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Q05306

- COAA1_MOUSE

UniProt

Q05306 - COAA1_MOUSE

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Protein

Collagen alpha-1(X) chain

Gene
Col10a1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage.

GO - Biological processi

  1. cartilage development Source: Ensembl
  2. endochondral ossification Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_196607. Non-integrin membrane-ECM interactions.
REACT_198984. Collagen biosynthesis and modifying enzymes.
REACT_199046. Assembly of collagen fibrils and other multimeric structures.
REACT_199055. Collagen degradation.
REACT_216309. Integrin cell surface interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(X) chain
Gene namesi
Name:Col10a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:88445. Col10a1.

Subcellular locationi

GO - Cellular componenti

  1. cell cortex Source: MGI
  2. collagen trimer Source: MGI
  3. proteinaceous extracellular matrix Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed predictionAdd
BLAST
Chaini19 – 680662Collagen alpha-1(X) chainPRO_0000005771Add
BLAST

Post-translational modificationi

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

Keywords - PTMi

Hydroxylation

Proteomic databases

PRIDEiQ05306.

Expressioni

Gene expression databases

BgeeiQ05306.
CleanExiMM_COL10A1.
GenevestigatoriQ05306.

Interactioni

Subunit structurei

Homotrimer.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101150.

Structurei

3D structure databases

ProteinModelPortaliQ05306.
SMRiQ05306. Positions 549-680.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini547 – 680134C1qAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni19 – 5638Nonhelical region (NC2)Add
BLAST
Regioni57 – 519463Triple-helical regionAdd
BLAST
Regioni520 – 680161Nonhelical region (NC1)Add
BLAST

Sequence similaritiesi

Contains 1 C1q domain.

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiNOG114228.
GeneTreeiENSGT00750000117378.
HOGENOMiHOG000085653.
HOVERGENiHBG108220.
InParanoidiQ05306.
OMAiKGPQPNT.
OrthoDBiEOG70ZZPW.
PhylomeDBiQ05306.
TreeFamiTF334029.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 6 hits.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05306-1 [UniParc]FASTAAdd to Basket

« Hide

MLPQIPFLLL MFLTLVHGMF YAERYQTPTG IKGPLASPKT QYFIPYAIKS    50
KGIPVRGEQG IPGPPGPTGP RGHPGPSGPP GKPGYGSPGL QGEPGLPGPP 100
GISATGKPGL PGPPGKPGER GPYGHKGDIG PAGLPGPRGP PGPPGIPGPA 150
GISVPGKPGQ QGLTGAPGPR GFPGEKGAQG APGVNGRKGE TGYGSPGRPG 200
ERGLPGPQGP IGPPGPSGVG RRGENGFPGQ PGIKGDRGFP GEMGPSGPPG 250
PQGPPGKQGR EGIGKPGAIG SPGQPGIPGE KGHPGAPGIA GPPGAPGFGK 300
QGLPGLRGQR GPAGLPGAPG AKGERGPAGH PGEPGLPGSP GNMGPQGPKG 350
IPGNHGIPGA KGEIGLVGPA GPPGARGARG PPGLDGKTGY PGEPGLNGPK 400
GNPGLPGQKG DPGVGGTPGL RGPVGPVGAK GVPGHNGEAG PRGEPGIPGT 450
RGPTGPPGVP GFPGSKGDPG NPGAPGPAGI ATKGLNGPTG PPGPPGPRGH 500
SGEPGLPGPP GPPGPPGQAV MPDGFIKAGQ RPRLSGMPLV SANHGVTGMP 550
VSAFTVILSK AYPAVGAPIP FDEILYNRQQ HYDPRSGIFT CKIPGIYYFS 600
YHVHVKGTHV WVGLYKNGTP TMYTYDEYSK GYLDQASGSA IMELTENDQV 650
WLQLPNAESN GLYSSEYVHS SFSGFLVAPM 680
Length:680
Mass (Da):66,775
Last modified:November 1, 1995 - v1
Checksum:iFE984CA99AF708E2
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 131L → F no nucleotide entry 1 Publication
Sequence conflicti27 – 271T → S no nucleotide entry 1 Publication
Sequence conflicti248 – 2481P → L no nucleotide entry 1 Publication
Sequence conflicti248 – 2481P → L in CAA46237. 1 Publication
Sequence conflicti286 – 2861A → S in CAA79736. 1 Publication
Sequence conflicti306 – 3061L → F no nucleotide entry 1 Publication
Sequence conflicti306 – 3061L → F in CAA46237. 1 Publication
Sequence conflicti417 – 4171T → S no nucleotide entry 1 Publication
Sequence conflicti417 – 4171T → S in CAA46237. 1 Publication
Sequence conflicti451 – 4511R → K in CAA44741. 1 Publication
Sequence conflicti500 – 5001H → L no nucleotide entry 1 Publication
Sequence conflicti500 – 5001H → L in CAA46237. 1 Publication
Sequence conflicti567 – 5726APIPFD → CPHPIY no nucleotide entry 1 Publication
Sequence conflicti567 – 5726APIPFD → CPHPIY in CAA46237. 1 Publication
Sequence conflicti635 – 6351Q → T no nucleotide entry 1 Publication
Sequence conflicti635 – 6351Q → T in CAA46237. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X67348 Genomic DNA. Translation: CAA47763.1.
Z21610 Genomic DNA. Translation: CAA79736.1.
X65121 Genomic DNA. Translation: CAA46237.1.
X63013 mRNA. Translation: CAA44741.1.
CCDSiCCDS23780.1.
PIRiS31216.
RefSeqiNP_034055.1. NM_009925.4.
UniGeneiMm.443177.

