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Q05204

- LAMP1_BOVIN

UniProt

Q05204 - LAMP1_BOVIN

Protein

Lysosome-associated membrane glycoprotein 1

Gene

LAMP1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 2 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. protein stabilization Source: UniProt

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysosome-associated membrane glycoprotein 1
    Short name:
    LAMP-1
    Short name:
    Lysosome-associated membrane protein 1
    Alternative name(s):
    CD107 antigen-like family member A
    Chromaffin granule-associated membrane glycoprotein IIA
    CD_antigen: CD107a
    Gene namesi
    Name:LAMP1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 12

    Subcellular locationi

    Cell membrane By similarity; Single-pass type I membrane protein PROSITE-ProRule annotation. Endosome membrane By similarity; Single-pass type I membrane protein PROSITE-ProRule annotation. Lysosome membrane PROSITE-ProRule annotation; Single-pass type I membrane protein PROSITE-ProRule annotation. Late endosome By similarity
    Note: This protein shuttles between lysosomes, endosomes, and the plasma membrane. Colocalizes with OSBPL1A at the late endosome By similarity.By similarity

    GO - Cellular componenti

    1. cytolytic granule Source: Ensembl
    2. endosome membrane Source: UniProtKB-SubCell
    3. external side of plasma membrane Source: Ensembl
    4. integral component of membrane Source: UniProtKB-KW
    5. lysosomal membrane Source: AgBase
    6. melanosome Source: Ensembl
    7. multivesicular body Source: Ensembl
    8. sarcolemma Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Endosome, Lysosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Add
    BLAST
    Chaini26 – 409384Lysosome-associated membrane glycoprotein 1PRO_0000017107Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi34 – 341N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi38 ↔ 76PROSITE-ProRule annotation
    Glycosylationi59 – 591N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi80 – 801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi126 – 1261N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi146 – 1461N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi151 ↔ 187PROSITE-ProRule annotation
    Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi215 – 2151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi223 ↔ 261PROSITE-ProRule annotation
    Glycosylationi241 – 2411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi253 – 2531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi260 – 2601N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi285 – 2851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi299 – 2991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi314 – 3141N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi330 ↔ 367PROSITE-ProRule annotation

    Post-translational modificationi

    O- and N-glycosylated; some of the N-linked glycans are polylactosaminoglycans.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ05204.
    PRIDEiQ05204.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000042536.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini26 – 374349LumenalSequence AnalysisAdd
    BLAST
    Topological domaini399 – 40911CytoplasmicPROSITE-ProRule annotationAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei375 – 39824HelicalPROSITE-ProRule annotationAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni26 – 187162First lumenal domainAdd
    BLAST
    Regioni188 – 21932HingeAdd
    BLAST
    Regioni220 – 374155Second lumenal domainAdd
    BLAST

    Sequence similaritiesi

    Belongs to the LAMP family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG301998.
    GeneTreeiENSGT00530000063068.
    HOGENOMiHOG000230942.
    HOVERGENiHBG052303.
    InParanoidiQ05204.
    KOiK06528.
    OMAiENNMLIP.
    OrthoDBiEOG7ZD1VH.
    TreeFamiTF316339.

