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Protein

Collagen alpha-1(X) chain

Gene

Col10a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage.

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-1442490. Collagen degradation.
R-MMU-1650814. Collagen biosynthesis and modifying enzymes.
R-MMU-2022090. Assembly of collagen fibrils and other multimeric structures.
R-MMU-3000171. Non-integrin membrane-ECM interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(X) chain
Gene namesi
Name:Col10a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:88445. Col10a1.

Subcellular locationi

GO - Cellular componenti

  • cell cortex Source: MGI
  • collagen trimer Source: MGI
  • proteinaceous extracellular matrix Source: MGI
  • receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000000577119 – 680Collagen alpha-1(X) chainAdd BLAST662

Post-translational modificationi

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

Keywords - PTMi

Hydroxylation

Proteomic databases

MaxQBiQ05306.
PaxDbiQ05306.
PRIDEiQ05306.

PTM databases

iPTMnetiQ05306.
PhosphoSitePlusiQ05306.

Expressioni

Gene expression databases

BgeeiENSMUSG00000039462.
CleanExiMM_COL10A1.
GenevisibleiQ05306. MM.

Interactioni

Subunit structurei

Homotrimer.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101150.

Structurei

3D structure databases

ProteinModelPortaliQ05306.
SMRiQ05306.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini547 – 680C1qPROSITE-ProRule annotationAdd BLAST134

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni19 – 56Nonhelical region (NC2)Add BLAST38
Regioni57 – 519Triple-helical regionAdd BLAST463
Regioni520 – 680Nonhelical region (NC1)Add BLAST161

Sequence similaritiesi

Contains 1 C1q domain.PROSITE-ProRule annotation

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IGA1. Eukaryota.
ENOG410XNMM. LUCA.
GeneTreeiENSGT00760000118830.
HOGENOMiHOG000085653.
HOVERGENiHBG108220.
InParanoidiQ05306.
KOiK19479.
OMAiMPMSAFT.
OrthoDBiEOG091G0L3Y.
PhylomeDBiQ05306.
TreeFamiTF334029.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q_dom.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 5 hits.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05306-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPQIPFLLL MFLTLVHGMF YAERYQTPTG IKGPLASPKT QYFIPYAIKS
60 70 80 90 100
KGIPVRGEQG IPGPPGPTGP RGHPGPSGPP GKPGYGSPGL QGEPGLPGPP
110 120 130 140 150
GISATGKPGL PGPPGKPGER GPYGHKGDIG PAGLPGPRGP PGPPGIPGPA
160 170 180 190 200
GISVPGKPGQ QGLTGAPGPR GFPGEKGAQG APGVNGRKGE TGYGSPGRPG
210 220 230 240 250
ERGLPGPQGP IGPPGPSGVG RRGENGFPGQ PGIKGDRGFP GEMGPSGPPG
260 270 280 290 300
PQGPPGKQGR EGIGKPGAIG SPGQPGIPGE KGHPGAPGIA GPPGAPGFGK
310 320 330 340 350
QGLPGLRGQR GPAGLPGAPG AKGERGPAGH PGEPGLPGSP GNMGPQGPKG
360 370 380 390 400
IPGNHGIPGA KGEIGLVGPA GPPGARGARG PPGLDGKTGY PGEPGLNGPK
410 420 430 440 450
GNPGLPGQKG DPGVGGTPGL RGPVGPVGAK GVPGHNGEAG PRGEPGIPGT
460 470 480 490 500
RGPTGPPGVP GFPGSKGDPG NPGAPGPAGI ATKGLNGPTG PPGPPGPRGH
510 520 530 540 550
SGEPGLPGPP GPPGPPGQAV MPDGFIKAGQ RPRLSGMPLV SANHGVTGMP
560 570 580 590 600
VSAFTVILSK AYPAVGAPIP FDEILYNRQQ HYDPRSGIFT CKIPGIYYFS
610 620 630 640 650
YHVHVKGTHV WVGLYKNGTP TMYTYDEYSK GYLDQASGSA IMELTENDQV
660 670 680
WLQLPNAESN GLYSSEYVHS SFSGFLVAPM
Length:680
Mass (Da):66,775
Last modified:November 1, 1995 - v1
Checksum:iFE984CA99AF708E2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13L → F no nucleotide entry (PubMed:8492743).Curated1
Sequence conflicti27T → S no nucleotide entry (PubMed:8492743).Curated1
Sequence conflicti248P → L no nucleotide entry (PubMed:8492743).Curated1
Sequence conflicti248P → L in CAA46237 (PubMed:1587271).Curated1
Sequence conflicti286A → S in CAA79736 (PubMed:8477738).Curated1
Sequence conflicti306L → F no nucleotide entry (PubMed:8492743).Curated1
Sequence conflicti306L → F in CAA46237 (PubMed:1587271).Curated1
Sequence conflicti417T → S no nucleotide entry (PubMed:8492743).Curated1
Sequence conflicti417T → S in CAA46237 (PubMed:1587271).Curated1
Sequence conflicti451R → K in CAA44741 (PubMed:1543751).Curated1
Sequence conflicti500H → L no nucleotide entry (PubMed:8492743).Curated1
Sequence conflicti500H → L in CAA46237 (PubMed:1587271).Curated1
Sequence conflicti567 – 572APIPFD → CPHPIY no nucleotide entry (PubMed:8492743).Curated6
Sequence conflicti567 – 572APIPFD → CPHPIY in CAA46237 (PubMed:1587271).Curated6
Sequence conflicti635Q → T no nucleotide entry (PubMed:8492743).Curated1
Sequence conflicti635Q → T in CAA46237 (PubMed:1587271).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67348 Genomic DNA. Translation: CAA47763.1.
Z21610 Genomic DNA. Translation: CAA79736.1.
X65121 Genomic DNA. Translation: CAA46237.1.
X63013 mRNA. Translation: CAA44741.1.
CCDSiCCDS23780.1.
PIRiS31216.
RefSeqiNP_034055.1. NM_009925.4.
UniGeneiMm.443177.

