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Protein

Zinc finger protein 91

Gene

ZNF91

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor specifically required to repress SINE-VNTR-Alu (SVA) retrotransposons: recognizes and binds SVA sequences and represses their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305). May also bind the promoter of the FCGR2B gene, leading to repress its expression; however, additional evidences are required to confirm this result in vivo (PubMed:11470777).IKR:1 Publication

Miscellaneous

ZNF91 is only present in primates and emerged in the last common ancestor of humans and Old-World monkeys. It underwent structural changes between 8-12 Million years ago, probably to improve the protein's ability to bind and repress SINE-VNTR-Alu (SVA) retrotransposons elements (PubMed:25274305).IKR:1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri154 – 176C2H2-type 1; degenerateIEP:Add BLAST23
Zinc fingeri179 – 200C2H2-type 2IEP:Add BLAST22
Zinc fingeri208 – 232C2H2-type 3IEP:Add BLAST25
Zinc fingeri238 – 260C2H2-type 4IEP:Add BLAST23
Zinc fingeri266 – 288C2H2-type 5IEP:Add BLAST23
Zinc fingeri294 – 316C2H2-type 6IEP:Add BLAST23
Zinc fingeri322 – 344C2H2-type 7IEP:Add BLAST23
Zinc fingeri350 – 372C2H2-type 8IEP:Add BLAST23
Zinc fingeri378 – 400C2H2-type 9IEP:Add BLAST23
Zinc fingeri406 – 428C2H2-type 10IEP:Add BLAST23
Zinc fingeri434 – 456C2H2-type 11IEP:Add BLAST23
Zinc fingeri462 – 484C2H2-type 12IEP:Add BLAST23
Zinc fingeri490 – 512C2H2-type 13IEP:Add BLAST23
Zinc fingeri518 – 540C2H2-type 14; degenerateIEP:Add BLAST23
Zinc fingeri546 – 568C2H2-type 15IEP:Add BLAST23
Zinc fingeri574 – 596C2H2-type 16IEP:Add BLAST23
Zinc fingeri602 – 624C2H2-type 17IEP:Add BLAST23
Zinc fingeri630 – 652C2H2-type 18IEP:Add BLAST23
Zinc fingeri658 – 680C2H2-type 19IEP:Add BLAST23
Zinc fingeri686 – 708C2H2-type 20IEP:Add BLAST23
Zinc fingeri714 – 736C2H2-type 21IEP:Add BLAST23
Zinc fingeri742 – 764C2H2-type 22IEP:Add BLAST23
Zinc fingeri770 – 792C2H2-type 23IEP:Add BLAST23
Zinc fingeri798 – 820C2H2-type 24IEP:Add BLAST23
Zinc fingeri826 – 848C2H2-type 25IEP:Add BLAST23
Zinc fingeri854 – 876C2H2-type 26IEP:Add BLAST23
Zinc fingeri885 – 904C2H2-type 27; degenerateIEP:Add BLAST20
Zinc fingeri910 – 932C2H2-type 28IEP:Add BLAST23
Zinc fingeri938 – 960C2H2-type 29IEP:Add BLAST23
Zinc fingeri966 – 988C2H2-type 30IEP:Add BLAST23
Zinc fingeri994 – 1016C2H2-type 31IEP:Add BLAST23
Zinc fingeri1022 – 1044C2H2-type 32IEP:Add BLAST23
Zinc fingeri1050 – 1072C2H2-type 33IEP:Add BLAST23
Zinc fingeri1078 – 1100C2H2-type 34IEP:Add BLAST23
Zinc fingeri1106 – 1128C2H2-type 35IEP:Add BLAST23
Zinc fingeri1134 – 1156C2H2-type 36IEP:Add BLAST23

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 91
Alternative name(s):
Zinc finger protein HPF7
Zinc finger protein HTF10
Gene namesi
Name:ZNF91
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000167232.13.
HGNCiHGNC:13166. ZNF91.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7644.
OpenTargetsiENSG00000167232.
PharmGKBiPA37739.

