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Protein

Polyketide synthase PksL

Gene

pksL

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism.1 Publication

Cofactori

pantetheine 4'-phosphateCuratedNote: Binds 5 phosphopantetheines covalently.Curated

Pathwayi: bacillaene biosynthesis

This protein is involved in the pathway bacillaene biosynthesis, which is part of Antibiotic biosynthesis.
View all proteins of this organism that are known to be involved in the pathway bacillaene biosynthesis and in Antibiotic biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei609 – 6091For beta-ketoacyl synthase 1 activityPROSITE-ProRule annotation
Active sitei2103 – 21031For beta-ketoacyl synthase 2 activityPROSITE-ProRule annotation
Active sitei3040 – 30401For beta-ketoacyl synthase 3 activityPROSITE-ProRule annotation
Active sitei4237 – 42371For beta-ketoacyl synthase 4 activityPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Antibiotic biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciBSUB:BSU17190-MONOMER.
UniPathwayiUPA01003.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyketide synthase PksL
Short name:
PKS
Gene namesi
Name:pksL
Synonyms:outG, pksA, pksX
Ordered Locus Names:BSU17190
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 45384538Polyketide synthase PksLPRO_0000180299Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei354 – 3541O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation
Modified residuei1834 – 18341O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation
Modified residuei2634 – 26341O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation
Modified residuei2775 – 27751O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation
Modified residuei3997 – 39971O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

PaxDbiQ05470.

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100009456.

Structurei

Secondary structure

1
4538
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2876 – 288510Combined sources
Beta strandi2888 – 28903Combined sources
Helixi2891 – 28999Combined sources
Beta strandi2905 – 29073Combined sources
Turni2910 – 29123Combined sources
Helixi2915 – 29173Combined sources
Beta strandi2933 – 29353Combined sources
Helixi2945 – 29484Combined sources
Helixi2952 – 29554Combined sources
Helixi2960 – 297617Combined sources
Helixi2980 – 29834Combined sources
Beta strandi2988 – 29936Combined sources
Helixi2998 – 30036Combined sources
Helixi3016 – 302712Combined sources
Beta strandi3033 – 30364Combined sources
Helixi3039 – 30413Combined sources
Helixi3042 – 305514Combined sources
Beta strandi3060 – 30689Combined sources
Helixi3073 – 30764Combined sources
Beta strandi3106 – 31149Combined sources
Helixi3115 – 31206Combined sources
Beta strandi3127 – 313610Combined sources
Helixi3148 – 316215Combined sources
Helixi3166 – 31683Combined sources
Beta strandi3171 – 31733Combined sources
Beta strandi3178 – 31803Combined sources
Helixi3182 – 319514Combined sources
Beta strandi3204 – 32074Combined sources
Helixi3210 – 32134Combined sources
Helixi3217 – 32193Combined sources
Helixi3220 – 323314Combined sources
Beta strandi3244 – 32463Combined sources
Helixi3252 – 32543Combined sources
Beta strandi3255 – 32595Combined sources
Beta strandi3275 – 32817Combined sources
Beta strandi3285 – 32939Combined sources
Beta strandi3311 – 33199Combined sources
Helixi3320 – 333617Combined sources
Helixi3342 – 335110Combined sources
Beta strandi3357 – 336610Combined sources
Helixi3367 – 337913Combined sources
Beta strandi3386 – 33905Combined sources
Helixi3391 – 33933Combined sources
Helixi3395 – 34039Combined sources
Helixi3405 – 341612Combined sources
Helixi3420 – 342910Combined sources
Helixi3435 – 34384Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5E5NX-ray2.00A/B/C/D2870-3466[»]
5E6KX-ray2.16A/B2870-3466[»]
5ENYX-ray4.00A/B/C/D/E/F/G/H2719-3462[»]
5ERFX-ray3.10A/B2870-3466[»]
ProteinModelPortaliQ05470.
SMRiQ05470. Positions 318-392, 432-1337, 1408-1765, 1799-1873, 1926-2367, 2741-2813, 2874-3381, 3565-3934, 3962-4037, 4082-4520.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini322 – 39170Acyl carrier 1PROSITE-ProRule annotationAdd
BLAST
Domaini1798 – 187073Acyl carrier 2PROSITE-ProRule annotationAdd
BLAST
Domaini2602 – 267170Acyl carrier 3PROSITE-ProRule annotationAdd
BLAST
Domaini2743 – 281270Acyl carrier 4PROSITE-ProRule annotationAdd
BLAST
Domaini3965 – 403470Acyl carrier 5PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni436 – 874439Beta-ketoacyl synthase 1Add
BLAST
Regioni1048 – 1226179DehydrataseAdd
BLAST
Regioni1520 – 1713194Beta-ketoacyl reductase 1Add
BLAST
Regioni1929 – 2368440Beta-ketoacyl synthase 2Add
BLAST
Regioni2876 – 3297422Beta-ketoacyl synthase 3Add
BLAST
Regioni3686 – 3887202Beta-ketoacyl reductase 2Add
BLAST
Regioni4085 – 4488404Beta-ketoacyl synthase 4Add
BLAST

