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Q05204

- LAMP1_BOVIN

UniProt

Q05204 - LAMP1_BOVIN

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Protein

Lysosome-associated membrane glycoprotein 1

Gene
LAMP1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. protein stabilization Source: UniProt
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosome-associated membrane glycoprotein 1
Short name:
LAMP-1
Short name:
Lysosome-associated membrane protein 1
Alternative name(s):
CD107 antigen-like family member A
Chromaffin granule-associated membrane glycoprotein IIA
CD_antigen: CD107a
Gene namesi
Name:LAMP1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 12

Subcellular locationi

Cell membrane; Single-pass type I membrane protein By similarity. Endosome membrane; Single-pass type I membrane protein By similarity. Lysosome membrane; Single-pass type I membrane protein By similarity. Late endosome By similarity
Note: This protein shuttles between lysosomes, endosomes, and the plasma membrane. Colocalizes with OSBPL1A at the late endosome By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 374349Lumenal Reviewed predictionAdd
BLAST
Transmembranei375 – 39824Helical; Reviewed predictionAdd
BLAST
Topological domaini399 – 40911Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cytolytic granule Source: Ensembl
  2. endosome membrane Source: UniProtKB-SubCell
  3. external side of plasma membrane Source: Ensembl
  4. integral component of membrane Source: UniProtKB-KW
  5. lysosomal membrane Source: AgBase
  6. melanosome Source: Ensembl
  7. multivesicular body Source: Ensembl
  8. sarcolemma Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Add
BLAST
Chaini26 – 409384Lysosome-associated membrane glycoprotein 1PRO_0000017107Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi34 – 341N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi38 ↔ 76 By similarity
Glycosylationi59 – 591N-linked (GlcNAc...) Reviewed prediction
Glycosylationi72 – 721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi80 – 801N-linked (GlcNAc...) Reviewed prediction
Glycosylationi103 – 1031N-linked (GlcNAc...) Reviewed prediction
Glycosylationi117 – 1171N-linked (GlcNAc...) Reviewed prediction
Glycosylationi126 – 1261N-linked (GlcNAc...) Reviewed prediction
Glycosylationi146 – 1461N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi151 ↔ 187 By similarity
Glycosylationi161 – 1611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi179 – 1791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi215 – 2151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi220 – 2201N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi223 ↔ 261 By similarity
Glycosylationi241 – 2411N-linked (GlcNAc...) Reviewed prediction
Glycosylationi253 – 2531N-linked (GlcNAc...) Reviewed prediction
Glycosylationi260 – 2601N-linked (GlcNAc...) Reviewed prediction
Glycosylationi285 – 2851N-linked (GlcNAc...) Reviewed prediction
Glycosylationi299 – 2991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi314 – 3141N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi330 ↔ 367 By similarity

Post-translational modificationi

O- and N-glycosylated; some of the N-linked glycans are polylactosaminoglycans By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ05204.
PRIDEiQ05204.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000042536.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni26 – 187162First lumenal domainAdd
BLAST
Regioni188 – 21932HingeAdd
BLAST
Regioni220 – 374155Second lumenal domainAdd
BLAST

Sequence similaritiesi

Belongs to the LAMP family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG301998.
GeneTreeiENSGT00530000063068.
HOGENOMiHOG000230942.
HOVERGENiHBG052303.
InParanoidiQ05204.
KOiK06528.
OMAiENNMLIP.
OrthoDBiEOG7ZD1VH.
TreeFamiTF316339.

Family and domain databases

InterProiIPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSiPR00336. LYSASSOCTDMP.
PROSITEiPS00310. LAMP_1. 2 hits.
PS00311. LAMP_2. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05204-1 [UniParc]FASTAAdd to Basket

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MAAPGGARRR PLLLLLFAGL VHGASAVFVV KNGNGTACIM ADFSATFLTS    50
YDTRSGPQNK SFELPAGAEV SNSSSCGKEN ASDSSLVITF GRGHTLTLIF 100
TRNATRYEVQ LMRFAYNLSD TDTFPNSSST GVKTVESATD IKADINKTYR 150
CVSETQVNMD NVTVTLRDAA IQAYLSSSNF SREETRCEQD LPTPTTPPQP 200
APTPAPASPA VFRYNVSGSN GTCLLASMGL QLNVTYRRVD NKTVTREFNV 250
NPNKTTFGGN CSATLATLEL HSENLLLLAL QFVMNESSSR VFLQGVQLNL 300
TLPDAKEGSF TATNSSLRAL QATAGNSYKC NAEQRLRVTS SFSLNMFRVW 350
LQAFRVDGDK FGPVEECQLD ENSMLIPIAV GGALAGLVLI VLLAYLIGRK 400
RSHAGYQTI 409
Length:409
Mass (Da):44,153
Last modified:October 17, 2006 - v2
Checksum:i36E955E7F1AB74F5
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 76AAPGGA → RPPAAP in AAA30548. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC118436 mRNA. Translation: AAI18437.1.
BC133619 mRNA. Translation: AAI33620.1.
BC140610 mRNA. Translation: AAI40611.1.
L09113 mRNA. Translation: AAA30548.1.
PIRiA46712.
RefSeqiNP_001068592.1. NM_001075124.2.
UniGeneiBt.5330.

Genome annotation databases

EnsembliENSBTAT00000045121; ENSBTAP00000042536; ENSBTAG00000010242.
GeneIDi281897.
KEGGibta:281897.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC118436 mRNA. Translation: AAI18437.1 .
BC133619 mRNA. Translation: AAI33620.1 .
BC140610 mRNA. Translation: AAI40611.1 .
L09113 mRNA. Translation: AAA30548.1 .
PIRi A46712.
RefSeqi NP_001068592.1. NM_001075124.2.
UniGenei Bt.5330.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000042536.

Proteomic databases

PaxDbi Q05204.
PRIDEi Q05204.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000045121 ; ENSBTAP00000042536 ; ENSBTAG00000010242 .
GeneIDi 281897.
KEGGi bta:281897.

Organism-specific databases

CTDi 3916.

Phylogenomic databases

eggNOGi NOG301998.
GeneTreei ENSGT00530000063068.
HOGENOMi HOG000230942.
HOVERGENi HBG052303.
InParanoidi Q05204.
KOi K06528.
OMAi ENNMLIP.
OrthoDBi EOG7ZD1VH.
TreeFami TF316339.

Miscellaneous databases

NextBioi 20805793.

Family and domain databases

InterProi IPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view ]
PANTHERi PTHR11506. PTHR11506. 1 hit.
Pfami PF01299. Lamp. 1 hit.
[Graphical view ]
PRINTSi PR00336. LYSASSOCTDMP.
PROSITEi PS00310. LAMP_1. 2 hits.
PS00311. LAMP_2. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus and Hereford.
    Tissue: Fetal brain, Fetal liver and Ileum.
  2. "Characterization of glycoprotein II from bovine adrenal medullary chromaffin granules. Identification of components representing the secretory vesicle counterparts of the lysosomal-associated membrane glycoproteins (lamp-1 and lamp-2)."
    Hieber A.D., Christie D.L.
    J. Biol. Chem. 268:11073-11078(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-409, PARTIAL PROTEIN SEQUENCE.
    Tissue: Adrenal medulla.

Entry informationi

Entry nameiLAMP1_BOVIN
AccessioniPrimary (citable) accession number: Q05204
Secondary accession number(s): A2VE82, A5D7M2, Q17QC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 17, 2006
Last modified: July 9, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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