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Reviewed, UniProtKB/Swiss-Prot Q05438 (BMR1B_CHICK)

Last modified November 25, 2008. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Bone morphogenetic protein receptor type-1B
    EC=2.7.11.30
Alternative name(s):
    Serine/threonine-protein kinase receptor R6
      Short name=SKR6
    Activin receptor-like kinase 6
      Short name=ALK-6
    RPK-1
Gene names
Name: BMPR1B
OrganismGallus gallus (Chicken)
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length502 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators By similarity.

Catalytic activity

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactor

Magnesium or manganese By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Sequence similarities

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Contains 1 GS domain.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1313 Potential
Chain14 – 502489Bone morphogenetic protein receptor type-1B
PRO_0000024414

Regions

Topological domain14 – 126113Extracellular Potential
Transmembrane127 – 14822 Potential
Topological domain149 – 502354Cytoplasmic Potential
Domain174 – 20330GS
Domain204 – 494291Protein kinase
Nucleotide binding210 – 2189ATP By similarity

Sites

Active site3321Proton acceptor By similarity
Binding site2311ATP By similarity

Amino acid modifications

Glycosylation441N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q05438-1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: D5D93CCEBF2A0680

FASTA50256,766
        10         20         30         40         50         60 
MPLLSSSKLS MESRKEDSEG TAPAPPQKKL SCQCHHHCPE DSVNSTCSTD GYCFTIIEED 

        70         80         90        100        110        120 
DSGGHLVTKG CLGLEGSDFQ CRDTPIPHQR RSIECCTGQD YCNKHLHPTL PPLKNRDFAE 

       130        140        150        160        170        180 
GNIHHKALLI SVTVCSILLV LIIIFCYFRY KRQEARPRYS IGLEQDETYI PPGESLKDLI 

       190        200        210        220        230        240 
EQSQSSGSGS GLPLLVQRTI AKQIQMVKQI GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS 

       250        260        270        280        290        300 
WFRETEIYQT VLMRHENILG FIAADIKGTG SWTQLYLITD YHENGSLYDY LKSTTLDTKG 

       310        320        330        340        350        360 
MLKLAYSSVS GLCHLHTGIF STQGKPAIAH RDLKSKNILV KKNGTCCIAD LGLAVKFISD 

       370        380        390        400        410        420 
TNEVDIPPNT RVGTKRYMPP EVLDESLNRN HFQSYIMADM YSFGLILWEI ARRCVSGGIV 

       430        440        450        460        470        480 
EEYQLPYHDL VPSDPSYEDM REIVCIKRLR PSFPNRWSSD ECLRQMGKLM MECWAHNPAS 

       490        500 
RLTALRVKKT LAKMSESQDI KL 

« Hide

References

[1]"A new receptor protein kinase from chick embryo related to type II receptor for TGF-beta."
Yamazaki Y., Saito T., Nohno T.
DNA Seq. 3:297-302(1993) [PubMed: 8400359] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

D13432 mRNA. Translation: BAA02694.1.
PIRA56683.
RefSeqNP_990463.1.
UniGeneGga.607

3D structure databases

HSSPHSSP built from PDB template 1IAS based on UniProtKB P36897.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP:5822N.

Genome annotation databases

EnsemblENSGALG00000012216. Gallus gallus. [Contig view]
GeneID396030.
KEGGgga:396030.

Phylogenomic databases

HOGENOMQ05438.
HOVERGENQ05438.

Family and domain databases

InterProIPR000333. Activin_II_recpt.
IPR000472. Activin_rcpt.
IPR000719. Prot_kinase_core.
IPR017441. Protein_kinase_ATP_bd_CS.
IPR017442. Se/Thr_pkinase-rel.
IPR008271. Ser_thr_pkin_AS.
IPR003605. TGF_beta_rcpt_GS.
[Graphical view]
PfamPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
PRINTSPR00653. ACTIVIN2R.
ProDomPD000001. Prot_kinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00467. GS. 1 hit.
[Graphical view]
PROSITEPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBMR1B_CHICK
AccessionPrimary (citable) accession number: Q05438
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 25, 2008
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents