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Q05262

- VG50_BPML5

UniProt

Q05262 - VG50_BPML5

Protein

Putative adenosylcobalamin-dependent ribonucleoside-triphosphate reductase

Gene

50

Organism
Mycobacterium phage L5 (Mycobacteriophage L5)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

    Cofactori

    Adenosylcobalamin.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei370 – 3701By similarity
    Active sitei372 – 3721By similarity

    GO - Molecular functioni

    1. cobalamin binding Source: UniProtKB-KW
    2. nucleotide binding Source: InterPro
    3. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: InterPro
    4. ribonucleoside-triphosphate reductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    Cobalamin, Cobalt

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative adenosylcobalamin-dependent ribonucleoside-triphosphate reductase (EC:1.17.4.2)
    Alternative name(s):
    Gp50
    Gene namesi
    Name:50
    OrganismiMycobacterium phage L5 (Mycobacteriophage L5)
    Taxonomic identifieri31757 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesSiphoviridaeL5likevirus
    Virus hostiMycobacterium [TaxID: 1763]
    ProteomesiUP000002123: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 682682Putative adenosylcobalamin-dependent ribonucleoside-triphosphate reductasePRO_0000221431Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi89 ↔ 381Redox-activeBy similarity

    Keywords - PTMi

    Disulfide bond

    Structurei

    3D structure databases

    ProteinModelPortaliQ05262.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Redox-active center

    Family and domain databases

    InterProiIPR000788. RNR_lg_C.
    IPR013345. RTP_Rdtase_AdoCbl-dep.
    [Graphical view]
    PfamiPF02867. Ribonuc_red_lgC. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR02505. RTPR. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q05262-1 [UniParc]FASTAAdd to Basket

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    MTDEIPWGPT GELVYNRTYA RTKPDGSKET WPETVERVVD GNLALVDRRH    50
    MLEGEREDLV RLMTKFKVLP AGRHLWASGV KNAQHLFNCW VAGWPEKISD 100
    HFQFTFMRLM EGGGVGANYS NHYLEGYPEV VNPLRVEIVC DPEHVDYQAM 150
    KDVGILSEHY SHDWAGAYAI EDSREGWAAA LVDLIDTHYR PGTVHYQRVY 200
    DVSRIRPQGA KLKTFGGVAS GPLPFAVMLQ KVANIFSEYA GITLDGIAAM 250
    EVDHAIAQCV VAGGVRRSAR MSMMHWDDYQ IDKFINIKAS TGEHWTTNIS 300
    VEVDDEFWRL AKEGYGSFAV AREDMPKQKR AHRVLKALSE GAVRNGEPGM 350
    WDSSLSNVGE PNRVVCTNPC GEITLEPWEP CNLGHINLAA FVTPAGKTDY 400
    LDLIRAHRLM TRFLIRATFS EVADPKSREV LDRNRRIGVG HLGVASYLAL 450
    TGSRYSEAPG DKRFTQFLRE MAAEVDSEAE RFAHDLRIPV PVKKRTIAPT 500
    GTVAKMPGVS EGIHPIFSRY FIRRVRFNLN SDMAELRRLA AEGYEIEKDL 550
    FAPNTEVVSI PTKDTLVQAV EELGWDEEIV ESADELTLHQ LLAFQALYQM 600
    CWADNAVSFT ANVHPDAYEA EDVAADLKRF AGLIKGSTIF PESSFPQAPY 650
    ERITKQQYES AAAKAVEDGV DEECANGACP IK 682
    Length:682
    Mass (Da):76,331
    Last modified:February 1, 1994 - v1
    Checksum:i8D2A71B873BC04A8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z18946 Genomic DNA. Translation: CAA79426.1.
    PIRiS30995.
    RefSeqiNP_039714.1. NC_001335.1.

    Genome annotation databases

    GeneIDi2942963.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z18946 Genomic DNA. Translation: CAA79426.1 .
    PIRi S30995.
    RefSeqi NP_039714.1. NC_001335.1.

    3D structure databases

    ProteinModelPortali Q05262.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2942963.

    Family and domain databases

    InterProi IPR000788. RNR_lg_C.
    IPR013345. RTP_Rdtase_AdoCbl-dep.
    [Graphical view ]
    Pfami PF02867. Ribonuc_red_lgC. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR02505. RTPR. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence, structure and gene expression of mycobacteriophage L5: a phage system for mycobacterial genetics."
      Hatfull G.F., Sarkis G.J.
      Mol. Microbiol. 7:395-405(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiVG50_BPML5
    AccessioniPrimary (citable) accession number: Q05262
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3