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Q05262 (VG50_BPML5) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Putative adenosylcobalamin-dependent ribonucleoside-triphosphate reductase

EC=1.17.4.2
Alternative name(s):
Gp50
Gene names
Name:50
OrganismMycobacterium phage L5 (Mycobacteriophage L5) [Reference proteome]
Taxonomic identifier31757 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageCaudoviralesSiphoviridaeL5likevirus
Virus hostMycobacterium [TaxID: 1763]

Protein attributes

Sequence length682 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

Cofactor

Adenosylcobalamin By similarity.

Sequence similarities

Belongs to the class II ribonucleoside-triphosphate reductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 682682Putative adenosylcobalamin-dependent ribonucleoside-triphosphate reductase
PRO_0000221431

Sites

Active site3701 By similarity
Active site3721 By similarity

Amino acid modifications

Disulfide bond89 ↔ 381Redox-active By similarity

Sequences

Sequence LengthMass (Da)Tools
Q05262 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 8D2A71B873BC04A8

FASTA68276,331
        10         20         30         40         50         60 
MTDEIPWGPT GELVYNRTYA RTKPDGSKET WPETVERVVD GNLALVDRRH MLEGEREDLV 

        70         80         90        100        110        120 
RLMTKFKVLP AGRHLWASGV KNAQHLFNCW VAGWPEKISD HFQFTFMRLM EGGGVGANYS 

       130        140        150        160        170        180 
NHYLEGYPEV VNPLRVEIVC DPEHVDYQAM KDVGILSEHY SHDWAGAYAI EDSREGWAAA 

       190        200        210        220        230        240 
LVDLIDTHYR PGTVHYQRVY DVSRIRPQGA KLKTFGGVAS GPLPFAVMLQ KVANIFSEYA 

       250        260        270        280        290        300 
GITLDGIAAM EVDHAIAQCV VAGGVRRSAR MSMMHWDDYQ IDKFINIKAS TGEHWTTNIS 

       310        320        330        340        350        360 
VEVDDEFWRL AKEGYGSFAV AREDMPKQKR AHRVLKALSE GAVRNGEPGM WDSSLSNVGE 

       370        380        390        400        410        420 
PNRVVCTNPC GEITLEPWEP CNLGHINLAA FVTPAGKTDY LDLIRAHRLM TRFLIRATFS 

       430        440        450        460        470        480 
EVADPKSREV LDRNRRIGVG HLGVASYLAL TGSRYSEAPG DKRFTQFLRE MAAEVDSEAE 

       490        500        510        520        530        540 
RFAHDLRIPV PVKKRTIAPT GTVAKMPGVS EGIHPIFSRY FIRRVRFNLN SDMAELRRLA 

       550        560        570        580        590        600 
AEGYEIEKDL FAPNTEVVSI PTKDTLVQAV EELGWDEEIV ESADELTLHQ LLAFQALYQM 

       610        620        630        640        650        660 
CWADNAVSFT ANVHPDAYEA EDVAADLKRF AGLIKGSTIF PESSFPQAPY ERITKQQYES 

       670        680 
AAAKAVEDGV DEECANGACP IK 

« Hide

References

[1]"DNA sequence, structure and gene expression of mycobacteriophage L5: a phage system for mycobacterial genetics."
Hatfull G.F., Sarkis G.J.
Mol. Microbiol. 7:395-405(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z18946 Genomic DNA. Translation: CAA79426.1.
PIRS30995.
RefSeqNP_039714.1. NC_001335.1.

3D structure databases

ProteinModelPortalQ05262.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2942963.

Family and domain databases

InterProIPR000788. RNR_lg_C.
IPR013345. RTP_Rdtase_AdoCbl-dep.
[Graphical view]
PfamPF02867. Ribonuc_red_lgC. 2 hits.
[Graphical view]
TIGRFAMsTIGR02505. RTPR. 1 hit.
ProtoNetSearch...

Entry information

Entry nameVG50_BPML5
AccessionPrimary (citable) accession number: Q05262
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 14, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families