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Q05547 (PP13_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase alpha-3 isoform

EC=3.1.3.16
Gene names
Name:Pp1-13C
ORF Names:CG9156
OrganismDrosophila melanogaster (Fruit fly) [Reference proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length302 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 1 iron ion per subunit By similarity.

Binds 1 manganese ion per subunit By similarity.

Subunit structure

Interacts with Nop17l. Ref.5

Sequence similarities

Belongs to the PPP phosphatase family. PP-1 subfamily.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Nop17lQ0E9G32EBI-157144,EBI-150380

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 302302Serine/threonine-protein phosphatase alpha-3 isoform
PRO_0000058793

Sites

Active site1231Proton donor By similarity
Metal binding621Iron By similarity
Metal binding641Iron By similarity
Metal binding901Iron By similarity
Metal binding901Manganese By similarity
Metal binding1221Manganese By similarity
Metal binding1711Manganese By similarity
Metal binding2461Manganese By similarity

Sequences

Sequence LengthMass (Da)Tools
Q05547 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: B01ACC651F5DAE14

FASTA30234,558
        10         20         30         40         50         60 
MAEVLNLESI ISRLLEVRGA RPGKNVQLSE GEIRGLCLKS REILLAQPIL LELEAPLKIC 

        70         80         90        100        110        120 
GDIHGQYYDL LRLFEYGGYP PEANYLFLGD YVDRGKQSLE TICLLLAYKI KYSENFFLLR 

       130        140        150        160        170        180 
GNHECASINR IYGFYDECKR RYTIKLWKTF TDCFNCLPVV AIVDEKIFCC HGGLSPDLTS 

       190        200        210        220        230        240 
MEQIRRIMRP TDVPDQGLLC DLLWSDPDKD TIGWGENDRG VSFTFGAEVV VKFLQKHDLD 

       250        260        270        280        290        300 
LICRAHQVVE DGYEFFAKRQ LVTLFSAPNY CGEFDNAGAM MSVDNTLMCS FQILKPVEKR 


KK 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of the fourth functional gene for protein phosphatase 1 in Drosophila melanogaster from its chromosomal location."
Dombradi V., Mann D.J., Saunders R.D., Cohen P.T.W.
Eur. J. Biochem. 212:177-183(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Oregon-R.
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[4]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Head.
[5]"Towards a comprehensive analysis of the protein phosphatase 1 interactome in Drosophila."
Bennett D., Lyulcheva E., Alphey L.
J. Mol. Biol. 364:196-212(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH NOP17L.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X69974 Genomic DNA. Translation: CAA49594.1.
AE014298 Genomic DNA. Translation: AAF48448.1.
AY060272 mRNA. Translation: AAL25311.1.
PIRS29396.
RefSeqNP_524921.1. NM_080182.3.
UniGeneDm.1527.

3D structure databases

ProteinModelPortalQ05547.
SMRQ05547. Positions 5-296.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid71473. 7 interactions.
DIPDIP-23332N.
IntActQ05547. 25 interactions.
MINTMINT-873916.
STRING7227.FBpp0073834.

Proteomic databases

PaxDbQ05547.
PRIDEQ05547.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0074017; FBpp0073834; FBgn0003132.
GeneID48531.
KEGGdme:Dmel_CG9156.

Organism-specific databases

CTD48531.
FlyBaseFBgn0003132. Pp1-13C.

Phylogenomic databases

eggNOGCOG0639.
GeneTreeENSGT00530000062911.
InParanoidQ05547.
KOK06269.
OMAKDASKMG.
OrthoDBEOG7TJ3K3.
PhylomeDBQ05547.

Enzyme and pathway databases

SignaLinkQ05547.

Gene expression databases

BgeeQ05547.

Family and domain databases

InterProIPR004843. Calcineurin-like_PHP_apaH.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSPR00114. STPHPHTASE.
SMARTSM00156. PP2Ac. 1 hit.
[Graphical view]
PROSITEPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi48531.
NextBio839441.

Entry information

Entry namePP13_DROME
AccessionPrimary (citable) accession number: Q05547
Secondary accession number(s): Q9VXW0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase