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Q05193

- DYN1_HUMAN

UniProt

Q05193 - DYN1_HUMAN

Protein

Dynamin-1

Gene

DNM1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 142 (01 Oct 2014)
      Sequence version 2 (18 Mar 2008)
      Previous versions | rss
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    Functioni

    Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis.

    Catalytic activityi

    GTP + H2O = GDP + phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi38 – 458GTPBy similarity
    Nucleotide bindingi136 – 1405GTPBy similarity
    Nucleotide bindingi205 – 2084GTPBy similarity

    GO - Molecular functioni

    1. GTPase activity Source: ProtInc
    2. GTP binding Source: UniProtKB-KW
    3. identical protein binding Source: IntAct
    4. poly(A) RNA binding Source: UniProtKB
    5. protein binding Source: IntAct
    6. protein kinase binding Source: ParkinsonsUK-UCL

    GO - Biological processi

    1. endocytosis Source: BHF-UCL
    2. endosome organization Source: BHF-UCL
    3. GTP catabolic process Source: GOC
    4. receptor internalization Source: Ensembl
    5. receptor-mediated endocytosis Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Motor protein

    Keywords - Biological processi

    Endocytosis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_11035. Gap junction degradation.
    REACT_11049. Formation of annular gap junctions.
    REACT_121399. MHC class II antigen presentation.
    REACT_12435. Retrograde neurotrophin signalling.
    REACT_22365. Recycling pathway of L1.
    REACT_6894. Toll Like Receptor 4 (TLR4) Cascade.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dynamin-1 (EC:3.6.5.5)
    Gene namesi
    Name:DNM1
    Synonyms:DNM
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:2972. DNM1.

    Subcellular locationi

    Cytoplasm 1 Publication. Cytoplasmcytoskeleton 1 Publication
    Note: Microtubule-associated.

    GO - Cellular componenti

    1. membrane coat Source: Ensembl
    2. microtubule Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Microtubule

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi44 – 441K → A: Inhibits receptor-mediated endocytosis. 1 Publication

    Organism-specific databases

    PharmGKBiPA27440.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 864864Dynamin-1PRO_0000206563Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei80 – 801PhosphotyrosineBy similarity
    Modified residuei125 – 1251Nitrated tyrosine; alternateBy similarity
    Modified residuei125 – 1251Phosphotyrosine; alternateBy similarity
    Modified residuei347 – 3471PhosphoserineBy similarity
    Modified residuei354 – 3541PhosphotyrosineBy similarity
    Modified residuei512 – 5121PhosphoserineBy similarity
    Modified residuei774 – 7741PhosphoserineBy similarity
    Modified residuei778 – 7781PhosphoserineBy similarity
    Modified residuei822 – 8221PhosphoserineBy similarity
    Modified residuei851 – 8511PhosphoserineBy similarity
    Modified residuei857 – 8571PhosphoserineBy similarity

    Keywords - PTMi

    Nitration, Phosphoprotein

    Proteomic databases

    MaxQBiQ05193.
    PaxDbiQ05193.
    PRIDEiQ05193.

    PTM databases

    PhosphoSiteiQ05193.

    Expressioni

    Gene expression databases

    BgeeiQ05193.
    CleanExiHS_DNM1.
    GenevestigatoriQ05193.

    Organism-specific databases

    HPAiCAB005920.
    HPA049910.

    Interactioni

    Subunit structurei

    Interacts with CAV1 and SH3GLB1. Binds SH3GL1, SH3GL2 and SH3GL3 By similarity. Interacts with PHOCN. Interacts with PACSIN1, PACSIN2 and PACSIN3 By similarity. Interacts with SNX9. Interacts with MYO1E (via SH3 domain). Interacts with SNX33 (via SH3 domain). Interacts with UNC119; leading to a decrease of DNM1 GTPase activity By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself7EBI-713135,EBI-713135
    ACTA1P681355EBI-8446026,EBI-367540From a different organism.
    FNBP1Q96RU35EBI-713135,EBI-1111248
    GRB2P629933EBI-713135,EBI-401755
    HTTP428583EBI-713135,EBI-466029
    LRRK2Q5S0074EBI-713135,EBI-5323863
    NCK1P163332EBI-713135,EBI-389883
    NOSTRINQ8IVI93EBI-713135,EBI-1391643

    Protein-protein interaction databases

    BioGridi108099. 52 interactions.
    DIPiDIP-36242N.
    IntActiQ05193. 25 interactions.
    MINTiMINT-233135.
    STRINGi9606.ENSP00000362014.

