as CYP2A10 in androstenedione formation; when associated with 62-SE-63; L-104 and V-117. 1 Publication
Mutagenesisi372 – 3721R → H: Significant increase in the rate of hydroxylation of testosterone, but not of coumarin. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 494494Cytochrome P450 2A11
PRO_0000051674Add
BLAST

Expressioni

Tissue specificityi

Expressed in liver and lung as well as in nasal tissues.

Structurei

3D structure databases

ProteinModelPortaliQ05556.
SMRiQ05556. Positions 31-494.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

HOVERGENiHBG015789.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008067. Cyt_P450_E_grp-I_CYP2A-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01684. EP450ICYP2A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05556-1 [UniParc]FASTAAdd to Basket

« Hide

MLASGLLLAA LLACLTVMIL LSVWRQRKLW GKLPPGPTPL PFIGNYLQLN    50
TEQMYDSLMK IRDRYGPVFT IHLGPRRIVV LCGQEAVKEA LVDQAEDFSG 100
RGEQATFDWL FKGYGVAFST WERARPLRRF AISTLRDFGV GKRGIEERIQ 150
EEAGFLIEAF RDTRGAFIDP TFFLSRTVSN VISSIVFGDR FDYEDKEFLS 200
LLRMMLGSFQ FTATPTGQLY EMFYSVMKHL PGPQQQAFKE LEGLRDFIAK 250
KVERNQRTLD PNSPRDFIDS FLIRMQEEKK DPKSEFHMKN LVLTTLNLFF 300
AGTETVSTTM RYGFLLLMKH PDVEAKVHEE IDRVIGRNRQ PKFEDRAKMP 350
YTEAVIHEIQ RFTDMIPMGL ARRVTRDTKF RDFLLPKGTE VFPMLGSVLK 400
DPKFFSKPRE FYPQHFLDEK GQFKKSDAFM PFSVGKRYCL GEGLARMELF 450
LFFTTIMQNF RFRSQQAPQD IDVSPKHVGF ATIPRTYTMS FVPR 494
Length:494
Mass (Da):57,277
Last modified:June 1, 1994 - v1
Checksum:i28D2E5C4E5D0861A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L10237 mRNA. Translation: AAA31372.1.
PIRiB47494.
RefSeqiNP_001164519.1. NM_001171048.1.
UniGeneiOcu.1915.

Genome annotation databases

GeneIDi100328596.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L10237 mRNA. Translation: AAA31372.1 .
PIRi B47494.
RefSeqi NP_001164519.1. NM_001171048.1.
UniGenei Ocu.1915.

3D structure databases

ProteinModelPortali Q05556.
SMRi Q05556. Positions 31-494.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100328596.

Organism-specific databases

CTDi 100328596.

Phylogenomic databases

HOVERGENi HBG015789.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008067. Cyt_P450_E_grp-I_CYP2A-like.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01684. EP450ICYP2A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and heterologous expression of cloned cDNAs for two rabbit nasal microsomal proteins, CYP2A10 and CYP2A11, that are related to nasal microsomal cytochrome P450 form a."
    Peng H.-M., Ding X., Coon M.J.
    J. Biol. Chem. 268:17253-17260(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: New Zealand white.
    Tissue: Nasal mucosa.
  2. "Structure-function analysis of CYP2A10 and CYP2A11, P450 cytochromes that differ in only eight amino acids but have strikingly different activities toward testosterone and coumarin."
    Ding X., Peng H.-M., Coon M.J.
    Biochem. Biophys. Res. Commun. 203:373-378(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, MUTAGENESIS OF 62-ARG-ASP-63; GLN-104; ALA-117; THR-120 AND ARG-372.

Entry informationi

Entry nameiCP2AB_RABIT
AccessioniPrimary (citable) accession number: Q05556
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: December 11, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi