Reviewed, UniProtKB/Swiss-Prot Q05197 (PMTA_RHOSH)

Names and origin

Protein names

Recommended name:
    Phosphatidylethanolamine N-methyltransferase
    EC=2.1.1.17

Gene names

Name:

pmtA

Organism

Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides)

Taxonomic identifier

1063 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Rhodobacter

Protein attributes

Sequence length	203 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Predicted.

General annotation (Comments)

Function	This enzyme catalyzes three distinct methylation reactions for converting phosphatidylethanolamine to phosphatidylcholine.
Catalytic activity	S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine.
Pathway	Phospholipid metabolism; phosphatidylcholine biosynthesis.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phosphatidylethanolamine N-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 203	203	Phosphatidylethanolamine N-methyltransferase		PRO_0000058470

Sequences

	Sequence		Length	Mass (Da)
	Q05197-1 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 2641E07949C1F10B	FASTA	203	22,892
	10 20 30 40 50 60 MELDAVSRSY KRWAIYDFSF GKVSESPRRR TAAHVNARGG RVLEVGVGTG LSLPLYSHRV 70 80 90 100 110 120 AVTGIDFSHE MLARAREKVE EMGLEPVKEL RQMDARELDF PDETFDTVVA MFLVSVVPEP 130 140 150 160 170 180 ERVVSEMARV CRKGGEVVIV NHFARDKGPL AAVEKALARF ENTLGWHSDF AIERVTADPR 190 200 LEVVEQTPMS PGGLFTFLRF QRR

References

[1]

"Isolation and functional expression in Escherichia coli of a gene encoding phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides." Arondel V., Benning C., Somerville C.R. J. Biol. Chem. 268:16002-16008(1993) [PubMed: 8340421] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	L07247 Genomic DNA. Translation: AAA26152.1.
PIR	A47149.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.1.1.17. 2796.
Family and domain databases
InterPro	IPR013216. Methyltransf_11. [Graphical view]
Pfam	PF08241. Methyltransf_11. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PMTA_RHOSH

Accession

Primary (citable) accession number: Q05197

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	January 20, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)