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Q05481 (ZNF91_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 135. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 91
Alternative name(s):
Zinc finger protein HPF7
Zinc finger protein HTF10
Gene names
Name:ZNF91
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1191 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Nucleus Ref.5.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 36 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Sequence caution

The sequence AAA58672.1 differs from that shown. Reason: Frameshift at positions 184 and 197.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranscription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from direct assay Ref.5. Source: UniProtKB

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

sequence-specific DNA binding transcription factor activity

Non-traceable author statement Ref.4. Source: UniProtKB

zinc ion binding

Non-traceable author statement Ref.1. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q05481-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q05481-2)

The sequence of this isoform differs from the canonical sequence as follows:
     55-86: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11911191Zinc finger protein 91
PRO_0000047400

Regions

Domain13 – 8472KRAB
Zinc finger154 – 17623C2H2-type 1; degenerate
Zinc finger179 – 20022C2H2-type 2
Zinc finger208 – 23225C2H2-type 3
Zinc finger238 – 26023C2H2-type 4
Zinc finger266 – 28823C2H2-type 5
Zinc finger294 – 31623C2H2-type 6
Zinc finger322 – 34423C2H2-type 7
Zinc finger350 – 37223C2H2-type 8
Zinc finger378 – 40023C2H2-type 9
Zinc finger406 – 42823C2H2-type 10
Zinc finger434 – 45623C2H2-type 11
Zinc finger462 – 48423C2H2-type 12
Zinc finger490 – 51223C2H2-type 13
Zinc finger518 – 54023C2H2-type 14; degenerate
Zinc finger546 – 56823C2H2-type 15
Zinc finger574 – 59623C2H2-type 16
Zinc finger602 – 62423C2H2-type 17
Zinc finger630 – 65223C2H2-type 18
Zinc finger658 – 68023C2H2-type 19
Zinc finger686 – 70823C2H2-type 20
Zinc finger714 – 73623C2H2-type 21
Zinc finger742 – 76423C2H2-type 22
Zinc finger770 – 79223C2H2-type 23
Zinc finger798 – 82023C2H2-type 24
Zinc finger826 – 84823C2H2-type 25
Zinc finger854 – 87623C2H2-type 26
Zinc finger885 – 90420C2H2-type 27; degenerate
Zinc finger910 – 93223C2H2-type 28
Zinc finger938 – 96023C2H2-type 29
Zinc finger966 – 98823C2H2-type 30
Zinc finger994 – 101623C2H2-type 31
Zinc finger1022 – 104423C2H2-type 32
Zinc finger1050 – 107223C2H2-type 33
Zinc finger1078 – 110023C2H2-type 34
Zinc finger1106 – 112823C2H2-type 35
Zinc finger1134 – 115623C2H2-type 36

Natural variations

Alternative sequence55 – 8632Missing in isoform 2.
VSP_040288
Natural variant1121Y → H.
Corresponds to variant rs296091 [ dbSNP | Ensembl ].
VAR_057393
Natural variant3361T → A. Ref.1
Corresponds to variant rs449447 [ dbSNP | Ensembl ].
VAR_060417
Natural variant3861A → T. Ref.1 Ref.2
Corresponds to variant rs403356 [ dbSNP | Ensembl ].
VAR_060418
Natural variant4551F → I.
Corresponds to variant rs440638 [ dbSNP | Ensembl ].
VAR_059897
Natural variant5211E → K.
Corresponds to variant rs12976753 [ dbSNP | Ensembl ].
VAR_060419
Natural variant8961T → A.
Corresponds to variant rs296093 [ dbSNP | Ensembl ].
VAR_057394
Natural variant10111R → I.
Corresponds to variant rs1821844 [ dbSNP | Ensembl ].
VAR_060420
Natural variant10331R → Q.
Corresponds to variant rs1821846 [ dbSNP | Ensembl ].
VAR_060421
Natural variant11641L → P.
Corresponds to variant rs428549 [ dbSNP | Ensembl ].
VAR_059898
Natural variant11641L → V.
Corresponds to variant rs385750 [ dbSNP | Ensembl ].
VAR_059899

