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Q05306 (COAA1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Collagen alpha-1(X) chain
Gene names
Name:Col10a1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length680 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage.

Subunit structure

Homotrimer.

Subcellular location

Secreted › extracellular space › extracellular matrix By similarity.

Post-translational modification

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

Sequence similarities

Contains 1 C1q domain.

Ontologies

Keywords
   Cellular componentExtracellular matrix
Secreted
   DomainCollagen
Repeat
Signal
   PTMHydroxylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcell cortex

Inferred from direct assay PubMed 9008714. Source: MGI

collagen

Inferred from direct assay PubMed 20812917. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 680662Collagen alpha-1(X) chain
PRO_0000005771

Regions

Domain547 – 680134C1q
Region19 – 5638Nonhelical region (NC2)
Region57 – 519463Triple-helical region
Region520 – 680161Nonhelical region (NC1)

Experimental info

Sequence conflict131L → F no nucleotide entry Ref.3
Sequence conflict271T → S no nucleotide entry Ref.3
Sequence conflict2481P → L no nucleotide entry Ref.3
Sequence conflict2481P → L in CAA46237. Ref.4
Sequence conflict2861A → S in CAA79736. Ref.2
Sequence conflict3061L → F no nucleotide entry Ref.3
Sequence conflict3061L → F in CAA46237. Ref.4
Sequence conflict4171T → S no nucleotide entry Ref.3
Sequence conflict4171T → S in CAA46237. Ref.4
Sequence conflict4511R → K in CAA44741. Ref.5
Sequence conflict5001H → L no nucleotide entry Ref.3
Sequence conflict5001H → L in CAA46237. Ref.4
Sequence conflict567 – 5726APIPFD → CPHPIY no nucleotide entry Ref.3
Sequence conflict567 – 5726APIPFD → CPHPIY in CAA46237. Ref.4
Sequence conflict6351Q → T no nucleotide entry Ref.3
Sequence conflict6351Q → T in CAA46237. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q05306 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: FE984CA99AF708E2

FASTA68066,775
        10         20         30         40         50         60 
MLPQIPFLLL MFLTLVHGMF YAERYQTPTG IKGPLASPKT QYFIPYAIKS KGIPVRGEQG 

        70         80         90        100        110        120 
IPGPPGPTGP RGHPGPSGPP GKPGYGSPGL QGEPGLPGPP GISATGKPGL PGPPGKPGER 

       130        140        150        160        170        180 
GPYGHKGDIG PAGLPGPRGP PGPPGIPGPA GISVPGKPGQ QGLTGAPGPR GFPGEKGAQG 

       190        200        210        220        230        240 
APGVNGRKGE TGYGSPGRPG ERGLPGPQGP IGPPGPSGVG RRGENGFPGQ PGIKGDRGFP 

       250        260        270        280        290        300 
GEMGPSGPPG PQGPPGKQGR EGIGKPGAIG SPGQPGIPGE KGHPGAPGIA GPPGAPGFGK 

       310        320        330        340        350        360 
QGLPGLRGQR GPAGLPGAPG AKGERGPAGH PGEPGLPGSP GNMGPQGPKG IPGNHGIPGA 

       370        380        390        400        410        420 
KGEIGLVGPA GPPGARGARG PPGLDGKTGY PGEPGLNGPK GNPGLPGQKG DPGVGGTPGL 

       430        440        450        460        470        480 
RGPVGPVGAK GVPGHNGEAG PRGEPGIPGT RGPTGPPGVP GFPGSKGDPG NPGAPGPAGI 

       490        500        510        520        530        540 
ATKGLNGPTG PPGPPGPRGH SGEPGLPGPP GPPGPPGQAV MPDGFIKAGQ RPRLSGMPLV 

       550        560        570        580        590        600 
SANHGVTGMP VSAFTVILSK AYPAVGAPIP FDEILYNRQQ HYDPRSGIFT CKIPGIYYFS 

       610        620        630        640        650        660 
YHVHVKGTHV WVGLYKNGTP TMYTYDEYSK GYLDQASGSA IMELTENDQV WLQLPNAESN 

       670        680 
GLYSSEYVHS SFSGFLVAPM

« Hide

References

[1]"The mouse collagen X gene: complete nucleotide sequence, exon structure and expression pattern."
Elima K., Eerola I., Rosati R., Metsaranta M., Garofalo S., Perala M., de Crombrugghe B., Vuorio E.
Biochem. J. 289:247-253(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: BALB/c.
[2]"Intron-exon structure, alternative use of promoter and expression of the mouse collagen X gene, Col10a-1."
Kong R.Y.C., Kwan K.M., Lau E.T., Thomas J.T., Boot-Handford R.P., Grant M.E., Cheah K.S.E.
Eur. J. Biochem. 213:99-111(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/Sv.
Tissue: Liver.
[3]"Characterization of the mouse type X collagen gene."
Apte S.S., Olsen B.R.
Matrix 13:165-179(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[4]"Cloning of the human and mouse type X collagen genes and mapping of the mouse type X collagen gene to chromosome 10."
Apte S.S., Seldin M.F., Hayashi M., Olsen B.R.
Eur. J. Biochem. 206:217-224(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 51-680.
Strain: DBA/2J.
[5]"Specific hybridization probes for mouse alpha 2(IX) and alpha 1(X) collagen mRNAs."
Elima K., Metsaeranta M., Kallio J., Peraelae M., Eerola I., Garofalo S., de Crombrugghe B., Vuorio E.
Biochim. Biophys. Acta 1130:78-80(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 385-627.
Strain: C57BL/6.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X67348 Genomic DNA. Translation: CAA47763.1.
Z21610 Genomic DNA. Translation: CAA79736.1.
X65121 Genomic DNA. Translation: CAA46237.1.
X63013 mRNA. Translation: CAA44741.1.
IPIIPI00109296.
PIRS31216.
RefSeqNP_034055.1. NM_009925.4.
UniGeneMm.443177.

3D structure databases

ProteinModelPortalQ05306.
SMRQ05306. Positions 549-680.
ModBaseSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000101150.

Proteomic databases

PRIDEQ05306.

Protocols and materials databases

DNASU12813.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000105511; ENSMUSP00000101150; ENSMUSG00000039462.
GeneID12813.
KEGGmmu:12813.
UCSCuc011xcr.1. mouse.

Organism-specific databases

CTD1300.
MGIMGI:88445. Col10a1.

Phylogenomic databases

eggNOGNOG114228.
GeneTreeENSGT00700000104270.
HOGENOMHOG000085653.
HOVERGENHBG108220.
InParanoidQ05306.
OMAKPGHGSP.
OrthoDBEOG4FFD29.

Gene expression databases

BgeeQ05306.
CleanExMM_COL10A1.
GenevestigatorQ05306.
GermOnlineENSMUSG00000039462. Mus musculus.

Family and domain databases

Gene3D2.60.120.40. 1 hit.
InterProIPR001073. C1q.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamPF00386. C1q. 1 hit.
PF01391. Collagen. 6 hits.
[Graphical view]
PRINTSPR00007. COMPLEMNTC1Q.
SMARTSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMSSF49842. TNF_like. 1 hit.
PROSITEPS50871. C1Q. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio282266.
SOURCESearch...

Entry information

Entry nameCOAA1_MOUSE
AccessionPrimary (citable) accession number: Q05306
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 3, 2013
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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