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Q05197 (PMTA_RHOSH) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphatidylethanolamine N-methyltransferase
EC=2.1.1.17
Gene names
Name:pmtA
OrganismRhodobacter sphaeroides (Rhodopseudomonas sphaeroides)
Taxonomic identifier1063 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Rhodobacter

Protein attributes

Sequence length203 AA.
Sequence statusComplete.
Protein existencePredicted

General annotation (Comments)

Function

This enzyme catalyzes three distinct methylation reactions for converting phosphatidylethanolamine to phosphatidylcholine.

Catalytic activity

S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine.

Pathway

Phospholipid metabolism; phosphatidylcholine biosynthesis.

Ontologies

Keywords
   Biological processPhospholipid biosynthesis
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
Gene Ontology (GO)
   Biological processphospholipid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionphosphatidylethanolamine N-methyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 203203Phosphatidylethanolamine N-methyltransferase
PRO_0000058470

Sequences

Sequence LengthMass (Da)Tools
Q05197 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 2641E07949C1F10B

FASTA20322,892
        10         20         30         40         50         60 
MELDAVSRSY KRWAIYDFSF GKVSESPRRR TAAHVNARGG RVLEVGVGTG LSLPLYSHRV 

        70         80         90        100        110        120 
AVTGIDFSHE MLARAREKVE EMGLEPVKEL RQMDARELDF PDETFDTVVA MFLVSVVPEP 

       130        140        150        160        170        180 
ERVVSEMARV CRKGGEVVIV NHFARDKGPL AAVEKALARF ENTLGWHSDF AIERVTADPR 

       190        200 
LEVVEQTPMS PGGLFTFLRF QRR

« Hide

References

[1]"Isolation and functional expression in Escherichia coli of a gene encoding phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides."
Arondel V., Benning C., Somerville C.R.
J. Biol. Chem. 268:16002-16008(1993) [PubMed: 8340421] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L07247 Genomic DNA. Translation: AAA26152.1.
PIRA47149.

3D structure databases

ProteinModelPortalQ05197.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR013216. Methyltransf_11.
[Graphical view]
PfamPF08241. Methyltransf_11. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePMTA_RHOSH
AccessionPrimary (citable) accession number: Q05197
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: September 21, 2011
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

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