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Protein

Bone morphogenetic protein receptor type-1B

Gene

BMPR1B

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators (By similarity).By similarity

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei231 – 2311ATPPROSITE-ProRule annotation
Active sitei332 – 3321Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi210 – 2189ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • chondrocyte development Source: AgBase
  • endochondral bone morphogenesis Source: AgBase
  • negative regulation of chondrocyte proliferation Source: AgBase
  • positive regulation of cartilage development Source: AgBase
  • proteoglycan biosynthetic process Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Chondrogenesis

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 1306.

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein receptor type-1B (EC:2.7.11.30)
Short name:
BMP type-1B receptor
Short name:
BMPR-1B
Alternative name(s):
Activin receptor-like kinase 6
Short name:
ALK-6
RPK-1
Serine/threonine-protein kinase receptor R6
Short name:
SKR6
Gene namesi
Name:BMPR1B
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini14 – 126113ExtracellularSequence AnalysisAdd
BLAST
Transmembranei127 – 14822HelicalSequence AnalysisAdd
BLAST
Topological domaini149 – 502354CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • spanning component of plasma membrane Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1313Sequence AnalysisAdd
BLAST
Chaini14 – 502489Bone morphogenetic protein receptor type-1BPRO_0000024414Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 53By similarity
Disulfide bondi34 ↔ 38By similarity
Glycosylationi44 – 441N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi47 ↔ 71By similarity
Disulfide bondi81 ↔ 95By similarity
Disulfide bondi96 ↔ 102By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ05438.

Interactioni

Protein-protein interaction databases

DIPiDIP-5822N.

Structurei

3D structure databases

ProteinModelPortaliQ05438.
SMRiQ05438. Positions 30-113, 170-498.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini174 – 20330GSPROSITE-ProRule annotationAdd
BLAST
Domaini204 – 494291Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 GS domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000230587.
HOVERGENiHBG054502.
InParanoidiQ05438.
KOiK13578.
PhylomeDBiQ05438.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR000472. TFB_recept_I/II_C.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTiSM00467. GS. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05438-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLLSSSKLS MESRKEDSEG TAPAPPQKKL SCQCHHHCPE DSVNSTCSTD
60 70 80 90 100
GYCFTIIEED DSGGHLVTKG CLGLEGSDFQ CRDTPIPHQR RSIECCTGQD
110 120 130 140 150
YCNKHLHPTL PPLKNRDFAE GNIHHKALLI SVTVCSILLV LIIIFCYFRY
160 170 180 190 200
KRQEARPRYS IGLEQDETYI PPGESLKDLI EQSQSSGSGS GLPLLVQRTI
210 220 230 240 250
AKQIQMVKQI GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS WFRETEIYQT
260 270 280 290 300
VLMRHENILG FIAADIKGTG SWTQLYLITD YHENGSLYDY LKSTTLDTKG
310 320 330 340 350
MLKLAYSSVS GLCHLHTGIF STQGKPAIAH RDLKSKNILV KKNGTCCIAD
360 370 380 390 400
LGLAVKFISD TNEVDIPPNT RVGTKRYMPP EVLDESLNRN HFQSYIMADM
410 420 430 440 450
YSFGLILWEI ARRCVSGGIV EEYQLPYHDL VPSDPSYEDM REIVCIKRLR
460 470 480 490 500
PSFPNRWSSD ECLRQMGKLM MECWAHNPAS RLTALRVKKT LAKMSESQDI

KL
Length:502
Mass (Da):56,766
Last modified:October 1, 1996 - v1
Checksum:iD5D93CCEBF2A0680
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13432 mRNA. Translation: BAA02694.1.
PIRiA56683.
RefSeqiNP_990463.1. NM_205132.1.
UniGeneiGga.607.

Genome annotation databases

GeneIDi396030.
KEGGigga:396030.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13432 mRNA. Translation: BAA02694.1.
PIRiA56683.
RefSeqiNP_990463.1. NM_205132.1.
UniGeneiGga.607.

3D structure databases

ProteinModelPortaliQ05438.
SMRiQ05438. Positions 30-113, 170-498.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-5822N.

Proteomic databases

PaxDbiQ05438.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396030.
KEGGigga:396030.

Organism-specific databases

CTDi658.

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000230587.
HOVERGENiHBG054502.
InParanoidiQ05438.
KOiK13578.
PhylomeDBiQ05438.

Enzyme and pathway databases

BRENDAi2.7.10.2. 1306.

Miscellaneous databases

NextBioi20816092.
PROiQ05438.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR000472. TFB_recept_I/II_C.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTiSM00467. GS. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A new receptor protein kinase from chick embryo related to type II receptor for TGF-beta."
    Yamazaki Y., Saito T., Nohno T.
    DNA Seq. 3:297-302(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiBMR1B_CHICK
AccessioniPrimary (citable) accession number: Q05438
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 27, 2015
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.