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Q054T5

- SYL_LEPBL

UniProt

Q054T5 - SYL_LEPBL

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Leptospira borgpetersenii serovar Hardjo-bovis (strain L550)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei639 – 6391ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLBOR355276:GHUQ-568-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:LBL_0571
    OrganismiLeptospira borgpetersenii serovar Hardjo-bovis (strain L550)
    Taxonomic identifieri355276 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira
    ProteomesiUP000000655: Chromosome 1

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 864864Leucine--tRNA ligasePRO_1000009365Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi355276.LBL_0571.

    Structurei

    3D structure databases

    ProteinModelPortaliQ054T5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5112"HIGH" regionAdd
    BLAST
    Motifi636 – 6405"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q054T5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQYPFQEVES FWQKFWEENK SFQTNIRSSK PKFYCLDMFP YPSGAGLHVG    50
    HPEGYTATDI LSRFKRMKGF EVLHPMGWDA FGLPAERYAM QTGIHPAITT 100
    KNNIDNFRRQ IQMIGLSYDW SRELSTTDPD YYKFTQWIFI QLYQSWFNPE 150
    LKKAESIETL IQRFSNKGSA DLDYKPFSAQ EWKQFSLVEK EKILSDFRLV 200
    YQAEIPVNWC EALGTVLANE EVEEWIDKGY EVVRKPMRQY MMRITAYADR 250
    LLEDLKLVQW PSSTLEMQKN WIGKSEGLEI TFPFKKPLKS GSDGIRIFTT 300
    RPDTIFGVTY MVVAPEHPIV SEITTPEQKQ KVEEYQKVSS LKSDLDRMEL 350
    TKEKTGVFTG SFVLNPANPS KEIPIWISDY VLYGYGTGAI MAVPAHDQRD 400
    YEFAKTFGLE ILPVIEGEIT DVAFDSKTSI CIHSSSSEIS IDGLDYSSAS 450
    SKIISWAESK RIGKKKTQFK LRDWLFARQR YWGEPIPLVH YPSGITKPIP 500
    ESELPLELPP NLEEFKPSGT GESPLALAKE WLQYKDPETG EIGTRETNTM 550
    PQWAGSCWYY LRYIDPKNGK LFCDPDLEKK WMPVDLYVGG AEHAVLHLLY 600
    SRFWHKFLYD IGVVSTQEPF AKLIHQGLIL GEDKRKMSKS LGNVINPDDV 650
    IRKYGADSLR LFEMFMGPLE MVKPWSTRGV EGVFRFLNRV WRLFHTGEGE 700
    SFRLDEIEPT TEELKILHKT IQKVGEDIPN FSFNTAISQL MIFVNEFTPS 750
    DRRPKEVLET FILLLAPFAP HIAEELWKRS GNNKSLSTEK FPEADPQYLV 800
    ESEILIVVQV NGKLRDEFKA PKDVSEADAI SIAKNLDKIK GILDGKTIRK 850
    EIYVPGKLIN LVIG 864
    Length:864
    Mass (Da):99,488
    Last modified:November 14, 2006 - v1
    Checksum:i15A6F0DFD8404D54
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000348 Genomic DNA. Translation: ABJ78160.1.
    RefSeqiYP_797093.1. NC_008508.1.

    Genome annotation databases

    EnsemblBacteriaiABJ78160; ABJ78160; LBL_0571.
    GeneIDi4408952.
    KEGGilbl:LBL_0571.
    PATRICi22364442. VBILepBor75619_0694.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000348 Genomic DNA. Translation: ABJ78160.1 .
    RefSeqi YP_797093.1. NC_008508.1.

    3D structure databases

    ProteinModelPortali Q054T5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 355276.LBL_0571.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ78160 ; ABJ78160 ; LBL_0571 .
    GeneIDi 4408952.
    KEGGi lbl:LBL_0571.
    PATRICi 22364442. VBILepBor75619_0694.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci LBOR355276:GHUQ-568-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: L550.

    Entry informationi

    Entry nameiSYL_LEPBL
    AccessioniPrimary (citable) accession number: Q054T5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3