    Structurei

    Secondary structure

    1
    864
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi10 – 2112
    Turni22 – 243
    Helixi26 – 283
    Beta strandi33 – 375
    Helixi44 – 496
    Turni50 – 523
    Beta strandi61 – 633
    Beta strandi69 – 757
    Beta strandi80 – 834
    Helixi84 – 863
    Helixi94 – 10916
    Turni110 – 1134
    Beta strandi120 – 1267
    Beta strandi131 – 1366
    Helixi152 – 16413
    Beta strandi169 – 1768
    Helixi181 – 1833
    Helixi185 – 1939
    Beta strandi200 – 2056
    Helixi207 – 2093
    Helixi217 – 2204
    Beta strandi231 – 2333
    Helixi239 – 2435
    Helixi248 – 26114
    Turni263 – 2653
    Helixi266 – 2716
    Helixi274 – 31744
    Beta strandi520 – 52910
    Helixi533 – 5353
    Beta strandi537 – 55519
    Beta strandi561 – 5666
    Beta strandi570 – 5745
    Beta strandi579 – 5824
    Beta strandi584 – 5907
    Beta strandi601 – 6099
    Helixi610 – 62213
    Helixi726 – 74116

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1DYNX-ray2.20A/B510-633[»]
    2DYNX-ray2.30A/B509-630[»]
    2X2EX-ray2.00A/D6-320[»]
    A/D726-750[»]
    2X2FX-ray2.00A/D6-320[»]
    A/D726-750[»]
    3SNHX-ray3.70A6-746[»]
    3ZYCX-ray2.20A/D6-320[»]
    A/D726-750[»]
    3ZYSelectron microscopy12.20A/D6-320[»]
    A/D726-750[»]
    C/F518-630[»]
    ProteinModelPortaliQ05193.
    SMRiQ05193. Positions 6-746.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ05193.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 294267Dynamin-type GAdd
    BLAST
    Domaini519 – 625107PHPROSITE-ProRule annotationAdd
    BLAST
    Domaini659 – 75092GEDPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 GED domain.PROSITE-ProRule annotation
    Contains 1 PH domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0699.
    HOGENOMiHOG000161069.
    HOVERGENiHBG107833.
    KOiK01528.
    OMAiQYPHLRE.
    OrthoDBiEOG76MK7N.
    PhylomeDBiQ05193.
    TreeFamiTF300362.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    3.40.50.300. 1 hit.
    InterProiIPR027741. DNM1.
    IPR000375. Dynamin_central.
    IPR001401. Dynamin_GTPase.
    IPR019762. Dynamin_GTPase_CS.
    IPR022812. Dynamin_SF.
    IPR003130. GED.
    IPR020850. GTPase_effector_domain_GED.
    IPR027417. P-loop_NTPase.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view]
    PANTHERiPTHR11566. PTHR11566. 1 hit.
    PTHR11566:SF32. PTHR11566:SF32. 1 hit.
    PfamiPF01031. Dynamin_M. 1 hit.
    PF00350. Dynamin_N. 1 hit.
    PF02212. GED. 1 hit.
    PF00169. PH. 1 hit.
    [Graphical view]
    PRINTSiPR00195. DYNAMIN.
    SMARTiSM00053. DYNc. 1 hit.
    SM00302. GED. 1 hit.
    SM00233. PH. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
    PS51718. G_DYNAMIN_2. 1 hit.
    PS51388. GED. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q05193-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGNRGMEDLI PLVNRLQDAF SAIGQNADLD LPQIAVVGGQ SAGKSSVLEN    50
    FVGRDFLPRG SGIVTRRPLV LQLVNATTEY AEFLHCKGKK FTDFEEVRLE 100
    IEAETDRVTG TNKGISPVPI NLRVYSPHVL NLTLVDLPGM TKVPVGDQPP 150
    DIEFQIRDML MQFVTKENCL ILAVSPANSD LANSDALKVA KEVDPQGQRT 200
    IGVITKLDLM DEGTDARDVL ENKLLPLRRG YIGVVNRSQK DIDGKKDITA 250
    ALAAERKFFL SHPSYRHLAD RMGTPYLQKV LNQQLTNHIR DTLPGLRNKL 300
    QSQLLSIEKE VEEYKNFRPD DPARKTKALL QMVQQFAVDF EKRIEGSGDQ 350
    IDTYELSGGA RINRIFHERF PFELVKMEFD EKELRREISY AIKNIHGIRT 400
    GLFTPDMAFE TIVKKQVKKI REPCLKCVDM VISELISTVR QCTKKLQQYP 450
    RLREEMERIV TTHIREREGR TKEQVMLLID IELAYMNTNH EDFIGFANAQ 500
    QRSNQMNKKK TSGNQDEILV IRKGWLTINN IGIMKGGSKE YWFVLTAENL 550
    SWYKDDEEKE KKYMLSVDNL KLRDVEKGFM SSKHIFALFN TEQRNVYKDY 600
    RQLELACETQ EEVDSWKASF LRAGVYPERV GDKEKASETE ENGSDSFMHS 650
    MDPQLERQVE TIRNLVDSYM AIVNKTVRDL MPKTIMHLMI NNTKEFIFSE 700
    LLANLYSCGD QNTLMEESAE QAQRRDEMLR MYHALKEALS IIGDINTTTV 750
    STPMPPPVDD SWLQVQSVPA GRRSPTSSPT PQRRAPAVPP ARPGSRGPAP 800
    GPPPAGSALG GAPPVPSRPG ASPDPFGPPP QVPSRPNRAP PGVPSRSGQA 850
    SPSRPESPRP PFDL 864
    Length:864
    Mass (Da):97,408
    Last modified:March 18, 2008 - v2
    Checksum:i7FCD8CB572FFEAEF
    GO
    Isoform 2 (identifier: Q05193-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         407-444: MAFETIVKKQ...LISTVRQCTK → LAFEATVKKQ...LTATIRKCSE

