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Q05547

- PP13_DROME

UniProt

Q05547 - PP13_DROME

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Protein
Serine/threonine-protein phosphatase alpha-3 isoform
Gene
Pp1-13C, CG9156
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi62 – 621Manganese 1 By similarity
Metal bindingi64 – 641Manganese 1 By similarity
Metal bindingi90 – 901Manganese 1 By similarity
Metal bindingi90 – 901Manganese 2 By similarity
Metal bindingi122 – 1221Manganese 2 By similarity
Active sitei123 – 1231Proton donor By similarity
Metal bindingi171 – 1711Manganese 2 By similarity
Metal bindingi246 – 2461Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein binding Source: IntAct
  3. protein serine/threonine phosphatase activity Source: FlyBase
Complete GO annotation...

GO - Biological processi

  1. neurogenesis Source: FlyBase
  2. protein dephosphorylation Source: FlyBase
  3. sperm competition Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

SignaLinkiQ05547.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase alpha-3 isoform (EC:3.1.3.16)
Gene namesi
Name:Pp1-13C
ORF Names:CG9156
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome X

Organism-specific databases

FlyBaseiFBgn0003132. Pp1-13C.

Subcellular locationi

GO - Cellular componenti

  1. protein phosphatase type 1 complex Source: FlyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 302302Serine/threonine-protein phosphatase alpha-3 isoform
PRO_0000058793Add
BLAST

Proteomic databases

PaxDbiQ05547.
PRIDEiQ05547.

Expressioni

Gene expression databases

BgeeiQ05547.

Interactioni

Subunit structurei

Interacts with Nop17l.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Nop17lQ0E9G32EBI-157144,EBI-150380

Protein-protein interaction databases

BioGridi71473. 7 interactions.
DIPiDIP-23332N.
IntActiQ05547. 25 interactions.
MINTiMINT-873916.
STRINGi7227.FBpp0073834.

Structurei

3D structure databases

ProteinModelPortaliQ05547.
SMRiQ05547. Positions 5-296.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0639.
GeneTreeiENSGT00530000062911.
InParanoidiQ05547.
KOiK06269.
OMAiPRSMITK.
OrthoDBiEOG7TJ3K3.
PhylomeDBiQ05547.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05547-1 [UniParc]FASTAAdd to Basket

« Hide

MAEVLNLESI ISRLLEVRGA RPGKNVQLSE GEIRGLCLKS REILLAQPIL    50
LELEAPLKIC GDIHGQYYDL LRLFEYGGYP PEANYLFLGD YVDRGKQSLE 100
TICLLLAYKI KYSENFFLLR GNHECASINR IYGFYDECKR RYTIKLWKTF 150
TDCFNCLPVV AIVDEKIFCC HGGLSPDLTS MEQIRRIMRP TDVPDQGLLC 200
DLLWSDPDKD TIGWGENDRG VSFTFGAEVV VKFLQKHDLD LICRAHQVVE 250
DGYEFFAKRQ LVTLFSAPNY CGEFDNAGAM MSVDNTLMCS FQILKPVEKR 300
KK 302
Length:302
Mass (Da):34,558
Last modified:February 1, 1996 - v1
Checksum:iB01ACC651F5DAE14
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X69974 Genomic DNA. Translation: CAA49594.1.
AE014298 Genomic DNA. Translation: AAF48448.1.
AY060272 mRNA. Translation: AAL25311.1.
PIRiS29396.
RefSeqiNP_524921.1. NM_080182.3.
UniGeneiDm.1527.

Genome annotation databases

EnsemblMetazoaiFBtr0074017; FBpp0073834; FBgn0003132.
GeneIDi48531.
KEGGidme:Dmel_CG9156.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X69974 Genomic DNA. Translation: CAA49594.1 .
AE014298 Genomic DNA. Translation: AAF48448.1 .
AY060272 mRNA. Translation: AAL25311.1 .
PIRi S29396.
RefSeqi NP_524921.1. NM_080182.3.
UniGenei Dm.1527.

3D structure databases

ProteinModelPortali Q05547.
SMRi Q05547. Positions 5-296.
ModBasei Search...

Protein-protein interaction databases

BioGridi 71473. 7 interactions.
DIPi DIP-23332N.
IntActi Q05547. 25 interactions.
MINTi MINT-873916.
STRINGi 7227.FBpp0073834.

Proteomic databases

PaxDbi Q05547.
PRIDEi Q05547.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0074017 ; FBpp0073834 ; FBgn0003132 .
GeneIDi 48531.
KEGGi dme:Dmel_CG9156.

Organism-specific databases

CTDi 48531.
FlyBasei FBgn0003132. Pp1-13C.

Phylogenomic databases

eggNOGi COG0639.
GeneTreei ENSGT00530000062911.
InParanoidi Q05547.
KOi K06269.
OMAi PRSMITK.
OrthoDBi EOG7TJ3K3.
PhylomeDBi Q05547.

Enzyme and pathway databases

SignaLinki Q05547.

Miscellaneous databases

GenomeRNAii 48531.
NextBioi 839441.

Gene expression databases

Bgeei Q05547.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the fourth functional gene for protein phosphatase 1 in Drosophila melanogaster from its chromosomal location."
    Dombradi V., Mann D.J., Saunders R.D., Cohen P.T.W.
    Eur. J. Biochem. 212:177-183(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Oregon-R.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Head.
  5. "Towards a comprehensive analysis of the protein phosphatase 1 interactome in Drosophila."
    Bennett D., Lyulcheva E., Alphey L.
    J. Mol. Biol. 364:196-212(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NOP17L.

Entry informationi

Entry nameiPP13_DROME
AccessioniPrimary (citable) accession number: Q05547
Secondary accession number(s): Q9VXW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: July 9, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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