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Q05516

- ZBT16_HUMAN

UniProt

Q05516 - ZBT16_HUMAN

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Protein
Zinc finger and BTB domain-containing protein 16
Gene
ZBTB16, PLZF, ZNF145
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Probable transcription factor. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.1 Publication

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei394 – 3952Breakpoint for translocation to form PLZF-RAR-alpha oncogene

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri404 – 42623C2H2-type 1
Add
BLAST
Zinc fingeri432 – 45423C2H2-type 2
Add
BLAST
Zinc fingeri461 – 48323C2H2-type 3
Add
BLAST
Zinc fingeri490 – 51223C2H2-type 4
Add
BLAST
Zinc fingeri518 – 54023C2H2-type 5
Add
BLAST
Zinc fingeri546 – 56823C2H2-type 6
Add
BLAST
Zinc fingeri574 – 59623C2H2-type 7
Add
BLAST
Zinc fingeri602 – 62423C2H2-type 8
Add
BLAST
Zinc fingeri630 – 65223C2H2-type 9
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. double-stranded DNA binding Source: Ensembl
  3. identical protein binding Source: IntAct
  4. metal ion binding Source: UniProtKB-KW
  5. protein binding Source: UniProtKB
  6. protein homodimerization activity Source: UniProtKB
  7. sequence-specific DNA binding transcription factor activity Source: Ensembl

GO - Biological processi

  1. anterior/posterior pattern specification Source: Ensembl
  2. apoptotic process Source: UniProtKB
  3. cartilage development Source: UniProtKB
  4. central nervous system development Source: UniProtKB
  5. embryonic digit morphogenesis Source: Ensembl
  6. embryonic hindlimb morphogenesis Source: Ensembl
  7. embryonic pattern specification Source: Ensembl
  8. forelimb morphogenesis Source: Ensembl
  9. hemopoiesis Source: UniProtKB
  10. male germ-line stem cell division Source: Ensembl
  11. mesonephros development Source: UniProtKB
  12. myeloid cell differentiation Source: UniProtKB
  13. negative regulation of cell proliferation Source: Ensembl
  14. negative regulation of myeloid cell differentiation Source: UniProtKB
  15. negative regulation of transcription, DNA-templated Source: UniProtKB
  16. positive regulation of apoptotic process Source: Ensembl
  17. positive regulation of cartilage development Source: UniProtKB
  18. positive regulation of chondrocyte differentiation Source: UniProtKB
  19. positive regulation of fat cell differentiation Source: UniProtKB
  20. positive regulation of ossification Source: UniProtKB
  21. positive regulation of transcription, DNA-templated Source: UniProtKB
  22. protein localization to nucleus Source: Ensembl
  23. protein ubiquitination Source: UniProtKB-UniPathway
  24. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation, Ubl conjugation pathway

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
SignaLinkiQ05516.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 16
Alternative name(s):
Promyelocytic leukemia zinc finger protein
Zinc finger protein 145
Zinc finger protein PLZF
Gene namesi
Name:ZBTB16
Synonyms:PLZF, ZNF145
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:12930. ZBTB16.

Subcellular locationi

GO - Cellular componenti

  1. PML body Source: UniProtKB
  2. cytosol Source: Ensembl
  3. nuclear body Source: UniProtKB
  4. nuclear speck Source: UniProtKB
  5. nucleus Source: UniProtKB
  6. plasma membrane Source: Ensembl
  7. transcriptional repressor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Skeletal defects, genital hypoplasia, and mental retardation (SGYMR) [MIM:612447]: A disorder characterized by mental retardation, craniofacial dysmorphism, microcephaly and short stature. Additional features include absence of the thumbs, hypoplasia of the radii and ulnae, additional vertebrae and ribs, retarded bone age and genital hypoplasia.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti617 – 6171M → V in SGYMR. 1 Publication
VAR_054912
A chromosomal aberration involving ZBTB16 may be a cause of acute promyelocytic leukemia (APL). Translocation t(11;17)(q32;q21) with RARA.