    Show »
    Length:864
    Mass (Da):97,263
    Checksum:iDC9E3D5259D891DF
    GO
    Isoform 3 (identifier: Q05193-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         845-864: SRSGQASPSRPESPRPPFDL → RITISDP

    Show »
    Length:851
    Mass (Da):96,041
    Checksum:i89040FCDDAC2870C
    GO
    Isoform 4 (identifier: Q05193-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         846-864: RSGQASPSRPESPRPPFDL → QPIGSGKSIPS

    Show »
    Length:856
    Mass (Da):96,397
    Checksum:i7FF33D80ED860B02
    GO
    Isoform 5 (identifier: Q05193-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         407-444: MAFETIVKKQ...LISTVRQCTK → LAFEATVKKQ...LTATIRKCSE
         845-864: SRSGQASPSRPESPRPPFDL → RITISDP

    Show »
    Length:851
    Mass (Da):95,895
    Checksum:i4230B9970D097B20
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti188 – 1881K → E in AAH50279. (PubMed:15489334)Curated
    Sequence conflicti287 – 2871N → D in AAH50279. (PubMed:15489334)Curated
    Sequence conflicti809 – 8091L → M in AAH50279. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti744 – 7441D → N.1 Publication
    Corresponds to variant rs1042007 [ dbSNP | Ensembl ].
    VAR_048904

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei407 – 44438MAFET…RQCTK → LAFEATVKKQVQKLKEPSIK CVDMVVSELTATIRKCSE in isoform 2 and isoform 5. 1 PublicationVSP_031518Add
    BLAST
    Alternative sequencei845 – 86420SRSGQ…PPFDL → RITISDP in isoform 3 and isoform 5. 2 PublicationsVSP_031519Add
    BLAST
    Alternative sequencei846 – 86419RSGQA…PPFDL → QPIGSGKSIPS in isoform 4. 1 PublicationVSP_031520Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L07807 mRNA. Translation: AAA02803.1.
    L07808 mRNA. Translation: AAA02804.1.
    L07809 mRNA. Translation: AAA02805.1.
    L07810 mRNA. Translation: AAA02806.1.
    AL590708 Genomic DNA. Translation: CAI13837.1.
    AL590708 Genomic DNA. Translation: CAI13839.2.
    BC050279 mRNA. Translation: AAH50279.2.
    BC063850 mRNA. Translation: AAH63850.1.
    CCDSiCCDS43882.1. [Q05193-3]
    CCDS6895.1. [Q05193-1]
    PIRiA40671.
    RefSeqiNP_001005336.1. NM_001005336.2. [Q05193-3]
    NP_001275666.1. NM_001288737.1. [Q05193-5]
    NP_001275667.1. NM_001288738.1. [Q05193-5]
    NP_001275668.1. NM_001288739.1. [Q05193-2]
    NP_004399.2. NM_004408.3. [Q05193-1]
    XP_005251825.1. XM_005251768.1. [Q05193-5]
    XP_005251826.1. XM_005251769.1. [Q05193-3]
    UniGeneiHs.522413.

