Bone morphogenetic protein receptor type-1B precursor

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Q05438 (BMR1B_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 100. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Bone morphogenetic protein receptor type-1B
Short name=BMP type-1B receptor
Short name=BMPR-1B
EC=2.7.11.30

Alternative name(s):
Activin receptor-like kinase 6
Short name=ALK-6
RPK-1
Serine/threonine-protein kinase receptor R6
Short name=SKR6

Gene names

Name:

BMPR1B

Organism

Gallus gallus (Chicken) [Reference proteome]

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	502 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators By similarity.
Catalytic activity	ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
Cofactor	Magnesium or manganese By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Sequence similarities	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 GS domain. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Chondrogenesis
Cellular component	Membrane
Domain	Signal Transmembrane Transmembrane helix
Ligand	ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding
Molecular function	Kinase Receptor Serine/threonine-protein kinase Transferase
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cartilage development Inferred from electronic annotation. Source: UniProtKB-KW transmembrane receptor protein serine/threonine kinase signaling pathway Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW transforming growth factor beta-activated receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 13

Potential

Chain

14 – 502

489

Bone morphogenetic protein receptor type-1B

PRO_0000024414

Regions

Topological domain

14 – 126

113

Extracellular Potential

Transmembrane

127 – 148

Helical; Potential

Topological domain

149 – 502

354

Cytoplasmic Potential

Domain

174 – 203

Domain

204 – 494

291

Protein kinase

Nucleotide binding

210 – 218

ATP By similarity

Sites

Active site

332

Proton acceptor By similarity

Binding site

231

ATP By similarity

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Disulfide bond

32 ↔ 53

By similarity

Disulfide bond

34 ↔ 38

By similarity

Disulfide bond

47 ↔ 71

By similarity

Disulfide bond

81 ↔ 95

By similarity

Disulfide bond

96 ↔ 102

By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q05438 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: D5D93CCEBF2A0680
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FASTA

502

56,766

        10         20         30         40         50         60 
MPLLSSSKLS MESRKEDSEG TAPAPPQKKL SCQCHHHCPE DSVNSTCSTD GYCFTIIEED 

        70         80         90        100        110        120 
DSGGHLVTKG CLGLEGSDFQ CRDTPIPHQR RSIECCTGQD YCNKHLHPTL PPLKNRDFAE 

       130        140        150        160        170        180 
GNIHHKALLI SVTVCSILLV LIIIFCYFRY KRQEARPRYS IGLEQDETYI PPGESLKDLI 

       190        200        210        220        230        240 
EQSQSSGSGS GLPLLVQRTI AKQIQMVKQI GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS 

       250        260        270        280        290        300 
WFRETEIYQT VLMRHENILG FIAADIKGTG SWTQLYLITD YHENGSLYDY LKSTTLDTKG 

       310        320        330        340        350        360 
MLKLAYSSVS GLCHLHTGIF STQGKPAIAH RDLKSKNILV KKNGTCCIAD LGLAVKFISD 

       370        380        390        400        410        420 
TNEVDIPPNT RVGTKRYMPP EVLDESLNRN HFQSYIMADM YSFGLILWEI ARRCVSGGIV 

       430        440        450        460        470        480 
EEYQLPYHDL VPSDPSYEDM REIVCIKRLR PSFPNRWSSD ECLRQMGKLM MECWAHNPAS 

       490        500 
RLTALRVKKT LAKMSESQDI KL

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References

[1]	"A new receptor protein kinase from chick embryo related to type II receptor for TGF-beta." Yamazaki Y., Saito T., Nohno T. DNA Seq. 3:297-302(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	D13432 mRNA. Translation: BAA02694.1.
IPI	IPI00583739.
PIR	A56683.
RefSeq	NP_990463.1. NM_205132.1.
UniGene	Gga.607.
3D structure databases
ProteinModelPortal	Q05438.
SMR	Q05438. Positions 30-113, 170-498.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5822N.
Proteomic databases
PaxDb	Q05438.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	396030.
KEGG	gga:396030.
Organism-specific databases
CTD	658.
Phylogenomic databases
eggNOG	COG0515.
HOGENOM	HOG000230587.
HOVERGEN	HBG054502.
InParanoid	Q05438.
KO	K13578.
OrthoDB	EOG40P46G.
Enzyme and pathway databases
BRENDA	2.7.10.2. 1306.
Family and domain databases
InterPro	IPR000472. Activin_rcpt. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR008271. Ser/Thr_kinase_AS. IPR003605. TGF_beta_rcpt_GS. [Graphical view]
Pfam	PF01064. Activin_recp. 1 hit. PF00069. Pkinase. 1 hit. PF08515. TGF_beta_GS. 1 hit. [Graphical view]
SMART	SM00467. GS. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS51256. GS. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20816092.

Entry information

Entry name

BMR1B_CHICK

Accession

Primary (citable) accession number: Q05438

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	April 3, 2013
This is version 100 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Other

Entry information

Relevant documents