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Protein

Lipase chaperone

Gene

lifO

Organism
Burkholderia glumae (Pseudomonas glumae)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the folding of the extracellular lipase during its passage through the periplasm.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lipase chaperone
Alternative name(s):
Lipase activator protein
Lipase foldase
Lipase helper protein
Lipase modulator
Gene namesi
Name:lifO
Synonyms:lipB
OrganismiBurkholderia glumae (Pseudomonas glumae)
Taxonomic identifieri337 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 353353Lipase chaperonePRO_0000218481Add
BLAST

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
lipAQ054892EBI-993746,EBI-993752

Protein-protein interaction databases

DIPiDIP-29068N.
IntActiQ05490. 1 interaction.

Structurei

Secondary structure

1
353
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni81 – 855Combined sources
Beta strandi97 – 993Combined sources
Helixi104 – 11310Combined sources
Helixi114 – 1185Combined sources
Helixi121 – 13616Combined sources
Beta strandi137 – 1393Combined sources
Helixi140 – 15718Combined sources
Helixi175 – 19218Combined sources
Helixi194 – 1963Combined sources
Helixi197 – 21822Combined sources
Helixi228 – 2358Combined sources
Helixi241 – 26525Combined sources
Helixi270 – 2789Combined sources
Helixi283 – 31432Combined sources
Helixi320 – 33415Combined sources
Helixi340 – 3489Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ES4X-ray1.85D/E42-352[»]
ProteinModelPortaliQ05490.
SMRiQ05490. Positions 73-350.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ05490.

Family & Domainsi

Sequence similaritiesi

Belongs to the lipase chaperone family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

HAMAPiMF_00790. Lipase_chap.
InterProiIPR004961. Lipase_chaperone.
[Graphical view]
PfamiPF03280. Lipase_chap. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05490-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQADRPARG GLAARPMRGA SFALAGLVAC AACAAVVLWL RPAAPSPAPA
60 70 80 90 100
GAVAGGPAAG VPAAASGAAE AAMPLPAALP GALAGSHAPR LPLAAGGRLA
110 120 130 140 150
RTRAVREFFD YCLTAQGELT PAALDALVRR EIAAQLDGSP AQAEALGVWR
160 170 180 190 200
RYRAYFDALA QLPGDGAVLG DKLDPAAMQL ALDQRAALAD RTLGEWAEPF
210 220 230 240 250
FGDEQRRQRH DLERIRIAND TTLSPEQKAA RLAALDAQLT PDERAQQAAL
260 270 280 290 300
HAQQDAVTKI ADLQKAGATP DQMRAQIAQT LGPEAAARAA QMQQDDEAWQ
310 320 330 340 350
TRYQAYAAER DRIAAQGLAP QDRDARIAQL RQQTFTAPGE AIRAASLDRG

AGG
Length:353
Mass (Da):36,831
Last modified:October 1, 1994 - v1
Checksum:i57C5916D78EBB643
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70354 Genomic DNA. Translation: CAA49813.1.
PIRiS36249.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70354 Genomic DNA. Translation: CAA49813.1.
PIRiS36249.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ES4X-ray1.85D/E42-352[»]
ProteinModelPortaliQ05490.
SMRiQ05490. Positions 73-350.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29068N.
IntActiQ05490. 1 interaction.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ05490.

Family and domain databases

HAMAPiMF_00790. Lipase_chap.
InterProiIPR004961. Lipase_chaperone.
[Graphical view]
PfamiPF03280. Lipase_chap. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "An accessory gene, lipB, required for the production of active Pseudomonas glumae lipase."
    Frenken L.G.J., Bos J.W., Visser C., Mueller W., Tommassen J., Verrips C.T.
    Mol. Microbiol. 9:579-589(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: PG1.
  2. "Role of the lipB gene product in the folding of the secreted lipase of Pseudomonas glumae."
    Frenken L.G.J., de Groot A., Tommassen J., Verrips C.T.
    Mol. Microbiol. 9:591-599(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiLIFO_BURGL
AccessioniPrimary (citable) accession number: Q05490
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: December 9, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.