Polymorphism and mutation databases

BioMutaiZNF91.
DMDMi313104067.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474001 – 1191Zinc finger protein 91Add BLAST1191

Proteomic databases

MaxQBiQ05481.
PaxDbiQ05481.
PeptideAtlasiQ05481.
PRIDEiQ05481.

PTM databases

iPTMnetiQ05481.
PhosphoSitePlusiQ05481.

Expressioni

Gene expression databases

BgeeiENSG00000167232.
CleanExiHS_ZNF91.
ExpressionAtlasiQ05481. baseline and differential.
GenevisibleiQ05481. HS.

Interactioni

Protein-protein interaction databases

BioGridi113460. 6 interactors.
IntActiQ05481. 6 interactors.
STRINGi9606.ENSP00000300619.

Structurei

3D structure databases

ProteinModelPortaliQ05481.
SMRiQ05481.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 84KRABIEP:Add BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri154 – 176C2H2-type 1; degenerateIEP:Add BLAST23
Zinc fingeri179 – 200C2H2-type 2IEP:Add BLAST22
Zinc fingeri208 – 232C2H2-type 3IEP:Add BLAST25
Zinc fingeri238 – 260C2H2-type 4IEP:Add BLAST23
Zinc fingeri266 – 288C2H2-type 5IEP:Add BLAST23
Zinc fingeri294 – 316C2H2-type 6IEP:Add BLAST23
Zinc fingeri322 – 344C2H2-type 7IEP:Add BLAST23
Zinc fingeri350 – 372C2H2-type 8IEP:Add BLAST23
Zinc fingeri378 – 400C2H2-type 9IEP:Add BLAST23
Zinc fingeri406 – 428C2H2-type 10IEP:Add BLAST23
Zinc fingeri434 – 456C2H2-type 11IEP:Add BLAST23
Zinc fingeri462 – 484C2H2-type 12IEP:Add BLAST23
Zinc fingeri490 – 512C2H2-type 13IEP:Add BLAST23
Zinc fingeri518 – 540C2H2-type 14; degenerateIEP:Add BLAST23
Zinc fingeri546 – 568C2H2-type 15IEP:Add BLAST23
Zinc fingeri574 – 596C2H2-type 16IEP:Add BLAST23
Zinc fingeri602 – 624C2H2-type 17IEP:Add BLAST23
Zinc fingeri630 – 652C2H2-type 18IEP:Add BLAST23
Zinc fingeri658 – 680C2H2-type 19IEP:Add BLAST23
Zinc fingeri686 – 708C2H2-type 20IEP:Add BLAST23
Zinc fingeri714 – 736C2H2-type 21IEP:Add BLAST23
Zinc fingeri742 – 764C2H2-type 22IEP:Add BLAST23
Zinc fingeri770 – 792C2H2-type 23IEP:Add BLAST23
Zinc fingeri798 – 820C2H2-type 24IEP:Add BLAST23
Zinc fingeri826 – 848C2H2-type 25IEP:Add BLAST23
Zinc fingeri854 – 876C2H2-type 26IEP:Add BLAST23
Zinc fingeri885 – 904C2H2-type 27; degenerateIEP:Add BLAST20
Zinc fingeri910 – 932C2H2-type 28IEP:Add BLAST23
Zinc fingeri938 – 960C2H2-type 29IEP:Add BLAST23
Zinc fingeri966 – 988C2H2-type 30IEP:Add BLAST23
Zinc fingeri994 – 1016C2H2-type 31IEP:Add BLAST23
Zinc fingeri1022 – 1044C2H2-type 32IEP:Add BLAST23
Zinc fingeri1050 – 1072C2H2-type 33IEP:Add BLAST23
Zinc fingeri1078 – 1100C2H2-type 34IEP:Add BLAST23
Zinc fingeri1106 – 1128C2H2-type 35IEP:Add BLAST23
