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Protein

Galectin-10

Gene

CLC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg).1 Publication

Miscellaneous

Forms hexagonal bipyramidal crystals, known as Charcot-Leyden crystals, in tissues and secretions from sites of eosinophil-associated inflammation and some myeloid leukemias.

GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB-KW
  • cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
  • identical protein binding Source: IntAct

GO - Biological processi

  • multicellular organism development Source: ProtInc
  • regulation of activated T cell proliferation Source: UniProtKB
  • regulation of T cell anergy Source: UniProtKB
  • regulation of T cell cytokine production Source: UniProtKB
  • T cell apoptotic process Source: UniProtKB

Keywordsi

LigandLectin

Enzyme and pathway databases

BRENDAi3.1.1.5. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-10
Short name:
Gal-10
Alternative name(s):
Charcot-Leyden crystal protein
Short name:
CLC
Eosinophil lysophospholipase
Lysolecithin acylhydrolase
Gene namesi
Name:CLC
Synonyms:LGALS10, LGALS10A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105205.6.
HGNCiHGNC:2014. CLC.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi1178.
OpenTargetsiENSG00000105205.
PharmGKBiPA26541.

Chemistry databases

DrugBankiDB02967. N-Ethylmaleimide.
DB02983. Para-Mercury-Benzenesulfonic Acid.

Polymorphism and mutation databases

BioMutaiCLC.
DMDMi317373429.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000769602 – 142Galectin-10Add BLAST141

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei136Not glycosylated1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ05315.
PeptideAtlasiQ05315.
PRIDEiQ05315.
TopDownProteomicsiQ05315.

PTM databases

iPTMnetiQ05315.
PhosphoSitePlusiQ05315.

Expressioni

Tissue specificityi

Expressed abundantly in the bone marrow. Expressed exclusively by eosinophils and basophils. Not detected in monocytes and neutrophils. Expressed in CD25-positive regulatory T-cells (Treg) (at protein level). Found in intestinal tissue from patients with Celiac disease, expression is directly related to the histological grade of mucosal damage and to the number of eosinophils found in the duodenal lesion (at protein level). Found in sputum of patients with eosinophilic inflammatory diseases such as asthma (at protein level).4 Publications

Gene expression databases

BgeeiENSG00000105205.
CleanExiHS_CLC.
GenevisibleiQ05315. HS.

Organism-specific databases

HPAiHPA041751.

Interactioni

Subunit structurei

Interacts with CEL.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-10485101,EBI-10485101

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi107592. 1 interactor.
STRINGi9606.ENSP00000221804.

Structurei

Secondary structure

1142
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 11Combined sources6
Beta strandi19 – 28Combined sources10
Helixi30 – 32Combined sources3
Beta strandi35 – 45Combined sources11
Beta strandi50 – 57Combined sources8
Turni58 – 60Combined sources3
Beta strandi61 – 68Combined sources8
Beta strandi76 – 78Combined sources3
Beta strandi89 – 95Combined sources7
Beta strandi97 – 104Combined sources8
Beta strandi107 – 113Combined sources7
Helixi118 – 120Combined sources3
Beta strandi123 – 137Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G86X-ray1.80A1-142[»]
1HDKX-ray1.80A2-142[»]
1LCLX-ray1.80A1-142[»]
1QKQX-ray1.80A1-142[»]
ProteinModelPortaliQ05315.
SMRiQ05315.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ05315.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 138GalectinPROSITE-ProRule annotationAdd BLAST133

Phylogenomic databases

eggNOGiKOG3587. Eukaryota.
ENOG4111EA0. LUCA.
GeneTreeiENSGT00530000064497.
HOGENOMiHOG000015090.
HOVERGENiHBG006255.
InParanoidiQ05315.
KOiK13334.
OMAiDKYQVMV.
OrthoDBiEOG091G0QKJ.
PhylomeDBiQ05315.
TreeFamiTF315551.

Family and domain databases

CDDicd00070. GLECT. 1 hit.
InterProiView protein in InterPro
IPR013320. ConA-like_dom_sf.
IPR030648. Galectin_10.
IPR001079. Galectin_CRD.
PANTHERiPTHR11346:SF15. PTHR11346:SF15. 1 hit.
PfamiView protein in Pfam
PF00337. Gal-bind_lectin. 1 hit.
SMARTiView protein in SMART
SM00908. Gal-bind_lectin. 1 hit.
SM00276. GLECT. 1 hit.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiView protein in PROSITE
PS51304. GALECTIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05315-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLPVPYTE AASLSTGSTV TIKGRPLACF LNEPYLQVDF HTEMKEESDI
60 70 80 90 100
VFHFQVCFGR RVVMNSREYG AWKQQVESKN MPFQDGQEFE LSISVLPDKY
110 120 130 140
QVMVNGQSSY TFDHRIKPEA VKMVQVWRDI SLTKFNVSYL KR
Length:142
Mass (Da):16,453
Last modified:January 11, 2011 - v3
Checksum:i2744F0C082C6446E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01476528A → V6 PublicationsCorresponds to variant dbSNP:rs17608Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01664 mRNA. Translation: AAA36190.1.
L01665 Genomic DNA. Translation: AAC37530.1.
U68398
, U68393, U68395, U68396 Genomic DNA. Translation: AAC51157.1.
FJ613334 mRNA. Translation: ACR09636.1.
FJ613335 mRNA. Translation: ACR09637.1.
AC005393 Genomic DNA. Translation: AAC28912.1.
AC006133 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW56914.1.
BC119711 mRNA. Translation: AAI19712.1.
BC119712 mRNA. Translation: AAI19713.1.
CCDSiCCDS33025.1.
PIRiA46523.
RefSeqiNP_001819.2. NM_001828.5.
UniGeneiHs.889.

Genome annotation databases

EnsembliENST00000221804; ENSP00000221804; ENSG00000105205.
GeneIDi1178.
KEGGihsa:1178.
UCSCiuc002omh.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLEG10_HUMAN
AccessioniPrimary (citable) accession number: Q05315
Secondary accession number(s): C5HZ13, C5HZ14, Q0VDE3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 11, 2011
Last modified: November 22, 2017
This is version 169 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was originally thought to possess lysophospholipase activity but the absence of this activity has been shown by PubMed:11834744.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references