Q05481 (ZNF91_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 91

Alternative name(s):
Zinc finger protein HPF7
Zinc finger protein HTF10

Gene names

Name:

ZNF91

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1191 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 36 C2H2-type zinc fingers. Contains 1 KRAB domain.
Sequence caution	The sequence AAA58672.1 differs from that shown. Reason: Frameshift at positions 184 and 197.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Non-traceable author statement. Source: UniProtKB
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Non-traceable author statement Ref.4. Source: UniProtKB zinc ion binding Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q05481-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q05481-2)

The sequence of this isoform differs from the canonical sequence as follows:
     55-86: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1191	1191	Zinc finger protein 91		PRO_0000047400
Regions
	Domain	13 – 84	72	KRAB
	Zinc finger	154 – 176	23	C2H2-type 1; degenerate
	Zinc finger	179 – 200	22	C2H2-type 2
	Zinc finger	208 – 232	25	C2H2-type 3
	Zinc finger	238 – 260	23	C2H2-type 4
	Zinc finger	266 – 288	23	C2H2-type 5
	Zinc finger	294 – 316	23	C2H2-type 6
	Zinc finger	322 – 344	23	C2H2-type 7
	Zinc finger	350 – 372	23	C2H2-type 8
	Zinc finger	378 – 400	23	C2H2-type 9
	Zinc finger	406 – 428	23	C2H2-type 10
	Zinc finger	434 – 456	23	C2H2-type 11
	Zinc finger	462 – 484	23	C2H2-type 12
	Zinc finger	490 – 512	23	C2H2-type 13
	Zinc finger	518 – 540	23	C2H2-type 14; degenerate
	Zinc finger	546 – 568	23	C2H2-type 15
	Zinc finger	574 – 596	23	C2H2-type 16
	Zinc finger	602 – 624	23	C2H2-type 17
	Zinc finger	630 – 652	23	C2H2-type 18
	Zinc finger	658 – 680	23	C2H2-type 19
	Zinc finger	686 – 708	23	C2H2-type 20
	Zinc finger	714 – 736	23	C2H2-type 21
	Zinc finger	742 – 764	23	C2H2-type 22
	Zinc finger	770 – 792	23	C2H2-type 23
	Zinc finger	798 – 820	23	C2H2-type 24
	Zinc finger	826 – 848	23	C2H2-type 25
	Zinc finger	854 – 876	23	C2H2-type 26
	Zinc finger	885 – 904	20	C2H2-type 27; degenerate
	Zinc finger	910 – 932	23	C2H2-type 28
	Zinc finger	938 – 960	23	C2H2-type 29
	Zinc finger	966 – 988	23	C2H2-type 30
	Zinc finger	994 – 1016	23	C2H2-type 31
	Zinc finger	1022 – 1044	23	C2H2-type 32
	Zinc finger	1050 – 1072	23	C2H2-type 33
	Zinc finger	1078 – 1100	23	C2H2-type 34
	Zinc finger	1106 – 1128	23	C2H2-type 35
	Zinc finger	1134 – 1156	23	C2H2-type 36
Natural variations
	Alternative sequence	55 – 86	32	Missing in isoform 2.		VSP_040288
	Natural variant	112	1	Y → H. Corresponds to variant rs296091 [ dbSNP | Ensembl ].		VAR_057393
	Natural variant	336	1	T → A. Ref.1 Corresponds to variant rs449447 [ dbSNP | Ensembl ].		VAR_060417
	Natural variant	386	1	A → T. Ref.1 Ref.2 Corresponds to variant rs403356 [ dbSNP | Ensembl ].		VAR_060418
	Natural variant	455	1	F → I. Corresponds to variant rs440638 [ dbSNP | Ensembl ].		VAR_059897
	Natural variant	521	1	E → K. Corresponds to variant rs12976753 [ dbSNP | Ensembl ].		VAR_060419
	Natural variant	896	1	T → A. Corresponds to variant rs296093 [ dbSNP | Ensembl ].		VAR_057394
	Natural variant	1011	1	R → I. Corresponds to variant rs1821844 [ dbSNP | Ensembl ].		VAR_060420
	Natural variant	1033	1	R → Q. Corresponds to variant rs1821846 [ dbSNP | Ensembl ].		VAR_060421
	Natural variant	1164	1	L → P. Corresponds to variant rs428549 [ dbSNP | Ensembl ].		VAR_059898
	Natural variant	1164	1	L → V. Corresponds to variant rs385750 [ dbSNP | Ensembl ].		VAR_059899
