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Protein

Inositol monophosphatase 2

Gene

INM2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and involved in the inositol cycle of calcium signaling.2 Publications

Catalytic activityi

Myo-inositol phosphate + H2O = myo-inositol + phosphate.

Cofactori

Enzyme regulationi

Inhibited by Li+ and Na+.1 Publication

Kineticsi

  1. KM=0.12 mM for inositol 1-phosphate1 Publication
  1. Vmax=16 µmol/min/mg enzyme for inositol 1-phosphate1 Publication

Pathwayi: myo-inositol biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes myo-inositol from D-glucose 6-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Inositol-3-phosphate synthase (INO1)
  2. Inositol monophosphatase 2 (INM2), Inositol monophosphatase 1 (INM1)
This subpathway is part of the pathway myo-inositol biosynthesis, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes myo-inositol from D-glucose 6-phosphate, the pathway myo-inositol biosynthesis and in Polyol metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi75Magnesium 1By similarity1
Binding sitei75SubstrateBy similarity1
Metal bindingi94Magnesium 1By similarity1
Metal bindingi94Magnesium 2By similarity1
Metal bindingi96Magnesium 1; via carbonyl oxygenBy similarity1
Metal bindingi97Magnesium 2By similarity1
Metal bindingi231Magnesium 2By similarity1
Binding sitei231SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandLithium, Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29851-MONOMER
YEAST:MONOMER3O-11
ReactomeiR-SCE-1855183 Synthesis of IP2, IP, and Ins in the cytosol
UniPathwayiUPA00823; UER00788

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol monophosphatase 2 (EC:3.1.3.25)
Short name:
IMP 2
Short name:
IMPase 2
Alternative name(s):
Inositol-1(or 4)-monophosphatase 2
Gene namesi
Name:INM2
Synonyms:IMP2
Ordered Locus Names:YDR287W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR287W
SGDiS000002695 INM2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002455681 – 292Inositol monophosphatase 2Add BLAST292

Proteomic databases

MaxQBiQ05533
PaxDbiQ05533
PRIDEiQ05533

Interactioni

Protein-protein interaction databases

BioGridi32340, 58 interactors
DIPiDIP-5626N
IntActiQ05533, 1 interactor
MINTiQ05533
STRINGi4932.YDR287W

Structurei

3D structure databases

ProteinModelPortaliQ05533
SMRiQ05533
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni96 – 99Substrate bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000014699
HOGENOMiHOG000282238
InParanoidiQ05533
KOiK01092
OMAiNNYAEFC
OrthoDBiEOG092C47JH

Family and domain databases

CDDicd01639 IMPase, 1 hit
InterProiView protein in InterPro
IPR033942 IMPase
IPR020583 Inositol_monoP_metal-BS
IPR000760 Inositol_monophosphatase-like
IPR020550 Inositol_monophosphatase_CS
PfamiView protein in Pfam
PF00459 Inositol_P, 1 hit
PRINTSiPR00377 IMPHPHTASES
PROSITEiView protein in PROSITE
PS00629 IMP_1, 1 hit
PS00630 IMP_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q05533-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLTRQVLEE VENTFIELLR SKIGPLVKSH AGTNFCSYDD KANGVDLVTA
60 70 80 90 100
LDKQIESIIK ENLTAKYPSF KFIGEETYVK GVTKITNGPT FIVDPIDGTT
110 120 130 140 150
NFIHGYPYSC TSLGLAEMGK PVVGVVFNPH LNQLFHASKG NGAFLNDQEI
160 170 180 190 200
KVSKRPLILQ KSLIALEGGS ERTEGSQGNF DKKMNTYKNL LSESGAFVHG
210 220 230 240 250
FRSAGSAAMN ICYVASGMLD AYWEGGCWAW DVCAGWCILE EAGGIMVGGN
260 270 280 290
CGEWNIPLDR RCYLAIRGGC ESMEQKRFAE SFWPHVAGEL EY
Length:292
Mass (Da):32,093
Last modified:November 1, 1996 - v1
Checksum:iCEA9D943F69E2082
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51031 Genomic DNA Translation: AAB64472.1
AY557746 Genomic DNA Translation: AAS56072.1
BK006938 Genomic DNA Translation: DAA12127.1
PIRiS70117
RefSeqiNP_010573.3, NM_001180595.3

Genome annotation databases

EnsemblFungiiYDR287W; YDR287W; YDR287W
GeneIDi851881
KEGGisce:YDR287W

Similar proteinsi

Entry informationi

Entry nameiINM2_YEAST
AccessioniPrimary (citable) accession number: Q05533
Secondary accession number(s): D6VSR7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health