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Q051Q7

- DEF_LEPBL

UniProt

Q051Q7 - DEF_LEPBL

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Protein

Peptide deformylase

Gene
def, LBL_1460
Organism
Leptospira borgpetersenii serovar Hardjo-bovis (strain L550)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions By similarity.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Binds 1 Fe2+ ion By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi102 – 1021Iron By similarity
Metal bindingi144 – 1441Iron By similarity
Active sitei145 – 1451 By similarity
Metal bindingi148 – 1481Iron By similarity

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. peptide deformylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciLBOR355276:GHUQ-1446-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylase (EC:3.5.1.88)
Short name:
PDF
Alternative name(s):
Polypeptide deformylase
Gene namesi
Name:def
Ordered Locus Names:LBL_1460
OrganismiLeptospira borgpetersenii serovar Hardjo-bovis (strain L550)
Taxonomic identifieri355276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira
ProteomesiUP000000655: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 178178Peptide deformylaseUniRule annotationPRO_0000301051Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi355276.LBL_1460.

Structurei

3D structure databases

ProteinModelPortaliQ051Q7.
SMRiQ051Q7. Positions 2-178.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0242.
HOGENOMiHOG000243508.
KOiK01462.
OMAiPNQYAEV.
OrthoDBiEOG664CMF.

Family and domain databases

Gene3Di3.90.45.10. 1 hit.
HAMAPiMF_00163. Pep_deformylase.
InterProiIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERiPTHR10458. PTHR10458. 1 hit.
PfamiPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFiPIRSF004749. Pep_def. 1 hit.
PRINTSiPR01576. PDEFORMYLASE.
SUPFAMiSSF56420. SSF56420. 1 hit.
TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

Sequencei

Sequence statusi: Complete.

Q051Q7-1 [UniParc]FASTAAdd to Basket

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MSVRKILRMG DSILRQVSIP VTENELQTKE FKKLIRDMFD TMRHAEGVGL    50
AAPQIGILKQ IVVVGSEDNE RYPDTPNVPE RVILNPIITP LTKDTSGFWE 100
GCLSVPGMRG YVERPNKIRM QWMDEKGDRF DETIDGYKAV VYQHECDHLS 150
GILYVDRLKD TKLFGFNDTL DSGRNVLD 178
Length:178
Mass (Da):20,344
Last modified:November 14, 2006 - v1
Checksum:iEC1415F75FE9E42C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000348 Genomic DNA. Translation: ABJ78938.1.
RefSeqiYP_797871.1. NC_008508.1.

Genome annotation databases

EnsemblBacteriaiABJ78938; ABJ78938; LBL_1460.
GeneIDi4406409.
KEGGilbl:LBL_1460.
PATRICi22366780. VBILepBor75619_1848.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000348 Genomic DNA. Translation: ABJ78938.1 .
RefSeqi YP_797871.1. NC_008508.1.

3D structure databases

ProteinModelPortali Q051Q7.
SMRi Q051Q7. Positions 2-178.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 355276.LBL_1460.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ78938 ; ABJ78938 ; LBL_1460 .
GeneIDi 4406409.
KEGGi lbl:LBL_1460.
PATRICi 22366780. VBILepBor75619_1848.

Phylogenomic databases

eggNOGi COG0242.
HOGENOMi HOG000243508.
KOi K01462.
OMAi PNQYAEV.
OrthoDBi EOG664CMF.

Enzyme and pathway databases

BioCyci LBOR355276:GHUQ-1446-MONOMER.

Family and domain databases

Gene3Di 3.90.45.10. 1 hit.
HAMAPi MF_00163. Pep_deformylase.
InterProi IPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view ]
PANTHERi PTHR10458. PTHR10458. 1 hit.
Pfami PF01327. Pep_deformylase. 1 hit.
[Graphical view ]
PIRSFi PIRSF004749. Pep_def. 1 hit.
PRINTSi PR01576. PDEFORMYLASE.
SUPFAMi SSF56420. SSF56420. 1 hit.
TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: L550.

Entry informationi

Entry nameiDEF_LEPBL
AccessioniPrimary (citable) accession number: Q051Q7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 14, 2006
Last modified: May 14, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi