Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q05187

- TGMH_TACTR

UniProt

Q05187 - TGMH_TACTR

Protein

Hemocyte protein-glutamine gamma-glutamyltransferase

Gene
N/A
Organism
Tachypleus tridentatus (Japanese horseshoe crab)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.

    Catalytic activityi

    Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.PROSITE-ProRule annotation

    Cofactori

    Binds 1 calcium ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei343 – 3431PROSITE-ProRule annotation
    Active sitei402 – 4021PROSITE-ProRule annotation
    Active sitei425 – 4251PROSITE-ProRule annotation
    Metal bindingi465 – 4651CalciumBy similarity
    Metal bindingi467 – 4671CalciumBy similarity
    Metal bindingi522 – 5221CalciumBy similarity
    Metal bindingi527 – 5271CalciumBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein-glutamine gamma-glutamyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. peptide cross-linking Source: InterPro

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hemocyte protein-glutamine gamma-glutamyltransferase (EC:2.3.2.13)
    Alternative name(s):
    Hemocyte transglutaminase
    Short name:
    TGase
    OrganismiTachypleus tridentatus (Japanese horseshoe crab)
    Taxonomic identifieri6853 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataMerostomataXiphosuraLimulidaeTachypleus

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 764764Hemocyte protein-glutamine gamma-glutamyltransferasePRO_0000213717Add
    BLAST

    Expressioni

    Tissue specificityi

    Mainly expressed in hemocytes, hepatopancreas, and gastric tissues. On the other hand nothing was detected in the heart, intestine and muscle.

    Structurei

    3D structure databases

    ProteinModelPortaliQ05187.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di2.60.40.10. 3 hits.
    3.90.260.10. 1 hit.
    InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002931. Transglutaminase-like.
    IPR008958. Transglutaminase_C.
    IPR013808. Transglutaminase_CS.
    IPR001102. Transglutaminase_N.
    [Graphical view]
    PANTHERiPTHR11590. PTHR11590. 1 hit.
    PfamiPF00927. Transglut_C. 2 hits.
    PF01841. Transglut_core. 1 hit.
    PF00868. Transglut_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
    SMARTiSM00460. TGc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49309. SSF49309. 2 hits.
    SSF81296. SSF81296. 1 hit.
    PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q05187-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYGFGRGNMF RNRSTRYRRR PRYRAENYHS YMLDLLENMN EEFGRNWWGT    50
    PESHQPDSGP SSLQVESVEL YTRDNAREHN TFMYDLVDGT KPVLILRRGQ 100
    PFSIAIRFKR NYNPQQDRLK LEIGFGQQPL ITKGTLIMLP VSGSDTFTKD 150
    KTQWDVRLRQ HDGAVITLEI QIPAAVAVGV WKMKIVSQLT SEEQPNVSAV 200
    THECKNKTYI LFNPWCKQDS VYMEDEQWRK EYVLSDVGKI FTGSFKQPVG 250
    RRWIFGQFTD SVLPACMLIL ERSGLDYTAR SNPIKVVRAI SAMVNNIDDE 300
    GVLEGRWQEP YDDGVAPWMW TGSSAILEKY LKTRGVPVKY GQCWVFAGVA 350
    NTVSRALGIP SRTVTNYDSA HDTDDTLTID KWFDKNGDKI EDATSDSIWN 400
    FHVWNDCWMA RPDLPTGYGG WQAYDSTPQE TSEGVYQTGP ASVLAVQRGE 450
    IGYMFDSPFV FSEVNADVVH WQEDDSSETG YKKLKIDSYR VGRLLLTKKI 500
    GVDDDFGDAD AEDITDQYKN KEGTDEERMS VLNAARSSGF NYAFNLPSPE 550
    KEDVYFNLLD IEKIKIGQPF HVTVNIENQS SETRRVSAVL SASSIYYTGI 600
    TGRKIKRENG NFSLQPHQKE VLSIEVTPDE YLEKLVDYAM IKLYAIATVK 650
    ETQQTWSEED DFMVEKPNLE LEIRGNLQVG TAFVLAISLT NPLKRVLDNC 700
    FFTIEAPGVT GAFRVTNRDI QPEEVAVHTV RLIPQKPGPR KIVATFSSRQ 750
    LIQVVGSKQV EVLD 764
    Length:764
    Mass (Da):86,996
    Last modified:October 1, 1996 - v1
    Checksum:iD4F1D392F1DA5811
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti452 – 4521G → R.
    Natural varianti477 – 4771S → C.
    Natural varianti486 – 4861I → S.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D12593 mRNA. Translation: BAA02134.1.
    PIRiA45321.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D12593 mRNA. Translation: BAA02134.1 .
    PIRi A45321.

    3D structure databases

    ProteinModelPortali Q05187.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.60.40.10. 3 hits.
    3.90.260.10. 1 hit.
    InterProi IPR023608. Gln_gamma-glutamylTfrase_euk.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002931. Transglutaminase-like.
    IPR008958. Transglutaminase_C.
    IPR013808. Transglutaminase_CS.
    IPR001102. Transglutaminase_N.
    [Graphical view ]
    PANTHERi PTHR11590. PTHR11590. 1 hit.
    Pfami PF00927. Transglut_C. 2 hits.
    PF01841. Transglut_core. 1 hit.
    PF00868. Transglut_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000459. TGM_EBP42. 1 hit.
    SMARTi SM00460. TGc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49309. SSF49309. 2 hits.
    SSF81296. SSF81296. 1 hit.
    PROSITEi PS00547. TRANSGLUTAMINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Limulus hemocyte transglutaminase. cDNA cloning, amino acid sequence, and tissue localization."
      Tokunaga F., Muta T., Iwanaga S., Ichinose A., Davie E.W., Kuma K., Miyata T.
      J. Biol. Chem. 268:262-268(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
      Tissue: Hemocyte.

    Entry informationi

    Entry nameiTGMH_TACTR
    AccessioniPrimary (citable) accession number: Q05187
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3