    Genome annotation databases

    EnsembliENST00000341179; ENSP00000345680; ENSG00000106976. [Q05193-3]
    ENST00000372923; ENSP00000362014; ENSG00000106976. [Q05193-1]
    ENST00000393594; ENSP00000377219; ENSG00000106976. [Q05193-5]
    ENST00000475805; ENSP00000419225; ENSG00000106976. [Q05193-5]
    ENST00000486160; ENSP00000420045; ENSG00000106976. [Q05193-2]
    GeneIDi1759.
    KEGGihsa:1759.
    UCSCiuc022bnx.1. human. [Q05193-5]
    uc022bny.1. human. [Q05193-3]
    uc022boa.1. human. [Q05193-1]

    Polymorphism databases

    DMDMi172046078.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L07807 mRNA. Translation: AAA02803.1 .
    L07808 mRNA. Translation: AAA02804.1 .
    L07809 mRNA. Translation: AAA02805.1 .
    L07810 mRNA. Translation: AAA02806.1 .
    AL590708 Genomic DNA. Translation: CAI13837.1 .
    AL590708 Genomic DNA. Translation: CAI13839.2 .
    BC050279 mRNA. Translation: AAH50279.2 .
    BC063850 mRNA. Translation: AAH63850.1 .
    CCDSi CCDS43882.1. [Q05193-3 ]
    CCDS6895.1. [Q05193-1 ]
    PIRi A40671.
    RefSeqi NP_001005336.1. NM_001005336.2. [Q05193-3 ]
    NP_001275666.1. NM_001288737.1. [Q05193-5 ]
    NP_001275667.1. NM_001288738.1. [Q05193-5 ]
    NP_001275668.1. NM_001288739.1. [Q05193-2 ]
    NP_004399.2. NM_004408.3. [Q05193-1 ]
    XP_005251825.1. XM_005251768.1. [Q05193-5 ]
    XP_005251826.1. XM_005251769.1. [Q05193-3 ]
    UniGenei Hs.522413.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1DYN X-ray 2.20 A/B 510-633 [» ]
    2DYN X-ray 2.30 A/B 509-630 [» ]
    2X2E X-ray 2.00 A/D 6-320 [» ]
    A/D 726-750 [» ]
    2X2F X-ray 2.00 A/D 6-320 [» ]
    A/D 726-750 [» ]
    3SNH X-ray 3.70 A 6-746 [» ]
    3ZYC X-ray 2.20 A/D 6-320 [» ]
    A/D 726-750 [» ]
    3ZYS electron microscopy 12.20 A/D 6-320 [» ]
    A/D 726-750 [» ]
    C/F 518-630 [» ]
    ProteinModelPortali Q05193.
    SMRi Q05193. Positions 6-746.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108099. 52 interactions.
    DIPi DIP-36242N.
    IntActi Q05193. 25 interactions.
    MINTi MINT-233135.
    STRINGi 9606.ENSP00000362014.

    Chemistry

    BindingDBi Q05193.
    ChEMBLi CHEMBL4958.

    PTM databases

    PhosphoSitei Q05193.

    Polymorphism databases

    DMDMi 172046078.

    Proteomic databases

    MaxQBi Q05193.
    PaxDbi Q05193.
    PRIDEi Q05193.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000341179 ; ENSP00000345680 ; ENSG00000106976 . [Q05193-3 ]
    ENST00000372923 ; ENSP00000362014 ; ENSG00000106976 . [Q05193-1 ]
    ENST00000393594 ; ENSP00000377219 ; ENSG00000106976 . [Q05193-5 ]
    ENST00000475805 ; ENSP00000419225 ; ENSG00000106976 . [Q05193-5 ]
    ENST00000486160 ; ENSP00000420045 ; ENSG00000106976 . [Q05193-2 ]
    GeneIDi 1759.
    KEGGi hsa:1759.
    UCSCi uc022bnx.1. human. [Q05193-5 ]
    uc022bny.1. human. [Q05193-3 ]
    uc022boa.1. human. [Q05193-1 ]

    Organism-specific databases

    CTDi 1759.
    GeneCardsi GC09P130965.
    H-InvDB HIX0026786.
    HIX0211497.
    HGNCi HGNC:2972. DNM1.
    HPAi CAB005920.
    HPA049910.
    MIMi 602377. gene.
    neXtProti NX_Q05193.
    PharmGKBi PA27440.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0699.
    HOGENOMi HOG000161069.
    HOVERGENi HBG107833.
    KOi K01528.
    OMAi QYPHLRE.
    OrthoDBi EOG76MK7N.
    PhylomeDBi Q05193.
    TreeFami TF300362.

