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Protein

Zinc finger protein 91

Gene

ZNF91

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor specifically required to repress SINE-VNTR-Alu (SVA) retrotransposons: recognizes and binds SVA sequences and represses their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305). May also bind the promoter of the FCGR2B gene, leading to repress its expression; however, additional evidences are required to confirm this result in vivo (PubMed:11470777).1 Publication1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri154 – 17623C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri179 – 20022C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri208 – 23225C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri238 – 26023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri266 – 28823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri294 – 31623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri322 – 34423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri350 – 37223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri378 – 40023C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri406 – 42823C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri434 – 45623C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri462 – 48423C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri490 – 51223C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri518 – 54023C2H2-type 14; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri546 – 56823C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri574 – 59623C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri602 – 62423C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri630 – 65223C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri658 – 68023C2H2-type 19PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri686 – 70823C2H2-type 20PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri714 – 73623C2H2-type 21PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri742 – 76423C2H2-type 22PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri770 – 79223C2H2-type 23PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri798 – 82023C2H2-type 24PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri826 – 84823C2H2-type 25PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri854 – 87623C2H2-type 26PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri885 – 90420C2H2-type 27; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri910 – 93223C2H2-type 28PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri938 – 96023C2H2-type 29PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri966 – 98823C2H2-type 30PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri994 – 101623C2H2-type 31PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1022 – 104423C2H2-type 32PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1050 – 107223C2H2-type 33PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1078 – 110023C2H2-type 34PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1106 – 112823C2H2-type 35PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1134 – 115623C2H2-type 36PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  3. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. negative regulation of transcription, DNA-templated Source: UniProtKB
  2. negative regulation of transposon integration Source: UniProtKB
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 91
Alternative name(s):
Zinc finger protein HPF7
Zinc finger protein HTF10
Gene namesi
Name:ZNF91
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13166. ZNF91.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37739.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11911191Zinc finger protein 91PRO_0000047400Add
BLAST

Proteomic databases

MaxQBiQ05481.
PaxDbiQ05481.
PRIDEiQ05481.

PTM databases

PhosphoSiteiQ05481.

Expressioni

Gene expression databases

BgeeiQ05481.
CleanExiHS_ZNF91.
ExpressionAtlasiQ05481. baseline and differential.
GenevestigatoriQ05481.

Interactioni

Protein-protein interaction databases

BioGridi113460. 6 interactions.
IntActiQ05481. 4 interactions.
STRINGi9606.ENSP00000300619.

Structurei

3D structure databases

ProteinModelPortaliQ05481.
SMRiQ05481. Positions 13-53, 152-1157.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 8472KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 36 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri154 – 17623C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri179 – 20022C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri208 – 23225C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri238 – 26023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri266 – 28823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri294 – 31623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri322 – 34423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri350 – 37223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri378 – 40023C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri406 – 42823C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri434 – 45623C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri462 – 48423C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri490 – 51223C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri518 – 54023C2H2-type 14; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri546 – 56823C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri574 – 59623C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri602 – 62423C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri630 – 65223C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri658 – 68023C2H2-type 19PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri686 – 70823C2H2-type 20PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri714 – 73623C2H2-type 21PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri742 – 76423C2H2-type 22PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri770 – 79223C2H2-type 23PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri798 – 82023C2H2-type 24PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri826 – 84823C2H2-type 25PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri854 – 87623C2H2-type 26PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri885 – 90420C2H2-type 27; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri910 – 93223C2H2-type 28PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri938 – 96023C2H2-type 29PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri966 – 98823C2H2-type 30PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri994 – 101623C2H2-type 31PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1022 – 104423C2H2-type 32PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1050 – 107223C2H2-type 33PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1078 – 110023C2H2-type 34PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1106 – 112823C2H2-type 35PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1134 – 115623C2H2-type 36PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00780000121884.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ05481.
KOiK09228.
OMAiLTIHKFI.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ05481.
TreeFamiTF343410.

