Reviewed, UniProtKB/Swiss-Prot Q05515 (SVF1_YEAST)

Names and origin

Protein names

Recommended name:
    Survival factor 1

Gene names

Name:	SVF1
Synonyms:	SGI1
Ordered Locus Names:	YDR346C

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	481 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Required for survival in response to oxidative stress. Involved in the diauxic shift. Ref.2 Ref.5
Subcellular location	Cytoplasm. Nucleus. Ref.3
Miscellaneous	Present with 45200 molecules/cell in log phase SD medium. Ref.4 Expression in mammalian cells increases survival under conditions inducing apoptosis.
Sequence similarities	Belongs to the SVF1 family.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	response to oxidative stress Ref.5 Inferred from mutant phenotype. Source: SGD
Cellular component	cytoplasm Ref.3 Inferred from direct assay. Source: SGD nucleus Ref.3 Inferred from direct assay. Source: SGD
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
	P38800	1	EBI-38400,EBI-24597
MRI1	Q06489	1	EBI-38400,EBI-29371
PEX29	Q03370	1	EBI-38400,EBI-36170
SPT16	P32558	1	EBI-38400,EBI-4334

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 481	481	Survival factor 1		PRO_0000072336
Regions
	Compositional bias	200 – 256	57	Glu-rich
	Compositional bias	359 – 395	37	Glu-rich

Sequences

	Sequence		Length	Mass (Da)
	Q05515-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 926A28FE140F87A5	FASTA	481	54,368
	10 20 30 40 50 60 MLKWIKGGIS AVTGMAEPEY GKDYIHSVAD RVKNKQPYRE TSREDFFWQA PDHTNVESVI 70 80 90 100 110 120 FYFSDLKTGI FGFAQVIHSN IIGLHTASQF TFRIFDSKNP EDLNIWTSTK LENFYIEGPN 130 140 150 160 170 180 FYADNLSVEL SEDGESYHIQ SSVCDLSVVD LHIRRLTPGA KIGDDPATYY GNNINEPWGS 190 200 210 220 230 240 MRHVFWPRNA CHGTIKVKKE VIPESDEEES SADEDDNEDE DEESGDSEEE SGSEEESDSE 250 260 270 280 290 300 EVEITYEDRT ITFKEEDPAI STFIMAFQGM KPHHAAKAWN FMFFHSEKYS AVLMEFTTPK 310 320 330 340 350 360 SYANTKISAG IITDDKEVLA MTTNNLVEHL NSEIDSVGWK VPKDIKITFK GINTKVKDEQ 370 380 390 400 410 420 LESENGTEQA LQGEDEKEDE KEDEEEEEYK NVAEENKICA VVEGPLNNLV ERIDVMGEIP 430 440 450 460 470 480 SFVKNIVSGV AGTKPFIYQY ADPKSSTLQI NGGEKIHGVA WTEVTFISES DVISEESYNE A

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P. Nature 387:75-78(1997) [PubMed: 9169867] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	"Bcl-x(L) complements Saccharomyces cerevisiae genes that facilitate the switch from glycolytic to oxidative metabolism." Vander Heiden M.G., Choy J.S., VanderWeele D.J., Brace J.L., Harris M.H., Bauer D.E., Prange B., Kron S.J., Thompson C.B., Rudin C.M. J. Biol. Chem. 277:44870-44876(2002) [PubMed: 12244097] [Abstract] Cited for: FUNCTION.
[3]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[4]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]	"Svf1 inhibits reactive oxygen species generation and promotes survival under conditions of oxidative stress in Saccharomyces cerevisiae." Brace J.L., Vanderweele D.J., Rudin C.M. Yeast 22:641-652(2005) [PubMed: 16034825] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U51032 Genomic DNA. Translation: AAB64782.1.
PIR	S70111.
RefSeq	NP_010633.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:5243N.
IntAct	Q05515. 14 interactions.
Proteomic databases
PeptideAtlas	Q05515.
Genome annotation databases
Ensembl	YDR346C. Saccharomyces cerevisiae. [Contig view]
GeneID	851947.
GenomeReviews	Gene locus YDR346C in contig Z71256_GR.
KEGG	sce:YDR346C.
NMPDR	fig|4932.3.peg.1399.
Organism-specific databases
CYGD	YDR346c.
SGD	S000002754. SVF1.
Yeast-GFP	Search...
Phylogenomic databases
HOGENOM	Q05515.
OMA	Q05515. GTKPYIY.
Gene expression databases
ArrayExpress	Q05515.
GermOnline	YDR346C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR013931. Oxidative_stress_survival. [Graphical view]
Pfam	PF08622. Svf1. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	970033.

Entry information

Entry name

SVF1_YEAST

Accession

Primary (citable) accession number: Q05515

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)