Sequence similaritiesi

Contains 5 acyl carrier domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4107SQU. Bacteria.
COG3321. LUCA.
HOGENOMiHOG000275973.
InParanoidiQ05470.
KOiK13612.
OMAiITGLEWI.

Family and domain databases

Gene3Di1.10.1200.10. 7 hits.
3.40.47.10. 8 hits.
3.40.50.720. 2 hits.
InterProiIPR032821. KAsynt_C_assoc.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016040. NAD(P)-bd_dom.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR020807. PKS_dehydratase.
IPR013968. PKS_KR.
IPR020806. PKS_PP-bd.
IPR009081. PP-bd_ACP.
IPR006162. Ppantetheine_attach_site.
IPR011254. Prismane-like.
IPR016039. Thiolase-like.
[Graphical view]
PfamiPF16197. KAsynt_C_assoc. 3 hits.
PF00109. ketoacyl-synt. 4 hits.
PF02801. Ketoacyl-synt_C. 4 hits.
PF08659. KR. 2 hits.
PF00550. PP-binding. 5 hits.
PF14765. PS-DH. 2 hits.
[Graphical view]
SMARTiSM00826. PKS_DH. 1 hit.
SM00825. PKS_KS. 4 hits.
SM00823. PKS_PP. 5 hits.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 6 hits.
SSF51735. SSF51735. 3 hits.
SSF53901. SSF53901. 5 hits.
SSF56821. SSF56821. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 5 hits.
PS00606. B_KETOACYL_SYNTHASE. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05470-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRWRSNVKKI TKQLTLSLKN PFIYHHVVYG QNVLPGLAYI DIIYQIFREH
60 70 80 90 100
GFSCSELQLR NLSIYQPLTA EQDAVIVLNI QCAEKKEGQW QITAKGIEKR
110 120 130 140 150
DGKEASEEKL YMKADMHADS PAIFEETLDL SQIKASAQNV VQLDDVYEQC
160 170 180 190 200
RRQELVHSEY MKAKGCIYEE EDGVLLELSL GSEAMLHAEG FMFHPTLIDG
210 220 230 240 250
SGVGANHLLT SLLKGEQRLY LPLFYESFSA SALLQTDCMT RIKRSSVRRE
260 270 280 290 300
KELIYVTLEF FNASGEKVAE LKNFTSKLVR EAELISGKHQ DAQETQMTRA
310 320 330 340 350
DTAERDKPAD MVSSPVNSYS EAEQFVSQLI AEKINKPVEQ VEKQVGYYQM
360 370 380 390 400
GLNSSGLLEV VETISDKIGE SLSPTLLFEH TTIAELSAFL AEEYAEHFSA
410 420 430 440 450
AGSLGQNERA RVSDSINDHK TVEGSRPAPI EAAGDIAIIG LAGRYPKAAN
460 470 480 490 500
IHEFWNNLKE GKDCVSEIPE SRWDWQRLEG ITSPSGKDIS KWGGFIDDPD
510 520 530 540 550
CFDPQFFRIT PREAETMDPQ ERLFLETCWE TIEDAGYTPK TLAKPKGRNK
560 570 580 590 600
RQHVGVFAGV MHKDYTLVGA EEASAENVFP LSLNYAQIAN RVSYFCNFHG
