Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Regulator of Ty1 transposition protein 103

Gene

RTT103

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in transcription termination by RNA polymerase II and in regulation of Ty1 transposition.2 Publications

Miscellaneous

Present with 3930 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • RNA polymerase II core binding Source: SGD

GO - Biological processi

  • DNA damage response, detection of DNA damage Source: SGD
  • mRNA 3'-end processing Source: SGD
  • negative regulation of transposition, RNA-mediated Source: SGD
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-29853-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of Ty1 transposition protein 103
Gene namesi
Name:RTT103
Ordered Locus Names:YDR289C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR289C
SGDiS000002697 RTT103

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002687071 – 409Regulator of Ty1 transposition protein 103Add BLAST409

Proteomic databases

MaxQBiQ05543
PaxDbiQ05543
PRIDEiQ05543

PTM databases

iPTMnetiQ05543

Interactioni

Subunit structurei

Interacts with PCF11, RAI1, RAT1, RPO21 AND RBP2.1 Publication

GO - Molecular functioni

  • RNA polymerase II core binding Source: SGD

Protein-protein interaction databases

BioGridi32342, 528 interactors
DIPiDIP-2583N
IntActiQ05543, 6 interactors
MINTiQ05543
STRINGi4932.YDR289C

Structurei

Secondary structure

1409
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 13Combined sources9
Helixi19 – 30Combined sources12
Helixi33 – 35Combined sources3
Helixi36 – 47Combined sources12
Beta strandi49 – 52Combined sources4
Helixi54 – 71Combined sources18
Helixi72 – 74Combined sources3
Helixi78 – 85Combined sources8
Helixi87 – 97Combined sources11
Helixi100 – 116Combined sources17
Helixi121 – 131Combined sources11
Helixi145 – 177Combined sources33
Beta strandi182 – 184Combined sources3
Helixi185 – 246Combined sources62

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KM4NMR-A1-131[»]
2L0INMR-A3-131[»]
5M48X-ray2.59A141-246[»]
5WOZNMR-A5-131[»]
ProteinModelPortaliQ05543
SMRiQ05543
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ05543

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 135CIDPROSITE-ProRule annotationAdd BLAST135

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi267 – 296Asp-richAdd BLAST30

Sequence similaritiesi

Belongs to the UPF0400 (RTT103) family.Curated

Phylogenomic databases

HOGENOMiHOG000141975
InParanoidiQ05543
KOiK15559
OMAiQQARHKR
OrthoDBiEOG092C38EY

Family and domain databases

Gene3Di1.25.40.90, 1 hit
InterProiView protein in InterPro
IPR006569 CID_dom
IPR008942 ENTH_VHS
IPR006903 RNA_pol_II-bd
PfamiView protein in Pfam
PF04818 CTD_bind, 1 hit
SMARTiView protein in SMART
SM00582 RPR, 1 hit
SUPFAMiSSF48464 SSF48464, 1 hit
PROSITEiView protein in PROSITE
PS51391 CID, 1 hit

Sequencei

Sequence statusi: Complete.

Q05543-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFSSEQFTT KLNTLEDSQE SISSASKWLL LQYRDAPKVA EMWKEYMLRP
60 70 80 90 100
SVNTRRKLLG LYLMNHVVQQ AKGQKIIQFQ DSFGKVAAEV LGRINQEFPR
110 120 130 140 150
DLKKKLSRVV NILKERNIFS KQVVNDIERS LKTESSPVEA LVLPQKLKDF
160 170 180 190 200
AKDYEKLVKM HHNVCAMKMR FDKSSDELDP SSSVYEENFK TISKIGNMAK
210 220 230 240 250
DIINESILKR ESGIHKLQST LDDEKRHLDE EQNMLSEIEF VLSAKDPSRL
260 270 280 290 300
NKNVDEDNII PTYEVGDGDD DDDDGDNDDD DDDDDDDKNY DDRSNDSNYG
310 320 330 340 350
VTNISTTDKK NEVVEKTDSE HKNSTHNPSD NQFGMKRTHD MIGHDDANDI
360 370 380 390 400
PEKKVHLDSK TSEDGTFNSE DGHYELDIEG HVGAQTDEGV ENSGGVSSSI

QDLLSKLAN
Length:409
Mass (Da):46,488
Last modified:November 1, 1996 - v1
Checksum:i08D37739466E3010
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51031 Genomic DNA Translation: AAB64467.1
AY557793 Genomic DNA Translation: AAS56119.1
BK006938 Genomic DNA Translation: DAA12129.1
PIRiS70119
RefSeqiNP_010575.1, NM_001180597.1

Genome annotation databases

EnsemblFungiiYDR289C; YDR289C; YDR289C
GeneIDi851884
KEGGisce:YDR289C

Similar proteinsi

Entry informationi

Entry nameiRT103_YEAST
AccessioniPrimary (citable) accession number: Q05543
Secondary accession number(s): D6VSR9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health