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Protein

Serine/arginine-rich splicing factor 11

Gene

SRSF11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function in pre-mRNA splicing.

GO - Molecular functioni

  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  • mRNA 3'-end processing Source: Reactome
  • mRNA export from nucleus Source: Reactome
  • mRNA processing Source: ProtInc
  • mRNA splicing, via spliceosome Source: Reactome
  • RNA export from nucleus Source: Reactome
  • RNA splicing Source: ProtInc
  • termination of RNA polymerase II transcription Source: Reactome
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-109688. Cleavage of Growing Transcript in the Termination Region.
R-HSA-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-HSA-72163. mRNA Splicing - Major Pathway.
R-HSA-72187. mRNA 3'-end processing.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/arginine-rich splicing factor 11
Alternative name(s):
Arginine-rich 54 kDa nuclear protein
Short name:
p54
Splicing factor, arginine/serine-rich 11
Gene namesi
Name:SRSF11
Synonyms:SFRS11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:10782. SRSF11.

Subcellular locationi

  • Nucleus

  • Note: Colocalizes with spliceosome components.

GO - Cellular componenti

  • nucleoplasm Source: HPA
  • nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35698.

Polymorphism and mutation databases

BioMutaiSRSF11.
DMDMi8134672.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 484483Serine/arginine-rich splicing factor 11PRO_0000081939Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineCombined sources
Modified residuei207 – 2071PhosphoserineCombined sources
Modified residuei212 – 2121PhosphoserineCombined sources
Modified residuei323 – 3231PhosphoserineCombined sources
Modified residuei325 – 3251PhosphothreonineCombined sources
Modified residuei414 – 4141PhosphoserineCombined sources
Modified residuei434 – 4341PhosphoserineCombined sources
Modified residuei447 – 4471PhosphothreonineCombined sources
Modified residuei449 – 4491PhosphoserineCombined sources
Modified residuei456 – 4561PhosphoserineCombined sources
Modified residuei464 – 4641PhosphoserineCombined sources
Modified residuei483 – 4831PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ05519.
MaxQBiQ05519.
PaxDbiQ05519.
PeptideAtlasiQ05519.
PRIDEiQ05519.

PTM databases

iPTMnetiQ05519.
PhosphoSiteiQ05519.
SwissPalmiQ05519.

Expressioni

Gene expression databases

BgeeiENSG00000116754.
CleanExiHS_SFRS11.
ExpressionAtlasiQ05519. baseline and differential.
GenevisibleiQ05519. HS.

Organism-specific databases

HPAiHPA008762.
HPA067471.

Interactioni

Subunit structurei

Interacts with PUF60.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
G4XUV33EBI-1051785,EBI-10177989
ARL6IP4Q66PJ3-33EBI-1051785,EBI-10248982
ARL6IP4Q66PJ3-43EBI-1051785,EBI-5280499
ETS1P149212EBI-1051785,EBI-913209
GATCO437163EBI-1051785,EBI-6929453
HYIQ5T0133EBI-1051785,EBI-749235
PUF60Q9UHX16EBI-1051785,EBI-1053259
RBM39Q144983EBI-1051785,EBI-395290
RBM39Q14498-33EBI-1051785,EBI-6654703
SDCBPO005603EBI-1051785,EBI-727004
SREK1Q8WXA93EBI-1051785,EBI-1044237
TANKQ928443EBI-1051785,EBI-356349

Protein-protein interaction databases

BioGridi114709. 83 interactions.
IntActiQ05519. 21 interactions.
MINTiMINT-4655237.
STRINGi9606.ENSP00000359988.

Structurei

3D structure databases

ProteinModelPortaliQ05519.
SMRiQ05519. Positions 35-112.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 11381RRMPROSITE-ProRule annotationAdd
BLAST
Repeati247 – 25591
Repeati258 – 26582
Repeati267 – 27483
Repeati275 – 28284
Repeati285 – 29285
Repeati293 – 30086
Repeati302 – 30987
Repeati321 – 32888
Repeati334 – 34189
Repeati346 – 353810

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni247 – 35310710 X 8 AA approximate repeats of R-R-S-R-S-R-S-RAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi17 – 3115Poly-GlyAdd
BLAST
Compositional biasi252 – 2598Poly-Arg
Compositional biasi291 – 2944Poly-Arg
Compositional biasi341 – 3499Poly-Arg
Compositional biasi397 – 4048Poly-Lys