    Family and domain databases

    InterProiIPR018134. LAMP_CS.
    IPR002000. Lysosome-assoc_membr_glycop.
    [Graphical view]
    PANTHERiPTHR11506. PTHR11506. 1 hit.
    PfamiPF01299. Lamp. 1 hit.
    [Graphical view]
    PRINTSiPR00336. LYSASSOCTDMP.
    PROSITEiPS00310. LAMP_1. 2 hits.
    PS00311. LAMP_2. 1 hit.
    PS51407. LAMP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q05204-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAPGGARRR PLLLLLFAGL VHGASAVFVV KNGNGTACIM ADFSATFLTS    50
    YDTRSGPQNK SFELPAGAEV SNSSSCGKEN ASDSSLVITF GRGHTLTLIF 100
    TRNATRYEVQ LMRFAYNLSD TDTFPNSSST GVKTVESATD IKADINKTYR 150
    CVSETQVNMD NVTVTLRDAA IQAYLSSSNF SREETRCEQD LPTPTTPPQP 200
    APTPAPASPA VFRYNVSGSN GTCLLASMGL QLNVTYRRVD NKTVTREFNV 250
    NPNKTTFGGN CSATLATLEL HSENLLLLAL QFVMNESSSR VFLQGVQLNL 300
    TLPDAKEGSF TATNSSLRAL QATAGNSYKC NAEQRLRVTS SFSLNMFRVW 350
    LQAFRVDGDK FGPVEECQLD ENSMLIPIAV GGALAGLVLI VLLAYLIGRK 400
    RSHAGYQTI 409
    Length:409
    Mass (Da):44,153
    Last modified:October 17, 2006 - v2
    Checksum:i36E955E7F1AB74F5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2 – 76AAPGGA → RPPAAP in AAA30548. (PubMed:8496169)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC118436 mRNA. Translation: AAI18437.1.
    BC133619 mRNA. Translation: AAI33620.1.
    BC140610 mRNA. Translation: AAI40611.1.
    L09113 mRNA. Translation: AAA30548.1.
    PIRiA46712.
    RefSeqiNP_001068592.1. NM_001075124.2.
    UniGeneiBt.5330.

    Genome annotation databases

    EnsembliENSBTAT00000045121; ENSBTAP00000042536; ENSBTAG00000010242.
    GeneIDi281897.
    KEGGibta:281897.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC118436 mRNA. Translation: AAI18437.1 .
    BC133619 mRNA. Translation: AAI33620.1 .
    BC140610 mRNA. Translation: AAI40611.1 .
    L09113 mRNA. Translation: AAA30548.1 .
    PIRi A46712.
    RefSeqi NP_001068592.1. NM_001075124.2.
    UniGenei Bt.5330.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000042536.

    Proteomic databases

    PaxDbi Q05204.
    PRIDEi Q05204.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000045121 ; ENSBTAP00000042536 ; ENSBTAG00000010242 .
    GeneIDi 281897.
    KEGGi bta:281897.

    Organism-specific databases

    CTDi 3916.

    Phylogenomic databases

    eggNOGi NOG301998.
    GeneTreei ENSGT00530000063068.
    HOGENOMi HOG000230942.
    HOVERGENi HBG052303.
    InParanoidi Q05204.
    KOi K06528.
    OMAi ENNMLIP.
    OrthoDBi EOG7ZD1VH.
    TreeFami TF316339.

    Miscellaneous databases

    NextBioi 20805793.

    Family and domain databases

    InterProi IPR018134. LAMP_CS.
    IPR002000. Lysosome-assoc_membr_glycop.
    [Graphical view ]
    PANTHERi PTHR11506. PTHR11506. 1 hit.
    Pfami PF01299. Lamp. 1 hit.
    [Graphical view ]
    PRINTSi PR00336. LYSASSOCTDMP.
    PROSITEi PS00310. LAMP_1. 2 hits.
    PS00311. LAMP_2. 1 hit.
    PS51407. LAMP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus and Hereford.
      Tissue: Fetal brain, Fetal liver and Ileum.
    2. "Characterization of glycoprotein II from bovine adrenal medullary chromaffin granules. Identification of components representing the secretory vesicle counterparts of the lysosomal-associated membrane glycoproteins (lamp-1 and lamp-2)."
      Hieber A.D., Christie D.L.
      J. Biol. Chem. 268:11073-11078(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-409, PARTIAL PROTEIN SEQUENCE.
      Tissue: Adrenal medulla.

    Entry informationi

    Entry nameiLAMP1_BOVIN
    AccessioniPrimary (citable) accession number: Q05204
    Secondary accession number(s): A2VE82, A5D7M2, Q17QC6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3