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Q05516

- ZBT16_HUMAN

UniProt

Q05516 - ZBT16_HUMAN

Protein

Zinc finger and BTB domain-containing protein 16

Gene

ZBTB16

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 161 (01 Oct 2014)
      Sequence version 2 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    Probable transcription factor. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.1 Publication

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei394 – 3952Breakpoint for translocation to form PLZF-RAR-alpha oncogene

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri404 – 42623C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri432 – 45423C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri461 – 48323C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri490 – 51223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri518 – 54023C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri546 – 56823C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri574 – 59623C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri602 – 62423C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri630 – 65223C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. double-stranded DNA binding Source: Ensembl
    3. identical protein binding Source: IntAct
    4. metal ion binding Source: UniProtKB-KW
    5. protein binding Source: UniProtKB
    6. protein homodimerization activity Source: UniProtKB
    7. sequence-specific DNA binding transcription factor activity Source: Ensembl

    GO - Biological processi

    1. anterior/posterior pattern specification Source: Ensembl
    2. apoptotic process Source: UniProtKB
    3. cartilage development Source: UniProtKB
    4. central nervous system development Source: UniProtKB
    5. embryonic digit morphogenesis Source: Ensembl
    6. embryonic hindlimb morphogenesis Source: Ensembl
    7. embryonic pattern specification Source: Ensembl
    8. forelimb morphogenesis Source: Ensembl
    9. hemopoiesis Source: UniProtKB
    10. male germ-line stem cell asymmetric division Source: Ensembl
    11. mesonephros development Source: UniProtKB
    12. myeloid cell differentiation Source: UniProtKB
    13. negative regulation of cell proliferation Source: Ensembl
    14. negative regulation of myeloid cell differentiation Source: UniProtKB
    15. negative regulation of transcription, DNA-templated Source: UniProtKB
    16. positive regulation of apoptotic process Source: Ensembl
    17. positive regulation of cartilage development Source: UniProtKB
    18. positive regulation of chondrocyte differentiation Source: UniProtKB
    19. positive regulation of fat cell differentiation Source: UniProtKB
    20. positive regulation of ossification Source: UniProtKB
    21. positive regulation of transcription, DNA-templated Source: UniProtKB
    22. protein localization to nucleus Source: Ensembl
    23. protein ubiquitination Source: UniProtKB-UniPathway
    24. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation, Ubl conjugation pathway

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
    SignaLinkiQ05516.
    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger and BTB domain-containing protein 16
    Alternative name(s):
    Promyelocytic leukemia zinc finger protein
    Zinc finger protein 145
    Zinc finger protein PLZF
    Gene namesi
    Name:ZBTB16
    Synonyms:PLZF, ZNF145
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:12930. ZBTB16.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. nuclear body Source: UniProtKB
    3. nuclear speck Source: UniProtKB
    4. nucleus Source: UniProtKB
    5. plasma membrane Source: Ensembl
    6. PML body Source: UniProtKB
    7. transcriptional repressor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Skeletal defects, genital hypoplasia, and mental retardation (SGYMR) [MIM:612447]: A disorder characterized by mental retardation, craniofacial dysmorphism, microcephaly and short stature. Additional features include absence of the thumbs, hypoplasia of the radii and ulnae, additional vertebrae and ribs, retarded bone age and genital hypoplasia.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti617 – 6171M → V in SGYMR. 1 Publication
    VAR_054912
    A chromosomal aberration involving ZBTB16 may be a cause of acute promyelocytic leukemia (APL). Translocation t(11;17)(q32;q21) with RARA.

    Keywords - Diseasei

    Disease mutation, Mental retardation, Proto-oncogene

    Organism-specific databases

    MIMi612447. phenotype.
    Orphaneti520. Acute promyelocytic leukemia.
    PharmGKBiPA37517.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 673673Zinc finger and BTB domain-containing protein 16PRO_0000047729Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei76 – 761Phosphoserine; by PDPK1Sequence Analysis
    Modified residuei184 – 1841Phosphoserine; by PDPK1Sequence Analysis
    Modified residuei197 – 1971Phosphoserine; by PDPK1Sequence Analysis
    Modified residuei256 – 2561Phosphoserine; by PDPK1Sequence Analysis
    Modified residuei282 – 2821Phosphothreonine; by PDPK1Sequence Analysis
    Modified residuei628 – 6281Phosphoserine; by PDPK1Sequence Analysis

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ05516.
    PRIDEiQ05516.

