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Protein

Lysosome-associated membrane glycoprotein 1

Gene

LAMP1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. establishment of protein localization to organelle Source: Ensembl
  2. Golgi to lysosome transport Source: Ensembl
  3. granzyme-mediated apoptotic signaling pathway Source: Ensembl
  4. positive regulation of natural killer cell degranulation Source: Ensembl
  5. protein stabilization Source: UniProtKB
  6. regulation of organelle transport along microtubule Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosome-associated membrane glycoprotein 1
Short name:
LAMP-1
Short name:
Lysosome-associated membrane protein 1
Alternative name(s):
CD107 antigen-like family member A
Chromaffin granule-associated membrane glycoprotein IIA
CD_antigen: CD107a
Gene namesi
Name:LAMP1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 12

Subcellular locationi

Cell membrane By similarity; Single-pass type I membrane protein PROSITE-ProRule annotation. Endosome membrane By similarity; Single-pass type I membrane protein PROSITE-ProRule annotation. Lysosome membrane PROSITE-ProRule annotation; Single-pass type I membrane protein PROSITE-ProRule annotation. Late endosome By similarity
Note: This protein shuttles between lysosomes, endosomes, and the plasma membrane. Colocalizes with OSBPL1A at the late endosome (By similarity).By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 374349LumenalSequence AnalysisAdd
BLAST
Transmembranei375 – 39824HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini399 – 40911CytoplasmicPROSITE-ProRule annotationAdd
BLAST

GO - Cellular componenti

  1. caveola Source: AgBase
  2. cytolytic granule Source: Ensembl
  3. endosome membrane Source: UniProtKB-SubCell
  4. external side of plasma membrane Source: Ensembl
  5. extracellular vesicular exosome Source: Ensembl
  6. integral component of membrane Source: UniProtKB-KW
  7. lysosomal membrane Source: AgBase
  8. melanosome Source: Ensembl
  9. membrane raft Source: AgBase
  10. multivesicular body Source: Ensembl
  11. phagolysosome membrane Source: Ensembl
  12. sarcolemma Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Add
BLAST
Chaini26 – 409384Lysosome-associated membrane glycoprotein 1PRO_0000017107Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi34 – 341N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi38 ↔ 76PROSITE-ProRule annotation
Glycosylationi59 – 591N-linked (GlcNAc...)Sequence Analysis
Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi80 – 801N-linked (GlcNAc...)Sequence Analysis
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi126 – 1261N-linked (GlcNAc...)Sequence Analysis
Glycosylationi146 – 1461N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi151 ↔ 187PROSITE-ProRule annotation
Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi215 – 2151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi223 ↔ 261PROSITE-ProRule annotation
Glycosylationi241 – 2411N-linked (GlcNAc...)Sequence Analysis
Glycosylationi253 – 2531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi260 – 2601N-linked (GlcNAc...)Sequence Analysis
Glycosylationi285 – 2851N-linked (GlcNAc...)Sequence Analysis
Glycosylationi299 – 2991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi314 – 3141N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi330 ↔ 367PROSITE-ProRule annotation

Post-translational modificationi

O- and N-glycosylated; some of the N-linked glycans are polylactosaminoglycans.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ05204.
PRIDEiQ05204.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000042536.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni26 – 187162First lumenal domainAdd
BLAST
Regioni188 – 21932HingeAdd
BLAST
Regioni220 – 374155Second lumenal domainAdd
BLAST

Sequence similaritiesi

Belongs to the LAMP family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG301998.
GeneTreeiENSGT00530000063068.
HOGENOMiHOG000230942.
HOVERGENiHBG052303.
InParanoidiQ05204.
KOiK06528.
OMAiGTACIMA.
OrthoDBiEOG7ZD1VH.
TreeFamiTF316339.

