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Protein

Serine/threonine-protein phosphatase alpha-3 isoform

Gene

Pp1-13C

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi62Manganese 1By similarity1
Metal bindingi64Manganese 1By similarity1
Metal bindingi90Manganese 1By similarity1
Metal bindingi90Manganese 2By similarity1
Metal bindingi122Manganese 2By similarity1
Active sitei123Proton donorBy similarity1
Metal bindingi171Manganese 2By similarity1
Metal bindingi246Manganese 2By similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • protein serine/threonine phosphatase activity Source: FlyBase

GO - Biological processi

  • circadian rhythm Source: Reactome
  • protein dephosphorylation Source: FlyBase
  • sperm competition Source: FlyBase

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandManganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-DME-538898 Dephosphorylation of TIM
SignaLinkiQ05547

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase alpha-3 isoform (EC:3.1.3.16)
Gene namesi
Name:Pp1-13C
ORF Names:CG9156
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0003132 Pp1-13C

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000587931 – 302Serine/threonine-protein phosphatase alpha-3 isoformAdd BLAST302

Proteomic databases

PaxDbiQ05547
PRIDEiQ05547

Expressioni

Gene expression databases

BgeeiFBgn0003132
ExpressionAtlasiQ05547 differential
GenevisibleiQ05547 DM

Interactioni

Subunit structurei

Interacts with Nop17l.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Nop17lQ0E9G32EBI-157144,EBI-150380

Protein-protein interaction databases

BioGridi71473, 28 interactors
DIPiDIP-23332N
IntActiQ05547, 25 interactors
STRINGi7227.FBpp0073834

Structurei

3D structure databases

ProteinModelPortaliQ05547
SMRiQ05547
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

Phylogenomic databases

eggNOGiENOG410IN85 Eukaryota
ENOG410XPVF LUCA
GeneTreeiENSGT00530000062911
InParanoidiQ05547
KOiK06269
OMAiQRGYEFF
OrthoDBiEOG091G0EKF
PhylomeDBiQ05547

Family and domain databases

Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR037981 PPP1CC
IPR006186 Ser/Thr-sp_prot-phosphatase
IPR031675 STPPase_N
PANTHERiPTHR11668:SF204 PTHR11668:SF204, 1 hit
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PF16891 STPPase_N, 1 hit
PRINTSiPR00114 STPHPHTASE
SMARTiView protein in SMART
SM00156 PP2Ac, 1 hit
PROSITEiView protein in PROSITE
PS00125 SER_THR_PHOSPHATASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q05547-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEVLNLESI ISRLLEVRGA RPGKNVQLSE GEIRGLCLKS REILLAQPIL
60 70 80 90 100
LELEAPLKIC GDIHGQYYDL LRLFEYGGYP PEANYLFLGD YVDRGKQSLE
110 120 130 140 150
TICLLLAYKI KYSENFFLLR GNHECASINR IYGFYDECKR RYTIKLWKTF
160 170 180 190 200
TDCFNCLPVV AIVDEKIFCC HGGLSPDLTS MEQIRRIMRP TDVPDQGLLC
210 220 230 240 250
DLLWSDPDKD TIGWGENDRG VSFTFGAEVV VKFLQKHDLD LICRAHQVVE
260 270 280 290 300
DGYEFFAKRQ LVTLFSAPNY CGEFDNAGAM MSVDNTLMCS FQILKPVEKR

KK
Length:302
Mass (Da):34,558
Last modified:February 1, 1996 - v1
Checksum:iB01ACC651F5DAE14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69974 Genomic DNA Translation: CAA49594.1
AE014298 Genomic DNA Translation: AAF48448.1
AY060272 mRNA Translation: AAL25311.1
PIRiS29396
RefSeqiNP_524921.1, NM_080182.3
UniGeneiDm.1527

Genome annotation databases

EnsemblMetazoaiFBtr0074017; FBpp0073834; FBgn0003132
GeneIDi48531
KEGGidme:Dmel_CG9156

Similar proteinsi

Entry informationi

Entry nameiPP13_DROME
AccessioniPrimary (citable) accession number: Q05547
Secondary accession number(s): Q9VXW0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: March 28, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health