Family and domain databases

Gene3Di3.30.160.60. 34 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 34 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 31 hits.
PS50157. ZINC_FINGER_C2H2_2. 35 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q05481-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGTPGSLEM GLLTFRDVAI EFSPEEWQCL DTAQQNLYRN VMLENYRNLA
60 70 80 90 100
FLGIALSKPD LITYLEQGKE PWNMKQHEMV DEPTGICPHF PQDFWPEQSM
110 120 130 140 150
EDSFQKVLLR KYEKCGHENL QLRKGCKSVD ECKVHKEGYN KLNQCLTTAQ
160 170 180 190 200
SKVFQCGKYL KVFYKFLNSN RHTIRHTGKK CFKCKKCVKS FCIRLHKTQH
210 220 230 240 250
KCVYITEKSC KCKECEKTFH WSSTLTNHKE IHTEDKPYKC EECGKAFKQL
260 270 280 290 300
STLTTHKIIC AKEKIYKCEE CGKAFLWSST LTRHKRIHTG EKPYKCEECG
310 320 330 340 350
KAFSHSSTLA KHKRIHTGEK PYKCEECGKA FSRSSTLAKH KRIHTGEKPY
360 370 380 390 400
KCKECGKAFS NSSTLANHKI THTEEKPYKC KECDKAFKRL STLTKHKIIH
410 420 430 440 450
AGEKLYKCEE CGKAFNRSSN LTIHKFIHTG EKPYKCEECG KAFNWSSSLT
460 470 480 490 500
KHKRFHTREK PFKCKECGKA FIWSSTLTRH KRIHTGEKPY KCEECGKAFR
510 520 530 540 550
QSSTLTKHKI IHTGEKPYKF EECGKAFRQS LTLNKHKIIH SREKPYKCKE
560 570 580 590 600
CGKAFKQFST LTTHKIIHAG KKLYKCEECG KAFNHSSSLS THKIIHTGEK
610 620 630 640 650
SYKCEECGKA FLWSSTLRRH KRIHTGEKPY KCEECGKAFS HSSALAKHKR
660 670 680 690 700
IHTGEKPYKC KECGKAFSNS STLANHKITH TEEKPYKCKE CDKTFKRLST
710 720 730 740 750
LTKHKIIHAG EKLYKCEECG KAFNRSSNLT IHKFIHTGEK PYKCEECGKA
760 770 780 790 800
FNWSSSLTKH KRIHTREKPF KCKECGKAFI WSSTLTRHKR IHTGEKPYKC
810 820 830 840 850
EECGKAFSRS STLTKHKTIH TGEKPYKCKE CGKAFKHSSA LAKHKIIHAG
860 870 880 890 900
EKLYKCEECG KAFNQSSNLT THKIIHTKEK PSKSEECDKA FIWSSTLTEH
910 920 930 940 950
KRIHTREKTY KCEECGKAFS QPSHLTTHKR MHTGEKPYKC EECGKAFSQS
960 970 980 990 1000
STLTTHKIIH TGEKPYKCEE CGKAFRKSST LTEHKIIHTG EKPYKCEECG
1010 1020 1030 1040 1050
KAFSQSSTLT RHTRMHTGEK PYKCEECGKA FNRSSKLTTH KIIHTGEKPY
1060 1070 1080 1090 1100
KCEECGKAFI SSSTLNGHKR IHTREKPYKC EECGKAFSQS STLTRHKRLH
1110 1120 1130 1140 1150
TGEKPYKCGE CGKAFKESSA LTKHKIIHTG EKPYKCEKCG KAFNQSSILT
1160 1170 1180 1190
NHKKIHTITP VIPLLWEAEA GGSRGQEMET ILANTVKPLL Y
Length:1,191
Mass (Da):137,217
Last modified:November 29, 2010 - v2
Checksum:iB8F5F0327A79EE3B
GO
Isoform 2 (identifier: Q05481-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     55-86: Missing.