Experimental info
	Sequence conflict	142	1	L → F in BAH13252. Ref.2
	Sequence conflict	333	1	R → H in AAA59469. Ref.1
	Sequence conflict	470	1	A → G in AAA59469. Ref.1
	Sequence conflict	493	1	E → V in BAF83945. Ref.2
	Sequence conflict	663	1	C → R in BAF83945. Ref.2
	Sequence conflict	760	1	H → R in BAH13252. Ref.2
	Sequence conflict	907	1	E → G in BAH13252. Ref.2
	Sequence conflict	909	1	T → P in AAA59469. Ref.1
	Sequence conflict	1140	1	G → C in AAA59469. Ref.1
	Sequence conflict	1164	1	L → A in BAF83945. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 30, 2010. Version 2. Checksum: B8F5F0327A79EE3B	FASTA	1,191	137,217
	10 20 30 40 50 60 MPGTPGSLEM GLLTFRDVAI EFSPEEWQCL DTAQQNLYRN VMLENYRNLA FLGIALSKPD 70 80 90 100 110 120 LITYLEQGKE PWNMKQHEMV DEPTGICPHF PQDFWPEQSM EDSFQKVLLR KYEKCGHENL 130 140 150 160 170 180 QLRKGCKSVD ECKVHKEGYN KLNQCLTTAQ SKVFQCGKYL KVFYKFLNSN RHTIRHTGKK 190 200 210 220 230 240 CFKCKKCVKS FCIRLHKTQH KCVYITEKSC KCKECEKTFH WSSTLTNHKE IHTEDKPYKC 250 260 270 280 290 300 EECGKAFKQL STLTTHKIIC AKEKIYKCEE CGKAFLWSST LTRHKRIHTG EKPYKCEECG 310 320 330 340 350 360 KAFSHSSTLA KHKRIHTGEK PYKCEECGKA FSRSSTLAKH KRIHTGEKPY KCKECGKAFS 370 380 390 400 410 420 NSSTLANHKI THTEEKPYKC KECDKAFKRL STLTKHKIIH AGEKLYKCEE CGKAFNRSSN 430 440 450 460 470 480 LTIHKFIHTG EKPYKCEECG KAFNWSSSLT KHKRFHTREK PFKCKECGKA FIWSSTLTRH 490 500 510 520 530 540 KRIHTGEKPY KCEECGKAFR QSSTLTKHKI IHTGEKPYKF EECGKAFRQS LTLNKHKIIH 550 560 570 580 590 600 SREKPYKCKE CGKAFKQFST LTTHKIIHAG KKLYKCEECG KAFNHSSSLS THKIIHTGEK 610 620 630 640 650 660 SYKCEECGKA FLWSSTLRRH KRIHTGEKPY KCEECGKAFS HSSALAKHKR IHTGEKPYKC 670 680 690 700 710 720 KECGKAFSNS STLANHKITH TEEKPYKCKE CDKTFKRLST LTKHKIIHAG EKLYKCEECG 730 740 750 760 770 780 KAFNRSSNLT IHKFIHTGEK PYKCEECGKA FNWSSSLTKH KRIHTREKPF KCKECGKAFI 790 800 810 820 830 840 WSSTLTRHKR IHTGEKPYKC EECGKAFSRS STLTKHKTIH TGEKPYKCKE CGKAFKHSSA 850 860 870 880 890 900 LAKHKIIHAG EKLYKCEECG KAFNQSSNLT THKIIHTKEK PSKSEECDKA FIWSSTLTEH 910 920 930 940 950 960 KRIHTREKTY KCEECGKAFS QPSHLTTHKR MHTGEKPYKC EECGKAFSQS STLTTHKIIH 970 980 990 1000 1010 1020 TGEKPYKCEE CGKAFRKSST LTEHKIIHTG EKPYKCEECG KAFSQSSTLT RHTRMHTGEK 1030 1040 1050 1060 1070 1080 PYKCEECGKA FNRSSKLTTH KIIHTGEKPY KCEECGKAFI SSSTLNGHKR IHTREKPYKC 1090 1100 1110 1120 1130 1140 EECGKAFSQS STLTRHKRLH TGEKPYKCGE CGKAFKESSA LTKHKIIHTG EKPYKCEKCG 1150 1160 1170 1180 1190 KAFNQSSILT NHKKIHTITP VIPLLWEAEA GGSRGQEMET ILANTVKPLL Y
	Isoform 2 [UniParc]. Checksum: 988520EB0A88BE5A	FASTA	1,159	133,536
	10 20 30 40 50 60 MPGTPGSLEM GLLTFRDVAI EFSPEEWQCL DTAQQNLYRN VMLENYRNLA FLGICPHFPQ 70 80 90 100 110 120 DFWPEQSMED SFQKVLLRKY EKCGHENLQL RKGCKSVDEC KVHKEGYNKL NQCLTTAQSK 130 140 150 160 170 180 VFQCGKYLKV FYKFLNSNRH TIRHTGKKCF KCKKCVKSFC IRLHKTQHKC VYITEKSCKC 190 200 210 220 230 240 KECEKTFHWS STLTNHKEIH TEDKPYKCEE CGKAFKQLST LTTHKIICAK EKIYKCEECG 250 260 270 280 290 300 KAFLWSSTLT RHKRIHTGEK PYKCEECGKA FSHSSTLAKH KRIHTGEKPY KCEECGKAFS 310 320 330 340 350 360 RSSTLAKHKR IHTGEKPYKC KECGKAFSNS STLANHKITH TEEKPYKCKE CDKAFKRLST 370 380 390 400 410 420 LTKHKIIHAG EKLYKCEECG KAFNRSSNLT IHKFIHTGEK PYKCEECGKA FNWSSSLTKH 430 440 450 460 470 480 KRFHTREKPF KCKECGKAFI WSSTLTRHKR IHTGEKPYKC EECGKAFRQS STLTKHKIIH 490 500 510 520 530 540 TGEKPYKFEE CGKAFRQSLT LNKHKIIHSR EKPYKCKECG KAFKQFSTLT THKIIHAGKK 550 560 570 580 590 600 LYKCEECGKA FNHSSSLSTH KIIHTGEKSY KCEECGKAFL WSSTLRRHKR IHTGEKPYKC 610 620 630 640 650 660 EECGKAFSHS SALAKHKRIH TGEKPYKCKE CGKAFSNSST LANHKITHTE EKPYKCKECD 670 680 690 700 710 720 KTFKRLSTLT