Family and domain databases

InterProiIPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSiPR00336. LYSASSOCTDMP.
PROSITEiPS00310. LAMP_1. 2 hits.
PS00311. LAMP_2. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05204-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPGGARRR PLLLLLFAGL VHGASAVFVV KNGNGTACIM ADFSATFLTS
60 70 80 90 100
YDTRSGPQNK SFELPAGAEV SNSSSCGKEN ASDSSLVITF GRGHTLTLIF
110 120 130 140 150
TRNATRYEVQ LMRFAYNLSD TDTFPNSSST GVKTVESATD IKADINKTYR
160 170 180 190 200
CVSETQVNMD NVTVTLRDAA IQAYLSSSNF SREETRCEQD LPTPTTPPQP
210 220 230 240 250
APTPAPASPA VFRYNVSGSN GTCLLASMGL QLNVTYRRVD NKTVTREFNV
260 270 280 290 300
NPNKTTFGGN CSATLATLEL HSENLLLLAL QFVMNESSSR VFLQGVQLNL
310 320 330 340 350
TLPDAKEGSF TATNSSLRAL QATAGNSYKC NAEQRLRVTS SFSLNMFRVW
360 370 380 390 400
LQAFRVDGDK FGPVEECQLD ENSMLIPIAV GGALAGLVLI VLLAYLIGRK

RSHAGYQTI
Length:409
Mass (Da):44,153
Last modified:October 17, 2006 - v2
Checksum:i36E955E7F1AB74F5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 76AAPGGA → RPPAAP in AAA30548 (PubMed:8496169).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118436 mRNA. Translation: AAI18437.1.
BC133619 mRNA. Translation: AAI33620.1.
BC140610 mRNA. Translation: AAI40611.1.
L09113 mRNA. Translation: AAA30548.1.
PIRiA46712.
RefSeqiNP_001068592.1. NM_001075124.2.
UniGeneiBt.5330.

Genome annotation databases

EnsembliENSBTAT00000045121; ENSBTAP00000042536; ENSBTAG00000010242.
GeneIDi281897.
KEGGibta:281897.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118436 mRNA. Translation: AAI18437.1.
BC133619 mRNA. Translation: AAI33620.1.
BC140610 mRNA. Translation: AAI40611.1.
L09113 mRNA. Translation: AAA30548.1.
PIRiA46712.
RefSeqiNP_001068592.1. NM_001075124.2.
UniGeneiBt.5330.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000042536.

Proteomic databases

PaxDbiQ05204.
PRIDEiQ05204.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000045121; ENSBTAP00000042536; ENSBTAG00000010242.
GeneIDi281897.
KEGGibta:281897.

Organism-specific databases

CTDi3916.

Phylogenomic databases

eggNOGiNOG301998.
GeneTreeiENSGT00530000063068.
HOGENOMiHOG000230942.
HOVERGENiHBG052303.
InParanoidiQ05204.
KOiK06528.
OMAiGTACIMA.
OrthoDBiEOG7ZD1VH.
TreeFamiTF316339.

Miscellaneous databases

NextBioi20805793.

Family and domain databases

InterProiIPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSiPR00336. LYSASSOCTDMP.
PROSITEiPS00310. LAMP_1. 2 hits.
PS00311. LAMP_2. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus and Hereford.
    Tissue: Fetal brain, Fetal liver and Ileum.
  2. "Characterization of glycoprotein II from bovine adrenal medullary chromaffin granules. Identification of components representing the secretory vesicle counterparts of the lysosomal-associated membrane glycoproteins (lamp-1 and lamp-2)."
    Hieber A.D., Christie D.L.
    J. Biol. Chem. 268:11073-11078(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-409, PARTIAL PROTEIN SEQUENCE.
    Tissue: Adrenal medulla.

Entry informationi

Entry nameiLAMP1_BOVIN
AccessioniPrimary (citable) accession number: Q05204
Secondary accession number(s): A2VE82, A5D7M2, Q17QC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 17, 2006
Last modified: February 4, 2015
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.