610 620 630 640 650
PSMAVDTVCS SSLTAVHLAL ESIRHGECDV ALAGGVNLSL HPNKYMTYGV
660 670 680 690 700
WDMFSTDGHC RTFGKDGDGY VPAEGIGAVL LKPLRQAEED GDRIYAVIKG
710 720 730 740 750
SAVNHVGTVS GISVPSPVSQ ADLIETCLEK TGIDPRTISY VEAHGTGTSL
760 770 780 790 800
GDPIEIQGLV KAFRQYTQDR QFCSIGSVKS NIGHAESAAG ISGLSKVALQ
810 820 830 840 850
LHHQKLVPSL HSEELNPYVD FEKSPFYVQH ETETWKQPVI KENGEDVPYP
860 870 880 890 900
RRAGISSFGA TGSNAHIILE EHIPQAAEQD VSLSSDSDIS AVIPLSARNQ
910 920 930 940 950
ERLRVYAKRL LDFLHDGIQI RDLAYTLQVG REPMEERVSF LASGIQELSD
960 970 980 990 1000
QLKAFIEGRK AIQHCWKGRV SRGSEPSRPA ESVHKLLEQR KLDQIAEQWA
1010 1020 1030 1040 1050
NGSGVDWKLL YEGSKPKRIS LPTYPFERVR YWVPKAEKKT DRSKQERHIL
1060 1070 1080 1090 1100
HPLLHQNVSD ISGVRFRSAF TGREFFLKDH VIKGEHVLPG AALLEMVRAA
1110 1120 1130 1140 1150
VERAAADQFP TGFRLRNIVW VRPFAVTEQQ KDIDVRLYPE ENGEITFEIC
1160 1170 1180 1190 1200
RDPESAEESP IVYGQGSAVL CEAGENPVIN IEELKASYNG RTLSPFDCYE
1210 1220 1230 1240 1250
AYTEMGIHYG DSHRAIDSLY AGENGVLVKL TMPPVISDTE DHYILHPSMI
1260 1270 1280 1290 1300
DSAFQASIGL RLGGATSLED RKAMLPFAIQ DVRIFKGCEA SMWARITYSE
1310 1320 1330 1340 1350
GSTAGDRMQK LDIDLCNEEG QVCVRLTSYS ARVLETDQEG PSEANDTLLF
1360 1370 1380 1390 1400
EHIWEERAAE RQELIEYDTY KVVVCDVGEQ MESLQNHLDC TVLQHDTETI
1410 1420 1430 1440 1450
DERFEGYAIQ LFEEIKQLMH SKTGGHTFIQ VAVPALDEPQ LLSGLTGLLK
1460 1470 1480 1490 1500
TAELENPKLT GQLIEIETGM SAGELFEILE ENRRYPRDTH IRHWQGKRFV
1510 1520 1530 1540 1550
SKWKEVSGEH LSADMPWKDK GVYLITGGAG GLGFIFATEI ANQTNDAVVI
1560 1570 1580 1590 1600
LTGRSPLDER KKKKLKALQK LGIQAIYRQA DLADKQTVDA LLKETQNVYG
1610 1620 1630 1640 1650
DLDGIIHSAG LIKDNFIMKK KKEEVQTVLA PKVAGLIHLD EATKDIPLDF
1660 1670 1680 1690 1700
FILFSSGAGA VGSAGQADYA MANAFMNAFS EYRNGQAELH KRYGKTLSVC
1710 1720 1730 1740 1750
WPLWKDGGMQ IDAETARMLK RETGMVAMET DRGIQALYHG WTSGKPQVLV
1760 1770 1780 1790 1800
ASGVTDRIRA FLHETGHGKG QSHNIKKSSL NQEAEKADMI GEIDEEILRE
1810 1820 1830 1840 1850
KAENYFKQVL SSVIKLPAGQ IDAEAPLEDY GIDSIMIMHV TGQLEKVFGS
1860 1870 1880 1890 1900
LSKTLFFEYQ DIRSLTRYFI DSRREKLLDI LGFETGKPSV ERKSEPEKQE
1910 1920 1930 1940 1950
IPVIPRKSGF LPLQDKEQKQ VREKETEEIA IIGISGRYPQ ADNIDELWEK
