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Q05215

- EGR4_HUMAN

UniProt

Q05215 - EGR4_HUMAN

Protein

Early growth response protein 4

Gene

EGR4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 3 (01 May 2013)
      Previous versions | rss
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    Functioni

    Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri483 – 50725C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri513 – 53523C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri541 – 56323C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: ProtInc

    GO - Biological processi

    1. cellular response to cAMP Source: RefGenome
    2. cellular response to gonadotropin stimulus Source: RefGenome
    3. negative regulation of apoptotic process Source: RefGenome
    4. positive regulation of cell proliferation Source: ProtInc
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Early growth response protein 4
    Short name:
    EGR-4
    Alternative name(s):
    AT133
    Gene namesi
    Name:EGR4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:3241. EGR4.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. nucleus Source: RefGenome

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27676.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 589589Early growth response protein 4PRO_0000047128Add
    BLAST

    Proteomic databases

    PaxDbiQ05215.
    PRIDEiQ05215.

    Expressioni

    Inductioni

    By PHA/PMA or by serum.

    Gene expression databases

    ArrayExpressiQ05215.
    BgeeiQ05215.
    CleanExiHS_EGR4.
    GenevestigatoriQ05215.

    Organism-specific databases

    HPAiHPA028983.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000419687.

    Structurei

    3D structure databases

    ProteinModelPortaliQ05215.
    SMRiQ05215. Positions 455-564.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi175 – 455281Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri483 – 50725C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri513 – 53523C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri541 – 56323C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000112347.
    HOVERGENiHBG005574.
    InParanoidiQ05215.
    KOiK12498.
    OMAiCFLEGPA.
    OrthoDBiEOG7Z69C7.
    PhylomeDBiQ05215.
    TreeFamiTF318980.

    Family and domain databases

    Gene3Di3.30.160.60. 3 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 3 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q05215-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVARGVGSP EPAPPQLYKW GGCGLGEPGS ALERRGAAAR GRCGRARAPR    50
    LPDSFPRGEC PKPGARAPRS VRCGEPLPPA SPPPARPQAQ RARPRAPHSR 100
    RRAMLHLSEF SEPDALLVKS TEGCCAEPSA ELPRLPARDA PAATGYPGAG 150
    DFLSWALNSC GASGDLADSC FLEGPAPTPP PGLSYSGSFF IQAVPEHPHD 200
    PEALFNLMSG ILGLAPFPGP EAAASRSPLD APFPAGSDAL LPGPPDLYSP 250
    DLGAAPFPEA FWEASPCAGA PSQCLYEPQL SPPDVKPGLR APPASPALDA 300
    VSAFKGPYAP WELLSVGAPG NCGSQGDYQA APEARFPVIG TKIEDLLSIS 350
    CPAELPAVPA NRLYPSGAYD AFPLAPGDLG EGAEGLPGLL TPPSGEGGSS 400
    GDGGEFLAST QPQLSPLGLR SAAAADFPKP LVADIPGSSG VAAPPVPPPP 450
    PTPFPQAKAR RKGRRGGKCS TRCFCPRPHA KAFACPVESC VRSFARSDEL 500
    NRHLRIHTGH KPFQCRICLR NFSRSDHLTT HVRTHTGEKP FACDVCGRRF 550
    ARSDEKKRHS KVHLKQKARA EERLKGLGFY SLGLSFASL 589
    Length:589
    Mass (Da):61,623
    Last modified:May 1, 2013 - v3
    Checksum:iEFB5A743541A07D7
    GO