Zinc fingeri1134 – 1156C2H2-type 36IEP:Add BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00900000140787.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ05481.
KOiK09228.
OMAiCEKTFHW.
OrthoDBiEOG091G02KC.
PhylomeDBiQ05481.
TreeFamiTF343410.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.40.10. 2 hits.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR036051. KRAB_dom_sf.
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 34 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 19 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 31 hits.
PS50157. ZINC_FINGER_C2H2_2. 35 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q05481-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGTPGSLEM GLLTFRDVAI EFSPEEWQCL DTAQQNLYRN VMLENYRNLA
60 70 80 90 100
FLGIALSKPD LITYLEQGKE PWNMKQHEMV DEPTGICPHF PQDFWPEQSM
110 120 130 140 150
EDSFQKVLLR KYEKCGHENL QLRKGCKSVD ECKVHKEGYN KLNQCLTTAQ
160 170 180 190 200
SKVFQCGKYL KVFYKFLNSN RHTIRHTGKK CFKCKKCVKS FCIRLHKTQH
210 220 230 240 250
KCVYITEKSC KCKECEKTFH WSSTLTNHKE IHTEDKPYKC EECGKAFKQL
260 270 280 290 300
STLTTHKIIC AKEKIYKCEE CGKAFLWSST LTRHKRIHTG EKPYKCEECG
310 320 330 340 350
KAFSHSSTLA KHKRIHTGEK PYKCEECGKA FSRSSTLAKH KRIHTGEKPY
360 370 380 390 400
KCKECGKAFS NSSTLANHKI THTEEKPYKC KECDKAFKRL STLTKHKIIH
410 420 430 440 450
AGEKLYKCEE CGKAFNRSSN LTIHKFIHTG EKPYKCEECG KAFNWSSSLT
460 470 480 490 500
KHKRFHTREK PFKCKECGKA FIWSSTLTRH KRIHTGEKPY KCEECGKAFR
510 520 530 540 550
QSSTLTKHKI IHTGEKPYKF EECGKAFRQS LTLNKHKIIH SREKPYKCKE
560 570 580 590 600
CGKAFKQFST LTTHKIIHAG KKLYKCEECG KAFNHSSSLS THKIIHTGEK
610 620 630 640 650
SYKCEECGKA FLWSSTLRRH KRIHTGEKPY KCEECGKAFS HSSALAKHKR
660 670 680 690 700
IHTGEKPYKC KECGKAFSNS STLANHKITH TEEKPYKCKE CDKTFKRLST
710 720 730 740 750
LTKHKIIHAG EKLYKCEECG KAFNRSSNLT IHKFIHTGEK PYKCEECGKA
760 770 780 790 800
FNWSSSLTKH KRIHTREKPF KCKECGKAFI WSSTLTRHKR IHTGEKPYKC
810 820 830 840 850
EECGKAFSRS STLTKHKTIH TGEKPYKCKE CGKAFKHSSA LAKHKIIHAG
860 870 880 890 900
EKLYKCEECG KAFNQSSNLT THKIIHTKEK PSKSEECDKA FIWSSTLTEH
910 920 930 940 950
KRIHTREKTY KCEECGKAFS QPSHLTTHKR MHTGEKPYKC EECGKAFSQS
960 970 980 990 1000
STLTTHKIIH TGEKPYKCEE CGKAFRKSST LTEHKIIHTG EKPYKCEECG
1010 1020 1030 1040 1050
KAFSQSSTLT RHTRMHTGEK PYKCEECGKA FNRSSKLTTH KIIHTGEKPY
1060 1070 1080 1090 1100
KCEECGKAFI SSSTLNGHKR IHTREKPYKC EECGKAFSQS STLTRHKRLH
1110 1120 1130 1140 1150
TGEKPYKCGE CGKAFKESSA LTKHKIIHTG EKPYKCEKCG KAFNQSSILT
1160 1170 1180 1190
NHKKIHTITP VIPLLWEAEA GGSRGQEMET ILANTVKPLL Y
Length:1,191
Mass (Da):137,217
Last modified:November 30, 2010 - v2
Checksum:iB8F5F0327A79EE3B
GO
Isoform 2 (identifier: Q05481-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     55-86: Missing.

