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Q05534 (PHOG_EMENI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein pacG
Alternative name(s):
Nonrepressible acid phosphatase regulator pacG
Gene names
Name:pacG
ORF Names:AN1414
OrganismEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) [Reference proteome]
Taxonomic identifier227321 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length566 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Transcription factor that acts as a positive regulator of nonrepressible acid phosphatase activity. Is a major regulator of responses to nitrogen and carbon starvation and is essential for the expression of genes involved in vegetative incompatibility (like pin-c, het-6, and tol). Vegetative incompatibility is a non-self-recognition system ubiquitous in filamentous fungi which results in programmed cell death By similarity.

Subcellular location

Nucleus. Cytoplasm By similarity.

Sequence similarities

Contains 1 NDT80 DNA-binding domain.

Caution

Was originally thought (Ref.3) to be a phosphatase.

Sequence caution

The sequence CBF84810.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence EAA64544.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 566566Protein pacG
PRO_0000023977

Regions

DNA binding79 – 326248NDT80

Experimental info

Sequence conflict3761G → R in AAA33289. Ref.3
Sequence conflict4231R → L in AAA33289. Ref.3
Sequence conflict4471G → C in AAA33289. Ref.3
Sequence conflict4511P → S in AAA33289. Ref.3
Sequence conflict460 – 4612AS → VV in AAA33289. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q05534 [UniParc].

Last modified November 16, 2011. Version 3.
Checksum: 9BC5AB22BCDC665E

FASTA56661,871
        10         20         30         40         50         60 
MEGFDTMALP YLASPLSLGN MQGTDYLNAL QGMDLPDQRS NFDSETFVSG DDLTFAHLSP 

        70         80         90        100        110        120 
QTLKRFSSGY EDSFPEMVTS FDPPPPAEPP ADSSIDHNNK LLSFSMPVYP WTLLDYSFRR 

       130        140        150        160        170        180 
ASISISAQLH GMFFLAESPW TTSPTENAPP QQGAELTCYR RNLFQITGSV TLPRALRYII 

       190        200        210        220        230        240 
TDTGDRIPIV AHELTVSATE SVEGNSVKII SVPWKTPAAN DAGKDTGNSS NTAAKVEKEP 

       250        260        270        280        290        300 
PAIPLDMLTG QDLDADYATF PIAWKRLQFR VATANNGRRK ELQQHFVVRL RVVATLSTGM 

       310        320        330        340        350        360 
KTPICEVHSG PVIVRGRSPR NFQSRKDLPL SGSAAASRKN AQAAAASNNL TRTSPSLTDK 

       370        380        390        400        410        420 
AKTVVKSSSP ETSSNGVPQQ SPPNWALATN STLPPPTTTT LPHSSVYSQS SPEFSRPVEA 

       430        440        450        460        470        480 
HRRTTSAIAA PINLSLLDDD SLNLSNGDSR PHTSFSNDLA SKSLSVDSGR PVKMRKVSHS 

       490        500        510        520        530        540 
MPQAQSRSTS ATFLNTANFQ QMLPVPFTSE SADVLYEYFP LGLEDWQGPV DAVYRPHVVH 

       550        560 
HTNMPQMKYI TARGQSKRYF AAEDVF 

« Hide

References

« Hide 'large scale' references
[1]"Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae."
Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S., Braus G.H. expand/collapse author list , Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L., Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.
Nature 438:1105-1115(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
[2]"The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G. expand/collapse author list , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
[3]"Characterization of an Aspergillus nidulans genomic DNA fragment conferring phosphate-non-repressible acid-phosphatase activity."
Macrae W.D., Buxton F.P., Sibley S., Garven S., Gwynne D.I., Arst H.N. Jr., Davies R.W.
Gene 130:247-251(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 132-461.
Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACD01000022 Genomic DNA. Translation: EAA64544.1. Sequence problems.
BN001307 Genomic DNA. Translation: CBF84810.1. Sequence problems.
M96993 Genomic DNA. Translation: AAA33289.1.
PIRJN0783.
RefSeqXP_659018.1. XM_653926.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ05534.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADANIAT00008025; CADANIAP00008025; CADANIAG00008025.
GeneID2875501.
KEGGani:AN1414.2.

Phylogenomic databases

eggNOGNOG79465.
HOGENOMHOG000157088.
OrthoDBEOG74J9HJ.

Family and domain databases

Gene3D2.60.40.1390. 1 hit.
InterProIPR024061. NDT80_DNA-bd_dom.
IPR008967. p53-like_TF_DNA-bd.
[Graphical view]
PfamPF05224. NDT80_PhoG. 1 hit.
[Graphical view]
SUPFAMSSF49417. SSF49417. 1 hit.
PROSITEPS51517. NDT80. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePHOG_EMENI
AccessionPrimary (citable) accession number: Q05534
Secondary accession number(s): C8VM27, Q5BDG6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 16, 2011
Last modified: April 16, 2014
This is version 87 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families