SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q05262

- VG50_BPML5

UniProt

Q05262 - VG50_BPML5

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Putative adenosylcobalamin-dependent ribonucleoside-triphosphate reductase
Gene
50
Organism
Mycobacterium phage L5 (Mycobacteriophage L5)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

Cofactori

Adenosylcobalamin By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei370 – 3701 By similarity
Active sitei372 – 3721 By similarity

GO - Molecular functioni

  1. cobalamin binding Source: UniProtKB-KW
  2. nucleotide binding Source: InterPro
  3. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: InterPro
  4. ribonucleoside-triphosphate reductase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Cobalamin, Cobalt

Names & Taxonomyi

Protein namesi
Recommended name:
Putative adenosylcobalamin-dependent ribonucleoside-triphosphate reductase (EC:1.17.4.2)
Alternative name(s):
Gp50
Gene namesi
Name:50
OrganismiMycobacterium phage L5 (Mycobacteriophage L5)
Taxonomic identifieri31757 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesSiphoviridaeL5likevirus
Virus hostiMycobacterium [TaxID: 1763]
ProteomesiUP000002123: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 682682Putative adenosylcobalamin-dependent ribonucleoside-triphosphate reductase
PRO_0000221431Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi89 ↔ 381Redox-active By similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliQ05262.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Family and domain databases

InterProiIPR000788. RNR_lg_C.
IPR013345. RTP_Rdtase_AdoCbl-dep.
[Graphical view]
PfamiPF02867. Ribonuc_red_lgC. 2 hits.
[Graphical view]
TIGRFAMsiTIGR02505. RTPR. 1 hit.

Sequencei

Sequence statusi: Complete.

Q05262-1 [UniParc]FASTAAdd to Basket

« Hide

MTDEIPWGPT GELVYNRTYA RTKPDGSKET WPETVERVVD GNLALVDRRH    50
MLEGEREDLV RLMTKFKVLP AGRHLWASGV KNAQHLFNCW VAGWPEKISD 100
HFQFTFMRLM EGGGVGANYS NHYLEGYPEV VNPLRVEIVC DPEHVDYQAM 150
KDVGILSEHY SHDWAGAYAI EDSREGWAAA LVDLIDTHYR PGTVHYQRVY 200
DVSRIRPQGA KLKTFGGVAS GPLPFAVMLQ KVANIFSEYA GITLDGIAAM 250
EVDHAIAQCV VAGGVRRSAR MSMMHWDDYQ IDKFINIKAS TGEHWTTNIS 300
VEVDDEFWRL AKEGYGSFAV AREDMPKQKR AHRVLKALSE GAVRNGEPGM 350
WDSSLSNVGE PNRVVCTNPC GEITLEPWEP CNLGHINLAA FVTPAGKTDY 400
LDLIRAHRLM TRFLIRATFS EVADPKSREV LDRNRRIGVG HLGVASYLAL 450
TGSRYSEAPG DKRFTQFLRE MAAEVDSEAE RFAHDLRIPV PVKKRTIAPT 500
GTVAKMPGVS EGIHPIFSRY FIRRVRFNLN SDMAELRRLA AEGYEIEKDL 550
FAPNTEVVSI PTKDTLVQAV EELGWDEEIV ESADELTLHQ LLAFQALYQM 600
CWADNAVSFT ANVHPDAYEA EDVAADLKRF AGLIKGSTIF PESSFPQAPY 650
ERITKQQYES AAAKAVEDGV DEECANGACP IK 682
Length:682
Mass (Da):76,331
Last modified:February 1, 1994 - v1
Checksum:i8D2A71B873BC04A8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z18946 Genomic DNA. Translation: CAA79426.1.
PIRiS30995.
RefSeqiNP_039714.1. NC_001335.1.

Genome annotation databases

GeneIDi2942963.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z18946 Genomic DNA. Translation: CAA79426.1 .
PIRi S30995.
RefSeqi NP_039714.1. NC_001335.1.

3D structure databases

ProteinModelPortali Q05262.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2942963.

Family and domain databases

InterProi IPR000788. RNR_lg_C.
IPR013345. RTP_Rdtase_AdoCbl-dep.
[Graphical view ]
Pfami PF02867. Ribonuc_red_lgC. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR02505. RTPR. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "DNA sequence, structure and gene expression of mycobacteriophage L5: a phage system for mycobacterial genetics."
    Hatfull G.F., Sarkis G.J.
    Mol. Microbiol. 7:395-405(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiVG50_BPML5
AccessioniPrimary (citable) accession number: Q05262
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 14, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi