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Q05555

- CP2AA_RABIT

UniProt

Q05555 - CP2AA_RABIT

Protein

Cytochrome P450 2A10

Gene

CYP2A10

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Catalyzes the oxygenation of a variety of substrates, including ethanol and procarcinogens such as N-nitrosodiethylamine and phenacetin. Exhibits a high coumarin 7-hydroxylase activity. Converts also testosterone to androstenedione.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi439 – 4391Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2A10 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIA10
    Cytochrome P450-IIA10
    Gene namesi
    Name:CYP2A10
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 494494Cytochrome P450 2A10PRO_0000051673Add
    BLAST

    Expressioni

    Tissue specificityi

    Expressed in liver and lung as well as in nasal tissues.

    Interactioni

    Protein-protein interaction databases

    STRINGi9986.ENSOCUP00000005874.

    Structurei

    3D structure databases

    ProteinModelPortaliQ05555.
    SMRiQ05555. Positions 31-494.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000036992.
    HOVERGENiHBG015789.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008067. Cyt_P450_E_grp-I_CYP2A-like.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01684. EP450ICYP2A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q05555-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLASGLLLAA LLACLTVMIL LSVWRQRKLW GKLPPGPTPL PFIGNYLQLN    50
    TEQMYDSLMK ISERYGPVFT IHLGPRRIVV LCGQEAVKEA LVDQAEDFSG 100
    RGELATFDWL FKGYGVVFSS WERARPLRRF AISTLRDFGV GKRGIEERIQ 150
    EEAGFLIEAF RDTRGAFIDP TFFLSRTVSN VISSIVFGDR FDYEDKEFLS 200
    LLRMMLGSFQ FTATPTGQLY EMFYSVMKHL PGPQQQAFKE LEGLRDFIAK 250
    KVERNQRTLD PNSPRDFIDS FLIRMQEEKK DPKSEFHMKN LVMTTLNLFF 300
    AGTETVSTTM RYGFLLLMKH PDVEAKVHEE IDRVIGRNRQ PKFEDRAKMP 350
    YTEAVIHEIQ RFTDMIPMGL AHRVTRDTKF RDFLLPKGAE VFPMLGSVLK 400
    DPKFFSKPRE FYPQHFLDEK GQFKKSDAFM PFSVGKRYCL GEGLARMELF 450
    LFFTTIMQNF RFRSQQAPQD IDVSPKHVGF ATIPRTYTMS FVPR 494
    Length:494
    Mass (Da):57,190
    Last modified:June 1, 1994 - v1
    Checksum:i82A58B6A064BDAD3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L10236 mRNA. Translation: AAA31371.1.
    PIRiA47494.
    RefSeqiNP_001164520.1. NM_001171049.1.
    UniGeneiOcu.7476.

    Genome annotation databases

    GeneIDi100328598.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L10236 mRNA. Translation: AAA31371.1 .
    PIRi A47494.
    RefSeqi NP_001164520.1. NM_001171049.1.
    UniGenei Ocu.7476.

    3D structure databases

    ProteinModelPortali Q05555.
    SMRi Q05555. Positions 31-494.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9986.ENSOCUP00000005874.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100328598.

    Organism-specific databases

    CTDi 100328598.

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000036992.
    HOVERGENi HBG015789.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008067. Cyt_P450_E_grp-I_CYP2A-like.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01684. EP450ICYP2A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and heterologous expression of cloned cDNAs for two rabbit nasal microsomal proteins, CYP2A10 and CYP2A11, that are related to nasal microsomal cytochrome P450 form a."
      Peng H.-M., Ding X., Coon M.J.
      J. Biol. Chem. 268:17253-17260(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: New Zealand white.
      Tissue: Nasal mucosa.
    2. "Structure-function analysis of CYP2A10 and CYP2A11, P450 cytochromes that differ in only eight amino acids but have strikingly different activities toward testosterone and coumarin."
      Ding X., Peng H.-M., Coon M.J.
      Biochem. Biophys. Res. Commun. 203:373-378(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.

    Entry informationi

    Entry nameiCP2AA_RABIT
    AccessioniPrimary (citable) accession number: Q05555
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3