Keywords - Diseasei

Disease mutation, Mental retardation, Proto-oncogene

Organism-specific databases

MIMi612447. phenotype.
Orphaneti520. Acute promyelocytic leukemia.
PharmGKBiPA37517.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 673673Zinc finger and BTB domain-containing protein 16
PRO_0000047729Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei76 – 761Phosphoserine; by PDPK1 Reviewed prediction
Modified residuei184 – 1841Phosphoserine; by PDPK1 Reviewed prediction
Modified residuei197 – 1971Phosphoserine; by PDPK1 Reviewed prediction
Modified residuei256 – 2561Phosphoserine; by PDPK1 Reviewed prediction
Modified residuei282 – 2821Phosphothreonine; by PDPK1 Reviewed prediction
Modified residuei628 – 6281Phosphoserine; by PDPK1 Reviewed prediction

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ05516.
PRIDEiQ05516.

PTM databases

PhosphoSiteiQ05516.

Expressioni

Tissue specificityi

Within the hematopoietic system, PLZF is expressed in bone marrow, early myeloid cell lines and peripheral blood mononuclear cells. Also expressed in the ovary, and at lower levels, in the kidney and lung.

Inductioni

By retinoic acid.

Gene expression databases

ArrayExpressiQ05516.
BgeeiQ05516.
CleanExiHS_ZBTB16.
GenevestigatoriQ05516.

Organism-specific databases

HPAiCAB004540.
HPA001499.

Interactioni

Subunit structurei

Binds EPN1. Interacts with ZBTB32 and CUL3.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-711925,EBI-711925
EEF1A1P681044EBI-711925,EBI-352162
GneO358262EBI-711925,EBI-7109445From a different organism.
Hoxa1P090223EBI-711925,EBI-3957603From a different organism.
PMLP295907EBI-711925,EBI-295890
PMLP29590-52EBI-711925,EBI-304008
TAB2Q9NYJ83EBI-711925,EBI-358708

Protein-protein interaction databases

BioGridi113498. 105 interactions.
DIPiDIP-2654N.
IntActiQ05516. 67 interactions.
MINTiMINT-158782.
STRINGi9606.ENSP00000338157.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi16 – 3015
Turni31 – 333
Beta strandi36 – 427
Beta strandi44 – 474
Helixi49 – 557
Helixi57 – 626
Helixi63 – 653
Beta strandi68 – 725
Helixi77 – 8913
Helixi96 – 983
Helixi99 – 10911
Helixi112 – 12514

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BUOX-ray1.90A6-126[»]
1CS3X-ray2.00A7-122[»]
ProteinModelPortaliQ05516.
SMRiQ05516. Positions 6-126, 405-656.

Miscellaneous databases

EvolutionaryTraceiQ05516.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 9663BTB
Add
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000130800.
HOVERGENiHBG057844.
InParanoidiQ05516.
KOiK10055.
OMAiPPAEKHL.
OrthoDBiEOG7N8ZTX.
PhylomeDBiQ05516.
TreeFamiTF350825.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform PLZFB (identifier: Q05516-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDLTKMGMIQ LQNPSHPTGL LCKANQMRLA GTLCDVVIMV DSQEFHAHRT    50
VLACTSKMFE ILFHRNSQHY TLDFLSPKTF QQILEYAYTA TLQAKAEDLD 100
DLLYAAEILE IEYLEEQCLK MLETIQASDD NDTEATMADG GAEEEEDRKA 150
RYLKNIFISK HSSEESGYAS VAGQSLPGPM VDQSPSVSTS FGLSAMSPTK 200
AAVDSLMTIG QSLLQGTLQP PAGPEEPTLA GGGRHPGVAE VKTEMMQVDE 250
VPSQDSPGAA ESSISGGMGD KVEERGKEGP GTPTRSSVIT SARELHYGRE 300
ESAEQVPPPA EAGQAPTGRP EHPAPPPEKH LGIYSVLPNH KADAVLSMPS 350
SVTSGLHVQP ALAVSMDFST YGGLLPQGFI QRELFSKLGE LAVGMKSESR 400
TIGEQCSVCG VELPDNEAVE QHRKLHSGMK TYGCELCGKR FLDSLRLRMH 450
LLAHSAGAKA FVCDQCGAQF SKEDALETHR QTHTGTDMAV FCLLCGKRFQ 500
AQSALQQHME VHAGVRSYIC SECNRTFPSH TALKRHLRSH TGDHPYECEF 550
CGSCFRDEST LKSHKRIHTG EKPYECNGCG KKFSLKHQLE THYRVHTGEK 600
PFECKLCHQR SRDYSAMIKH LRTHNGASPY QCTICTEYCP SLSSMQKHMK 650
GHKPEEIPPD WRIEKTYLYL CYV 673
Length:673
Mass (Da):74,274
Last modified:March 7, 2006 - v2
Checksum:i51F8E361FA31239E
GO
Isoform PLZFA (identifier: Q05516-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     255-377: Missing.