Show »
Length:1,159
Mass (Da):133,536
Checksum:i988520EB0A88BE5A
GO

Sequence cautioni

The sequence AAA58672 differs from that shown. Reason: Frameshift at positions 184 and 197.IKR:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti142L → F in BAH13252 (PubMed:14702039).IKR:1
Sequence conflicti333R → H in AAA59469 (PubMed:8467795).IKR:1
Sequence conflicti470A → G in AAA59469 (PubMed:8467795).IKR:1
Sequence conflicti493E → V in BAF83945 (PubMed:14702039).IKR:1
Sequence conflicti663C → R in BAF83945 (PubMed:14702039).IKR:1
Sequence conflicti760H → R in BAH13252 (PubMed:14702039).IKR:1
Sequence conflicti907E → G in BAH13252 (PubMed:14702039).IKR:1
Sequence conflicti909T → P in AAA59469 (PubMed:8467795).IKR:1
Sequence conflicti1140G → C in AAA59469 (PubMed:8467795).IKR:1
Sequence conflicti1164L → A in BAF83945 (PubMed:14702039).IKR:1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057393112Y → H. Corresponds to variant dbSNP:rs296091Ensembl.1
Natural variantiVAR_060417336T → A1 PublicationCorresponds to variant dbSNP:rs449447Ensembl.1
Natural variantiVAR_060418386A → T2 PublicationsCorresponds to variant dbSNP:rs403356Ensembl.1
Natural variantiVAR_059897455F → I. Corresponds to variant dbSNP:rs440638Ensembl.1
Natural variantiVAR_060419521E → K. Corresponds to variant dbSNP:rs12976753Ensembl.1
Natural variantiVAR_057394896T → A. Corresponds to variant dbSNP:rs296093Ensembl.1
Natural variantiVAR_0604201011R → I. Corresponds to variant dbSNP:rs1821844Ensembl.1
Natural variantiVAR_0604211033R → Q. Corresponds to variant dbSNP:rs1821846Ensembl.1
Natural variantiVAR_0598981164L → P. Corresponds to variant dbSNP:rs428549Ensembl.1
Natural variantiVAR_0598991164L → V. Corresponds to variant dbSNP:rs385750Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04028855 – 86Missing in isoform 2. IBD:Add BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11672 mRNA. Translation: AAA59469.1.
AK300294 mRNA. Translation: BAH13252.1.
AK291256 mRNA. Translation: BAF83945.1.
AC010300 Genomic DNA. No translation available.
AC016628 Genomic DNA. No translation available.
AC022409 Genomic DNA. No translation available.
AC093058 Genomic DNA. No translation available.
M61871 mRNA. Translation: AAA58672.1. Frameshift.
CCDSiCCDS42541.1. [Q05481-1]
CCDS74322.1. [Q05481-2]
PIRiF39384.
PQ0636.
S35305.
RefSeqiNP_001287880.1. NM_001300951.1. [Q05481-2]
NP_003421.2. NM_003430.3. [Q05481-1]
UniGeneiHs.531632.
Hs.58834.
Hs.654471.
Hs.741490.

Genome annotation databases

EnsembliENST00000300619; ENSP00000300619; ENSG00000167232. [Q05481-1]
ENST00000397082; ENSP00000380272; ENSG00000167232. [Q05481-2]
GeneIDi7644.
KEGGihsa:7644.
UCSCiuc002nre.4. human. [Q05481-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZNF91_HUMAN
AccessioniPrimary (citable) accession number: Q05481
Secondary accession number(s): A8K5E1, B7Z6G6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 30, 2010
Last modified: October 25, 2017
This is version 166 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families