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Q05359

- ERP1_YEAST

UniProt

Q05359 - ERP1_YEAST

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Protein

Protein ERP1

Gene
ERP1, YAR002C-A, YAR002A
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in vesicular protein trafficking.

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. ER to Golgi vesicle-mediated transport Source: SGD
  2. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-28890-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ERP1
Gene namesi
Name:ERP1
Ordered Locus Names:YAR002C-A
ORF Names:YAR002A
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome I

Organism-specific databases

CYGDiYAR002c-a.
SGDiS000002129. ERP1.

Subcellular locationi

Endoplasmic reticulum membrane; Single-pass type I membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 186164Lumenal Reviewed predictionAdd
BLAST
Transmembranei187 – 20721Helical; Reviewed predictionAdd
BLAST
Topological domaini208 – 21912Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. ER to Golgi transport vesicle Source: SGD
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 22221 PublicationAdd
BLAST
Chaini23 – 219197Protein ERP1PRO_0000010408Add
BLAST

Proteomic databases

MaxQBiQ05359.
PaxDbiQ05359.
PeptideAtlasiQ05359.

Expressioni

Gene expression databases

GenevestigatoriQ05359.

Interactioni

Subunit structurei

Associates with EMP24, ERV25 and ERP2.

Binary interactionsi

WithEntry#Exp.IntActNotes
ERP4Q124503EBI-6581,EBI-6598
ERV25P548376EBI-6581,EBI-6642

Protein-protein interaction databases

BioGridi31791. 129 interactions.
DIPiDIP-5147N.
IntActiQ05359. 56 interactions.
MINTiMINT-524284.
STRINGi4932.YAR002C-A.

Structurei

3D structure databases

ProteinModelPortaliQ05359.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 131100GOLDAdd
BLAST

Sequence similaritiesi

Belongs to the EMP24/GP25L family.
Contains 1 GOLD domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG323830.
GeneTreeiENSGT00430000030848.
HOGENOMiHOG000160228.
OMAiQICLHLE.
OrthoDBiEOG7WX0N2.

Family and domain databases

InterProiIPR009038. GOLD.
IPR015720. TMP21-related.
[Graphical view]
PANTHERiPTHR22811. PTHR22811. 1 hit.
PfamiPF01105. EMP24_GP25L. 1 hit.
[Graphical view]
PROSITEiPS50866. GOLD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05359-1 [UniParc]FASTAAdd to Basket

« Hide

MLLTSLLQVF ACCLVLPAQV TAFYYYTSGA ERKCFHKELS KGTLFQATYK    50
AQIYDDQLQN YRDAGAQDFG VLIDIEETFD DNHLVVHQKG SASGDLTFLA 100
SDSGEHKICI QPEAGGWLIK AKTKIDVEFQ VGSDEKLDSK GKATIDILHA 150
KVNVLNSKIG EIRREQKLMR DREATFRDAS EAVNSRAMWW IVIQLIVLAV 200
TCGWQMKHLG KFFVKQKIL 219
Length:219
Mass (Da):24,723
Last modified:November 1, 1996 - v1
Checksum:i16236C1886FC42E8
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti152 – 1521V → I in AAS56036. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L22015 Genomic DNA. Translation: AAC04958.1.
AY557710 Genomic DNA. Translation: AAS56036.1.
BK006935 Genomic DNA. Translation: DAA06987.1.
PIRiS70311.
RefSeqiNP_009402.1. NM_001180033.1.

Genome annotation databases

EnsemblFungiiYAR002C-A; YAR002C-A; YAR002C-A.
GeneIDi851264.
KEGGisce:YAR002C-A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L22015 Genomic DNA. Translation: AAC04958.1 .
AY557710 Genomic DNA. Translation: AAS56036.1 .
BK006935 Genomic DNA. Translation: DAA06987.1 .
PIRi S70311.
RefSeqi NP_009402.1. NM_001180033.1.

3D structure databases

ProteinModelPortali Q05359.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31791. 129 interactions.
DIPi DIP-5147N.
IntActi Q05359. 56 interactions.
MINTi MINT-524284.
STRINGi 4932.YAR002C-A.

Proteomic databases

MaxQBi Q05359.
PaxDbi Q05359.
PeptideAtlasi Q05359.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YAR002C-A ; YAR002C-A ; YAR002C-A .
GeneIDi 851264.
KEGGi sce:YAR002C-A.

Organism-specific databases

CYGDi YAR002c-a.
SGDi S000002129. ERP1.

Phylogenomic databases

eggNOGi NOG323830.
GeneTreei ENSGT00430000030848.
HOGENOMi HOG000160228.
OMAi QICLHLE.
OrthoDBi EOG7WX0N2.

Enzyme and pathway databases

BioCyci YEAST:G3O-28890-MONOMER.

Miscellaneous databases

NextBioi 968228.

Gene expression databases

Genevestigatori Q05359.

Family and domain databases

InterProi IPR009038. GOLD.
IPR015720. TMP21-related.
[Graphical view ]
PANTHERi PTHR22811. PTHR22811. 1 hit.
Pfami PF01105. EMP24_GP25L. 1 hit.
[Graphical view ]
PROSITEi PS50866. GOLD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 42 kbp SPO7-CENI-CDC15 region."
    Clark M.W., Keng T., Storms R.K., Zhong W.-W., Fortin N., Zeng B., Delaney S., Ouellette B.F.F., Barton A.B., Kaback D.B., Bussey H.
    Yeast 10:535-541(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204511 / S288c / AB972.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. Cited for: CHARACTERIZATION.
  6. "Proteins in the early Golgi compartment of Saccharomyces cerevisiae immunoisolated by Sed5p."
    Cho J.-H., Noda Y., Yoda K.
    FEBS Lett. 469:151-154(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 23-27, SUBCELLULAR LOCATION.
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  8. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiERP1_YEAST
AccessioniPrimary (citable) accession number: Q05359
Secondary accession number(s): D6VPL7, E9P8S8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 20700 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

External Data

Dasty 3

Similar proteinsi