Sequence similaritiesi

Belongs to the splicing factor SR family.Curated
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4676. Eukaryota.
ENOG410YJ1Y. LUCA.
GeneTreeiENSGT00730000110872.
HOGENOMiHOG000121772.
HOVERGENiHBG058422.
InParanoidiQ05519.
KOiK12899.
OrthoDBiEOG091G0QKH.
PhylomeDBiQ05519.
TreeFamiTF106266.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q05519-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSNTTVVPST AGPGPSGGPG GGGGGGGGGG GTEVIQVTNV SPSASSEQMR
60 70 80 90 100
TLFGFLGKID ELRLFPPDDS PLPVSSRVCF VKFHDPDSAV VAQHLTNTVF
110 120 130 140 150
VDRALIVVPY AEGVIPDEAK ALSLLAPANA VAGLLPGGGL LPTPNPLTQI
160 170 180 190 200
GAVPLAALGA PTLDPALAAL GLPGANLNSQ SLAADQLLKL MSTVDPKLNH
210 220 230 240 250
VAAGLVSPSL KSDTSSKEIE EAMKRVREAQ SLISAAIEPD KKEEKRRHSR
260 270 280 290 300
SRSRSRRRRT PSSSRHRRSR SRSRRRSHSK SRSRRRSKSP RRRRSHSRER
310 320 330 340 350
GRRSRSTSKT RDKKKEDKEK KRSKTPPKSY STARRSRSAS RERRRRRSRS
360 370 380 390 400
GTRSPKKPRS PKRKLSRSPS PRRHKKEKKK DKDKERSRDE RERSTSKKKK
410 420 430 440 450
SKDKEKDRER KSESDKDVKQ VTRDYDEEEQ GYDSEKEKKE EKKPIETGSP
460 470 480
KTKECSVEKG TGDSLRESKV NGDDHHEEDM DMSD
Length:484
Mass (Da):53,542
Last modified:November 1, 1996 - v1
Checksum:i1211E96DDC0A3182
GO
Isoform 2 (identifier: Q05519-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     420-420: Missing.

Note: No experimental confirmation available.
Show »
Length:483
Mass (Da):53,414
Checksum:i5A40AFD8B7599976
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei420 – 4201Missing in isoform 2. 1 PublicationVSP_043376

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74002 mRNA. Translation: AAA35554.1.
AL353771 Genomic DNA. Translation: CAI22334.1.
AL353771 Genomic DNA. Translation: CAI22335.1.
CH471059 Genomic DNA. Translation: EAX06459.1.
BC040436 mRNA. Translation: AAH40436.1.
CCDSiCCDS53332.1. [Q05519-2]
CCDS647.1. [Q05519-1]
PIRiA40988.
RefSeqiNP_001177916.1. NM_001190987.1. [Q05519-2]
NP_004759.1. NM_004768.3. [Q05519-1]
XP_011540729.1. XM_011542427.2. [Q05519-1]
UniGeneiHs.479693.

Genome annotation databases

EnsembliENST00000370950; ENSP00000359988; ENSG00000116754. [Q05519-1]
ENST00000370951; ENSP00000359989; ENSG00000116754. [Q05519-2]
GeneIDi9295.
KEGGihsa:9295.
UCSCiuc001des.4. human. [Q05519-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74002 mRNA. Translation: AAA35554.1.
AL353771 Genomic DNA. Translation: CAI22334.1.
AL353771 Genomic DNA. Translation: CAI22335.1.
CH471059 Genomic DNA. Translation: EAX06459.1.
BC040436 mRNA. Translation: AAH40436.1.
CCDSiCCDS53332.1. [Q05519-2]
CCDS647.1. [Q05519-1]
PIRiA40988.
RefSeqiNP_001177916.1. NM_001190987.1. [Q05519-2]
NP_004759.1. NM_004768.3. [Q05519-1]
XP_011540729.1. XM_011542427.2. [Q05519-1]
UniGeneiHs.479693.

3D structure databases

ProteinModelPortaliQ05519.
SMRiQ05519. Positions 35-112.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114709. 83 interactions.
IntActiQ05519. 21 interactions.
MINTiMINT-4655237.
STRINGi9606.ENSP00000359988.

PTM databases

iPTMnetiQ05519.
PhosphoSiteiQ05519.
SwissPalmiQ05519.

Polymorphism and mutation databases

BioMutaiSRSF11.
DMDMi8134672.

Proteomic databases

EPDiQ05519.
MaxQBiQ05519.
PaxDbiQ05519.
PeptideAtlasiQ05519.
PRIDEiQ05519.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370950; ENSP00000359988; ENSG00000116754. [Q05519-1]
ENST00000370951; ENSP00000359989; ENSG00000116754. [Q05519-2]
GeneIDi9295.
KEGGihsa:9295.
UCSCiuc001des.4. human. [Q05519-1]

Organism-specific databases

CTDi9295.
GeneCardsiSRSF11.
HGNCiHGNC:10782. SRSF11.
HPAiHPA008762.
HPA067471.
MIMi602010. gene.
neXtProtiNX_Q05519.
PharmGKBiPA35698.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4676. Eukaryota.
ENOG410YJ1Y. LUCA.
GeneTreeiENSGT00730000110872.
HOGENOMiHOG000121772.
HOVERGENiHBG058422.
InParanoidiQ05519.
KOiK12899.
OrthoDBiEOG091G0QKH.
PhylomeDBiQ05519.
TreeFamiTF106266.

Enzyme and pathway databases

ReactomeiR-HSA-109688. Cleavage of Growing Transcript in the Termination Region.
R-HSA-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-HSA-72163. mRNA Splicing - Major Pathway.
R-HSA-72187. mRNA 3'-end processing.

Miscellaneous databases

ChiTaRSiSRSF11. human.
GeneWikiiSFRS11.
GenomeRNAii9295.
PROiQ05519.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000116754.
CleanExiHS_SFRS11.
ExpressionAtlasiQ05519. baseline and differential.
GenevisibleiQ05519. HS.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSRS11_HUMAN
AccessioniPrimary (citable) accession number: Q05519
Secondary accession number(s): Q5T758, Q8IWE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 156 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.