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Protein

Collagen alpha-1(X) chain

Gene

Col10a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage.

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_285754. Collagen biosynthesis and modifying enzymes.
REACT_313067. Collagen degradation.
REACT_318656. Assembly of collagen fibrils and other multimeric structures.
REACT_319261. Integrin cell surface interactions.
REACT_320075. Non-integrin membrane-ECM interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(X) chain
Gene namesi
Name:Col10a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:88445. Col10a1.

Subcellular locationi

GO - Cellular componenti

  • cell cortex Source: MGI
  • collagen trimer Source: MGI
  • proteinaceous extracellular matrix Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 680662Collagen alpha-1(X) chainPRO_0000005771Add
BLAST

Post-translational modificationi

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

Keywords - PTMi

Hydroxylation

Proteomic databases

PRIDEiQ05306.

Expressioni

Gene expression databases

BgeeiQ05306.
CleanExiMM_COL10A1.
GenevisibleiQ05306. MM.

Interactioni

Subunit structurei

Homotrimer.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101150.

Structurei

3D structure databases

ProteinModelPortaliQ05306.
SMRiQ05306. Positions 549-680.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini547 – 680134C1qPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni19 – 5638Nonhelical region (NC2)Add
BLAST
Regioni57 – 519463Triple-helical regionAdd
BLAST
Regioni520 – 680161Nonhelical region (NC1)Add
BLAST

Sequence similaritiesi

Contains 1 C1q domain.PROSITE-ProRule annotation

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiNOG114228.
GeneTreeiENSGT00760000118830.
HOGENOMiHOG000085653.
HOVERGENiHBG108220.
InParanoidiQ05306.
OMAiKGPQPNT.
OrthoDBiEOG70ZZPW.
PhylomeDBiQ05306.
TreeFamiTF334029.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 6 hits.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05306-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPQIPFLLL MFLTLVHGMF YAERYQTPTG IKGPLASPKT QYFIPYAIKS
60 70 80 90 100
KGIPVRGEQG IPGPPGPTGP RGHPGPSGPP GKPGYGSPGL QGEPGLPGPP
110 120 130 140 150
GISATGKPGL PGPPGKPGER GPYGHKGDIG PAGLPGPRGP PGPPGIPGPA
160 170 180 190 200
GISVPGKPGQ QGLTGAPGPR GFPGEKGAQG APGVNGRKGE TGYGSPGRPG
210 220 230 240 250
ERGLPGPQGP IGPPGPSGVG RRGENGFPGQ PGIKGDRGFP GEMGPSGPPG
260 270 280 290 300
PQGPPGKQGR EGIGKPGAIG SPGQPGIPGE KGHPGAPGIA GPPGAPGFGK
310 320 330 340 350
QGLPGLRGQR GPAGLPGAPG AKGERGPAGH PGEPGLPGSP GNMGPQGPKG
360 370 380 390 400
IPGNHGIPGA KGEIGLVGPA GPPGARGARG PPGLDGKTGY PGEPGLNGPK
410 420 430 440 450
GNPGLPGQKG DPGVGGTPGL RGPVGPVGAK GVPGHNGEAG PRGEPGIPGT
460 470 480 490 500
RGPTGPPGVP GFPGSKGDPG NPGAPGPAGI ATKGLNGPTG PPGPPGPRGH
510 520 530 540 550
SGEPGLPGPP GPPGPPGQAV MPDGFIKAGQ RPRLSGMPLV SANHGVTGMP
560 570 580 590 600
VSAFTVILSK AYPAVGAPIP FDEILYNRQQ HYDPRSGIFT CKIPGIYYFS
610 620 630 640 650
YHVHVKGTHV WVGLYKNGTP TMYTYDEYSK GYLDQASGSA IMELTENDQV
660 670 680
WLQLPNAESN GLYSSEYVHS SFSGFLVAPM
Length:680
Mass (Da):66,775
Last modified:November 1, 1995 - v1
Checksum:iFE984CA99AF708E2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 131L → F no nucleotide entry (PubMed:8492743).Curated
Sequence conflicti27 – 271T → S no nucleotide entry (PubMed:8492743).Curated
Sequence conflicti248 – 2481P → L no nucleotide entry (PubMed:8492743).Curated
Sequence conflicti248 – 2481P → L in CAA46237 (PubMed:1587271).Curated
Sequence conflicti286 – 2861A → S in CAA79736 (PubMed:8477738).Curated
Sequence conflicti306 – 3061L → F no nucleotide entry (PubMed:8492743).Curated
Sequence conflicti306 – 3061L → F in CAA46237 (PubMed:1587271).Curated
Sequence conflicti417 – 4171T → S no nucleotide entry (PubMed:8492743).Curated
Sequence conflicti417 – 4171T → S in CAA46237 (PubMed:1587271).Curated
Sequence conflicti451 – 4511R → K in CAA44741 (PubMed:1543751).Curated
Sequence conflicti500 – 5001H → L no nucleotide entry (PubMed:8492743).Curated
Sequence conflicti500 – 5001H → L in CAA46237 (PubMed:1587271).Curated
Sequence conflicti567 – 5726APIPFD → CPHPIY no nucleotide entry (PubMed:8492743).Curated
Sequence conflicti567 – 5726APIPFD → CPHPIY in CAA46237 (PubMed:1587271).Curated
Sequence conflicti635 – 6351Q → T no nucleotide entry (PubMed:8492743).Curated
Sequence conflicti635 – 6351Q → T in CAA46237 (PubMed:1587271).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67348 Genomic DNA. Translation: CAA47763.1.
Z21610 Genomic DNA. Translation: CAA79736.1.
X65121 Genomic DNA. Translation: CAA46237.1.
X63013 mRNA. Translation: CAA44741.1.
CCDSiCCDS23780.1.
PIRiS31216.
RefSeqiNP_034055.1. NM_009925.4.
UniGeneiMm.443177.

