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Protein

Arginine--tRNA ligase, cytoplasmic

Gene

YDR341C

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis.By similarity

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).

GO - Molecular functioni

  • arginine-tRNA ligase activity Source: SGD
  • ATP binding Source: UniProtKB-KW

GO - Biological processi

  • arginyl-tRNA aminoacylation Source: SGD
  • mitochondrial translation Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29896-MONOMER.
BRENDAi6.1.1.19. 984.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligase, cytoplasmic (EC:6.1.1.19)
Alternative name(s):
Arginyl-tRNA synthetase
Short name:
ArgRS
Gene namesi
Ordered Locus Names:YDR341C
ORF Names:D9651.10
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR341C.
SGDiS000002749. YDR341C.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001516642 – 607Arginine--tRNA ligase, cytoplasmicAdd BLAST606

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei15PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ05506.
PRIDEiQ05506.
TopDownProteomicsiQ05506.

PTM databases

iPTMnetiQ05506.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi32398. 58 interactors.
DIPiDIP-5046N.
IntActiQ05506. 1 interactor.
MINTiMINT-482020.

Structurei

Secondary structure

1607
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 13Combined sources11
Helixi19 – 22Combined sources4
Turni27 – 29Combined sources3
Helixi31 – 47Combined sources17
Helixi51 – 54Combined sources4
Helixi55 – 57Combined sources3
Helixi64 – 66Combined sources3
Beta strandi68 – 72Combined sources5
Helixi73 – 76Combined sources4
Helixi83 – 92Combined sources10
Turni97 – 99Combined sources3
Beta strandi100 – 106Combined sources7
Beta strandi109 – 114Combined sources6
Helixi116 – 130Combined sources15
Helixi131 – 133Combined sources3
Beta strandi144 – 148Combined sources5
Helixi160 – 162Combined sources3
Helixi163 – 178Combined sources16
Beta strandi182 – 190Combined sources9
Helixi194 – 206Combined sources13
Helixi209 – 214Combined sources6
Helixi216 – 233Combined sources18
Beta strandi235 – 238Combined sources4
Turni240 – 242Combined sources3
Beta strandi243 – 245Combined sources3
Helixi246 – 257Combined sources12
Helixi260 – 283Combined sources24
Beta strandi289 – 293Combined sources5
Helixi294 – 296Combined sources3
Helixi299 – 311Combined sources13
Beta strandi315 – 318Combined sources4
Beta strandi321 – 325Combined sources5
Helixi326 – 328Combined sources3
Turni331 – 333Combined sources3
Beta strandi335 – 339Combined sources5
Turni341 – 343Combined sources3
Helixi347 – 362Combined sources16
Beta strandi365 – 370Combined sources6
Helixi373 – 375Combined sources3
Helixi376 – 388Combined sources13
Helixi392 – 396Combined sources5
Beta strandi397 – 400Combined sources4
Beta strandi405 – 407Combined sources3
Turni410 – 413Combined sources4
Helixi418 – 434Combined sources17
Helixi437 – 440Combined sources4
Helixi446 – 463Combined sources18
Helixi475 – 479Combined sources5
Beta strandi482 – 485Combined sources4
Helixi486 – 502Combined sources17
Turni503 – 505Combined sources3
Helixi508 – 511Combined sources4
Helixi516 – 518Combined sources3
Helixi522 – 531Combined sources10
Helixi534 – 544Combined sources11
Helixi547 – 567Combined sources21
Helixi575 – 599Combined sources25

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BS2X-ray2.75A1-607[»]
1F7UX-ray2.20A1-607[»]
1F7VX-ray2.90A1-607[»]
ProteinModelPortaliQ05506.
SMRiQ05506.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ05506.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi151 – 162"HIGH" regionAdd BLAST12

