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Q05204 (LAMP1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysosome-associated membrane glycoprotein 1

Short name=LAMP-1
Short name=Lysosome-associated membrane protein 1
Alternative name(s):
CD107 antigen-like family member A
Chromaffin granule-associated membrane glycoprotein IIA
CD_antigen=CD107a
Gene names
Name:LAMP1
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length409 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Cell membrane; Single-pass type I membrane protein By similarity. Endosome membrane; Single-pass type I membrane protein By similarity. Lysosome membrane; Single-pass type I membrane protein By similarity. Late endosome By similarity. Note: This protein shuttles between lysosomes, endosomes, and the plasma membrane. Colocalizes with OSBPL1A at the late endosome By similarity.

Post-translational modification

O- and N-glycosylated; some of the N-linked glycans are polylactosaminoglycans By similarity.

Sequence similarities

Belongs to the LAMP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525
Chain26 – 409384Lysosome-associated membrane glycoprotein 1
PRO_0000017107

Regions

Topological domain26 – 374349Lumenal Potential
Transmembrane375 – 39824Helical; Potential
Topological domain399 – 40911Cytoplasmic Potential
Region26 – 187162First lumenal domain
Region188 – 21932Hinge
Region220 – 374155Second lumenal domain

Amino acid modifications

Glycosylation341N-linked (GlcNAc...) Potential
Glycosylation591N-linked (GlcNAc...) Potential
Glycosylation721N-linked (GlcNAc...) Potential
Glycosylation801N-linked (GlcNAc...) Potential
Glycosylation1031N-linked (GlcNAc...) Potential
Glycosylation1171N-linked (GlcNAc...) Potential
Glycosylation1261N-linked (GlcNAc...) Potential
Glycosylation1461N-linked (GlcNAc...) Potential
Glycosylation1611N-linked (GlcNAc...) Potential
Glycosylation1791N-linked (GlcNAc...) Potential
Glycosylation2151N-linked (GlcNAc...) Potential
Glycosylation2201N-linked (GlcNAc...) Potential
Glycosylation2411N-linked (GlcNAc...) Potential
Glycosylation2531N-linked (GlcNAc...) Potential
Glycosylation2601N-linked (GlcNAc...) Potential
Glycosylation2851N-linked (GlcNAc...) Potential
Glycosylation2991N-linked (GlcNAc...) Potential
Glycosylation3141N-linked (GlcNAc...) Potential
Disulfide bond38 ↔ 76 By similarity
Disulfide bond151 ↔ 187 By similarity
Disulfide bond223 ↔ 261 By similarity
Disulfide bond330 ↔ 367 By similarity

Experimental info

Sequence conflict2 – 76AAPGGA → RPPAAP in AAA30548. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q05204 [UniParc].

Last modified October 17, 2006. Version 2.
Checksum: 36E955E7F1AB74F5

FASTA40944,153
        10         20         30         40         50         60 
MAAPGGARRR PLLLLLFAGL VHGASAVFVV KNGNGTACIM ADFSATFLTS YDTRSGPQNK 

        70         80         90        100        110        120 
SFELPAGAEV SNSSSCGKEN ASDSSLVITF GRGHTLTLIF TRNATRYEVQ LMRFAYNLSD 

       130        140        150        160        170        180 
TDTFPNSSST GVKTVESATD IKADINKTYR CVSETQVNMD NVTVTLRDAA IQAYLSSSNF 

       190        200        210        220        230        240 
SREETRCEQD LPTPTTPPQP APTPAPASPA VFRYNVSGSN GTCLLASMGL QLNVTYRRVD 

       250        260        270        280        290        300 
NKTVTREFNV NPNKTTFGGN CSATLATLEL HSENLLLLAL QFVMNESSSR VFLQGVQLNL 

       310        320        330        340        350        360 
TLPDAKEGSF TATNSSLRAL QATAGNSYKC NAEQRLRVTS SFSLNMFRVW LQAFRVDGDK 

       370        380        390        400 
FGPVEECQLD ENSMLIPIAV GGALAGLVLI VLLAYLIGRK RSHAGYQTI 

« Hide

References

« Hide 'large scale' references
[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus and Hereford.
Tissue: Fetal brain, Fetal liver and Ileum.
[2]"Characterization of glycoprotein II from bovine adrenal medullary chromaffin granules. Identification of components representing the secretory vesicle counterparts of the lysosomal-associated membrane glycoproteins (lamp-1 and lamp-2)."
Hieber A.D., Christie D.L.
J. Biol. Chem. 268:11073-11078(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-409, PARTIAL PROTEIN SEQUENCE.
Tissue: Adrenal medulla.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC118436 mRNA. Translation: AAI18437.1.
BC133619 mRNA. Translation: AAI33620.1.
BC140610 mRNA. Translation: AAI40611.1.
L09113 mRNA. Translation: AAA30548.1.
PIRA46712.
RefSeqNP_001068592.1. NM_001075124.2.
UniGeneBt.5330.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000042536.

Proteomic databases

PaxDbQ05204.
PRIDEQ05204.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000045121; ENSBTAP00000042536; ENSBTAG00000010242.
GeneID281897.
KEGGbta:281897.

Organism-specific databases

CTD3916.

Phylogenomic databases

eggNOGNOG301998.
GeneTreeENSGT00530000063068.
HOGENOMHOG000230942.
HOVERGENHBG052303.
InParanoidQ05204.
KOK06528.
OMAGTACIMA.
OrthoDBEOG7ZD1VH.
TreeFamTF316339.

Family and domain databases

InterProIPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERPTHR11506. PTHR11506. 1 hit.
PfamPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSPR00336. LYSASSOCTDMP.
PROSITEPS00310. LAMP_1. 2 hits.
PS00311. LAMP_2. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20805793.

Entry information

Entry nameLAMP1_BOVIN
AccessionPrimary (citable) accession number: Q05204
Secondary accession number(s): A2VE82, A5D7M2, Q17QC6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 17, 2006
Last modified: April 16, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families