Show »
Length:1,159
Mass (Da):133,536
Checksum:i988520EB0A88BE5A
GO

Sequence cautioni

The sequence AAA58672.1 differs from that shown. Reason: Frameshift at positions 184 and 197. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti142 – 1421L → F in BAH13252 (PubMed:14702039).Curated
Sequence conflicti333 – 3331R → H in AAA59469 (PubMed:8467795).Curated
Sequence conflicti470 – 4701A → G in AAA59469 (PubMed:8467795).Curated
Sequence conflicti493 – 4931E → V in BAF83945 (PubMed:14702039).Curated
Sequence conflicti663 – 6631C → R in BAF83945 (PubMed:14702039).Curated
Sequence conflicti760 – 7601H → R in BAH13252 (PubMed:14702039).Curated
Sequence conflicti907 – 9071E → G in BAH13252 (PubMed:14702039).Curated
Sequence conflicti909 – 9091T → P in AAA59469 (PubMed:8467795).Curated
Sequence conflicti1140 – 11401G → C in AAA59469 (PubMed:8467795).Curated
Sequence conflicti1164 – 11641L → A in BAF83945 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti112 – 1121Y → H.
Corresponds to variant rs296091 [ dbSNP | Ensembl ].
VAR_057393
Natural varianti336 – 3361T → A.1 Publication
Corresponds to variant rs449447 [ dbSNP | Ensembl ].
VAR_060417
Natural varianti386 – 3861A → T.2 Publications
Corresponds to variant rs403356 [ dbSNP | Ensembl ].
VAR_060418
Natural varianti455 – 4551F → I.
Corresponds to variant rs440638 [ dbSNP | Ensembl ].
VAR_059897
Natural varianti521 – 5211E → K.
Corresponds to variant rs12976753 [ dbSNP | Ensembl ].
VAR_060419
Natural varianti896 – 8961T → A.
Corresponds to variant rs296093 [ dbSNP | Ensembl ].
VAR_057394
Natural varianti1011 – 10111R → I.
Corresponds to variant rs1821844 [ dbSNP | Ensembl ].
VAR_060420
Natural varianti1033 – 10331R → Q.
Corresponds to variant rs1821846 [ dbSNP | Ensembl ].
VAR_060421
Natural varianti1164 – 11641L → P.
Corresponds to variant rs428549 [ dbSNP | Ensembl ].
VAR_059898
Natural varianti1164 – 11641L → V.
Corresponds to variant rs385750 [ dbSNP | Ensembl ].
VAR_059899

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei55 – 8632Missing in isoform 2. 1 PublicationVSP_040288Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11672 mRNA. Translation: AAA59469.1.
AK300294 mRNA. Translation: BAH13252.1.
AK291256 mRNA. Translation: BAF83945.1.
AC010300 Genomic DNA. No translation available.
AC016628 Genomic DNA. No translation available.
AC022409 Genomic DNA. No translation available.
AC093058 Genomic DNA. No translation available.
M61871 mRNA. Translation: AAA58672.1. Frameshift.
CCDSiCCDS42541.1. [Q05481-1]
CCDS74322.1. [Q05481-2]
PIRiF39384.
PQ0636.
S35305.
RefSeqiNP_001287880.1. NM_001300951.1. [Q05481-2]
NP_003421.2. NM_003430.3. [Q05481-1]
UniGeneiHs.654471.

Genome annotation databases

EnsembliENST00000300619; ENSP00000300619; ENSG00000167232. [Q05481-1]
ENST00000397082; ENSP00000380272; ENSG00000167232. [Q05481-2]
GeneIDi7644.
KEGGihsa:7644.
UCSCiuc002nre.3. human. [Q05481-1]
uc010xrj.2. human. [Q05481-2]

Polymorphism databases

DMDMi313104067.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11672 mRNA. Translation: AAA59469.1.
AK300294 mRNA. Translation: BAH13252.1.
AK291256 mRNA. Translation: BAF83945.1.
AC010300 Genomic DNA. No translation available.
AC016628 Genomic DNA. No translation available.
AC022409 Genomic DNA. No translation available.
AC093058 Genomic DNA. No translation available.
M61871 mRNA. Translation: AAA58672.1. Frameshift.
CCDSiCCDS42541.1. [Q05481-1]
CCDS74322.1. [Q05481-2]
PIRiF39384.
PQ0636.
S35305.
RefSeqiNP_001287880.1. NM_001300951.1. [Q05481-2]
NP_003421.2. NM_003430.3. [Q05481-1]
UniGeneiHs.654471.

