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Protein

Protein ERP1

Gene

ERP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in vesicular protein trafficking.

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: SGD
  • protein retention in ER lumen Source: SGD
  • protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-28890-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ERP1
Gene namesi
Name:ERP1
Ordered Locus Names:YAR002C-A
ORF Names:YAR002A
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome I

Organism-specific databases

CYGDiYAR002c-a.
EuPathDBiFungiDB:YAR002C-A.
SGDiS000002129. ERP1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 186164LumenalSequence AnalysisAdd
BLAST
Transmembranei187 – 20721HelicalSequence AnalysisAdd
BLAST
Topological domaini208 – 21912CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 22221 PublicationAdd
BLAST
Chaini23 – 219197Protein ERP1PRO_0000010408Add
BLAST

Proteomic databases

MaxQBiQ05359.
PaxDbiQ05359.
PeptideAtlasiQ05359.

Interactioni

Subunit structurei

Associates with EMP24, ERV25 and ERP2.

Binary interactionsi

WithEntry#Exp.IntActNotes
ERP4Q124503EBI-6581,EBI-6598
ERV25P548376EBI-6581,EBI-6642

Protein-protein interaction databases

BioGridi31791. 139 interactions.
DIPiDIP-5147N.
IntActiQ05359. 56 interactions.
MINTiMINT-524284.

Structurei

3D structure databases

ProteinModelPortaliQ05359.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 131100GOLDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the EMP24/GP25L family.Curated
Contains 1 GOLD domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG323830.
GeneTreeiENSGT00430000030848.
HOGENOMiHOG000160228.
InParanoidiQ05359.
OMAiQICLHLE.
OrthoDBiEOG7WX0N2.

Family and domain databases

InterProiIPR009038. GOLD.
IPR015720. TMP21-related.
[Graphical view]
PANTHERiPTHR22811. PTHR22811. 1 hit.
PfamiPF01105. EMP24_GP25L. 1 hit.
[Graphical view]
PROSITEiPS50866. GOLD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05359-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLTSLLQVF ACCLVLPAQV TAFYYYTSGA ERKCFHKELS KGTLFQATYK
60 70 80 90 100
AQIYDDQLQN YRDAGAQDFG VLIDIEETFD DNHLVVHQKG SASGDLTFLA
110 120 130 140 150
SDSGEHKICI QPEAGGWLIK AKTKIDVEFQ VGSDEKLDSK GKATIDILHA
160 170 180 190 200
KVNVLNSKIG EIRREQKLMR DREATFRDAS EAVNSRAMWW IVIQLIVLAV
210
TCGWQMKHLG KFFVKQKIL
Length:219
Mass (Da):24,723
Last modified:November 1, 1996 - v1
Checksum:i16236C1886FC42E8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti152 – 1521V → I in AAS56036 (PubMed:17322287).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22015 Genomic DNA. Translation: AAC04958.1.
AY557710 Genomic DNA. Translation: AAS56036.1.
BK006935 Genomic DNA. Translation: DAA06987.1.
PIRiS70311.
RefSeqiNP_009402.1. NM_001180033.1.

Genome annotation databases

EnsemblFungiiYAR002C-A; YAR002C-A; YAR002C-A.
GeneIDi851264.
KEGGisce:YAR002C-A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22015 Genomic DNA. Translation: AAC04958.1.
AY557710 Genomic DNA. Translation: AAS56036.1.
BK006935 Genomic DNA. Translation: DAA06987.1.
PIRiS70311.
RefSeqiNP_009402.1. NM_001180033.1.

3D structure databases

ProteinModelPortaliQ05359.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31791. 139 interactions.
DIPiDIP-5147N.
IntActiQ05359. 56 interactions.
MINTiMINT-524284.

Proteomic databases

MaxQBiQ05359.
PaxDbiQ05359.
PeptideAtlasiQ05359.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYAR002C-A; YAR002C-A; YAR002C-A.
GeneIDi851264.
KEGGisce:YAR002C-A.

Organism-specific databases

CYGDiYAR002c-a.
EuPathDBiFungiDB:YAR002C-A.
SGDiS000002129. ERP1.

Phylogenomic databases

eggNOGiNOG323830.
GeneTreeiENSGT00430000030848.
HOGENOMiHOG000160228.
InParanoidiQ05359.
OMAiQICLHLE.
OrthoDBiEOG7WX0N2.

Enzyme and pathway databases

BioCyciYEAST:G3O-28890-MONOMER.

Miscellaneous databases

NextBioi968228.
PROiQ05359.

Family and domain databases

InterProiIPR009038. GOLD.
IPR015720. TMP21-related.
[Graphical view]
PANTHERiPTHR22811. PTHR22811. 1 hit.
PfamiPF01105. EMP24_GP25L. 1 hit.
[Graphical view]
PROSITEiPS50866. GOLD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 42 kbp SPO7-CENI-CDC15 region."
    Clark M.W., Keng T., Storms R.K., Zhong W.-W., Fortin N., Zeng B., Delaney S., Ouellette B.F.F., Barton A.B., Kaback D.B., Bussey H.
    Yeast 10:535-541(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204511 / S288c / AB972.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. Cited for: CHARACTERIZATION.
  6. "Proteins in the early Golgi compartment of Saccharomyces cerevisiae immunoisolated by Sed5p."
    Cho J.-H., Noda Y., Yoda K.
    FEBS Lett. 469:151-154(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 23-27, SUBCELLULAR LOCATION.
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  8. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiERP1_YEAST
AccessioniPrimary (citable) accession number: Q05359
Secondary accession number(s): D6VPL7, E9P8S8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: November 1, 1996
Last modified: July 22, 2015
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 20700 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.