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Protein

Early growth response protein 4

Gene

EGR4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri483 – 50725C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri513 – 53523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri541 – 56323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: ProtInc

GO - Biological processi

  1. cellular response to cAMP Source: GO_Central
  2. cellular response to gonadotropin stimulus Source: GO_Central
  3. negative regulation of apoptotic process Source: GO_Central
  4. positive regulation of cell proliferation Source: ProtInc
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Early growth response protein 4
Short name:
EGR-4
Alternative name(s):
AT133
Gene namesi
Name:EGR4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:3241. EGR4.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. cytoplasm Source: GO_Central
  2. nucleus Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27676.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 589589Early growth response protein 4PRO_0000047128Add
BLAST

Proteomic databases

PaxDbiQ05215.
PRIDEiQ05215.

Expressioni

Inductioni

By PHA/PMA or by serum.

Gene expression databases

BgeeiQ05215.
CleanExiHS_EGR4.
ExpressionAtlasiQ05215. baseline and differential.
GenevestigatoriQ05215.

Organism-specific databases

HPAiHPA028983.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000419687.

Structurei

3D structure databases

ProteinModelPortaliQ05215.
SMRiQ05215. Positions 481-564.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi175 – 455281Pro-richAdd
BLAST

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri483 – 50725C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri513 – 53523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri541 – 56323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00550000074455.
HOGENOMiHOG000112347.
HOVERGENiHBG005574.
InParanoidiQ05215.
KOiK12498.
OMAiKCSARCF.
OrthoDBiEOG7Z69C7.
PhylomeDBiQ05215.
TreeFamiTF318980.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05215-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVARGVGSP EPAPPQLYKW GGCGLGEPGS ALERRGAAAR GRCGRARAPR
60 70 80 90 100
LPDSFPRGEC PKPGARAPRS VRCGEPLPPA SPPPARPQAQ RARPRAPHSR
110 120 130 140 150
RRAMLHLSEF SEPDALLVKS TEGCCAEPSA ELPRLPARDA PAATGYPGAG
160 170 180 190 200
DFLSWALNSC GASGDLADSC FLEGPAPTPP PGLSYSGSFF IQAVPEHPHD
210 220 230 240 250
PEALFNLMSG ILGLAPFPGP EAAASRSPLD APFPAGSDAL LPGPPDLYSP
260 270 280 290 300
DLGAAPFPEA FWEASPCAGA PSQCLYEPQL SPPDVKPGLR APPASPALDA
310 320 330 340 350
VSAFKGPYAP WELLSVGAPG NCGSQGDYQA APEARFPVIG TKIEDLLSIS
360 370 380 390 400
CPAELPAVPA NRLYPSGAYD AFPLAPGDLG EGAEGLPGLL TPPSGEGGSS
410 420 430 440 450
GDGGEFLAST QPQLSPLGLR SAAAADFPKP LVADIPGSSG VAAPPVPPPP
460 470 480 490 500
PTPFPQAKAR RKGRRGGKCS TRCFCPRPHA KAFACPVESC VRSFARSDEL
510 520 530 540 550
NRHLRIHTGH KPFQCRICLR NFSRSDHLTT HVRTHTGEKP FACDVCGRRF
560 570 580
ARSDEKKRHS KVHLKQKARA EERLKGLGFY SLGLSFASL
Length:589
Mass (Da):61,623
Last modified:April 30, 2013 - v3
Checksum:iEFB5A743541A07D7
GO

Sequence cautioni

The sequence AAX88903.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG36840.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA42698.1 differs from that shown. Reason: Frameshift at position 66. Curated
The sequence CAA49214.1 differs from that shown. Reason: Frameshift at position 66. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti211 – 2111I → V in CAA42698 (PubMed:1658795).Curated
Sequence conflicti211 – 2111I → V in CAA49214 (PubMed:8504297).Curated
Sequence conflicti291 – 2911A → R in CAA42698 (PubMed:1658795).Curated
Sequence conflicti291 – 2911A → R in CAA49214 (PubMed:8504297).Curated
Sequence conflicti446 – 4461V → M in BAG36840 (PubMed:14702039).Curated
Sequence conflicti530 – 5301T → S in CAA49214 (PubMed:8504297).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69438 Genomic DNA. Translation: CAA49214.1. Frameshift.
AK314154 mRNA. Translation: BAG36840.1. Different initiation.
AC010913 Genomic DNA. Translation: AAX88903.1. Different initiation.
CH471053 Genomic DNA. Translation: EAW99734.1.
X60104 mRNA. Translation: CAA42698.1. Frameshift.
CCDSiCCDS1925.2.
PIRiA41537.
RefSeqiNP_001956.3. NM_001965.3.
UniGeneiHs.3052.

Genome annotation databases

EnsembliENST00000545030; ENSP00000445626; ENSG00000135625.
GeneIDi1961.
KEGGihsa:1961.
UCSCiuc010yrj.2. human.

Polymorphism databases

DMDMi485956294.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69438 Genomic DNA. Translation: CAA49214.1. Frameshift.
AK314154 mRNA. Translation: BAG36840.1. Different initiation.
AC010913 Genomic DNA. Translation: AAX88903.1. Different initiation.
CH471053 Genomic DNA. Translation: EAW99734.1.
X60104 mRNA. Translation: CAA42698.1. Frameshift.
CCDSiCCDS1925.2.
PIRiA41537.
RefSeqiNP_001956.3. NM_001965.3.
UniGeneiHs.3052.

3D structure databases

ProteinModelPortaliQ05215.
SMRiQ05215. Positions 481-564.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000419687.

Polymorphism databases

DMDMi485956294.

Proteomic databases

PaxDbiQ05215.
PRIDEiQ05215.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000545030; ENSP00000445626; ENSG00000135625.
GeneIDi1961.
KEGGihsa:1961.
UCSCiuc010yrj.2. human.

Organism-specific databases

CTDi1961.
GeneCardsiGC02M073518.
HGNCiHGNC:3241. EGR4.
HPAiHPA028983.
MIMi128992. gene.
neXtProtiNX_Q05215.
PharmGKBiPA27676.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00550000074455.
HOGENOMiHOG000112347.
HOVERGENiHBG005574.
InParanoidiQ05215.
KOiK12498.
OMAiKCSARCF.
OrthoDBiEOG7Z69C7.
PhylomeDBiQ05215.
TreeFamiTF318980.

Miscellaneous databases

GeneWikiiEGR4.
GenomeRNAii1961.
NextBioi7957.
PROiQ05215.
SOURCEiSearch...

Gene expression databases

BgeeiQ05215.
CleanExiHS_EGR4.
ExpressionAtlasiQ05215. baseline and differential.
GenevestigatoriQ05215.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic organization, chromosomal localization and promoter function of the human zinc-finger gene pAT133."
    Holst C., Skerka C., Lichter P., Bialonski A., Zipfel P.F.
    Hum. Mol. Genet. 2:367-372(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Clone pAT133 identifies a gene that encodes another human member of a class of growth factor-induced genes with almost identical zinc-finger domains."
    Mueller H.-J., Skerka C., Bialonski A., Zipfel P.F.
    Proc. Natl. Acad. Sci. U.S.A. 88:10079-10083(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 49-589.

Entry informationi

Entry nameiEGR4_HUMAN
AccessioniPrimary (citable) accession number: Q05215
Secondary accession number(s): B2RAE3, G3V1T5, Q2Z1P5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 31, 1994
Last sequence update: April 30, 2013
Last modified: March 3, 2015
This is version 132 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-104 is the initiator. Some orthologous sequences can not be extended.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.