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Protein

Lumican

Gene

LUM

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-BTA-2022854 Keratan sulfate biosynthesis
R-BTA-2022857 Keratan sulfate degradation
R-BTA-216083 Integrin cell surface interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Lumican
Alternative name(s):
Corneal keratan sulfate proteoglycan 37B core protein
Keratan sulfate proteoglycan
Short name:
KSPG
Gene namesi
Name:LUM
Synonyms:LDC
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Organism-specific databases

VGNCiVGNC:31081 LUM

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 181 PublicationAdd BLAST18
ChainiPRO_000003273219 – 342LumicanAdd BLAST324

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei20SulfotyrosineBy similarity1
Modified residuei23SulfotyrosineBy similarity1
Modified residuei34SulfotyrosineBy similarity1
Glycosylationi92N-linked (GlcNAc...) (keratan sulfate) asparagineSequence analysis1
Glycosylationi131N-linked (GlcNAc...) (keratan sulfate) asparagineSequence analysis1
Glycosylationi164N-linked (GlcNAc...) (keratan sulfate) asparagineSequence analysis1
Glycosylationi256N-linked (GlcNAc...) (keratan sulfate) asparagineSequence analysis1
Disulfide bondi299 ↔ 332By similarity
Modified residuei308PhosphoserineBy similarity1

Post-translational modificationi

Sulfated on tyrosine residue(s).1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan, Sulfation

Proteomic databases

PaxDbiQ05443
PeptideAtlasiQ05443
PRIDEiQ05443

Miscellaneous databases

PMAP-CutDBiQ05443

Expressioni

Tissue specificityi

Cornea and other tissues.

Gene expression databases

BgeeiENSBTAG00000001745

Interactioni

Subunit structurei

Binds to laminin.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000002279

Structurei

3D structure databases

ProteinModelPortaliQ05443
SMRiQ05443
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 70LRRNTAdd BLAST39
Repeati71 – 92LRR 1Add BLAST22
Repeati95 – 118LRR 2Add BLAST24
Repeati121 – 141LRR 3Add BLAST21
Repeati142 – 163LRR 4Add BLAST22
Repeati164 – 185LRR 5Add BLAST22
Repeati189 – 209LRR 6Add BLAST21
Repeati210 – 231LRR 7Add BLAST22
Repeati234 – 254LRR 8Add BLAST21
Repeati259 – 280LRR 9Add BLAST22
Repeati281 – 300LRR 10Add BLAST20
Repeati309 – 330LRR 11Add BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi41 – 57Cys-richAdd BLAST17

Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000118969
HOGENOMiHOG000234447
HOVERGENiHBG108061
InParanoidiQ05443
KOiK08122
OMAiKKLHINY
OrthoDBiEOG091G09XE
TreeFamiTF334562

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR025875 Leu-rich_rpt_4
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
IPR027219 Lumican
PANTHERiPTHR24373:SF119 PTHR24373:SF119, 1 hit
PfamiView protein in Pfam
PF12799 LRR_4, 1 hit
PF13855 LRR_8, 2 hits
PF01462 LRRNT, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 9 hits
SM00013 LRRNT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 10 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05443-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLGVFPLLL ALIGGASSTY PDYYEYYDFP QALYGRSSPN CAPECNCPES
60 70 80 90 100
YPSAMYCDEL KLKSVPMVPP GIKYLYLRNN QIDHIDDKAF ENVTDLQWLI
110 120 130 140 150
LDHNLLENSK IKGKVFSKLK QLKKLHINYN NLTESVGPLP KSLVDLQLTN
160 170 180 190 200
NKISKLGSFD GLVNLTFIHL QHNQLKEDAV SAALKGLKSL EYLDLSFNQM
210 220 230 240 250
TKLPSGLPVS LLTLYLDNNK ISNIPDEYFK RFSALQYLRL SHNELADSGV
260 270 280 290 300
PGNSFNVSSL LELDLSYNKL KSIPTVNENL ENYYLEVNEL EKFDVKSFCK
310 320 330 340
ILGPLSYSKI KHLRLDGNHI TQTSLPPDMY ECLRVANEIT VN
Length:342
Mass (Da):38,756
Last modified:October 1, 1996 - v1
Checksum:i592DEE9A489AEB79
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11063 mRNA Translation: AAA30608.1
BC102271 mRNA Translation: AAI02272.1
PIRiA46743
RefSeqiNP_776359.1, NM_173934.1
XP_005206099.1, XM_005206042.2
UniGeneiBt.2452

Genome annotation databases

EnsembliENSBTAT00000002279; ENSBTAP00000002279; ENSBTAG00000001745
GeneIDi280847
KEGGibta:280847

Similar proteinsi

Entry informationi

Entry nameiLUM_BOVIN
AccessioniPrimary (citable) accession number: Q05443
Secondary accession number(s): Q3T0T2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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