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Q05187

- TGMH_TACTR

UniProt

Q05187 - TGMH_TACTR

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Protein

Hemocyte protein-glutamine gamma-glutamyltransferase

Gene
N/A
Organism
Tachypleus tridentatus (Japanese horseshoe crab)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.

Catalytic activityi

Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.PROSITE-ProRule annotation

Cofactori

Ca2+By similarityNote: Binds 1 Ca(2+) ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei343 – 3431PROSITE-ProRule annotation
Active sitei402 – 4021PROSITE-ProRule annotation
Active sitei425 – 4251PROSITE-ProRule annotation
Metal bindingi465 – 4651CalciumBy similarity
Metal bindingi467 – 4671CalciumBy similarity
Metal bindingi522 – 5221CalciumBy similarity
Metal bindingi527 – 5271CalciumBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein-glutamine gamma-glutamyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. peptide cross-linking Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemocyte protein-glutamine gamma-glutamyltransferase (EC:2.3.2.13)
Alternative name(s):
Hemocyte transglutaminase
Short name:
TGase
OrganismiTachypleus tridentatus (Japanese horseshoe crab)
Taxonomic identifieri6853 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataMerostomataXiphosuraLimulidaeTachypleus

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 764764Hemocyte protein-glutamine gamma-glutamyltransferasePRO_0000213717Add
BLAST

Expressioni

Tissue specificityi

Mainly expressed in hemocytes, hepatopancreas, and gastric tissues. On the other hand nothing was detected in the heart, intestine and muscle.

Structurei

3D structure databases

ProteinModelPortaliQ05187.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05187-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYGFGRGNMF RNRSTRYRRR PRYRAENYHS YMLDLLENMN EEFGRNWWGT
60 70 80 90 100
PESHQPDSGP SSLQVESVEL YTRDNAREHN TFMYDLVDGT KPVLILRRGQ
110 120 130 140 150
PFSIAIRFKR NYNPQQDRLK LEIGFGQQPL ITKGTLIMLP VSGSDTFTKD
160 170 180 190 200
KTQWDVRLRQ HDGAVITLEI QIPAAVAVGV WKMKIVSQLT SEEQPNVSAV
210 220 230 240 250
THECKNKTYI LFNPWCKQDS VYMEDEQWRK EYVLSDVGKI FTGSFKQPVG
260 270 280 290 300
RRWIFGQFTD SVLPACMLIL ERSGLDYTAR SNPIKVVRAI SAMVNNIDDE
310 320 330 340 350
GVLEGRWQEP YDDGVAPWMW TGSSAILEKY LKTRGVPVKY GQCWVFAGVA
360 370 380 390 400
NTVSRALGIP SRTVTNYDSA HDTDDTLTID KWFDKNGDKI EDATSDSIWN
410 420 430 440 450
FHVWNDCWMA RPDLPTGYGG WQAYDSTPQE TSEGVYQTGP ASVLAVQRGE
460 470 480 490 500
IGYMFDSPFV FSEVNADVVH WQEDDSSETG YKKLKIDSYR VGRLLLTKKI
510 520 530 540 550
GVDDDFGDAD AEDITDQYKN KEGTDEERMS VLNAARSSGF NYAFNLPSPE
560 570 580 590 600
KEDVYFNLLD IEKIKIGQPF HVTVNIENQS SETRRVSAVL SASSIYYTGI
610 620 630 640 650
TGRKIKRENG NFSLQPHQKE VLSIEVTPDE YLEKLVDYAM IKLYAIATVK
660 670 680 690 700
ETQQTWSEED DFMVEKPNLE LEIRGNLQVG TAFVLAISLT NPLKRVLDNC
710 720 730 740 750
FFTIEAPGVT GAFRVTNRDI QPEEVAVHTV RLIPQKPGPR KIVATFSSRQ
760
LIQVVGSKQV EVLD
Length:764
Mass (Da):86,996
Last modified:October 1, 1996 - v1
Checksum:iD4F1D392F1DA5811
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti452 – 4521G → R.
Natural varianti477 – 4771S → C.
Natural varianti486 – 4861I → S.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D12593 mRNA. Translation: BAA02134.1.
PIRiA45321.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D12593 mRNA. Translation: BAA02134.1 .
PIRi A45321.

3D structure databases

ProteinModelPortali Q05187.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProi IPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view ]
PANTHERi PTHR11590. PTHR11590. 1 hit.
Pfami PF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000459. TGM_EBP42. 1 hit.
SMARTi SM00460. TGc. 1 hit.
[Graphical view ]
SUPFAMi SSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEi PS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Limulus hemocyte transglutaminase. cDNA cloning, amino acid sequence, and tissue localization."
    Tokunaga F., Muta T., Iwanaga S., Ichinose A., Davie E.W., Kuma K., Miyata T.
    J. Biol. Chem. 268:262-268(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Hemocyte.

Entry informationi

Entry nameiTGMH_TACTR
AccessioniPrimary (citable) accession number: Q05187
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 26, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3