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Q05438 (BMR1B_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bone morphogenetic protein receptor type-1B

Short name=BMP type-1B receptor
Short name=BMPR-1B
EC=2.7.11.30
Alternative name(s):
Activin receptor-like kinase 6
Short name=ALK-6
RPK-1
Serine/threonine-protein kinase receptor R6
Short name=SKR6
Gene names
Name:BMPR1B
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length502 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators By similarity.

Catalytic activity

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactor

Magnesium or manganese By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Sequence similarities

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Contains 1 GS domain.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1313 Potential
Chain14 – 502489Bone morphogenetic protein receptor type-1B
PRO_0000024414

Regions

Topological domain14 – 126113Extracellular Potential
Transmembrane127 – 14822Helical; Potential
Topological domain149 – 502354Cytoplasmic Potential
Domain174 – 20330GS
Domain204 – 494291Protein kinase
Nucleotide binding210 – 2189ATP By similarity

Sites

Active site3321Proton acceptor By similarity
Binding site2311ATP By similarity

Amino acid modifications

Glycosylation441N-linked (GlcNAc...) Potential
Disulfide bond32 ↔ 53 By similarity
Disulfide bond34 ↔ 38 By similarity
Disulfide bond47 ↔ 71 By similarity
Disulfide bond81 ↔ 95 By similarity
Disulfide bond96 ↔ 102 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q05438 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: D5D93CCEBF2A0680

FASTA50256,766
        10         20         30         40         50         60 
MPLLSSSKLS MESRKEDSEG TAPAPPQKKL SCQCHHHCPE DSVNSTCSTD GYCFTIIEED 

        70         80         90        100        110        120 
DSGGHLVTKG CLGLEGSDFQ CRDTPIPHQR RSIECCTGQD YCNKHLHPTL PPLKNRDFAE 

       130        140        150        160        170        180 
GNIHHKALLI SVTVCSILLV LIIIFCYFRY KRQEARPRYS IGLEQDETYI PPGESLKDLI 

       190        200        210        220        230        240 
EQSQSSGSGS GLPLLVQRTI AKQIQMVKQI GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS 

       250        260        270        280        290        300 
WFRETEIYQT VLMRHENILG FIAADIKGTG SWTQLYLITD YHENGSLYDY LKSTTLDTKG 

       310        320        330        340        350        360 
MLKLAYSSVS GLCHLHTGIF STQGKPAIAH RDLKSKNILV KKNGTCCIAD LGLAVKFISD 

       370        380        390        400        410        420 
TNEVDIPPNT RVGTKRYMPP EVLDESLNRN HFQSYIMADM YSFGLILWEI ARRCVSGGIV 

       430        440        450        460        470        480 
EEYQLPYHDL VPSDPSYEDM REIVCIKRLR PSFPNRWSSD ECLRQMGKLM MECWAHNPAS 

       490        500 
RLTALRVKKT LAKMSESQDI KL 

« Hide

References

[1]"A new receptor protein kinase from chick embryo related to type II receptor for TGF-beta."
Yamazaki Y., Saito T., Nohno T.
DNA Seq. 3:297-302(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D13432 mRNA. Translation: BAA02694.1.
PIRA56683.
RefSeqNP_990463.1. NM_205132.1.
UniGeneGga.607.

3D structure databases

ProteinModelPortalQ05438.
SMRQ05438. Positions 30-113, 170-498.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-5822N.

Proteomic databases

PaxDbQ05438.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID396030.
KEGGgga:396030.

Organism-specific databases

CTD658.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000230587.
HOVERGENHBG054502.
InParanoidQ05438.
KOK13578.
PhylomeDBQ05438.

Enzyme and pathway databases

BRENDA2.7.10.2. 1306.

Family and domain databases

InterProIPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERPTHR23255. PTHR23255. 1 hit.
PfamPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTSM00467. GS. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20816092.
PROQ05438.

Entry information

Entry nameBMR1B_CHICK
AccessionPrimary (citable) accession number: Q05438
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families