Show »
Length:550
Mass (Da):61,601
Checksum:i1051E16C91FDC089
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti617 – 6171M → V in SGYMR. 1 Publication
VAR_054912

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei255 – 377123Missing in isoform PLZFA.
VSP_006896Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti580 – 5801G → D in CAA79489. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z19002 mRNA. Translation: CAA79489.1.
AF060568 Genomic DNA. Translation: AAD03619.1.
BC026902 mRNA. Translation: AAH26902.1.
BC029812 mRNA. Translation: AAH29812.1.
S60093 Genomic DNA. Translation: AAC60590.2.
CCDSiCCDS8367.1. [Q05516-1]
PIRiS36336.
RefSeqiNP_001018011.1. NM_001018011.1. [Q05516-1]
NP_005997.2. NM_006006.4. [Q05516-1]
UniGeneiHs.591945.
Hs.682144.

Genome annotation databases

EnsembliENST00000335953; ENSP00000338157; ENSG00000109906. [Q05516-1]
ENST00000392996; ENSP00000376721; ENSG00000109906. [Q05516-1]
GeneIDi7704.
KEGGihsa:7704.
UCSCiuc001poo.1. human. [Q05516-1]

Polymorphism databases

DMDMi90109930.

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z19002 mRNA. Translation: CAA79489.1 .
AF060568 Genomic DNA. Translation: AAD03619.1 .
BC026902 mRNA. Translation: AAH26902.1 .
BC029812 mRNA. Translation: AAH29812.1 .
S60093 Genomic DNA. Translation: AAC60590.2 .
CCDSi CCDS8367.1. [Q05516-1 ]
PIRi S36336.
RefSeqi NP_001018011.1. NM_001018011.1. [Q05516-1 ]
NP_005997.2. NM_006006.4. [Q05516-1 ]
UniGenei Hs.591945.
Hs.682144.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1BUO X-ray 1.90 A 6-126 [» ]
1CS3 X-ray 2.00 A 7-122 [» ]
ProteinModelPortali Q05516.
SMRi Q05516. Positions 6-126, 405-656.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113498. 105 interactions.
DIPi DIP-2654N.
IntActi Q05516. 67 interactions.
MINTi MINT-158782.
STRINGi 9606.ENSP00000338157.

PTM databases

PhosphoSitei Q05516.

Polymorphism databases

DMDMi 90109930.

Proteomic databases

PaxDbi Q05516.
PRIDEi Q05516.

Protocols and materials databases

DNASUi 7704.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000335953 ; ENSP00000338157 ; ENSG00000109906 . [Q05516-1 ]
ENST00000392996 ; ENSP00000376721 ; ENSG00000109906 . [Q05516-1 ]
GeneIDi 7704.
KEGGi hsa:7704.
UCSCi uc001poo.1. human. [Q05516-1 ]

Organism-specific databases

CTDi 7704.
GeneCardsi GC11P113930.
HGNCi HGNC:12930. ZBTB16.
HPAi CAB004540.
HPA001499.
MIMi 176797. gene.
612447. phenotype.
neXtProti NX_Q05516.
Orphaneti 520. Acute promyelocytic leukemia.
PharmGKBi PA37517.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000130800.
HOVERGENi HBG057844.
InParanoidi Q05516.
KOi K10055.
OMAi PPAEKHL.
OrthoDBi EOG7N8ZTX.
PhylomeDBi Q05516.
TreeFami TF350825.