Genome annotation databases

EnsembliENSMUST00000105511; ENSMUSP00000101150; ENSMUSG00000039462.
GeneIDi12813.
KEGGimmu:12813.
UCSCiuc011xcr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67348 Genomic DNA. Translation: CAA47763.1.
Z21610 Genomic DNA. Translation: CAA79736.1.
X65121 Genomic DNA. Translation: CAA46237.1.
X63013 mRNA. Translation: CAA44741.1.
CCDSiCCDS23780.1.
PIRiS31216.
RefSeqiNP_034055.1. NM_009925.4.
UniGeneiMm.443177.

3D structure databases

ProteinModelPortaliQ05306.
SMRiQ05306. Positions 549-680.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101150.

Proteomic databases

PRIDEiQ05306.

Protocols and materials databases

DNASUi12813.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000105511; ENSMUSP00000101150; ENSMUSG00000039462.
GeneIDi12813.
KEGGimmu:12813.
UCSCiuc011xcr.1. mouse.

Organism-specific databases

CTDi1300.
MGIiMGI:88445. Col10a1.

Phylogenomic databases

eggNOGiNOG114228.
GeneTreeiENSGT00760000118830.
HOGENOMiHOG000085653.
HOVERGENiHBG108220.
InParanoidiQ05306.
OMAiKGPQPNT.
OrthoDBiEOG70ZZPW.
PhylomeDBiQ05306.
TreeFamiTF334029.

Enzyme and pathway databases

ReactomeiREACT_285754. Collagen biosynthesis and modifying enzymes.
REACT_313067. Collagen degradation.
REACT_318656. Assembly of collagen fibrils and other multimeric structures.
REACT_319261. Integrin cell surface interactions.
REACT_320075. Non-integrin membrane-ECM interactions.

Miscellaneous databases

NextBioi282266.
PROiQ05306.
SOURCEiSearch...

Gene expression databases

BgeeiQ05306.
CleanExiMM_COL10A1.
GenevisibleiQ05306. MM.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 6 hits.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The mouse collagen X gene: complete nucleotide sequence, exon structure and expression pattern."
    Elima K., Eerola I., Rosati R., Metsaranta M., Garofalo S., Perala M., de Crombrugghe B., Vuorio E.
    Biochem. J. 289:247-253(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c.
  2. "Intron-exon structure, alternative use of promoter and expression of the mouse collagen X gene, Col10a-1."
    Kong R.Y.C., Kwan K.M., Lau E.T., Thomas J.T., Boot-Handford R.P., Grant M.E., Cheah K.S.E.
    Eur. J. Biochem. 213:99-111(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
    Tissue: Liver.
  3. "Characterization of the mouse type X collagen gene."
    Apte S.S., Olsen B.R.
    Matrix 13:165-179(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  4. "Cloning of the human and mouse type X collagen genes and mapping of the mouse type X collagen gene to chromosome 10."
    Apte S.S., Seldin M.F., Hayashi M., Olsen B.R.
    Eur. J. Biochem. 206:217-224(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 51-680.
    Strain: DBA/2J.
  5. "Specific hybridization probes for mouse alpha 2(IX) and alpha 1(X) collagen mRNAs."
    Elima K., Metsaeranta M., Kallio J., Peraelae M., Eerola I., Garofalo S., de Crombrugghe B., Vuorio E.
    Biochim. Biophys. Acta 1130:78-80(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 385-627.
    Strain: C57BL/6.

Entry informationi

Entry nameiCOAA1_MOUSE
AccessioniPrimary (citable) accession number: Q05306
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 24, 2015
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.