    PTM databases

    PhosphoSiteiQ05516.

    Expressioni

    Tissue specificityi

    Within the hematopoietic system, PLZF is expressed in bone marrow, early myeloid cell lines and peripheral blood mononuclear cells. Also expressed in the ovary, and at lower levels, in the kidney and lung.

    Inductioni

    By retinoic acid.

    Gene expression databases

    ArrayExpressiQ05516.
    BgeeiQ05516.
    CleanExiHS_ZBTB16.
    GenevestigatoriQ05516.

    Organism-specific databases

    HPAiCAB004540.
    HPA001499.

    Interactioni

    Subunit structurei

    Binds EPN1. Interacts with ZBTB32 and CUL3.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself2EBI-711925,EBI-711925
    EEF1A1P681044EBI-711925,EBI-352162
    GneO358262EBI-711925,EBI-7109445From a different organism.
    Hoxa1P090223EBI-711925,EBI-3957603From a different organism.
    IL6P052312EBI-711925,EBI-720533
    PMLP295907EBI-711925,EBI-295890
    PMLP29590-52EBI-711925,EBI-304008
    TAB2Q9NYJ83EBI-711925,EBI-358708
    TRAF2Q129332EBI-711925,EBI-355744

    Protein-protein interaction databases

    BioGridi113498. 109 interactions.
    DIPiDIP-2654N.
    IntActiQ05516. 69 interactions.
    MINTiMINT-158782.
    STRINGi9606.ENSP00000338157.

    Structurei

    Secondary structure

    1
    673
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi16 – 3015
    Turni31 – 333
    Beta strandi36 – 427
    Beta strandi44 – 474
    Helixi49 – 557
    Helixi57 – 626
    Helixi63 – 653
    Beta strandi68 – 725
    Helixi77 – 8913
    Helixi96 – 983
    Helixi99 – 10911
    Helixi112 – 12514

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1BUOX-ray1.90A6-126[»]
    1CS3X-ray2.00A7-122[»]
    ProteinModelPortaliQ05516.
    SMRiQ05516. Positions 6-126, 405-656.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ05516.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini34 – 9663BTBPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
    Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri404 – 42623C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri432 – 45423C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri461 – 48323C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri490 – 51223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri518 – 54023C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri546 – 56823C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri574 – 59623C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri602 – 62423C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri630 – 65223C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000130800.
    HOVERGENiHBG057844.
    InParanoidiQ05516.
    KOiK10055.
    OMAiPPAEKHL.
    OrthoDBiEOG7N8ZTX.
    PhylomeDBiQ05516.
    TreeFamiTF350825.

    Family and domain databases

    Gene3Di3.30.160.60. 8 hits.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00651. BTB. 1 hit.
    PF00096. zf-C2H2. 2 hits.
    [Graphical view]
    SMARTiSM00225. BTB. 1 hit.
    SM00355. ZnF_C2H2. 9 hits.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.
    PROSITEiPS50097. BTB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 8 hits.
    PS50157. ZINC_FINGER_C2H2_2. 9 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform PLZFB (identifier: Q05516-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDLTKMGMIQ LQNPSHPTGL LCKANQMRLA GTLCDVVIMV DSQEFHAHRT    50
    VLACTSKMFE ILFHRNSQHY TLDFLSPKTF QQILEYAYTA TLQAKAEDLD 100
    DLLYAAEILE IEYLEEQCLK MLETIQASDD NDTEATMADG GAEEEEDRKA 150
    RYLKNIFISK HSSEESGYAS VAGQSLPGPM VDQSPSVSTS FGLSAMSPTK 200
    AAVDSLMTIG QSLLQGTLQP PAGPEEPTLA GGGRHPGVAE VKTEMMQVDE 250
    VPSQDSPGAA ESSISGGMGD KVEERGKEGP GTPTRSSVIT SARELHYGRE 300
    ESAEQVPPPA EAGQAPTGRP EHPAPPPEKH LGIYSVLPNH KADAVLSMPS 350
    SVTSGLHVQP ALAVSMDFST YGGLLPQGFI QRELFSKLGE LAVGMKSESR 400
    TIGEQCSVCG VELPDNEAVE QHRKLHSGMK TYGCELCGKR FLDSLRLRMH 450
    LLAHSAGAKA FVCDQCGAQF SKEDALETHR QTHTGTDMAV FCLLCGKRFQ 500
    AQSALQQHME VHAGVRSYIC SECNRTFPSH TALKRHLRSH TGDHPYECEF 550
    CGSCFRDEST LKSHKRIHTG EKPYECNGCG KKFSLKHQLE THYRVHTGEK 600
    PFECKLCHQR SRDYSAMIKH LRTHNGASPY QCTICTEYCP SLSSMQKHMK 650
    GHKPEEIPPD WRIEKTYLYL CYV 673
    Length:673
    Mass (Da):74,274
    Last modified:March 7, 2006 - v2
    Checksum:i51F8E361FA31239E
    GO
    Isoform PLZFA (identifier: Q05516-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         255-377: Missing.

