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Protein

Homeobox-leucine zipper protein HAT4

Gene

HAT4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable transcription factor involved in the negative regulation of cell elongation and specific cell proliferation processes such as lateral root formation and secondary growth of the vascular system. Acts as mediator of the red/far-red light effects on leaf cell expansion in the shading response. Binds to the DNA sequence 5'-CAAT[GC]ATTG-3'. Negatively regulates its own expression.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi126 – 185HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • protein homodimerization activity Source: TAIR
  • sequence-specific DNA binding Source: TAIR
  • transcription factor activity, sequence-specific DNA binding Source: TAIR

GO - Biological processi

  • cell proliferation Source: TAIR
  • negative regulation of transcription, DNA-templated Source: TAIR
  • red, far-red light phototransduction Source: UniProtKB-KW
  • red or far-red light signaling pathway Source: TAIR
  • response to auxin Source: TAIR
  • response to cytokinin Source: TAIR
  • response to far red light Source: TAIR
  • root development Source: TAIR
  • shade avoidance Source: TAIR
  • shoot system morphogenesis Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW
  • unidimensional cell growth Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Phytochrome signaling pathway, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox-leucine zipper protein HAT4
Alternative name(s):
HD-ZIP protein ATHB-2
Homeodomain transcription factor ATHB-2
Homeodomain-leucine zipper protein HAT4
Short name:
HD-ZIP protein 4
Gene namesi
Name:HAT4
Synonyms:ATHB-2
Ordered Locus Names:At4g16780
ORF Names:dl4415w, FCAALL.101
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G16780.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi172V → A: Abolishes DNA-binding. 1 Publication1
Mutagenesisi176N → A: Abolishes DNA-binding. 1 Publication1
Mutagenesisi180R → A: Abolishes DNA-binding. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000489011 – 284Homeobox-leucine zipper protein HAT4Add BLAST284

Proteomic databases

PaxDbiQ05466.
PRIDEiQ05466.

PTM databases

iPTMnetiQ05466.

Expressioni

Tissue specificityi

Predominantly expressed in leaves and stems.1 Publication

Inductioni

Rapidly and strongly induced by lowering the ratio of red to far-red light.1 Publication

Gene expression databases

GenevisibleiQ05466. AT.

Interactioni

Subunit structurei

Interacts with DNA as homodimer.

GO - Molecular functioni

  • protein homodimerization activity Source: TAIR

Protein-protein interaction databases

BioGridi12677. 12 interactors.
IntActiQ05466. 15 interactors.
STRINGi3702.AT4G16780.1.

Structurei

3D structure databases

ProteinModelPortaliQ05466.
SMRiQ05466.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni193 – 214Leucine-zipperAdd BLAST22

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0483. Eukaryota.
ENOG410Z2UE. LUCA.
InParanoidiQ05466.
KOiK09338.
OMAiASACHEM.
OrthoDBiEOG09360QI5.
PhylomeDBiQ05466.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR006712. HD-ZIP_N.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
IPR003106. Leu_zip_homeo.
[Graphical view]
PfamiPF02183. HALZ. 1 hit.
PF04618. HD-ZIP_N. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00031. HTHREPRESSR.
SMARTiSM00340. HALZ. 1 hit.
SM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05466-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMFEKDDLGL SLGLNFPKKQ INLKSNPSVS VTPSSSSFGL FRRSSWNESF
60 70 80 90 100
TSSVPNSDSS QKETRTFIRG IDVNRPPSTA EYGDEDAGVS SPNSTVSSST
110 120 130 140 150
GKRSEREEDT DPQGSRGISD DEDGDNSRKK LRLSKDQSAI LEETFKDHST
160 170 180 190 200
LNPKQKQALA KQLGLRARQV EVWFQNRRAR TKLKQTEVDC EFLRRCCENL
210 220 230 240 250
TEENRRLQKE VTELRALKLS PQFYMHMSPP TTLTMCPSCE HVSVPPPQPQ
260 270 280
AATSAHHRSL PVNAWAPATR ISHGLTFDAL RPRS
Length:284
Mass (Da):31,853
Last modified:February 1, 1994 - v1
Checksum:i4BBC0D069E9D56F7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti216A → V in AAA32815 (PubMed:1349174).Curated1
Sequence conflicti216A → V in CAA79670 (PubMed:8449400).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti35S → P in strain: cv. Tsu-1. 1 Publication1
Natural varianti79T → I in strain: cv. Kl-1. 1 Publication1
Natural varianti88G → V in strain: cv. Bla-6, cv. Bu-2, cv. Di-1 and cv. Pi-0. 1 Publication1
Natural varianti123D → Y in strain: cv. Tsu-1. 1 Publication1
Natural varianti162Q → K in strain: cv. Bla-6. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M90394 mRNA. Translation: AAA32815.1.
Z19602 Genomic DNA. Translation: CAA79670.1.
X68145 mRNA. Translation: CAA48246.1.
X68146 Genomic DNA. Translation: CAA48248.1.
Z97342 Genomic DNA. Translation: CAB10452.1.
AL161544 Genomic DNA. Translation: CAB78720.1.
CP002687 Genomic DNA. Translation: AEE83803.1.
AF375453 mRNA. Translation: AAK53037.1.
AY081747 mRNA. Translation: AAL87400.1.
EF193551 Genomic DNA. Translation: ABP96504.1.
EF193552 Genomic DNA. Translation: ABP96505.1.
EF193553 Genomic DNA. Translation: ABP96506.1.
EF193554 Genomic DNA. Translation: ABP96507.1.
EF193555 Genomic DNA. Translation: ABP96508.1.
EF193556 Genomic DNA. Translation: ABP96509.1.
EF193557 Genomic DNA. Translation: ABP96510.1.
EF193558 Genomic DNA. Translation: ABP96511.1.
EF193559 Genomic DNA. Translation: ABP96512.1.
EF193560 Genomic DNA. Translation: ABP96513.1.
EF193561 Genomic DNA. Translation: ABP96514.1.
EF193562 Genomic DNA. Translation: ABP96515.1.
EF193563 Genomic DNA. Translation: ABP96516.1.
EF193564 Genomic DNA. Translation: ABP96517.1.
EF193565 Genomic DNA. Translation: ABP96518.1.
AY174653 Genomic DNA. Translation: AAO19435.1.
AY174654 Genomic DNA. Translation: AAO19436.1.
AY174655 Genomic DNA. Translation: AAO19437.1.
AY174656 Genomic DNA. Translation: AAO19438.1.
PIRiS31424.
RefSeqiNP_193411.1. NM_117780.4.
UniGeneiAt.24419.
At.74809.

