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Q05215

- EGR4_HUMAN

UniProt

Q05215 - EGR4_HUMAN

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Protein
Early growth response protein 4
Gene
EGR4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri483 – 50725C2H2-type 1
Add
BLAST
Zinc fingeri513 – 53523C2H2-type 2
Add
BLAST
Zinc fingeri541 – 56323C2H2-type 3
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: ProtInc

GO - Biological processi

  1. cellular response to cAMP Source: RefGenome
  2. cellular response to gonadotropin stimulus Source: RefGenome
  3. negative regulation of apoptotic process Source: RefGenome
  4. positive regulation of cell proliferation Source: ProtInc
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Early growth response protein 4
Short name:
EGR-4
Alternative name(s):
AT133
Gene namesi
Name:EGR4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:3241. EGR4.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. nucleus Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27676.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 589589Early growth response protein 4
PRO_0000047128Add
BLAST

Proteomic databases

PaxDbiQ05215.
PRIDEiQ05215.

Expressioni

Inductioni

By PHA/PMA or by serum.

Gene expression databases

ArrayExpressiQ05215.
BgeeiQ05215.
CleanExiHS_EGR4.
GenevestigatoriQ05215.

Organism-specific databases

HPAiHPA028983.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000419687.

Structurei

3D structure databases

ProteinModelPortaliQ05215.
SMRiQ05215. Positions 455-564.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi175 – 455281Pro-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000112347.
HOVERGENiHBG005574.
InParanoidiQ05215.
KOiK12498.
OMAiCFLEGPA.
OrthoDBiEOG7Z69C7.
PhylomeDBiQ05215.
TreeFamiTF318980.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05215-1 [UniParc]FASTAAdd to Basket

« Hide

MAVARGVGSP EPAPPQLYKW GGCGLGEPGS ALERRGAAAR GRCGRARAPR    50
LPDSFPRGEC PKPGARAPRS VRCGEPLPPA SPPPARPQAQ RARPRAPHSR 100
RRAMLHLSEF SEPDALLVKS TEGCCAEPSA ELPRLPARDA PAATGYPGAG 150
DFLSWALNSC GASGDLADSC FLEGPAPTPP PGLSYSGSFF IQAVPEHPHD 200
PEALFNLMSG ILGLAPFPGP EAAASRSPLD APFPAGSDAL LPGPPDLYSP 250
DLGAAPFPEA FWEASPCAGA PSQCLYEPQL SPPDVKPGLR APPASPALDA 300
VSAFKGPYAP WELLSVGAPG NCGSQGDYQA APEARFPVIG TKIEDLLSIS 350
CPAELPAVPA NRLYPSGAYD AFPLAPGDLG EGAEGLPGLL TPPSGEGGSS 400
GDGGEFLAST QPQLSPLGLR SAAAADFPKP LVADIPGSSG VAAPPVPPPP 450
PTPFPQAKAR RKGRRGGKCS TRCFCPRPHA KAFACPVESC VRSFARSDEL 500
NRHLRIHTGH KPFQCRICLR NFSRSDHLTT HVRTHTGEKP FACDVCGRRF 550
ARSDEKKRHS KVHLKQKARA EERLKGLGFY SLGLSFASL 589
Length:589
Mass (Da):61,623
Last modified:May 1, 2013 - v3
Checksum:iEFB5A743541A07D7
GO

Sequence cautioni

The sequence CAA42698.1 differs from that shown. Reason: Frameshift at position 66.
The sequence CAA49214.1 differs from that shown. Reason: Frameshift at position 66.
The sequence AAX88903.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAG36840.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti211 – 2111I → V in CAA42698. 1 Publication
Sequence conflicti211 – 2111I → V in CAA49214. 1 Publication
Sequence conflicti291 – 2911A → R in CAA42698. 1 Publication
Sequence conflicti291 – 2911A → R in CAA49214. 1 Publication
Sequence conflicti446 – 4461V → M in BAG36840. 1 Publication
Sequence conflicti530 – 5301T → S in CAA49214. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X69438 Genomic DNA. Translation: CAA49214.1. Frameshift.
AK314154 mRNA. Translation: BAG36840.1. Different initiation.
AC010913 Genomic DNA. Translation: AAX88903.1. Different initiation.
CH471053 Genomic DNA. Translation: EAW99734.1.
X60104 mRNA. Translation: CAA42698.1. Frameshift.
CCDSiCCDS1925.2.
PIRiA41537.
RefSeqiNP_001956.3. NM_001965.3.
UniGeneiHs.3052.

Genome annotation databases

EnsembliENST00000436467; ENSP00000419687; ENSG00000135625.
ENST00000545030; ENSP00000445626; ENSG00000135625.
GeneIDi1961.
KEGGihsa:1961.
UCSCiuc010yrj.2. human.

Polymorphism databases

DMDMi485956294.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X69438 Genomic DNA. Translation: CAA49214.1 . Frameshift.
AK314154 mRNA. Translation: BAG36840.1 . Different initiation.
AC010913 Genomic DNA. Translation: AAX88903.1 . Different initiation.
CH471053 Genomic DNA. Translation: EAW99734.1 .
X60104 mRNA. Translation: CAA42698.1 . Frameshift.
CCDSi CCDS1925.2.
PIRi A41537.
RefSeqi NP_001956.3. NM_001965.3.
UniGenei Hs.3052.

3D structure databases

ProteinModelPortali Q05215.
SMRi Q05215. Positions 455-564.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000419687.

Polymorphism databases

DMDMi 485956294.

Proteomic databases

PaxDbi Q05215.
PRIDEi Q05215.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000436467 ; ENSP00000419687 ; ENSG00000135625 .
ENST00000545030 ; ENSP00000445626 ; ENSG00000135625 .
GeneIDi 1961.
KEGGi hsa:1961.
UCSCi uc010yrj.2. human.

Organism-specific databases

CTDi 1961.
GeneCardsi GC02M073518.
HGNCi HGNC:3241. EGR4.
HPAi HPA028983.
MIMi 128992. gene.
neXtProti NX_Q05215.
PharmGKBi PA27676.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000112347.
HOVERGENi HBG005574.
InParanoidi Q05215.
KOi K12498.
OMAi CFLEGPA.
OrthoDBi EOG7Z69C7.
PhylomeDBi Q05215.
TreeFami TF318980.

Miscellaneous databases

GeneWikii EGR4.
GenomeRNAii 1961.
NextBioi 7957.
PROi Q05215.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q05215.
Bgeei Q05215.
CleanExi HS_EGR4.
Genevestigatori Q05215.

Family and domain databases

Gene3Di 3.30.160.60. 3 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 3 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic organization, chromosomal localization and promoter function of the human zinc-finger gene pAT133."
    Holst C., Skerka C., Lichter P., Bialonski A., Zipfel P.F.
    Hum. Mol. Genet. 2:367-372(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Clone pAT133 identifies a gene that encodes another human member of a class of growth factor-induced genes with almost identical zinc-finger domains."
    Mueller H.-J., Skerka C., Bialonski A., Zipfel P.F.
    Proc. Natl. Acad. Sci. U.S.A. 88:10079-10083(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 49-589.

Entry informationi

Entry nameiEGR4_HUMAN
AccessioniPrimary (citable) accession number: Q05215
Secondary accession number(s): B2RAE3, G3V1T5, Q2Z1P5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: May 1, 2013
Last modified: July 9, 2014
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-104 is the initiator. Some orthologous sequences can not be extended.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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