1960 1970 1980 1990 2000
LRDGRDCITE IPADRWDHSL YYDEDKDKPG KTYSKWGGFM KDVDKFDPQF
2010 2020 2030 2040 2050
FHISPREAKL MDPQERLFLQ CVYETMEDAG YTREHLGRKR DAELGGSVGV
2060 2070 2080 2090 2100
YVGVMYEEYQ LYGAQEQVRG RSLALTGNPS SIANRVSYYF DFHGPSIALD
2110 2120 2130 2140 2150
TMCSSSLTAI HLACQSLQRG ECEAAFAGGV NVSIHPNKYL MLGQNKFMSS
2160 2170 2180 2190 2200
KGRCESFGQG GDGYVPGEGV GAVLLKPLSK AVEDGDHIYG IIKGTAINHG
2210 2220 2230 2240 2250
GKTNGYSVPN PNAQADVIKK AFVEAKVDPR TVSYIEAHGT GTSLGDPIEI
2260 2270 2280 2290 2300
TGLSKVFTQE TDDKQFCAIG SAKSNIGHCE SAAGIAGVTK VLLQMKYRQL
2310 2320 2330 2340 2350
APSLHSNVLN PNIDFLNSPF KVQQELEEWK RPIISVNGKD IELPRIAGVS
2360 2370 2380 2390 2400
SFGAGGVNAH ILIEEYAPEP VEERLPARKQ PAVIVLSAKN EERLQKRAER
2410 2420 2430 2440 2450
LLHAIREQTY VEADLHRIAY TLQVGREAMK ERLAFVAETM QELEEKLYEC
2460 2470 2480 2490 2500
ISGTENREYV YRGQVKSNKE AIAAFAADED MSKTIEAWLQ KGKYAKVLDL
2510 2520 2530 2540 2550
WVRGLRIDWS TLYQDQKPRR ISLPAYPFAR DRYWIDVNAK AEEKRTEEPF
2560 2570 2580 2590 2600
APVQPVIPKP SVDREASGKP ANITLQPLMT NQDRLERVPS DTETETITAE
2610 2620 2630 2640 2650
ALCDELTAGL AEVLYMDQNE IDPDEAFIDI GMDSITGLEW IKAINKQYGT
2660 2670 2680 2690 2700
SLNVTKVYDY PTTRDFAVYL AHELSTQAGE KKQTETYTPI RQKTVVPAAK
2710 2720 2730 2740 2750
PANISLQPLE HHQPVQEEAE ETIQYAAAEI SASRQYTVAI ETLHENLRES
2760 2770 2780 2790 2800
IADVLYMEPY EVDIDEAFID IGMDSITGLE WIKAVNKQYG TSFTVTRVYD
2810 2820 2830 2840 2850
YPTIRDFAEM LKSELGTHLD RKIEHTDSFE AAQQKPAASS HPKPAERPLQ
2860 2870 2880 2890 2900
PVQHPIKKEH EKKTVPVLQD RPEDAIAIVG MSGRYPGARN VREYWDNLVH
2910 2920 2930 2940 2950
ARNAIRDIPT SRWDVDKYYD PVLNKKGKVY CKSMGMLDDI EHFDPLFFNI
2960 2970 2980 2990 3000
PPSEAELMDP QHRIFLQEGY KAFEDAGYNA RTLNEKKCGV YLGIMSNEYG
3010 3020 3030 3040 3050
VMLNRQSRAN ATGNSFAIAA ARIPYFLNLK GPAIPIDTAC SSSLVGTHLA
3060 3070 3080 3090 3100
RQALINKEID MALVGGVSLY LTPESYMSMC EAGMLSPDGQ CKAFDNGANG
3110 3120 3130 3140 3150
FVPGEGAGAL VLKRLKDAEA DRDHIYGIII GSGINQDGKT NGITAPSAKS
3160 3170 3180 3190 3200
QMDLERDIYE TYGIHPESIS YVEMHGTGTK QGDPIELEAL STVFQEKTDK
3210 3220 3230 3240 3250
KQFCAIGSVK SNIGHTSAAA GVAGVQKVLL CMNHKTLVPT LNFTTPNEHF
3260 3270 3280 3290 3300
