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Protein

Cytochrome P450 2A10

Gene

CYP2A10

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the oxygenation of a variety of substrates, including ethanol and procarcinogens such as N-nitrosodiethylamine and phenacetin. Exhibits a high coumarin 7-hydroxylase activity. Converts also testosterone to androstenedione.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi439Iron (heme axial ligand)By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2A10 (EC:1.14.14.1)
Alternative name(s):
CYPIIA10
Cytochrome P450-IIA10
Gene namesi
Name:CYP2A10
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000516731 – 494Cytochrome P450 2A10Add BLAST494

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei379N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Expressioni

Tissue specificityi

Expressed in liver and lung as well as in nasal tissues.

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000005874.

Structurei

3D structure databases

ProteinModelPortaliQ05555.
SMRiQ05555.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiQ05555.
KOiK17685.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiView protein in InterPro
IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008067. Cyt_P450_E_grp-I_CYP2A-like.
IPR036396. Cyt_P450_sf.
PfamiView protein in Pfam
PF00067. p450. 1 hit.
PRINTSiPR00463. EP450I.
PR01684. EP450ICYP2A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiView protein in PROSITE
PS00086. CYTOCHROME_P450. 1 hit.

Sequencei

Sequence statusi: Complete.

Q05555-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLASGLLLAA LLACLTVMIL LSVWRQRKLW GKLPPGPTPL PFIGNYLQLN
60 70 80 90 100
TEQMYDSLMK ISERYGPVFT IHLGPRRIVV LCGQEAVKEA LVDQAEDFSG
110 120 130 140 150
RGELATFDWL FKGYGVVFSS WERARPLRRF AISTLRDFGV GKRGIEERIQ
160 170 180 190 200
EEAGFLIEAF RDTRGAFIDP TFFLSRTVSN VISSIVFGDR FDYEDKEFLS
210 220 230 240 250
LLRMMLGSFQ FTATPTGQLY EMFYSVMKHL PGPQQQAFKE LEGLRDFIAK
260 270 280 290 300
KVERNQRTLD PNSPRDFIDS FLIRMQEEKK DPKSEFHMKN LVMTTLNLFF
310 320 330 340 350
AGTETVSTTM RYGFLLLMKH PDVEAKVHEE IDRVIGRNRQ PKFEDRAKMP
360 370 380 390 400
YTEAVIHEIQ RFTDMIPMGL AHRVTRDTKF RDFLLPKGAE VFPMLGSVLK
410 420 430 440 450
DPKFFSKPRE FYPQHFLDEK GQFKKSDAFM PFSVGKRYCL GEGLARMELF
460 470 480 490
LFFTTIMQNF RFRSQQAPQD IDVSPKHVGF ATIPRTYTMS FVPR
Length:494
Mass (Da):57,190
Last modified:June 1, 1994 - v1
Checksum:i82A58B6A064BDAD3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10236 mRNA. Translation: AAA31371.1.
PIRiA47494.
RefSeqiNP_001164520.1. NM_001171049.1.
UniGeneiOcu.1915.
Ocu.7476.

Genome annotation databases

GeneIDi100328598.
KEGGiocu:100328598.

Similar proteinsi

Entry informationi

Entry nameiCP2AA_RABIT
AccessioniPrimary (citable) accession number: Q05555
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 25, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families