Genome annotation databases

EnsembliENSMUST00000105511; ENSMUSP00000101150; ENSMUSG00000039462.
GeneIDi12813.
KEGGimmu:12813.
UCSCiuc011xcr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X67348 Genomic DNA. Translation: CAA47763.1 .
Z21610 Genomic DNA. Translation: CAA79736.1 .
X65121 Genomic DNA. Translation: CAA46237.1 .
X63013 mRNA. Translation: CAA44741.1 .
CCDSi CCDS23780.1.
PIRi S31216.
RefSeqi NP_034055.1. NM_009925.4.
UniGenei Mm.443177.

3D structure databases

ProteinModelPortali Q05306.
SMRi Q05306. Positions 549-680.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000101150.

Proteomic databases

PRIDEi Q05306.

Protocols and materials databases

DNASUi 12813.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000105511 ; ENSMUSP00000101150 ; ENSMUSG00000039462 .
GeneIDi 12813.
KEGGi mmu:12813.
UCSCi uc011xcr.1. mouse.

Organism-specific databases

CTDi 1300.
MGIi MGI:88445. Col10a1.

Phylogenomic databases

eggNOGi NOG114228.
GeneTreei ENSGT00750000117378.
HOGENOMi HOG000085653.
HOVERGENi HBG108220.
InParanoidi Q05306.
OMAi KGPQPNT.
OrthoDBi EOG70ZZPW.
PhylomeDBi Q05306.
TreeFami TF334029.

Enzyme and pathway databases

Reactomei REACT_196607. Non-integrin membrane-ECM interactions.
REACT_198984. Collagen biosynthesis and modifying enzymes.
REACT_199046. Assembly of collagen fibrils and other multimeric structures.
REACT_199055. Collagen degradation.
REACT_216309. Integrin cell surface interactions.

Miscellaneous databases

NextBioi 282266.
PROi Q05306.
SOURCEi Search...

Gene expression databases

Bgeei Q05306.
CleanExi MM_COL10A1.
Genevestigatori Q05306.

Family and domain databases

Gene3Di 2.60.120.40. 1 hit.
InterProi IPR001073. C1q.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view ]
Pfami PF00386. C1q. 1 hit.
PF01391. Collagen. 6 hits.
[Graphical view ]
PRINTSi PR00007. COMPLEMNTC1Q.
SMARTi SM00110. C1Q. 1 hit.
[Graphical view ]
SUPFAMi SSF49842. SSF49842. 1 hit.
PROSITEi PS50871. C1Q. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The mouse collagen X gene: complete nucleotide sequence, exon structure and expression pattern."
    Elima K., Eerola I., Rosati R., Metsaranta M., Garofalo S., Perala M., de Crombrugghe B., Vuorio E.
    Biochem. J. 289:247-253(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c.
  2. "Intron-exon structure, alternative use of promoter and expression of the mouse collagen X gene, Col10a-1."
    Kong R.Y.C., Kwan K.M., Lau E.T., Thomas J.T., Boot-Handford R.P., Grant M.E., Cheah K.S.E.
    Eur. J. Biochem. 213:99-111(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
    Tissue: Liver.
  3. "Characterization of the mouse type X collagen gene."
    Apte S.S., Olsen B.R.
    Matrix 13:165-179(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  4. "Cloning of the human and mouse type X collagen genes and mapping of the mouse type X collagen gene to chromosome 10."
    Apte S.S., Seldin M.F., Hayashi M., Olsen B.R.
    Eur. J. Biochem. 206:217-224(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 51-680.
    Strain: DBA/2J.
  5. "Specific hybridization probes for mouse alpha 2(IX) and alpha 1(X) collagen mRNAs."
    Elima K., Metsaeranta M., Kallio J., Peraelae M., Eerola I., Garofalo S., de Crombrugghe B., Vuorio E.
    Biochim. Biophys. Acta 1130:78-80(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 385-627.
    Strain: C57BL/6.

Entry informationi

Entry nameiCOAA1_MOUSE
AccessioniPrimary (citable) accession number: Q05306
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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