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Q05359 (ERP1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein ERP1
Gene names
Name:ERP1
Ordered Locus Names:YAR002C-A
ORF Names:YAR002A
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length219 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in vesicular protein trafficking.

Subunit structure

Associates with EMP24, ERV25 and ERP2.

Subcellular location

Endoplasmic reticulum membrane; Single-pass type I membrane protein Ref.6.

Miscellaneous

Present with 20700 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the EMP24/GP25L family.

Contains 1 GOLD domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ERP4Q124503EBI-6581,EBI-6598
ERV25P548376EBI-6581,EBI-6642

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Ref.6
Chain23 – 219197Protein ERP1
PRO_0000010408

Regions

Topological domain23 – 186164Lumenal Potential
Transmembrane187 – 20721Helical; Potential
Topological domain208 – 21912Cytoplasmic Potential
Domain32 – 131100GOLD

Experimental info

Sequence conflict1521V → I in AAS56036. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q05359 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 16236C1886FC42E8

FASTA21924,723
        10         20         30         40         50         60 
MLLTSLLQVF ACCLVLPAQV TAFYYYTSGA ERKCFHKELS KGTLFQATYK AQIYDDQLQN 

        70         80         90        100        110        120 
YRDAGAQDFG VLIDIEETFD DNHLVVHQKG SASGDLTFLA SDSGEHKICI QPEAGGWLIK 

       130        140        150        160        170        180 
AKTKIDVEFQ VGSDEKLDSK GKATIDILHA KVNVLNSKIG EIRREQKLMR DREATFRDAS 

       190        200        210 
EAVNSRAMWW IVIQLIVLAV TCGWQMKHLG KFFVKQKIL 

« Hide

References

« Hide 'large scale' references
[1]"Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 42 kbp SPO7-CENI-CDC15 region."
Clark M.W., Keng T., Storms R.K., Zhong W.-W., Fortin N., Zeng B., Delaney S., Ouellette B.F.F., Barton A.B., Kaback D.B., Bussey H.
Yeast 10:535-541(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]"The nucleotide sequence of chromosome I from Saccharomyces cerevisiae."
Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N., Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J., Storms R.K.
Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[5]"Erp1p and Erp2p, partners for Emp24p and Erv25p in a yeast p24 complex."
Marzioch M., Henthorn D.C., Herrmann J.M., Wilson R., Thomas D.Y., Bergeron J.J.M., Solari R.C., Rowley A.
Mol. Biol. Cell 10:1923-1938(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[6]"Proteins in the early Golgi compartment of Saccharomyces cerevisiae immunoisolated by Sed5p."
Cho J.-H., Noda Y., Yoda K.
FEBS Lett. 469:151-154(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 23-27, SUBCELLULAR LOCATION.
[7]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[8]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L22015 Genomic DNA. Translation: AAC04958.1.
AY557710 Genomic DNA. Translation: AAS56036.1.
BK006935 Genomic DNA. Translation: DAA06987.1.
PIRS70311.
RefSeqNP_009402.1. NM_001180033.1.

3D structure databases

ProteinModelPortalQ05359.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31791. 129 interactions.
DIPDIP-5147N.
IntActQ05359. 56 interactions.
MINTMINT-524284.
STRING4932.YAR002C-A.

Proteomic databases

PaxDbQ05359.
PeptideAtlasQ05359.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYAR002C-A; YAR002C-A; YAR002C-A.
GeneID851264.
KEGGsce:YAR002C-A.

Organism-specific databases

CYGDYAR002c-a.
SGDS000002129. ERP1.

Phylogenomic databases

eggNOGNOG323830.
GeneTreeENSGT00430000030848.
HOGENOMHOG000160228.
OMAPSPQWIN.
OrthoDBEOG7WX0N2.

Enzyme and pathway databases

BioCycYEAST:G3O-28890-MONOMER.

Gene expression databases

GenevestigatorQ05359.

Family and domain databases

InterProIPR009038. GOLD.
[Graphical view]
PfamPF01105. EMP24_GP25L. 1 hit.
[Graphical view]
PROSITEPS50866. GOLD. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio968228.

Entry information

Entry nameERP1_YEAST
AccessionPrimary (citable) accession number: Q05359
Secondary accession number(s): D6VPL7, E9P8S8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome I

Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families