Experimental info

Sequence conflict1421L → F in BAH13252. Ref.2
Sequence conflict3331R → H in AAA59469. Ref.1
Sequence conflict4701A → G in AAA59469. Ref.1
Sequence conflict4931E → V in BAF83945. Ref.2
Sequence conflict6631C → R in BAF83945. Ref.2
Sequence conflict7601H → R in BAH13252. Ref.2
Sequence conflict9071E → G in BAH13252. Ref.2
Sequence conflict9091T → P in AAA59469. Ref.1
Sequence conflict11401G → C in AAA59469. Ref.1
Sequence conflict11641L → A in BAF83945. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 30, 2010. Version 2.
Checksum: B8F5F0327A79EE3B

FASTA1,191137,217
        10         20         30         40         50         60 
MPGTPGSLEM GLLTFRDVAI EFSPEEWQCL DTAQQNLYRN VMLENYRNLA FLGIALSKPD 

        70         80         90        100        110        120 
LITYLEQGKE PWNMKQHEMV DEPTGICPHF PQDFWPEQSM EDSFQKVLLR KYEKCGHENL 

       130        140        150        160        170        180 
QLRKGCKSVD ECKVHKEGYN KLNQCLTTAQ SKVFQCGKYL KVFYKFLNSN RHTIRHTGKK 

       190        200        210        220        230        240 
CFKCKKCVKS FCIRLHKTQH KCVYITEKSC KCKECEKTFH WSSTLTNHKE IHTEDKPYKC 

       250        260        270        280        290        300 
EECGKAFKQL STLTTHKIIC AKEKIYKCEE CGKAFLWSST LTRHKRIHTG EKPYKCEECG 

       310        320        330        340        350        360 
KAFSHSSTLA KHKRIHTGEK PYKCEECGKA FSRSSTLAKH KRIHTGEKPY KCKECGKAFS 

       370        380        390        400        410        420 
NSSTLANHKI THTEEKPYKC KECDKAFKRL STLTKHKIIH AGEKLYKCEE CGKAFNRSSN 

       430        440        450        460        470        480 
LTIHKFIHTG EKPYKCEECG KAFNWSSSLT KHKRFHTREK PFKCKECGKA FIWSSTLTRH 

       490        500        510        520        530        540 
KRIHTGEKPY KCEECGKAFR QSSTLTKHKI IHTGEKPYKF EECGKAFRQS LTLNKHKIIH 

       550        560        570        580        590        600 
SREKPYKCKE CGKAFKQFST LTTHKIIHAG KKLYKCEECG KAFNHSSSLS THKIIHTGEK 

       610        620        630        640        650        660 
SYKCEECGKA FLWSSTLRRH KRIHTGEKPY KCEECGKAFS HSSALAKHKR IHTGEKPYKC 

       670        680        690        700        710        720 
KECGKAFSNS STLANHKITH TEEKPYKCKE CDKTFKRLST LTKHKIIHAG EKLYKCEECG 

       730        740        750        760        770        780 
KAFNRSSNLT IHKFIHTGEK PYKCEECGKA FNWSSSLTKH KRIHTREKPF KCKECGKAFI 

       790        800        810        820        830        840 
WSSTLTRHKR IHTGEKPYKC EECGKAFSRS STLTKHKTIH TGEKPYKCKE CGKAFKHSSA 

       850        860        870        880        890        900 
LAKHKIIHAG EKLYKCEECG KAFNQSSNLT THKIIHTKEK PSKSEECDKA FIWSSTLTEH 

       910        920        930        940        950        960 
KRIHTREKTY KCEECGKAFS QPSHLTTHKR MHTGEKPYKC EECGKAFSQS STLTTHKIIH 

       970        980        990       1000       1010       1020 
TGEKPYKCEE CGKAFRKSST LTEHKIIHTG EKPYKCEECG KAFSQSSTLT RHTRMHTGEK 