KHKIIHAGEK LYKCEECGKA FNRSSNLTIH KFIHTGEKPY KCEECGKAFN 730 740 750 760 770 780 WSSSLTKHKR IHTREKPFKC KECGKAFIWS STLTRHKRIH TGEKPYKCEE CGKAFSRSST 790 800 810 820 830 840 LTKHKTIHTG EKPYKCKECG KAFKHSSALA KHKIIHAGEK LYKCEECGKA FNQSSNLTTH 850 860 870 880 890 900 KIIHTKEKPS KSEECDKAFI WSSTLTEHKR IHTREKTYKC EECGKAFSQP SHLTTHKRMH 910 920 930 940 950 960 TGEKPYKCEE CGKAFSQSST LTTHKIIHTG EKPYKCEECG KAFRKSSTLT EHKIIHTGEK 970 980 990 1000 1010 1020 PYKCEECGKA FSQSSTLTRH TRMHTGEKPY KCEECGKAFN RSSKLTTHKI IHTGEKPYKC 1030 1040 1050 1060 1070 1080 EECGKAFISS STLNGHKRIH TREKPYKCEE CGKAFSQSST LTRHKRLHTG EKPYKCGECG 1090 1100 1110 1120 1130 1140 KAFKESSALT KHKIIHTGEK PYKCEKCGKA FNQSSILTNH KKIHTITPVI PLLWEAEAGG 1150 SRGQEMETIL ANTVKPLLY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells." Bellefroid E.J., Marine J.-C., Ried T., Lecocq P.J., Riviere M., Amemiya C.T., Poncelet D.A., Coulie P.G., de Jong P.J., Szpirer C., Ward D.C., Martial J.A. EMBO J. 12:1363-1374(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ALA-336 AND THR-386.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT THR-386. Tissue: Placenta.
[3]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins." Bellefroid E.J., Poncelet D.A., Lecocq P.J., Revelant O., Martial J.A. Proc. Natl. Acad. Sci. U.S.A. 88:3608-3612(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 15-204 (ISOFORM 1).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L11672 mRNA. Translation: AAA59469.1. AK300294 mRNA. Translation: BAH13252.1. AK291256 mRNA. Translation: BAF83945.1. AC010300 Genomic DNA. No translation available. AC016628 Genomic DNA. No translation available. AC022409 Genomic DNA. No translation available. AC093058 Genomic DNA. No translation available. M61871 mRNA. Translation: AAA58672.1. Frameshift.
IPI	IPI00013437. IPI00873227.
PIR	F39384. PQ0636. S35305.
RefSeq	NP_003421.2. NM_003430.2.
UniGene	Hs.654471.
3D structure databases
ProteinModelPortal	Q05481.
SMR	Q05481. Positions 13-53, 152-1157.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q05481. 3 interactions.
STRING	9606.ENSP00000300619.
PTM databases
PhosphoSite	Q05481.
Polymorphism databases
DMDM	549839.
Proteomic databases
PaxDb	Q05481.
PRIDE	Q05481.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000300619; ENSP00000300619; ENSG00000167232. ENST00000397082; ENSP00000380272; ENSG00000167232.
GeneID	7644.
KEGG	hsa:7644.
UCSC	uc002nre.3. human. uc010xrj.2. human.
Organism-specific databases
CTD	7644.
GeneCards	GC19M023540.
HGNC	HGNC:13166. ZNF91.
MIM	603971. gene.
neXtProt	NX_Q05481.
PharmGKB	PA37739.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000234617.
HOVERGEN	HBG018163.
KO	K09228.
OMA	NLTIHKF.
OrthoDB	EOG4V9TSW.
Gene expression databases
Bgee	Q05481.
CleanEx	HS_ZNF91.
Genevestigator	Q05481.
GermOnline	ENSG00000167232. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 34 hits.
InterPro	IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF01352. KRAB. 1 hit. PF00096. zf-C2H2. 1 hit. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 34 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 31 hits. PS50157. ZINC_FINGER_C2H2_2. 35 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	7644.
NextBio	29762.
SOURCE	Search...

Entry information

Entry name

ZNF91_HUMAN

Accession

Primary (citable) accession number: Q05481
Secondary accession number(s): A8K5E1, B7Z6G6

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	November 30, 2010
Last modified:	May 1, 2013
This is version 123 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.