Enzyme and pathway databases

UniPathwayi UPA00143 .
Reactomei REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
SignaLinki Q05516.

Miscellaneous databases

ChiTaRSi ZBTB16. human.
EvolutionaryTracei Q05516.
GeneWikii Zinc_finger_and_BTB_domain-containing_protein_16.
GenomeRNAii 7704.
NextBioi 29862.
PROi Q05516.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q05516.
Bgeei Q05516.
CleanExi HS_ZBTB16.
Genevestigatori Q05516.

Family and domain databases

Gene3Di 3.30.160.60. 8 hits.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00651. BTB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view ]
SMARTi SM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
PROSITEi PS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Fusion between a novel Kruppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia."
    Chen Z., Brand N.J., Chen A., Chen S.-J., Tong J.-H., Wang Z.-Y., Waxman S., Zelent A.
    EMBO J. 12:1161-1167(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PLZFB), ALTERNATIVE SPLICING, CHROMOSOMAL TRANSLOCATION WITH RARA.
    Tissue: Heart ventricle.
  2. "Genomic sequence, structural organization, molecular evolution, and aberrant rearrangement of promyelocytic leukemia zinc finger gene."
    Zhang T., Xiong H., Kan L.-X., Zhang C.-K., Jiao X.-F., Fu G., Zhang Q.-H., Lu L., Tong J.-H., Gu B.-W., Yu M., Liu J.-X., Licht J., Waxman S., Zelent A., Chen E., Chen S.-J.
    Proc. Natl. Acad. Sci. U.S.A. 96:11422-11427(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM PLZFB).
    Tissue: Brain.
  4. "Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia."
    Chen S.-J., Zelent A., Tong J.-H., Yu H.-Q., Wang Z.-Y., Derre J., Berger R., Waxman S., Chen Z.
    J. Clin. Invest. 91:2260-2267(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 424-455.
  5. "A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF."
    Hoatlin M.E., Zhi Y., Ball H., Silvey K., Melnick A., Stone S., Arai S., Hawe N., Owen G., Zelent A., Licht J.D.
    Blood 94:3737-3747(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ZBTB32.
  6. "Role of the ENTH domain in phosphatidylinositol-4,5-bisphosphate binding and endocytosis."
    Itoh T., Koshiba S., Kigawa T., Kikuchi A., Yokoyama S., Takenawa T.
    Science 291:1047-1051(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH EPN1.
  7. "Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases."
    Furukawa M., He Y.J., Borchers C., Xiong Y.
    Nat. Cell Biol. 5:1001-1007(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS AN E3 UBIQUITIN-PROTEIN LIGASE, INTERACTION WITH CUL3.
  8. Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 6-126.
  9. "Structure-function studies of the BTB/POZ transcriptional repression domain from the promyelocytic leukemia zinc finger oncoprotein."
    Li X., Peng H., Schultz D.C., Lopez-Guisa J.M., Rauscher F.J. III, Marmorstein R.
    Cancer Res. 59:5275-5282(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 7-122.
  10. "Biallelic loss of function of the promyelocytic leukaemia zinc finger (PLZF) gene causes severe skeletal defects and genital hypoplasia."
    Fischer S., Kohlhase J., Boehm D., Schweiger B., Hoffmann D., Heitmann M., Horsthemke B., Wieczorek D.
    J. Med. Genet. 45:731-737(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT SGYMR VAL-617.

Entry informationi

Entry nameiZBT16_HUMAN
AccessioniPrimary (citable) accession number: Q05516
Secondary accession number(s): Q8TAL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: March 7, 2006
Last modified: September 3, 2014
This is version 160 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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