    Show »
    Length:550
    Mass (Da):61,601
    Checksum:i1051E16C91FDC089
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti580 – 5801G → D in CAA79489. (PubMed:8384553)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti617 – 6171M → V in SGYMR. 1 Publication
    VAR_054912

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei255 – 377123Missing in isoform PLZFA. CuratedVSP_006896Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z19002 mRNA. Translation: CAA79489.1.
    AF060568 Genomic DNA. Translation: AAD03619.1.
    BC026902 mRNA. Translation: AAH26902.1.
    BC029812 mRNA. Translation: AAH29812.1.
    S60093 Genomic DNA. Translation: AAC60590.2.
    CCDSiCCDS8367.1. [Q05516-1]
    PIRiS36336.
    RefSeqiNP_001018011.1. NM_001018011.1. [Q05516-1]
    NP_005997.2. NM_006006.4. [Q05516-1]
    UniGeneiHs.591945.
    Hs.682144.

    Genome annotation databases

    EnsembliENST00000335953; ENSP00000338157; ENSG00000109906. [Q05516-1]
    ENST00000392996; ENSP00000376721; ENSG00000109906. [Q05516-1]
    GeneIDi7704.
    KEGGihsa:7704.
    UCSCiuc001poo.1. human. [Q05516-1]

    Polymorphism databases

    DMDMi90109930.

    Keywords - Coding sequence diversityi

    Alternative splicing, Chromosomal rearrangement

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z19002 mRNA. Translation: CAA79489.1 .
    AF060568 Genomic DNA. Translation: AAD03619.1 .
    BC026902 mRNA. Translation: AAH26902.1 .
    BC029812 mRNA. Translation: AAH29812.1 .
    S60093 Genomic DNA. Translation: AAC60590.2 .
    CCDSi CCDS8367.1. [Q05516-1 ]
    PIRi S36336.
    RefSeqi NP_001018011.1. NM_001018011.1. [Q05516-1 ]
    NP_005997.2. NM_006006.4. [Q05516-1 ]
    UniGenei Hs.591945.
    Hs.682144.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1BUO X-ray 1.90 A 6-126 [» ]
    1CS3 X-ray 2.00 A 7-122 [» ]
    ProteinModelPortali Q05516.
    SMRi Q05516. Positions 6-126, 405-656.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113498. 109 interactions.
    DIPi DIP-2654N.
    IntActi Q05516. 69 interactions.
    MINTi MINT-158782.
    STRINGi 9606.ENSP00000338157.

    PTM databases

    PhosphoSitei Q05516.

    Polymorphism databases

    DMDMi 90109930.

    Proteomic databases

    PaxDbi Q05516.
    PRIDEi Q05516.

    Protocols and materials databases

    DNASUi 7704.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000335953 ; ENSP00000338157 ; ENSG00000109906 . [Q05516-1 ]
    ENST00000392996 ; ENSP00000376721 ; ENSG00000109906 . [Q05516-1 ]
    GeneIDi 7704.
    KEGGi hsa:7704.
    UCSCi uc001poo.1. human. [Q05516-1 ]

    Organism-specific databases

    CTDi 7704.
    GeneCardsi GC11P113930.
    HGNCi HGNC:12930. ZBTB16.
    HPAi CAB004540.
    HPA001499.
    MIMi 176797. gene.
    612447. phenotype.
    neXtProti NX_Q05516.
    Orphaneti 520. Acute promyelocytic leukemia.
    PharmGKBi PA37517.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000130800.
    HOVERGENi HBG057844.
    InParanoidi Q05516.
    KOi K10055.
    OMAi PPAEKHL.
    OrthoDBi EOG7N8ZTX.
    PhylomeDBi Q05516.
    TreeFami TF350825.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .
    Reactomei REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
    SignaLinki Q05516.