      1030       1040       1050       1060       1070       1080 
PYKCEECGKA FNRSSKLTTH KIIHTGEKPY KCEECGKAFI SSSTLNGHKR IHTREKPYKC 

      1090       1100       1110       1120       1130       1140 
EECGKAFSQS STLTRHKRLH TGEKPYKCGE CGKAFKESSA LTKHKIIHTG EKPYKCEKCG 

      1150       1160       1170       1180       1190 
KAFNQSSILT NHKKIHTITP VIPLLWEAEA GGSRGQEMET ILANTVKPLL Y 

« Hide

Isoform 2 [UniParc].

Checksum: 988520EB0A88BE5A
Show »

FASTA1,159133,536

References

« Hide 'large scale' references
[1]"Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells."
Bellefroid E.J., Marine J.-C., Ried T., Lecocq P.J., Riviere M., Amemiya C.T., Poncelet D.A., Coulie P.G., de Jong P.J., Szpirer C., Ward D.C., Martial J.A.
EMBO J. 12:1363-1374(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ALA-336 AND THR-386.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT THR-386.
Tissue: Placenta.
[3]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins."
Bellefroid E.J., Poncelet D.A., Lecocq P.J., Revelant O., Martial J.A.
Proc. Natl. Acad. Sci. U.S.A. 88:3608-3612(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 15-204 (ISOFORM 1).
[5]"Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1."
Wang W., Cai J., Wu Y., Hu L., Chen Z., Hu J., Chen Z., Li W., Guo M., Huang Z.
Cell. Mol. Life Sci. 70:3947-3958(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L11672 mRNA. Translation: AAA59469.1.
AK300294 mRNA. Translation: BAH13252.1.
AK291256 mRNA. Translation: BAF83945.1.
AC010300 Genomic DNA. No translation available.
AC016628 Genomic DNA. No translation available.
AC022409 Genomic DNA. No translation available.
AC093058 Genomic DNA. No translation available.
M61871 mRNA. Translation: AAA58672.1. Frameshift.
CCDSCCDS42541.1. [Q05481-1]
PIRF39384.
PQ0636.
S35305.
RefSeqNP_003421.2. NM_003430.2. [Q05481-1]
XP_006722942.1. XM_006722879.1. [Q05481-2]
UniGeneHs.654471.

3D structure databases

ProteinModelPortalQ05481.
SMRQ05481. Positions 152-1157.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113460. 6 interactions.
IntActQ05481. 4 interactions.
STRING9606.ENSP00000300619.

PTM databases

PhosphoSiteQ05481.

Polymorphism databases

DMDM313104067.

Proteomic databases

MaxQBQ05481.
PaxDbQ05481.
PRIDEQ05481.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000300619; ENSP00000300619; ENSG00000167232. [Q05481-1]
ENST00000397082; ENSP00000380272; ENSG00000167232. [Q05481-2]
GeneID7644.
KEGGhsa:7644.
UCSCuc002nre.3. human. [Q05481-1]
uc010xrj.2. human. [Q05481-2]

Organism-specific databases

CTD7644.
GeneCardsGC19M023489.
HGNCHGNC:13166. ZNF91.
MIM603971. gene.
neXtProtNX_Q05481.
PharmGKBPA37739.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
KOK09228.
OMANLTIHKF.
OrthoDBEOG7KSX7Q.
PhylomeDBQ05481.
TreeFamTF343410.

Gene expression databases

ArrayExpressQ05481.
BgeeQ05481.
CleanExHS_ZNF91.
GenevestigatorQ05481.

Family and domain databases

Gene3D3.30.160.60. 34 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 34 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 31 hits.
PS50157. ZINC_FINGER_C2H2_2. 35 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi7644.
NextBio29762.
PROQ05481.
SOURCESearch...

Entry information

Entry nameZNF91_HUMAN
AccessionPrimary (citable) accession number: Q05481
Secondary accession number(s): A8K5E1, B7Z6G6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 30, 2010
Last modified: July 9, 2014
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM