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Protein

Lysosome-associated membrane glycoprotein 1

Gene

LAMP1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-BTA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosome-associated membrane glycoprotein 1
Short name:
LAMP-1
Short name:
Lysosome-associated membrane protein 1
Alternative name(s):
CD107 antigen-like family member A
Chromaffin granule-associated membrane glycoprotein IIA
CD_antigen: CD107a
Gene namesi
Name:LAMP1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 12

Subcellular locationi

  • Cell membrane By similarity; Single-pass type I membrane protein By similarity
  • Endosome membrane By similarity; Single-pass type I membrane protein By similarity
  • Lysosome membrane By similarity; Single-pass type I membrane protein By similarity
  • Late endosome By similarity

  • Note: This protein shuttles between lysosomes, endosomes, and the plasma membrane. Colocalizes with OSBPL1A at the late endosome.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 374LumenalSequence analysisAdd BLAST349
Transmembranei375 – 398HelicalPROSITE-ProRule annotationAdd BLAST24
Topological domaini399 – 409CytoplasmicPROSITE-ProRule annotationAdd BLAST11

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25By similarityAdd BLAST25
ChainiPRO_000001710726 – 409Lysosome-associated membrane glycoprotein 1Add BLAST384

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi34N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi38 ↔ 76PROSITE-ProRule annotation
Glycosylationi59N-linked (GlcNAc...)Sequence analysis1
Glycosylationi72N-linked (GlcNAc...)Sequence analysis1
Glycosylationi80N-linked (GlcNAc...)Sequence analysis1
Glycosylationi103N-linked (GlcNAc...)Sequence analysis1
Glycosylationi117N-linked (GlcNAc...)Sequence analysis1
Glycosylationi126N-linked (GlcNAc...)Sequence analysis1
Glycosylationi146N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi151 ↔ 187PROSITE-ProRule annotation
Glycosylationi161N-linked (GlcNAc...)Sequence analysis1
Glycosylationi179N-linked (GlcNAc...)Sequence analysis1
Glycosylationi215N-linked (GlcNAc...)Sequence analysis1
Glycosylationi220N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi223 ↔ 261PROSITE-ProRule annotation
Glycosylationi241N-linked (GlcNAc...)Sequence analysis1
Glycosylationi253N-linked (GlcNAc...)Sequence analysis1
Glycosylationi260N-linked (GlcNAc...)Sequence analysis1
Glycosylationi285N-linked (GlcNAc...)Sequence analysis1
Glycosylationi299N-linked (GlcNAc...)Sequence analysis1
Glycosylationi314N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi330 ↔ 367PROSITE-ProRule annotation

Post-translational modificationi

O- and N-glycosylated; some of the N-linked glycans are polylactosaminoglycans.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ05204.
PeptideAtlasiQ05204.
PRIDEiQ05204.

Expressioni

Gene expression databases

BgeeiENSBTAG00000010242.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000042536.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni26 – 187First lumenal domainAdd BLAST162
Regioni188 – 219HingeAdd BLAST32
Regioni220 – 374Second lumenal domainAdd BLAST155

Sequence similaritiesi

Belongs to the LAMP family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4818. Eukaryota.
ENOG410XQ96. LUCA.
GeneTreeiENSGT00530000063068.
HOGENOMiHOG000230942.
HOVERGENiHBG052303.
InParanoidiQ05204.
KOiK06528.
OMAiETRCEQD.
OrthoDBiEOG091G09EV.
TreeFamiTF316339.

Family and domain databases

InterProiIPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSiPR00336. LYSASSOCTDMP.
PROSITEiPS00310. LAMP_1. 2 hits.
PS00311. LAMP_2. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05204-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPGGARRR PLLLLLFAGL VHGASAVFVV KNGNGTACIM ADFSATFLTS
60 70 80 90 100
YDTRSGPQNK SFELPAGAEV SNSSSCGKEN ASDSSLVITF GRGHTLTLIF
110 120 130 140 150
TRNATRYEVQ LMRFAYNLSD TDTFPNSSST GVKTVESATD IKADINKTYR
160 170 180 190 200
CVSETQVNMD NVTVTLRDAA IQAYLSSSNF SREETRCEQD LPTPTTPPQP
210 220 230 240 250
APTPAPASPA VFRYNVSGSN GTCLLASMGL QLNVTYRRVD NKTVTREFNV
260 270 280 290 300
NPNKTTFGGN CSATLATLEL HSENLLLLAL QFVMNESSSR VFLQGVQLNL
310 320 330 340 350
TLPDAKEGSF TATNSSLRAL QATAGNSYKC NAEQRLRVTS SFSLNMFRVW
360 370 380 390 400
LQAFRVDGDK FGPVEECQLD ENSMLIPIAV GGALAGLVLI VLLAYLIGRK

RSHAGYQTI
Length:409
Mass (Da):44,153
Last modified:October 17, 2006 - v2
Checksum:i36E955E7F1AB74F5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2 – 7AAPGGA → RPPAAP in AAA30548 (PubMed:8496169).Curated6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118436 mRNA. Translation: AAI18437.1.
BC133619 mRNA. Translation: AAI33620.1.
BC140610 mRNA. Translation: AAI40611.1.
L09113 mRNA. Translation: AAA30548.1.
PIRiA46712.
RefSeqiNP_001068592.1. NM_001075124.2.
UniGeneiBt.5330.

Genome annotation databases

EnsembliENSBTAT00000045121; ENSBTAP00000042536; ENSBTAG00000010242.
GeneIDi281897.
KEGGibta:281897.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118436 mRNA. Translation: AAI18437.1.
BC133619 mRNA. Translation: AAI33620.1.
BC140610 mRNA. Translation: AAI40611.1.
L09113 mRNA. Translation: AAA30548.1.
PIRiA46712.
RefSeqiNP_001068592.1. NM_001075124.2.
UniGeneiBt.5330.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000042536.

Proteomic databases

PaxDbiQ05204.
PeptideAtlasiQ05204.
PRIDEiQ05204.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000045121; ENSBTAP00000042536; ENSBTAG00000010242.
GeneIDi281897.
KEGGibta:281897.

Organism-specific databases

CTDi3916.

Phylogenomic databases

eggNOGiKOG4818. Eukaryota.
ENOG410XQ96. LUCA.
GeneTreeiENSGT00530000063068.
HOGENOMiHOG000230942.
HOVERGENiHBG052303.
InParanoidiQ05204.
KOiK06528.
OMAiETRCEQD.
OrthoDBiEOG091G09EV.
TreeFamiTF316339.

Enzyme and pathway databases

ReactomeiR-BTA-6798695. Neutrophil degranulation.

Gene expression databases

BgeeiENSBTAG00000010242.

Family and domain databases

InterProiIPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSiPR00336. LYSASSOCTDMP.
PROSITEiPS00310. LAMP_1. 2 hits.
PS00311. LAMP_2. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLAMP1_BOVIN
AccessioniPrimary (citable) accession number: Q05204
Secondary accession number(s): A2VE82, A5D7M2, Q17QC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 17, 2006
Last modified: November 30, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.