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Q05306

- COAA1_MOUSE

UniProt

Q05306 - COAA1_MOUSE

Protein

Collagen alpha-1(X) chain

Gene

Col10a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage.

    GO - Biological processi

    1. cartilage development Source: Ensembl
    2. endochondral ossification Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_196607. Non-integrin membrane-ECM interactions.
    REACT_198984. Collagen biosynthesis and modifying enzymes.
    REACT_199046. Assembly of collagen fibrils and other multimeric structures.
    REACT_199055. Collagen degradation.
    REACT_216309. Integrin cell surface interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Collagen alpha-1(X) chain
    Gene namesi
    Name:Col10a1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:88445. Col10a1.

    Subcellular locationi

    GO - Cellular componenti

    1. cell cortex Source: MGI
    2. collagen trimer Source: MGI
    3. proteinaceous extracellular matrix Source: MGI

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 680662Collagen alpha-1(X) chainPRO_0000005771Add
    BLAST

    Post-translational modificationi

    Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

    Keywords - PTMi

    Hydroxylation

    Proteomic databases

    PRIDEiQ05306.

    Expressioni

    Gene expression databases

    BgeeiQ05306.
    CleanExiMM_COL10A1.
    GenevestigatoriQ05306.

    Interactioni

    Subunit structurei

    Homotrimer.

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000101150.

    Structurei

    3D structure databases

    ProteinModelPortaliQ05306.
    SMRiQ05306. Positions 549-680.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini547 – 680134C1qPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni19 – 5638Nonhelical region (NC2)Add
    BLAST
    Regioni57 – 519463Triple-helical regionAdd
    BLAST
    Regioni520 – 680161Nonhelical region (NC1)Add
    BLAST

    Sequence similaritiesi

    Contains 1 C1q domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Collagen, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG114228.
    GeneTreeiENSGT00750000117378.
    HOGENOMiHOG000085653.
    HOVERGENiHBG108220.
    InParanoidiQ05306.
    OMAiKGPQPNT.
    OrthoDBiEOG70ZZPW.
    PhylomeDBiQ05306.
    TreeFamiTF334029.

    Family and domain databases

    Gene3Di2.60.120.40. 1 hit.
    InterProiIPR001073. C1q.
    IPR008160. Collagen.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view]
    PfamiPF00386. C1q. 1 hit.
    PF01391. Collagen. 6 hits.
    [Graphical view]
    PRINTSiPR00007. COMPLEMNTC1Q.
    SMARTiSM00110. C1Q. 1 hit.
    [Graphical view]
    SUPFAMiSSF49842. SSF49842. 1 hit.
    PROSITEiPS50871. C1Q. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q05306-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLPQIPFLLL MFLTLVHGMF YAERYQTPTG IKGPLASPKT QYFIPYAIKS    50
    KGIPVRGEQG IPGPPGPTGP RGHPGPSGPP GKPGYGSPGL QGEPGLPGPP 100
    GISATGKPGL PGPPGKPGER GPYGHKGDIG PAGLPGPRGP PGPPGIPGPA 150
    GISVPGKPGQ QGLTGAPGPR GFPGEKGAQG APGVNGRKGE TGYGSPGRPG 200
    ERGLPGPQGP IGPPGPSGVG RRGENGFPGQ PGIKGDRGFP GEMGPSGPPG 250
    PQGPPGKQGR EGIGKPGAIG SPGQPGIPGE KGHPGAPGIA GPPGAPGFGK 300
    QGLPGLRGQR GPAGLPGAPG AKGERGPAGH PGEPGLPGSP GNMGPQGPKG 350
    IPGNHGIPGA KGEIGLVGPA GPPGARGARG PPGLDGKTGY PGEPGLNGPK 400
    GNPGLPGQKG DPGVGGTPGL RGPVGPVGAK GVPGHNGEAG PRGEPGIPGT 450
    RGPTGPPGVP GFPGSKGDPG NPGAPGPAGI ATKGLNGPTG PPGPPGPRGH 500
    SGEPGLPGPP GPPGPPGQAV MPDGFIKAGQ RPRLSGMPLV SANHGVTGMP 550
    VSAFTVILSK AYPAVGAPIP FDEILYNRQQ HYDPRSGIFT CKIPGIYYFS 600
    YHVHVKGTHV WVGLYKNGTP TMYTYDEYSK GYLDQASGSA IMELTENDQV 650
    WLQLPNAESN GLYSSEYVHS SFSGFLVAPM 680
    Length:680
    Mass (Da):66,775
    Last modified:November 1, 1995 - v1
    Checksum:iFE984CA99AF708E2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti13 – 131L → F no nucleotide entry (PubMed:8492743)Curated
    Sequence conflicti27 – 271T → S no nucleotide entry (PubMed:8492743)Curated
    Sequence conflicti248 – 2481P → L no nucleotide entry (PubMed:8492743)Curated
    Sequence conflicti248 – 2481P → L in CAA46237. (PubMed:1587271)Curated
    Sequence conflicti286 – 2861A → S in CAA79736. (PubMed:8477738)Curated
    Sequence conflicti306 – 3061L → F no nucleotide entry (PubMed:8492743)Curated
    Sequence conflicti306 – 3061L → F in CAA46237. (PubMed:1587271)Curated
    Sequence conflicti417 – 4171T → S no nucleotide entry (PubMed:8492743)Curated
    Sequence conflicti417 – 4171T → S in CAA46237. (PubMed:1587271)Curated
    Sequence conflicti451 – 4511R → K in CAA44741. (PubMed:1543751)Curated
    Sequence conflicti500 – 5001H → L no nucleotide entry (PubMed:8492743)Curated
    Sequence conflicti500 – 5001H → L in CAA46237. (PubMed:1587271)Curated
    Sequence conflicti567 – 5726APIPFD → CPHPIY no nucleotide entry (PubMed:8492743)Curated
    Sequence conflicti567 – 5726APIPFD → CPHPIY in CAA46237. (PubMed:1587271)Curated
    Sequence conflicti635 – 6351Q → T no nucleotide entry (PubMed:8492743)Curated
    Sequence conflicti635 – 6351Q → T in CAA46237. (PubMed:1587271)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X67348 Genomic DNA. Translation: CAA47763.1.
    Z21610 Genomic DNA. Translation: CAA79736.1.
    X65121 Genomic DNA. Translation: CAA46237.1.
    X63013 mRNA. Translation: CAA44741.1.
    CCDSiCCDS23780.1.
    PIRiS31216.
    RefSeqiNP_034055.1. NM_009925.4.
    UniGeneiMm.443177.

