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Q05438

- BMR1B_CHICK

UniProt

Q05438 - BMR1B_CHICK

Protein

Bone morphogenetic protein receptor type-1B

Gene

BMPR1B

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators By similarity.By similarity

    Catalytic activityi

    ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

    Cofactori

    Magnesium or manganese.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei231 – 2311ATPPROSITE-ProRule annotation
    Active sitei332 – 3321Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi210 – 2189ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. receptor signaling protein serine/threonine kinase activity Source: InterPro
    4. transforming growth factor beta-activated receptor activity Source: InterPro

    GO - Biological processi

    1. chondrocyte development Source: AgBase
    2. negative regulation of chondrocyte proliferation Source: AgBase

    Keywords - Molecular functioni

    Kinase, Receptor, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Chondrogenesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 1306.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bone morphogenetic protein receptor type-1B (EC:2.7.11.30)
    Short name:
    BMP type-1B receptor
    Short name:
    BMPR-1B
    Alternative name(s):
    Activin receptor-like kinase 6
    Short name:
    ALK-6
    RPK-1
    Serine/threonine-protein kinase receptor R6
    Short name:
    SKR6
    Gene namesi
    Name:BMPR1B
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. fully spanning plasma membrane Source: AgBase
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1313Sequence AnalysisAdd
    BLAST
    Chaini14 – 502489Bone morphogenetic protein receptor type-1BPRO_0000024414Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi32 ↔ 53By similarity
    Disulfide bondi34 ↔ 38By similarity
    Glycosylationi44 – 441N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi47 ↔ 71By similarity
    Disulfide bondi81 ↔ 95By similarity
    Disulfide bondi96 ↔ 102By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ05438.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-5822N.

    Structurei

    3D structure databases

    ProteinModelPortaliQ05438.
    SMRiQ05438. Positions 30-113, 170-498.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini14 – 126113ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini149 – 502354CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei127 – 14822HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini174 – 20330GSPROSITE-ProRule annotationAdd
    BLAST
    Domaini204 – 494291Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 GS domain.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000230587.
    HOVERGENiHBG054502.
    InParanoidiQ05438.
    KOiK13578.
    PhylomeDBiQ05438.

    Family and domain databases

    InterProiIPR000472. Activin_rcpt.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    IPR003605. TGF_beta_rcpt_GS.
    IPR000333. TGFB_receptor.
    [Graphical view]
    PANTHERiPTHR23255. PTHR23255. 1 hit.
    PfamiPF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF08515. TGF_beta_GS. 1 hit.
    [Graphical view]
    SMARTiSM00467. GS. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS51256. GS. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q05438-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPLLSSSKLS MESRKEDSEG TAPAPPQKKL SCQCHHHCPE DSVNSTCSTD    50
    GYCFTIIEED DSGGHLVTKG CLGLEGSDFQ CRDTPIPHQR RSIECCTGQD 100
    YCNKHLHPTL PPLKNRDFAE GNIHHKALLI SVTVCSILLV LIIIFCYFRY 150
    KRQEARPRYS IGLEQDETYI PPGESLKDLI EQSQSSGSGS GLPLLVQRTI 200
    AKQIQMVKQI GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS WFRETEIYQT 250
    VLMRHENILG FIAADIKGTG SWTQLYLITD YHENGSLYDY LKSTTLDTKG 300
    MLKLAYSSVS GLCHLHTGIF STQGKPAIAH RDLKSKNILV KKNGTCCIAD 350
    LGLAVKFISD TNEVDIPPNT RVGTKRYMPP EVLDESLNRN HFQSYIMADM 400
    YSFGLILWEI ARRCVSGGIV EEYQLPYHDL VPSDPSYEDM REIVCIKRLR 450
    PSFPNRWSSD ECLRQMGKLM MECWAHNPAS RLTALRVKKT LAKMSESQDI 500
    KL 502
    Length:502
    Mass (Da):56,766
    Last modified:October 1, 1996 - v1
    Checksum:iD5D93CCEBF2A0680
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D13432 mRNA. Translation: BAA02694.1.
    PIRiA56683.
    RefSeqiNP_990463.1. NM_205132.1.
    UniGeneiGga.607.

    Genome annotation databases

    GeneIDi396030.
    KEGGigga:396030.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D13432 mRNA. Translation: BAA02694.1 .
    PIRi A56683.
    RefSeqi NP_990463.1. NM_205132.1.
    UniGenei Gga.607.

    3D structure databases

    ProteinModelPortali Q05438.
    SMRi Q05438. Positions 30-113, 170-498.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-5822N.

    Proteomic databases

    PaxDbi Q05438.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 396030.
    KEGGi gga:396030.

    Organism-specific databases

    CTDi 658.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000230587.
    HOVERGENi HBG054502.
    InParanoidi Q05438.
    KOi K13578.
    PhylomeDBi Q05438.

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 1306.

    Miscellaneous databases

    NextBioi 20816092.
    PROi Q05438.

    Family and domain databases

    InterProi IPR000472. Activin_rcpt.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    IPR003605. TGF_beta_rcpt_GS.
    IPR000333. TGFB_receptor.
    [Graphical view ]
    PANTHERi PTHR23255. PTHR23255. 1 hit.
    Pfami PF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF08515. TGF_beta_GS. 1 hit.
    [Graphical view ]
    SMARTi SM00467. GS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS51256. GS. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A new receptor protein kinase from chick embryo related to type II receptor for TGF-beta."
      Yamazaki Y., Saito T., Nohno T.
      DNA Seq. 3:297-302(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiBMR1B_CHICK
    AccessioniPrimary (citable) accession number: Q05438
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3