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Protein

Serine/threonine-protein phosphatase alpha-3 isoform

Gene

Pp1-13C

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi62Manganese 1By similarity1
Metal bindingi64Manganese 1By similarity1
Metal bindingi90Manganese 1By similarity1
Metal bindingi90Manganese 2By similarity1
Metal bindingi122Manganese 2By similarity1
Active sitei123Proton donorBy similarity1
Metal bindingi171Manganese 2By similarity1
Metal bindingi246Manganese 2By similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • protein serine/threonine phosphatase activity Source: FlyBase

GO - Biological processi

  • neurogenesis Source: FlyBase
  • protein dephosphorylation Source: FlyBase
  • sperm competition Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

SignaLinkiQ05547.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase alpha-3 isoform (EC:3.1.3.16)
Gene namesi
Name:Pp1-13C
ORF Names:CG9156
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0003132. Pp1-13C.

Subcellular locationi

GO - Cellular componenti

  • protein phosphatase type 1 complex Source: FlyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000587931 – 302Serine/threonine-protein phosphatase alpha-3 isoformAdd BLAST302

Proteomic databases

PaxDbiQ05547.
PRIDEiQ05547.

Expressioni

Gene expression databases

BgeeiFBgn0003132.
ExpressionAtlasiQ05547. baseline.
GenevisibleiQ05547. DM.

Interactioni

Subunit structurei

Interacts with Nop17l.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Nop17lQ0E9G32EBI-157144,EBI-150380

Protein-protein interaction databases

BioGridi71473. 7 interactors.
DIPiDIP-23332N.
IntActiQ05547. 25 interactors.
MINTiMINT-873916.
STRINGi7227.FBpp0073834.

Structurei

3D structure databases

ProteinModelPortaliQ05547.
SMRiQ05547.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

Phylogenomic databases

eggNOGiENOG410IN85. Eukaryota.
ENOG410XPVF. LUCA.
GeneTreeiENSGT00530000062911.
InParanoidiQ05547.
KOiK06269.
OMAiRNIARPM.
OrthoDBiEOG091G0EKF.
PhylomeDBiQ05547.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
IPR031675. STPPase_N.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
PF16891. STPPase_N. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05547-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEVLNLESI ISRLLEVRGA RPGKNVQLSE GEIRGLCLKS REILLAQPIL
60 70 80 90 100
LELEAPLKIC GDIHGQYYDL LRLFEYGGYP PEANYLFLGD YVDRGKQSLE
110 120 130 140 150
TICLLLAYKI KYSENFFLLR GNHECASINR IYGFYDECKR RYTIKLWKTF
160 170 180 190 200
TDCFNCLPVV AIVDEKIFCC HGGLSPDLTS MEQIRRIMRP TDVPDQGLLC
210 220 230 240 250
DLLWSDPDKD TIGWGENDRG VSFTFGAEVV VKFLQKHDLD LICRAHQVVE
260 270 280 290 300
DGYEFFAKRQ LVTLFSAPNY CGEFDNAGAM MSVDNTLMCS FQILKPVEKR

KK
Length:302
Mass (Da):34,558
Last modified:February 1, 1996 - v1
Checksum:iB01ACC651F5DAE14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69974 Genomic DNA. Translation: CAA49594.1.
AE014298 Genomic DNA. Translation: AAF48448.1.
AY060272 mRNA. Translation: AAL25311.1.
PIRiS29396.
RefSeqiNP_524921.1. NM_080182.3.
UniGeneiDm.1527.

Genome annotation databases

EnsemblMetazoaiFBtr0074017; FBpp0073834; FBgn0003132.
GeneIDi48531.
KEGGidme:Dmel_CG9156.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69974 Genomic DNA. Translation: CAA49594.1.
AE014298 Genomic DNA. Translation: AAF48448.1.
AY060272 mRNA. Translation: AAL25311.1.
PIRiS29396.
RefSeqiNP_524921.1. NM_080182.3.
UniGeneiDm.1527.

3D structure databases

ProteinModelPortaliQ05547.
SMRiQ05547.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi71473. 7 interactors.
DIPiDIP-23332N.
IntActiQ05547. 25 interactors.
MINTiMINT-873916.
STRINGi7227.FBpp0073834.

Proteomic databases

PaxDbiQ05547.
PRIDEiQ05547.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0074017; FBpp0073834; FBgn0003132.
GeneIDi48531.
KEGGidme:Dmel_CG9156.

Organism-specific databases

CTDi48531.
FlyBaseiFBgn0003132. Pp1-13C.

Phylogenomic databases

eggNOGiENOG410IN85. Eukaryota.
ENOG410XPVF. LUCA.
GeneTreeiENSGT00530000062911.
InParanoidiQ05547.
KOiK06269.
OMAiRNIARPM.
OrthoDBiEOG091G0EKF.
PhylomeDBiQ05547.

Enzyme and pathway databases

SignaLinkiQ05547.

Miscellaneous databases

GenomeRNAii48531.
PROiQ05547.

Gene expression databases

BgeeiFBgn0003132.
ExpressionAtlasiQ05547. baseline.
GenevisibleiQ05547. DM.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
IPR031675. STPPase_N.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
PF16891. STPPase_N. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPP13_DROME
AccessioniPrimary (citable) accession number: Q05547
Secondary accession number(s): Q9VXW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.