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Q05262

- VG50_BPML5

UniProt

Q05262 - VG50_BPML5

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Protein

Putative adenosylcobalamin-dependent ribonucleoside-triphosphate reductase

Gene

50

Organism
Mycobacterium phage L5 (Mycobacteriophage L5)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

Cofactori

Adenosylcobalamin.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei370 – 3701By similarity
Active sitei372 – 3721By similarity

GO - Molecular functioni

  1. cobalamin binding Source: UniProtKB-KW
  2. nucleotide binding Source: InterPro
  3. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: InterPro
  4. ribonucleoside-triphosphate reductase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Cobalamin, Cobalt

Names & Taxonomyi

Protein namesi
Recommended name:
Putative adenosylcobalamin-dependent ribonucleoside-triphosphate reductase (EC:1.17.4.2)
Alternative name(s):
Gp50
Gene namesi
Name:50
OrganismiMycobacterium phage L5 (Mycobacteriophage L5)
Taxonomic identifieri31757 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesSiphoviridaeL5likevirus
Virus hostiMycobacterium [TaxID: 1763]
ProteomesiUP000002123: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 682682Putative adenosylcobalamin-dependent ribonucleoside-triphosphate reductasePRO_0000221431Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi89 ↔ 381Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliQ05262.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Family and domain databases

InterProiIPR000788. RNR_lg_C.
IPR013345. RTP_Rdtase_AdoCbl-dep.
[Graphical view]
PfamiPF02867. Ribonuc_red_lgC. 2 hits.
[Graphical view]
TIGRFAMsiTIGR02505. RTPR. 1 hit.

Sequencei

Sequence statusi: Complete.

Q05262 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDEIPWGPT GELVYNRTYA RTKPDGSKET WPETVERVVD GNLALVDRRH
60 70 80 90 100
MLEGEREDLV RLMTKFKVLP AGRHLWASGV KNAQHLFNCW VAGWPEKISD
110 120 130 140 150
HFQFTFMRLM EGGGVGANYS NHYLEGYPEV VNPLRVEIVC DPEHVDYQAM
160 170 180 190 200
KDVGILSEHY SHDWAGAYAI EDSREGWAAA LVDLIDTHYR PGTVHYQRVY
210 220 230 240 250
DVSRIRPQGA KLKTFGGVAS GPLPFAVMLQ KVANIFSEYA GITLDGIAAM
260 270 280 290 300
EVDHAIAQCV VAGGVRRSAR MSMMHWDDYQ IDKFINIKAS TGEHWTTNIS
310 320 330 340 350
VEVDDEFWRL AKEGYGSFAV AREDMPKQKR AHRVLKALSE GAVRNGEPGM
360 370 380 390 400
WDSSLSNVGE PNRVVCTNPC GEITLEPWEP CNLGHINLAA FVTPAGKTDY
410 420 430 440 450
LDLIRAHRLM TRFLIRATFS EVADPKSREV LDRNRRIGVG HLGVASYLAL
460 470 480 490 500
TGSRYSEAPG DKRFTQFLRE MAAEVDSEAE RFAHDLRIPV PVKKRTIAPT
510 520 530 540 550
GTVAKMPGVS EGIHPIFSRY FIRRVRFNLN SDMAELRRLA AEGYEIEKDL
560 570 580 590 600
FAPNTEVVSI PTKDTLVQAV EELGWDEEIV ESADELTLHQ LLAFQALYQM
610 620 630 640 650
CWADNAVSFT ANVHPDAYEA EDVAADLKRF AGLIKGSTIF PESSFPQAPY
660 670 680
ERITKQQYES AAAKAVEDGV DEECANGACP IK
Length:682
Mass (Da):76,331
Last modified:February 1, 1994 - v1
Checksum:i8D2A71B873BC04A8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z18946 Genomic DNA. Translation: CAA79426.1.
PIRiS30995.
RefSeqiNP_039714.1. NC_001335.1.

Genome annotation databases

GeneIDi2942963.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z18946 Genomic DNA. Translation: CAA79426.1 .
PIRi S30995.
RefSeqi NP_039714.1. NC_001335.1.

3D structure databases

ProteinModelPortali Q05262.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2942963.

Family and domain databases

InterProi IPR000788. RNR_lg_C.
IPR013345. RTP_Rdtase_AdoCbl-dep.
[Graphical view ]
Pfami PF02867. Ribonuc_red_lgC. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR02505. RTPR. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "DNA sequence, structure and gene expression of mycobacteriophage L5: a phage system for mycobacterial genetics."
    Hatfull G.F., Sarkis G.J.
    Mol. Microbiol. 7:395-405(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiVG50_BPML5
AccessioniPrimary (citable) accession number: Q05262
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: October 1, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3