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00530000063407.
HOGENOMiHOG000247211.
InParanoidiQ05506.
KOiK01887.
OMAiKLVGNYY.
OrthoDBiEOG092C0Z3M.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05506-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTANMISQ LKKLSIAEPA VAKDSHPDVN IVDLMRNYIS QELSKISGVD
60 70 80 90 100
SSLIFPALEW TNTMERGDLL IPIPRLRIKG ANPKDLAVQW AEKFPCGDFL
110 120 130 140 150
EKVEANGPFI QFFFNPQFLA KLVIPDILTR KEDYGSCKLV ENKKVIIEFS
160 170 180 190 200
SPNIAKPFHA GHLRSTIIGG FLANLYEKLG WEVIRMNYLG DWGKQFGLLA
210 220 230 240 250
VGFERYGNEE ALVKDPIHHL FDVYVRINKD IEEEGDSIPL EQSTNGKARE
260 270 280 290 300
YFKRMEDGDE EALKIWKRFR EFSIEKYIDT YARLNIKYDV YSGESQVSKE
310 320 330 340 350
SMLKAIDLFK EKGLTHEDKG AVLIDLTKFN KKLGKAIVQK SDGTTLYLTR
360 370 380 390 400
DVGAAMDRYE KYHFDKMIYV IASQQDLHAA QFFEILKQMG FEWAKDLQHV
410 420 430 440 450
NFGMVQGMST RKGTVVFLDN ILEETKEKMH EVMKKNENKY AQIEHPEEVA
460 470 480 490 500
DLVGISAVMI QDMQGKRINN YEFKWERMLS FEGDTGPYLQ YAHSRLRSVE
510 520 530 540 550
RNASGITQEK WINADFSLLK EPAAKLLIRL LGQYPDVLRN AIKTHEPTTV
560 570 580 590 600
VTYLFKLTHQ VSSCYDVLWV AGQTEELATA RLALYGAARQ VLYNGMRLLG

LTPVERM
Length:607
Mass (Da):69,525
Last modified:November 1, 1996 - v1
Checksum:i8349ABC0E30E50F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51032 Genomic DNA. Translation: AAB64777.1.
BK006938 Genomic DNA. Translation: DAA12182.1.
PIRiS70106.
RefSeqiNP_010628.3. NM_001180649.3.

Genome annotation databases

EnsemblFungiiYDR341C; YDR341C; YDR341C.
GeneIDi851942.
KEGGisce:YDR341C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51032 Genomic DNA. Translation: AAB64777.1.
BK006938 Genomic DNA. Translation: DAA12182.1.
PIRiS70106.
RefSeqiNP_010628.3. NM_001180649.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BS2X-ray2.75A1-607[»]
1F7UX-ray2.20A1-607[»]
1F7VX-ray2.90A1-607[»]
ProteinModelPortaliQ05506.
SMRiQ05506.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32398. 58 interactors.
DIPiDIP-5046N.
IntActiQ05506. 1 interactor.
MINTiMINT-482020.

PTM databases

iPTMnetiQ05506.

Proteomic databases

MaxQBiQ05506.
PRIDEiQ05506.
TopDownProteomicsiQ05506.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR341C; YDR341C; YDR341C.
GeneIDi851942.
KEGGisce:YDR341C.

Organism-specific databases

EuPathDBiFungiDB:YDR341C.
SGDiS000002749. YDR341C.

Phylogenomic databases

GeneTreeiENSGT00530000063407.
HOGENOMiHOG000247211.
InParanoidiQ05506.
KOiK01887.
OMAiKLVGNYY.
OrthoDBiEOG092C0Z3M.

Enzyme and pathway databases

BioCyciYEAST:G3O-29896-MONOMER.
BRENDAi6.1.1.19. 984.

Miscellaneous databases

EvolutionaryTraceiQ05506.
PROiQ05506.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYRC_YEAST
AccessioniPrimary (citable) accession number: Q05506
Secondary accession number(s): D6VSX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 159 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 20600 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.