EFEHSPLYVN TELKPWETAD GKPRRACVSS FGYSGTNAHI VIEEYQPEKR
3310 3320 3330 3340 3350
NDRLTKQHRS ALFVLSAKKE KQLKAYAEAM KDFVTSNEDI DLEDMAYTLQ
3360 3370 3380 3390 3400
TGREAMDYRM AFLADSREML IKALDDYLAE MPNGSIFAAH VKTKKSEIKL
3410 3420 3430 3440 3450
FETDHDAKAL LQTWIEKKRL EKVAELWVKG LQIDWNKLYG EYTPRRISLP
3460 3470 3480 3490 3500
AYPFAEEYYW LPTQEGEPET IATAMPQFEL MPKRCFLRKQ WQPCPIEPAE
3510 3520 3530 3540 3550
MTNQTVAILA NEETMALAEE LSAYFSTYRI FDSQELDRVS AADYEHVAGA
3560 3570 3580 3590 3600
IDLIGCGTSH EHSMGWINWL QKLIEQGRAS KHHLTVLGVT KGLEAYANEG
3610 3620 3630 3640 3650
VLLSGASRAG LYRMLQSEYS HLTSRHADME CEASHEELAR LIAVEYYAKS
3660 3670 3680 3690 3700
TESEVCYRNG QRYRAYLTEQ PAEAALSHKQ VSFSTDKVLL ITGGTRGLGL
3710 3720 3730 3740 3750
LCARHFVKTY GVKRLVLIGR EELPPRDQWN SVKISSLAEK IKAVQELEDM
3760 3770 3780 3790 3800
GAQVQVLSLD LTDRVAVEQS LKTIHETMGA IGGVIHCAGM VNKQNPAFIR
3810 3820 3830 3840 3850
KSLEEIGQVL EPKVEGLQTL FDLLQDEPLA FFTLFSSVSA AIPALAAGQA
3860 3870 3880 3890 3900
DYAMANAFMD YFAEAHQDKC PIVSIQWPNW KETGLGEVRS KALEQTGLIS
3910 3920 3930 3940 3950
LTNDEGLQLL DQILSDRQYA VVLPAVPDTN VWKPDKLMQP SLPVEALSHP
3960 3970 3980 3990 4000
ETKEQTSTRN LFPETVDWLV TLFSDELKIA AEDFETDEPF QEYGIDSIIL
4010 4020 4030 4040 4050
AQLVQQMNQQ LNGDIDPSIL FEYPTIESFA HWLISKYDIS AVLQPSVPEK
4060 4070 4080 4090 4100
QTPLKPQSAM KQKLVPEQRP QQISHEKTAL LAEDIAIIGL SCRFPGAETL
4110 4120 4130 4140 4150
EEYWDLIRDG RSAIAPVPPE RFGNSSSNYA GLIDEMNRFD HDFFMMSESD
4160 4170 4180 4190 4200
VRAMDPQALA VLEESLKLWY HAGYTEKEVK GMRAGVYIGG RSQHKPDPAS
4210 4220 4230 4240 4250
LSKAKNPIVA GGQNYLAANI SQFFDLKGPS IVLDTACSSA LVGLNMAIQA
4260 4270 4280 4290 4300
LRSGDIEAAV VGGVSLLDAD AHRMFHERGL LCDKPSFHIF DKRADGVILG
4310 4320 4330 4340 4350
EGVGMVLVKT VNQAVEDGDS IYAVIKAAAI NNDGRTAGPS SPNLEAQKDV
4360 4370 4380 4390 4400
MLSALEKSGK KTEEISYLEA NGSGSAVTDL LELKAIQSIY RSESKAPLGL
4410 4420 4430 4440 4450
GSVKPNIGHP LCAEGIASLI KVALMLKHRQ LVPFLSGNEN MPYFDIEKTD
4460 4470 4480 4490 4500
LYFSRSQAEW KETTPAAAIN CFADGGTNAH LIIEGWRDSA ERPIRRKPLP
4510 4520 4530
LPELNRQPVL IKPSAQNVQK KVHSDTGASK DMFWKTFK
Length:4,538
Mass (Da):506,182
Last modified:July 28, 2009 - v3
Checksum:i398353DEC864EBF2
GO