    Sequence cautioni

    The sequence CAA42698.1 differs from that shown. Reason: Frameshift at position 66.
    The sequence CAA49214.1 differs from that shown. Reason: Frameshift at position 66.
    The sequence AAX88903.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAG36840.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti211 – 2111I → V in CAA42698. (PubMed:1658795)Curated
    Sequence conflicti211 – 2111I → V in CAA49214. (PubMed:8504297)Curated
    Sequence conflicti291 – 2911A → R in CAA42698. (PubMed:1658795)Curated
    Sequence conflicti291 – 2911A → R in CAA49214. (PubMed:8504297)Curated
    Sequence conflicti446 – 4461V → M in BAG36840. (PubMed:14702039)Curated
    Sequence conflicti530 – 5301T → S in CAA49214. (PubMed:8504297)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69438 Genomic DNA. Translation: CAA49214.1. Frameshift.
    AK314154 mRNA. Translation: BAG36840.1. Different initiation.
    AC010913 Genomic DNA. Translation: AAX88903.1. Different initiation.
    CH471053 Genomic DNA. Translation: EAW99734.1.
    X60104 mRNA. Translation: CAA42698.1. Frameshift.
    CCDSiCCDS1925.2.
    PIRiA41537.
    RefSeqiNP_001956.3. NM_001965.3.
    UniGeneiHs.3052.

    Genome annotation databases

    EnsembliENST00000436467; ENSP00000419687; ENSG00000135625.
    ENST00000545030; ENSP00000445626; ENSG00000135625.
    GeneIDi1961.
    KEGGihsa:1961.
    UCSCiuc010yrj.2. human.

    Polymorphism databases

    DMDMi485956294.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69438 Genomic DNA. Translation: CAA49214.1 . Frameshift.
    AK314154 mRNA. Translation: BAG36840.1 . Different initiation.
    AC010913 Genomic DNA. Translation: AAX88903.1 . Different initiation.
    CH471053 Genomic DNA. Translation: EAW99734.1 .
    X60104 mRNA. Translation: CAA42698.1 . Frameshift.
    CCDSi CCDS1925.2.
    PIRi A41537.
    RefSeqi NP_001956.3. NM_001965.3.
    UniGenei Hs.3052.

    3D structure databases

    ProteinModelPortali Q05215.
    SMRi Q05215. Positions 455-564.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000419687.

    Polymorphism databases

    DMDMi 485956294.

    Proteomic databases

    PaxDbi Q05215.
    PRIDEi Q05215.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000436467 ; ENSP00000419687 ; ENSG00000135625 .
    ENST00000545030 ; ENSP00000445626 ; ENSG00000135625 .
    GeneIDi 1961.
    KEGGi hsa:1961.
    UCSCi uc010yrj.2. human.

    Organism-specific databases

    CTDi 1961.
    GeneCardsi GC02M073518.
    HGNCi HGNC:3241. EGR4.
    HPAi HPA028983.
    MIMi 128992. gene.
    neXtProti NX_Q05215.
    PharmGKBi PA27676.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000112347.
    HOVERGENi HBG005574.
    InParanoidi Q05215.
    KOi K12498.
    OMAi CFLEGPA.
    OrthoDBi EOG7Z69C7.
    PhylomeDBi Q05215.
    TreeFami TF318980.

    Miscellaneous databases

    GeneWikii EGR4.
    GenomeRNAii 1961.
    NextBioi 7957.
    PROi Q05215.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q05215.
    Bgeei Q05215.
    CleanExi HS_EGR4.
    Genevestigatori Q05215.

    Family and domain databases

    Gene3Di 3.30.160.60. 3 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 3 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic organization, chromosomal localization and promoter function of the human zinc-finger gene pAT133."
      Holst C., Skerka C., Lichter P., Bialonski A., Zipfel P.F.
      Hum. Mol. Genet. 2:367-372(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Clone pAT133 identifies a gene that encodes another human member of a class of growth factor-induced genes with almost identical zinc-finger domains."
      Mueller H.-J., Skerka C., Bialonski A., Zipfel P.F.
      Proc. Natl. Acad. Sci. U.S.A. 88:10079-10083(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 49-589.

    Entry informationi

    Entry nameiEGR4_HUMAN
    AccessioniPrimary (citable) accession number: Q05215
    Secondary accession number(s): B2RAE3, G3V1T5, Q2Z1P5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: May 1, 2013
    Last modified: October 1, 2014
    This is version 128 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-104 is the initiator. Some orthologous sequences can not be extended.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3