Genome annotation databases

EnsemblPlantsiAT4G16780.1; AT4G16780.1; AT4G16780.
GeneIDi827384.
GrameneiAT4G16780.1; AT4G16780.1; AT4G16780.
KEGGiath:AT4G16780.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M90394 mRNA. Translation: AAA32815.1.
Z19602 Genomic DNA. Translation: CAA79670.1.
X68145 mRNA. Translation: CAA48246.1.
X68146 Genomic DNA. Translation: CAA48248.1.
Z97342 Genomic DNA. Translation: CAB10452.1.
AL161544 Genomic DNA. Translation: CAB78720.1.
CP002687 Genomic DNA. Translation: AEE83803.1.
AF375453 mRNA. Translation: AAK53037.1.
AY081747 mRNA. Translation: AAL87400.1.
EF193551 Genomic DNA. Translation: ABP96504.1.
EF193552 Genomic DNA. Translation: ABP96505.1.
EF193553 Genomic DNA. Translation: ABP96506.1.
EF193554 Genomic DNA. Translation: ABP96507.1.
EF193555 Genomic DNA. Translation: ABP96508.1.
EF193556 Genomic DNA. Translation: ABP96509.1.
EF193557 Genomic DNA. Translation: ABP96510.1.
EF193558 Genomic DNA. Translation: ABP96511.1.
EF193559 Genomic DNA. Translation: ABP96512.1.
EF193560 Genomic DNA. Translation: ABP96513.1.
EF193561 Genomic DNA. Translation: ABP96514.1.
EF193562 Genomic DNA. Translation: ABP96515.1.
EF193563 Genomic DNA. Translation: ABP96516.1.
EF193564 Genomic DNA. Translation: ABP96517.1.
EF193565 Genomic DNA. Translation: ABP96518.1.
AY174653 Genomic DNA. Translation: AAO19435.1.
AY174654 Genomic DNA. Translation: AAO19436.1.
AY174655 Genomic DNA. Translation: AAO19437.1.
AY174656 Genomic DNA. Translation: AAO19438.1.
PIRiS31424.
RefSeqiNP_193411.1. NM_117780.4.
UniGeneiAt.24419.
At.74809.

3D structure databases

ProteinModelPortaliQ05466.
SMRiQ05466.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi12677. 12 interactors.
IntActiQ05466. 15 interactors.
STRINGi3702.AT4G16780.1.

PTM databases

iPTMnetiQ05466.

Proteomic databases

PaxDbiQ05466.
PRIDEiQ05466.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G16780.1; AT4G16780.1; AT4G16780.
GeneIDi827384.
GrameneiAT4G16780.1; AT4G16780.1; AT4G16780.
KEGGiath:AT4G16780.

Organism-specific databases

TAIRiAT4G16780.

Phylogenomic databases

eggNOGiKOG0483. Eukaryota.
ENOG410Z2UE. LUCA.
InParanoidiQ05466.
KOiK09338.
OMAiASACHEM.
OrthoDBiEOG09360QI5.
PhylomeDBiQ05466.

Miscellaneous databases

PROiQ05466.

Gene expression databases

GenevisibleiQ05466. AT.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR006712. HD-ZIP_N.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
IPR003106. Leu_zip_homeo.
[Graphical view]
PfamiPF02183. HALZ. 1 hit.
PF04618. HD-ZIP_N. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00031. HTHREPRESSR.
SMARTiSM00340. HALZ. 1 hit.
SM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHAT4_ARATH
AccessioniPrimary (citable) accession number: Q05466
Secondary accession number(s): A5Y7H1
, A5Y7H2, A5Y7H3, A5Y7H4, A5Y7H5, A5Y7H6, A5Y7H7, A5Y7H8, A5Y7H9, A5Y7I0, A5Y7I1, A5Y7I2, A5Y7I3, A5Y7I4, A5Y7I5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 30, 2016
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.