Sequence cautioni

The sequence AAA85145 differs from that shown. Reason: Frameshift at position 34. Curated
The sequence CAA78479 differs from that shown. Reason: Frameshift at position 34. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2299 – 23002QL → HV in AAA85145 (PubMed:8344529).Curated
Sequence conflicti2299 – 23002QL → HV in CAA78479 (PubMed:8344529).Curated
Sequence conflicti2398 – 23981A → P in AAA85145 (PubMed:8344529).Curated
Sequence conflicti2398 – 23981A → P in CAA78479 (PubMed:8344529).Curated
Sequence conflicti3384 – 33841G → A in AAA85145 (PubMed:8344529).Curated
Sequence conflicti3384 – 33841G → A in CAA78479 (PubMed:8344529).Curated
Sequence conflicti4041 – 40411A → R in AAA85145 (PubMed:8344529).Curated
Sequence conflicti4041 – 40411A → R in CAA78479 (PubMed:8344529).Curated
Sequence conflicti4041 – 40411A → R in CAA84504 (Ref. 5) Curated
Sequence conflicti4232 – 42321V → L in AAA85145 (PubMed:8344529).Curated
Sequence conflicti4232 – 42321V → L in CAA78479 (PubMed:8344529).Curated
Sequence conflicti4232 – 42321V → L in CAA84504 (Ref. 5) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11039 Genomic DNA. Translation: AAA85145.1. Frameshift.
AL009126 Genomic DNA. Translation: CAB13602.3.
Z14098 Genomic DNA. Translation: CAA78479.1. Frameshift.
Z35133 Genomic DNA. Translation: CAA84504.1.
PIRiS25021. PN0637.
RefSeqiNP_389600.3. NC_000964.3.
WP_010886513.1. NC_000964.3.

Genome annotation databases

EnsemblBacteriaiCAB13602; CAB13602; BSU17190.
GeneIDi940032.
KEGGibsu:BSU17190.
PATRICi18975247. VBIBacSub10457_1815.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11039 Genomic DNA. Translation: AAA85145.1. Frameshift.
AL009126 Genomic DNA. Translation: CAB13602.3.
Z14098 Genomic DNA. Translation: CAA78479.1. Frameshift.
Z35133 Genomic DNA. Translation: CAA84504.1.
PIRiS25021. PN0637.
RefSeqiNP_389600.3. NC_000964.3.
WP_010886513.1. NC_000964.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5E5NX-ray2.00A/B/C/D2870-3466[»]
5E6KX-ray2.16A/B2870-3466[»]
5ENYX-ray4.00A/B/C/D/E/F/G/H2719-3462[»]
5ERFX-ray3.10A/B2870-3466[»]
ProteinModelPortaliQ05470.
SMRiQ05470. Positions 318-392, 432-1337, 1408-1765, 1799-1873, 1926-2367, 2741-2813, 2874-3381, 3565-3934, 3962-4037, 4082-4520.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100009456.

Proteomic databases

PaxDbiQ05470.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB13602; CAB13602; BSU17190.
GeneIDi940032.
KEGGibsu:BSU17190.
PATRICi18975247. VBIBacSub10457_1815.

Phylogenomic databases

eggNOGiENOG4107SQU. Bacteria.
COG3321. LUCA.
HOGENOMiHOG000275973.
InParanoidiQ05470.
KOiK13612.
OMAiITGLEWI.

Enzyme and pathway databases

UniPathwayiUPA01003.
BioCyciBSUB:BSU17190-MONOMER.

Family and domain databases

Gene3Di1.10.1200.10. 7 hits.
3.40.47.10. 8 hits.
3.40.50.720. 2 hits.
InterProiIPR032821. KAsynt_C_assoc.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016040. NAD(P)-bd_dom.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR020807. PKS_dehydratase.
IPR013968. PKS_KR.
IPR020806. PKS_PP-bd.
IPR009081. PP-bd_ACP.
IPR006162. Ppantetheine_attach_site.
IPR011254. Prismane-like.
IPR016039. Thiolase-like.
[Graphical view]
PfamiPF16197. KAsynt_C_assoc. 3 hits.
PF00109. ketoacyl-synt. 4 hits.
PF02801. Ketoacyl-synt_C. 4 hits.
PF08659. KR. 2 hits.
PF00550. PP-binding. 5 hits.
PF14765. PS-DH. 2 hits.
[Graphical view]
SMARTiSM00826. PKS_DH. 1 hit.
SM00825. PKS_KS. 4 hits.
SM00823. PKS_PP. 5 hits.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 6 hits.
SSF51735. SSF51735. 3 hits.
SSF53901. SSF53901. 5 hits.
SSF56821. SSF56821. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 5 hits.
PS00606. B_KETOACYL_SYNTHASE. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPKSL_BACSU
AccessioniPrimary (citable) accession number: Q05470
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 28, 2009
Last modified: September 7, 2016
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.