Genome annotation databases

EnsembliENSMUST00000105511; ENSMUSP00000101150; ENSMUSG00000039462.
GeneIDi12813.
KEGGimmu:12813.
UCSCiuc011xcr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67348 Genomic DNA. Translation: CAA47763.1.
Z21610 Genomic DNA. Translation: CAA79736.1.
X65121 Genomic DNA. Translation: CAA46237.1.
X63013 mRNA. Translation: CAA44741.1.
CCDSiCCDS23780.1.
PIRiS31216.
RefSeqiNP_034055.1. NM_009925.4.
UniGeneiMm.443177.

3D structure databases

ProteinModelPortaliQ05306.
SMRiQ05306.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101150.

PTM databases

iPTMnetiQ05306.
PhosphoSitePlusiQ05306.

Proteomic databases

MaxQBiQ05306.
PaxDbiQ05306.
PRIDEiQ05306.

Protocols and materials databases

DNASUi12813.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000105511; ENSMUSP00000101150; ENSMUSG00000039462.
GeneIDi12813.
KEGGimmu:12813.
UCSCiuc011xcr.1. mouse.

Organism-specific databases

CTDi1300.
MGIiMGI:88445. Col10a1.

Phylogenomic databases

eggNOGiENOG410IGA1. Eukaryota.
ENOG410XNMM. LUCA.
GeneTreeiENSGT00760000118830.
HOGENOMiHOG000085653.
HOVERGENiHBG108220.
InParanoidiQ05306.
KOiK19479.
OMAiMPMSAFT.
OrthoDBiEOG091G0L3Y.
PhylomeDBiQ05306.
TreeFamiTF334029.

Enzyme and pathway databases

ReactomeiR-MMU-1442490. Collagen degradation.
R-MMU-1650814. Collagen biosynthesis and modifying enzymes.
R-MMU-2022090. Assembly of collagen fibrils and other multimeric structures.
R-MMU-3000171. Non-integrin membrane-ECM interactions.

Miscellaneous databases

PROiQ05306.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039462.
CleanExiMM_COL10A1.
GenevisibleiQ05306. MM.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q_dom.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 5 hits.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOAA1_MOUSE
AccessioniPrimary (citable) accession number: Q05306
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.