    Enzyme and pathway databases

    Reactomei REACT_11035. Gap junction degradation.
    REACT_11049. Formation of annular gap junctions.
    REACT_121399. MHC class II antigen presentation.
    REACT_12435. Retrograde neurotrophin signalling.
    REACT_22365. Recycling pathway of L1.
    REACT_6894. Toll Like Receptor 4 (TLR4) Cascade.

    Miscellaneous databases

    ChiTaRSi DNM1. human.
    EvolutionaryTracei Q05193.
    GeneWikii DNM1.
    GenomeRNAii 1759.
    NextBioi 7163.
    PROi Q05193.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q05193.
    CleanExi HS_DNM1.
    Genevestigatori Q05193.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    3.40.50.300. 1 hit.
    InterProi IPR027741. DNM1.
    IPR000375. Dynamin_central.
    IPR001401. Dynamin_GTPase.
    IPR019762. Dynamin_GTPase_CS.
    IPR022812. Dynamin_SF.
    IPR003130. GED.
    IPR020850. GTPase_effector_domain_GED.
    IPR027417. P-loop_NTPase.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view ]
    PANTHERi PTHR11566. PTHR11566. 1 hit.
    PTHR11566:SF32. PTHR11566:SF32. 1 hit.
    Pfami PF01031. Dynamin_M. 1 hit.
    PF00350. Dynamin_N. 1 hit.
    PF02212. GED. 1 hit.
    PF00169. PH. 1 hit.
    [Graphical view ]
    PRINTSi PR00195. DYNAMIN.
    SMARTi SM00053. DYNc. 1 hit.
    SM00302. GED. 1 hit.
    SM00233. PH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00410. G_DYNAMIN_1. 1 hit.
    PS51718. G_DYNAMIN_2. 1 hit.
    PS51388. GED. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mutations in human dynamin block an intermediate stage in coated vesicle formation."
      van der Bliek A.M., Redelmeier T.E., Tisdale E.J., Meyerowitz E.M., Schmid S.L.
      J. Cell Biol. 122:553-563(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 387-466 (ISOFORM 2), NUCLEOTIDE SEQUENCE [MRNA] OF 726-856 (ISOFORMS 3 AND 4), MUTAGENESIS OF LYS-44, VARIANT ASN-744.
    2. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Brain and PNS.
    4. "SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis."
      Soulet F., Yarar D., Leonard M., Schmid S.L.
      Mol. Biol. Cell 16:2058-2067(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH SNX9.
    5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "Myosin 1E interacts with synaptojanin-1 and dynamin and is involved in endocytosis."
      Krendel M., Osterweil E.K., Mooseker M.S.
      FEBS Lett. 581:644-650(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MYO1E.
    7. "A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein."
      Schobel S., Neumann S., Hertweck M., Dislich B., Kuhn P.H., Kremmer E., Seed B., Baumeister R., Haass C., Lichtenthaler S.F.
      J. Biol. Chem. 283:14257-14268(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SNX33.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Platelet.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Three-dimensional solution structure of the pleckstrin homology domain from dynamin."
      Downing A.K., Driscoll P.C., Gout I., Salim K., Zvelebil M.J., Waterfield M.D.
      Curr. Biol. 4:884-891(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 511-630.
    11. "Crystal structure at 2.2-A resolution of the pleckstrin homology domain from human dynamin."
      Ferguson K.M., Lemmon M.A., Schlessinger J., Sigler P.B.
      Cell 79:199-209(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 509-633.
    12. "Crystal structure of the pleckstrin homology domain from dynamin."
      Timm D., Salim K., Gout I., Guruprasad L., Waterfield M., Blundell T.
      Nat. Struct. Biol. 1:782-788(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 509-630.

    Entry informationi

    Entry nameiDYN1_HUMAN
    AccessioniPrimary (citable) accession number: Q05193
    Secondary accession number(s): A6NLM6
    , Q5SYX0, Q5SYX2, Q6P3T6, Q86VD2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: March 18, 2008
    Last modified: October 1, 2014
    This is version 142 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3