    Miscellaneous databases

    ChiTaRSi ZBTB16. human.
    EvolutionaryTracei Q05516.
    GeneWikii Zinc_finger_and_BTB_domain-containing_protein_16.
    GenomeRNAii 7704.
    NextBioi 29862.
    PROi Q05516.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q05516.
    Bgeei Q05516.
    CleanExi HS_ZBTB16.
    Genevestigatori Q05516.

    Family and domain databases

    Gene3Di 3.30.160.60. 8 hits.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00651. BTB. 1 hit.
    PF00096. zf-C2H2. 2 hits.
    [Graphical view ]
    SMARTi SM00225. BTB. 1 hit.
    SM00355. ZnF_C2H2. 9 hits.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    PROSITEi PS50097. BTB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 8 hits.
    PS50157. ZINC_FINGER_C2H2_2. 9 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Fusion between a novel Kruppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia."
      Chen Z., Brand N.J., Chen A., Chen S.-J., Tong J.-H., Wang Z.-Y., Waxman S., Zelent A.
      EMBO J. 12:1161-1167(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PLZFB), ALTERNATIVE SPLICING, CHROMOSOMAL TRANSLOCATION WITH RARA.
      Tissue: Heart ventricle.
    2. "Genomic sequence, structural organization, molecular evolution, and aberrant rearrangement of promyelocytic leukemia zinc finger gene."
      Zhang T., Xiong H., Kan L.-X., Zhang C.-K., Jiao X.-F., Fu G., Zhang Q.-H., Lu L., Tong J.-H., Gu B.-W., Yu M., Liu J.-X., Licht J., Waxman S., Zelent A., Chen E., Chen S.-J.
      Proc. Natl. Acad. Sci. U.S.A. 96:11422-11427(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM PLZFB).
      Tissue: Brain.
    4. "Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia."
      Chen S.-J., Zelent A., Tong J.-H., Yu H.-Q., Wang Z.-Y., Derre J., Berger R., Waxman S., Chen Z.
      J. Clin. Invest. 91:2260-2267(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 424-455.
    5. "A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF."
      Hoatlin M.E., Zhi Y., Ball H., Silvey K., Melnick A., Stone S., Arai S., Hawe N., Owen G., Zelent A., Licht J.D.
      Blood 94:3737-3747(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ZBTB32.
    6. "Role of the ENTH domain in phosphatidylinositol-4,5-bisphosphate binding and endocytosis."
      Itoh T., Koshiba S., Kigawa T., Kikuchi A., Yokoyama S., Takenawa T.
      Science 291:1047-1051(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH EPN1.
    7. "Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases."
      Furukawa M., He Y.J., Borchers C., Xiong Y.
      Nat. Cell Biol. 5:1001-1007(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS AN E3 UBIQUITIN-PROTEIN LIGASE, INTERACTION WITH CUL3.
    8. Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 6-126.
    9. "Structure-function studies of the BTB/POZ transcriptional repression domain from the promyelocytic leukemia zinc finger oncoprotein."
      Li X., Peng H., Schultz D.C., Lopez-Guisa J.M., Rauscher F.J. III, Marmorstein R.
      Cancer Res. 59:5275-5282(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 7-122.
    10. "Biallelic loss of function of the promyelocytic leukaemia zinc finger (PLZF) gene causes severe skeletal defects and genital hypoplasia."
      Fischer S., Kohlhase J., Boehm D., Schweiger B., Hoffmann D., Heitmann M., Horsthemke B., Wieczorek D.
      J. Med. Genet. 45:731-737(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT SGYMR VAL-617.

    Entry informationi

    Entry nameiZBT16_HUMAN
    AccessioniPrimary (citable) accession number: Q05516
    Secondary accession number(s): Q8TAL4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 161 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3