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Q05359

- ERP1_YEAST

UniProt

Q05359 - ERP1_YEAST

Protein

Protein ERP1

Gene

ERP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Involved in vesicular protein trafficking.

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. ER to Golgi vesicle-mediated transport Source: SGD
    2. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    ER-Golgi transport, Protein transport, Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-28890-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein ERP1
    Gene namesi
    Name:ERP1
    Ordered Locus Names:YAR002C-A
    ORF Names:YAR002A
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome I

    Organism-specific databases

    CYGDiYAR002c-a.
    SGDiS000002129. ERP1.

    Subcellular locationi

    Endoplasmic reticulum membrane 1 Publication; Single-pass type I membrane protein 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. ER to Golgi transport vesicle Source: SGD
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 22221 PublicationAdd
    BLAST
    Chaini23 – 219197Protein ERP1PRO_0000010408Add
    BLAST

    Proteomic databases

    MaxQBiQ05359.
    PaxDbiQ05359.
    PeptideAtlasiQ05359.

    Expressioni

    Gene expression databases

    GenevestigatoriQ05359.

    Interactioni

    Subunit structurei

    Associates with EMP24, ERV25 and ERP2.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ERP4Q124503EBI-6581,EBI-6598
    ERV25P548376EBI-6581,EBI-6642

    Protein-protein interaction databases

    BioGridi31791. 129 interactions.
    DIPiDIP-5147N.
    IntActiQ05359. 56 interactions.
    MINTiMINT-524284.
    STRINGi4932.YAR002C-A.

    Structurei

    3D structure databases

    ProteinModelPortaliQ05359.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 186164LumenalSequence AnalysisAdd
    BLAST
    Topological domaini208 – 21912CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei187 – 20721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini32 – 131100GOLDPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the EMP24/GP25L family.Curated
    Contains 1 GOLD domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG323830.
    GeneTreeiENSGT00430000030848.
    HOGENOMiHOG000160228.
    OMAiQICLHLE.
    OrthoDBiEOG7WX0N2.

    Family and domain databases

    InterProiIPR009038. GOLD.
    IPR015720. TMP21-related.
    [Graphical view]
    PANTHERiPTHR22811. PTHR22811. 1 hit.
    PfamiPF01105. EMP24_GP25L. 1 hit.
    [Graphical view]
    PROSITEiPS50866. GOLD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q05359-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLTSLLQVF ACCLVLPAQV TAFYYYTSGA ERKCFHKELS KGTLFQATYK    50
    AQIYDDQLQN YRDAGAQDFG VLIDIEETFD DNHLVVHQKG SASGDLTFLA 100
    SDSGEHKICI QPEAGGWLIK AKTKIDVEFQ VGSDEKLDSK GKATIDILHA 150
    KVNVLNSKIG EIRREQKLMR DREATFRDAS EAVNSRAMWW IVIQLIVLAV 200
    TCGWQMKHLG KFFVKQKIL 219
    Length:219
    Mass (Da):24,723
    Last modified:November 1, 1996 - v1
    Checksum:i16236C1886FC42E8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti152 – 1521V → I in AAS56036. (PubMed:17322287)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L22015 Genomic DNA. Translation: AAC04958.1.
    AY557710 Genomic DNA. Translation: AAS56036.1.
    BK006935 Genomic DNA. Translation: DAA06987.1.
    PIRiS70311.
    RefSeqiNP_009402.1. NM_001180033.1.

    Genome annotation databases

    EnsemblFungiiYAR002C-A; YAR002C-A; YAR002C-A.
    GeneIDi851264.
    KEGGisce:YAR002C-A.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L22015 Genomic DNA. Translation: AAC04958.1 .
    AY557710 Genomic DNA. Translation: AAS56036.1 .
    BK006935 Genomic DNA. Translation: DAA06987.1 .
    PIRi S70311.
    RefSeqi NP_009402.1. NM_001180033.1.

    3D structure databases

    ProteinModelPortali Q05359.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31791. 129 interactions.
    DIPi DIP-5147N.
    IntActi Q05359. 56 interactions.
    MINTi MINT-524284.
    STRINGi 4932.YAR002C-A.

    Proteomic databases

    MaxQBi Q05359.
    PaxDbi Q05359.
    PeptideAtlasi Q05359.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YAR002C-A ; YAR002C-A ; YAR002C-A .
    GeneIDi 851264.
    KEGGi sce:YAR002C-A.

    Organism-specific databases

    CYGDi YAR002c-a.
    SGDi S000002129. ERP1.

    Phylogenomic databases

    eggNOGi NOG323830.
    GeneTreei ENSGT00430000030848.
    HOGENOMi HOG000160228.
    OMAi QICLHLE.
    OrthoDBi EOG7WX0N2.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-28890-MONOMER.

    Miscellaneous databases

    NextBioi 968228.

    Gene expression databases

    Genevestigatori Q05359.

    Family and domain databases

    InterProi IPR009038. GOLD.
    IPR015720. TMP21-related.
    [Graphical view ]
    PANTHERi PTHR22811. PTHR22811. 1 hit.
    Pfami PF01105. EMP24_GP25L. 1 hit.
    [Graphical view ]
    PROSITEi PS50866. GOLD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 42 kbp SPO7-CENI-CDC15 region."
      Clark M.W., Keng T., Storms R.K., Zhong W.-W., Fortin N., Zeng B., Delaney S., Ouellette B.F.F., Barton A.B., Kaback D.B., Bussey H.
      Yeast 10:535-541(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204511 / S288c / AB972.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. Cited for: CHARACTERIZATION.
    6. "Proteins in the early Golgi compartment of Saccharomyces cerevisiae immunoisolated by Sed5p."
      Cho J.-H., Noda Y., Yoda K.
      FEBS Lett. 469:151-154(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 23-27, SUBCELLULAR LOCATION.
    7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    8. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.

    Entry informationi

    Entry nameiERP1_YEAST
    AccessioniPrimary (citable) accession number: Q05359
    Secondary accession number(s): D6VPL7, E9P8S8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 23, 2003
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 20700 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome I
      Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

    External Data

    Dasty 3