Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Regulator of Ty1 transposition protein 103

Gene

RTT103

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in transcription termination by RNA polymerase II and in regulation of Ty1 transposition.2 Publications

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • RNA polymerase II core binding Source: SGD

GO - Biological processi

  • DNA damage response, detection of DNA damage Source: SGD
  • mRNA 3'-end processing Source: SGD
  • negative regulation of transposition, RNA-mediated Source: SGD
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29853-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of Ty1 transposition protein 103
Gene namesi
Name:RTT103
Ordered Locus Names:YDR289C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR289C.
SGDiS000002697. RTT103.

Subcellular locationi

GO - Cellular componenti

  • nuclear chromatin Source: SGD
  • site of double-strand break Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002687071 – 409Regulator of Ty1 transposition protein 103Add BLAST409

Proteomic databases

MaxQBiQ05543.
PRIDEiQ05543.

PTM databases

iPTMnetiQ05543.

Interactioni

Subunit structurei

Interacts with PCF11, RAI1, RAT1, RPO21 AND RBP2.1 Publication

GO - Molecular functioni

  • RNA polymerase II core binding Source: SGD

Protein-protein interaction databases

BioGridi32342. 307 interactors.
DIPiDIP-2583N.
IntActiQ05543. 5 interactors.
MINTiMINT-425860.

Structurei

Secondary structure

1409
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 13Combined sources9
Helixi19 – 30Combined sources12
Helixi33 – 35Combined sources3
Helixi36 – 47Combined sources12
Beta strandi49 – 52Combined sources4
Helixi54 – 71Combined sources18
Helixi72 – 74Combined sources3
Helixi78 – 85Combined sources8
Helixi87 – 97Combined sources11
Helixi100 – 116Combined sources17
Helixi121 – 131Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KM4NMR-A1-131[»]
2L0INMR-A3-131[»]
ProteinModelPortaliQ05543.
SMRiQ05543.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ05543.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 135CIDPROSITE-ProRule annotationAdd BLAST135

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi267 – 296Asp-richAdd BLAST30

Sequence similaritiesi

Belongs to the UPF0400 (RTT103) family.Curated
Contains 1 CID domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00400000022016.
HOGENOMiHOG000141975.
InParanoidiQ05543.
KOiK15559.
OMAiHYELDIE.
OrthoDBiEOG092C38EY.

Family and domain databases

Gene3Di1.25.40.90. 1 hit.
InterProiIPR006569. CID_dom.
IPR008942. ENTH_VHS.
IPR006903. RNA_pol_II-bd.
[Graphical view]
PfamiPF04818. CTD_bind. 1 hit.
[Graphical view]
SMARTiSM00582. RPR. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
PROSITEiPS51391. CID. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05543-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFSSEQFTT KLNTLEDSQE SISSASKWLL LQYRDAPKVA EMWKEYMLRP
60 70 80 90 100
SVNTRRKLLG LYLMNHVVQQ AKGQKIIQFQ DSFGKVAAEV LGRINQEFPR
110 120 130 140 150
DLKKKLSRVV NILKERNIFS KQVVNDIERS LKTESSPVEA LVLPQKLKDF
160 170 180 190 200
AKDYEKLVKM HHNVCAMKMR FDKSSDELDP SSSVYEENFK TISKIGNMAK
210 220 230 240 250
DIINESILKR ESGIHKLQST LDDEKRHLDE EQNMLSEIEF VLSAKDPSRL
260 270 280 290 300
NKNVDEDNII PTYEVGDGDD DDDDGDNDDD DDDDDDDKNY DDRSNDSNYG
310 320 330 340 350
VTNISTTDKK NEVVEKTDSE HKNSTHNPSD NQFGMKRTHD MIGHDDANDI
360 370 380 390 400
PEKKVHLDSK TSEDGTFNSE DGHYELDIEG HVGAQTDEGV ENSGGVSSSI

QDLLSKLAN
Length:409
Mass (Da):46,488
Last modified:November 1, 1996 - v1
Checksum:i08D37739466E3010
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51031 Genomic DNA. Translation: AAB64467.1.
AY557793 Genomic DNA. Translation: AAS56119.1.
BK006938 Genomic DNA. Translation: DAA12129.1.
PIRiS70119.
RefSeqiNP_010575.1. NM_001180597.1.

Genome annotation databases

EnsemblFungiiYDR289C; YDR289C; YDR289C.
GeneIDi851884.
KEGGisce:YDR289C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51031 Genomic DNA. Translation: AAB64467.1.
AY557793 Genomic DNA. Translation: AAS56119.1.
BK006938 Genomic DNA. Translation: DAA12129.1.
PIRiS70119.
RefSeqiNP_010575.1. NM_001180597.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KM4NMR-A1-131[»]
2L0INMR-A3-131[»]
ProteinModelPortaliQ05543.
SMRiQ05543.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32342. 307 interactors.
DIPiDIP-2583N.
IntActiQ05543. 5 interactors.
MINTiMINT-425860.

PTM databases

iPTMnetiQ05543.

Proteomic databases

MaxQBiQ05543.
PRIDEiQ05543.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR289C; YDR289C; YDR289C.
GeneIDi851884.
KEGGisce:YDR289C.

Organism-specific databases

EuPathDBiFungiDB:YDR289C.
SGDiS000002697. RTT103.

Phylogenomic databases

GeneTreeiENSGT00400000022016.
HOGENOMiHOG000141975.
InParanoidiQ05543.
KOiK15559.
OMAiHYELDIE.
OrthoDBiEOG092C38EY.

Enzyme and pathway databases

BioCyciYEAST:G3O-29853-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ05543.
PROiQ05543.

Family and domain databases

Gene3Di1.25.40.90. 1 hit.
InterProiIPR006569. CID_dom.
IPR008942. ENTH_VHS.
IPR006903. RNA_pol_II-bd.
[Graphical view]
PfamiPF04818. CTD_bind. 1 hit.
[Graphical view]
SMARTiSM00582. RPR. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
PROSITEiPS51391. CID. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRT103_YEAST
AccessioniPrimary (citable) accession number: Q05543
Secondary accession number(s): D6VSR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3930 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.