3D structure databases

ProteinModelPortaliQ05481.
SMRiQ05481. Positions 13-53, 152-1157.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113460. 6 interactions.
IntActiQ05481. 4 interactions.
STRINGi9606.ENSP00000300619.

PTM databases

PhosphoSiteiQ05481.

Polymorphism databases

DMDMi313104067.

Proteomic databases

MaxQBiQ05481.
PaxDbiQ05481.
PRIDEiQ05481.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300619; ENSP00000300619; ENSG00000167232. [Q05481-1]
ENST00000397082; ENSP00000380272; ENSG00000167232. [Q05481-2]
GeneIDi7644.
KEGGihsa:7644.
UCSCiuc002nre.3. human. [Q05481-1]
uc010xrj.2. human. [Q05481-2]

Organism-specific databases

CTDi7644.
GeneCardsiGC19M023489.
HGNCiHGNC:13166. ZNF91.
MIMi603971. gene.
neXtProtiNX_Q05481.
PharmGKBiPA37739.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00780000121884.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ05481.
KOiK09228.
OMAiLTIHKFI.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ05481.
TreeFamiTF343410.

Miscellaneous databases

GenomeRNAii7644.
NextBioi29762.
PROiQ05481.
SOURCEiSearch...

Gene expression databases

BgeeiQ05481.
CleanExiHS_ZNF91.
ExpressionAtlasiQ05481. baseline and differential.
GenevestigatoriQ05481.

Family and domain databases

Gene3Di3.30.160.60. 34 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 34 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 31 hits.
PS50157. ZINC_FINGER_C2H2_2. 35 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells."
    Bellefroid E.J., Marine J.-C., Ried T., Lecocq P.J., Riviere M., Amemiya C.T., Poncelet D.A., Coulie P.G., de Jong P.J., Szpirer C., Ward D.C., Martial J.A.
    EMBO J. 12:1363-1374(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ALA-336 AND THR-386.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT THR-386.
    Tissue: Placenta.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins."
    Bellefroid E.J., Poncelet D.A., Lecocq P.J., Revelant O., Martial J.A.
    Proc. Natl. Acad. Sci. U.S.A. 88:3608-3612(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 15-204 (ISOFORM 1).
  5. "Emergence of the ZNF91 Kruppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea."
    Bellefroid E.J., Marine J.C., Matera A.G., Bourguignon C., Desai T., Healy K.C., Bray-Ward P., Martial J.A., Ihle J.N., Ward D.C.
    Proc. Natl. Acad. Sci. U.S.A. 92:10757-10761(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  6. "Characterization of the human Fc gamma RIIB gene promoter: human zinc-finger proteins (ZNF140 and ZNF91) that bind to different regions function as transcription repressors."
    Nishimura T., Narita T., Miyazaki E., Ito T., Nishimoto N., Yoshizaki K., Martial J.A., Bellfroid E.J., Vissing H., Taniyama T.
    Int. Immunol. 13:1075-1084(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Evolutionary expansion and divergence in the ZNF91 subfamily of primate-specific zinc finger genes."
    Hamilton A.T., Huntley S., Tran-Gyamfi M., Baggott D.M., Gordon L., Stubbs L.
    Genome Res. 16:584-594(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  8. "Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1."
    Wang W., Cai J., Wu Y., Hu L., Chen Z., Hu J., Chen Z., Li W., Guo M., Huang Z.
    Cell. Mol. Life Sci. 70:3947-3958(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  9. "An evolutionary arms race between KRAB zinc-finger genes ZNF91/93 and SVA/L1 retrotransposons."
    Jacobs F.M., Greenberg D., Nguyen N., Haeussler M., Ewing A.D., Katzman S., Paten B., Salama S.R., Haussler D.
    Nature 516:242-245(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiZNF91_HUMAN
AccessioniPrimary (citable) accession number: Q05481
Secondary accession number(s): A8K5E1, B7Z6G6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 31, 1994
Last sequence update: November 29, 2010
Last modified: March 31, 2015
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

ZNF91 is only present in primates and emerged in the last common ancestor of humans and Old-World monkeys. It underwent structural changes between 8-12 Million years ago, probably to improve the protein's ability to bind and repress SINE-VNTR-Alu (SVA) retrotransposons elements (PubMed:25274305).2 Publications1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.