    Genome annotation databases

    EnsembliENSMUST00000105511; ENSMUSP00000101150; ENSMUSG00000039462.
    GeneIDi12813.
    KEGGimmu:12813.
    UCSCiuc011xcr.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X67348 Genomic DNA. Translation: CAA47763.1 .
    Z21610 Genomic DNA. Translation: CAA79736.1 .
    X65121 Genomic DNA. Translation: CAA46237.1 .
    X63013 mRNA. Translation: CAA44741.1 .
    CCDSi CCDS23780.1.
    PIRi S31216.
    RefSeqi NP_034055.1. NM_009925.4.
    UniGenei Mm.443177.

    3D structure databases

    ProteinModelPortali Q05306.
    SMRi Q05306. Positions 549-680.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000101150.

    Proteomic databases

    PRIDEi Q05306.

    Protocols and materials databases

    DNASUi 12813.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000105511 ; ENSMUSP00000101150 ; ENSMUSG00000039462 .
    GeneIDi 12813.
    KEGGi mmu:12813.
    UCSCi uc011xcr.1. mouse.

    Organism-specific databases

    CTDi 1300.
    MGIi MGI:88445. Col10a1.

    Phylogenomic databases

    eggNOGi NOG114228.
    GeneTreei ENSGT00750000117378.
    HOGENOMi HOG000085653.
    HOVERGENi HBG108220.
    InParanoidi Q05306.
    OMAi KGPQPNT.
    OrthoDBi EOG70ZZPW.
    PhylomeDBi Q05306.
    TreeFami TF334029.

    Enzyme and pathway databases

    Reactomei REACT_196607. Non-integrin membrane-ECM interactions.
    REACT_198984. Collagen biosynthesis and modifying enzymes.
    REACT_199046. Assembly of collagen fibrils and other multimeric structures.
    REACT_199055. Collagen degradation.
    REACT_216309. Integrin cell surface interactions.

    Miscellaneous databases

    NextBioi 282266.
    PROi Q05306.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q05306.
    CleanExi MM_COL10A1.
    Genevestigatori Q05306.

    Family and domain databases

    Gene3Di 2.60.120.40. 1 hit.
    InterProi IPR001073. C1q.
    IPR008160. Collagen.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view ]
    Pfami PF00386. C1q. 1 hit.
    PF01391. Collagen. 6 hits.
    [Graphical view ]
    PRINTSi PR00007. COMPLEMNTC1Q.
    SMARTi SM00110. C1Q. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49842. SSF49842. 1 hit.
    PROSITEi PS50871. C1Q. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The mouse collagen X gene: complete nucleotide sequence, exon structure and expression pattern."
      Elima K., Eerola I., Rosati R., Metsaranta M., Garofalo S., Perala M., de Crombrugghe B., Vuorio E.
      Biochem. J. 289:247-253(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: BALB/c.
    2. "Intron-exon structure, alternative use of promoter and expression of the mouse collagen X gene, Col10a-1."
      Kong R.Y.C., Kwan K.M., Lau E.T., Thomas J.T., Boot-Handford R.P., Grant M.E., Cheah K.S.E.
      Eur. J. Biochem. 213:99-111(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
      Tissue: Liver.
    3. "Characterization of the mouse type X collagen gene."
      Apte S.S., Olsen B.R.
      Matrix 13:165-179(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    4. "Cloning of the human and mouse type X collagen genes and mapping of the mouse type X collagen gene to chromosome 10."
      Apte S.S., Seldin M.F., Hayashi M., Olsen B.R.
      Eur. J. Biochem. 206:217-224(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 51-680.
      Strain: DBA/2J.
    5. "Specific hybridization probes for mouse alpha 2(IX) and alpha 1(X) collagen mRNAs."
      Elima K., Metsaeranta M., Kallio J., Peraelae M., Eerola I., Garofalo S., de Crombrugghe B., Vuorio E.
      Biochim. Biophys. Acta 1130:78-80(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 385-627.
      Strain: C57BL/6.

    Entry informationi

    Entry nameiCOAA1_MOUSE
    AccessioniPrimary (citable) accession number: Q05306
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3