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Protein

Fatty acid-binding protein, brain

Gene

FABP7

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

ReactomeiR-GGA-163560. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid-binding protein, brain
Alternative name(s):
Brain-type fatty acid-binding protein
Short name:
B-FABP
Fatty acid-binding protein 7
Fatty acid-binding protein, retina
R-FABP
Gene namesi
Name:FABP7
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 3

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 132131Fatty acid-binding protein, brainPRO_0000067371Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylvalineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ05423.
PRIDEiQ05423.

Expressioni

Developmental stagei

Highest expression in early stages of retinal development with a 50-100 fold decrease from day 3 to day 19 of retina maturation.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000036589.

Structurei

3D structure databases

ProteinModelPortaliQ05423.
SMRiQ05423. Positions 2-132.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni127 – 1293Fatty acid bindingBy similarity

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004829.
HOVERGENiHBG005633.
InParanoidiQ05423.
KOiK08756.
OMAiWKLTESQ.
OrthoDBiEOG7NW6BZ.
PhylomeDBiQ05423.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05423-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEAFCATWK LADSHNFDEY MKALGVGFAM RQVGNVTKPT VIISSEGDKV
60 70 80 90 100
VIRTQSTFKN TEISFKLGEE FDETTPDDRN CKSVVTLDGD KLVHVQKWDG
110 120 130
KETNFVREIK DGRMVMTLTF GDVVAVRHYE KA
Length:132
Mass (Da):14,927
Last modified:January 23, 2007 - v2
Checksum:iFE84481C2C64BEA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65459 mRNA. Translation: CAA46451.1.
PIRiA49184.
RefSeqiNP_990639.1. NM_205308.2.
UniGeneiGga.4318.

Genome annotation databases

EnsembliENSGALT00000023987; ENSGALP00000023941; ENSGALG00000014866.
GeneIDi396246.
KEGGigga:396246.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65459 mRNA. Translation: CAA46451.1.
PIRiA49184.
RefSeqiNP_990639.1. NM_205308.2.
UniGeneiGga.4318.

3D structure databases

ProteinModelPortaliQ05423.
SMRiQ05423. Positions 2-132.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000036589.

Proteomic databases

PaxDbiQ05423.
PRIDEiQ05423.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000023987; ENSGALP00000023941; ENSGALG00000014866.
GeneIDi396246.
KEGGigga:396246.

Organism-specific databases

CTDi2173.

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004829.
HOVERGENiHBG005633.
InParanoidiQ05423.
KOiK08756.
OMAiWKLTESQ.
OrthoDBiEOG7NW6BZ.
PhylomeDBiQ05423.

Enzyme and pathway databases

ReactomeiR-GGA-163560. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.

Miscellaneous databases

NextBioi20816298.
PROiQ05423.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification and characterization of transcripts present at elevated levels in the undifferentiated chick retina."
    Godbout R.
    Exp. Eye Res. 56:95-106(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
    Tissue: Embryonic retina.

Entry informationi

Entry nameiFABP7_CHICK
AccessioniPrimary (citable) accession number: Q05423
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 23, 2007
Last modified: May 11, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.