Q05359 (ERP1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein ERP1

Gene names

Name:	ERP1
Ordered Locus Names:	YAR002C-A
ORF Names:	YAR002A

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	219 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in vesicular protein trafficking.
Subunit structure	Associates with EMP24, ERV25 and ERP2.
Subcellular location	Endoplasmic reticulum membrane; Single-pass type I membrane protein Ref.6.
Miscellaneous	Present with 20700 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the EMP24/GP25L family. Contains 1 GOLD domain.

Ontologies

Keywords
Biological process	ER-Golgi transport Protein transport Transport
Cellular component	Endoplasmic reticulum Membrane
Domain	Signal Transmembrane Transmembrane helix
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	ER to Golgi vesicle-mediated transport Inferred from physical interaction PubMed 11157978. Source: SGD protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	ER to Golgi transport vesicle Inferred from direct assay PubMed 11157978. Source: SGD endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrion Inferred from direct assay PubMed 14576278PubMed 16823961. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ERP4	Q12450	3	EBI-6581,EBI-6598
ERV25	P54837	6	EBI-6581,EBI-6642

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Ref.6
	Chain	23 – 219	197	Protein ERP1		PRO_0000010408
Regions
	Topological domain	23 – 186	164	Lumenal Potential
	Transmembrane	187 – 207	21	Helical; Potential
	Topological domain	208 – 219	12	Cytoplasmic Potential
	Domain	32 – 131	100	GOLD
Experimental info
	Sequence conflict	152	1	V → I in AAS56036. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q05359 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 16236C1886FC42E8	FASTA	219	24,723
	10 20 30 40 50 60 MLLTSLLQVF ACCLVLPAQV TAFYYYTSGA ERKCFHKELS KGTLFQATYK AQIYDDQLQN 70 80 90 100 110 120 YRDAGAQDFG VLIDIEETFD DNHLVVHQKG SASGDLTFLA SDSGEHKICI QPEAGGWLIK 130 140 150 160 170 180 AKTKIDVEFQ VGSDEKLDSK GKATIDILHA KVNVLNSKIG EIRREQKLMR DREATFRDAS 190 200 210 EAVNSRAMWW IVIQLIVLAV TCGWQMKHLG KFFVKQKIL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 42 kbp SPO7-CENI-CDC15 region." Clark M.W., Keng T., Storms R.K., Zhong W.-W., Fortin N., Zeng B., Delaney S., Ouellette B.F.F., Barton A.B., Kaback D.B., Bussey H. Yeast 10:535-541(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	"The nucleotide sequence of chromosome I from Saccharomyces cerevisiae." Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N., Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J., Storms R.K. Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[5]	"Erp1p and Erp2p, partners for Emp24p and Erv25p in a yeast p24 complex." Marzioch M., Henthorn D.C., Herrmann J.M., Wilson R., Thomas D.Y., Bergeron J.J.M., Solari R.C., Rowley A. Mol. Biol. Cell 10:1923-1938(1999) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION.
[6]	"Proteins in the early Golgi compartment of Saccharomyces cerevisiae immunoisolated by Sed5p." Cho J.-H., Noda Y., Yoda K. FEBS Lett. 469:151-154(2000) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 23-27, SUBCELLULAR LOCATION.
[7]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[8]	"A global topology map of the Saccharomyces cerevisiae membrane proteome." Kim H., Melen K., Oesterberg M., von Heijne G. Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract] Cited for: TOPOLOGY [LARGE SCALE ANALYSIS]. Strain: ATCC 208353 / W303-1A.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L22015 Genomic DNA. Translation: AAC04958.1. AY557710 Genomic DNA. Translation: AAS56036.1. BK006935 Genomic DNA. Translation: DAA06987.1.
PIR	S70311.
RefSeq	NP_009402.1. NM_001180033.1.
3D structure databases
ProteinModelPortal	Q05359.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5147N.
IntAct	Q05359. 56 interactions.
MINT	MINT-524284.
STRING	4932.YAR002C-A.
Proteomic databases
PaxDb	Q05359.
PeptideAtlas	Q05359.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YAR002C-A; YAR002C-A; YAR002C-A.
GeneID	851264.
KEGG	sce:YAR002C-A.
Organism-specific databases
CYGD	YAR002c-a.
SGD	S000002129. ERP1.
Phylogenomic databases
eggNOG	NOG323830.
GeneTree	ENSGT00430000030848.
HOGENOM	HOG000160228.
OMA	PSPQWIN.
OrthoDB	EOG4D82FW.
Gene expression databases
Genevestigator	Q05359.
GermOnline	YAR002C-A. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR009038. GOLD. [Graphical view]
Pfam	PF01105. EMP24_GP25L. 1 hit. [Graphical view]
PROSITE	PS50866. GOLD. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	968228.

Entry information

Entry name

ERP1_YEAST

Accession

Primary (citable) accession number: Q05359
Secondary accession number(s): D6VPL7, E9P8S8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 23, 2003
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 104 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program