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Protein

Reticulocalbin-1

Gene

Rcn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi86 – 971Add BLAST12
Calcium bindingi122 – 1332; possibly ancestralAdd BLAST12
Calcium bindingi173 – 1843Add BLAST12
Calcium bindingi210 – 2214Add BLAST12
Calcium bindingi251 – 2625Add BLAST12
Calcium bindingi287 – 2986; possibly ancestralAdd BLAST12

GO - Molecular functioni

GO - Biological processi

  • camera-type eye development Source: MGI
  • in utero embryonic development Source: MGI
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulocalbin-1
Gene namesi
Name:Rcn1
Synonyms:Rca1, Rcn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:104559. Rcn1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000000414624 – 325Reticulocalbin-1Add BLAST302

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi47N-linked (GlcNAc...); partial1
Modified residuei49PhosphoserineBy similarity1
Modified residuei74PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ05186.
MaxQBiQ05186.
PaxDbiQ05186.
PeptideAtlasiQ05186.
PRIDEiQ05186.

2D gel databases

REPRODUCTION-2DPAGEIPI00137831.

PTM databases

iPTMnetiQ05186.
PhosphoSitePlusiQ05186.

Expressioni

Gene expression databases

BgeeiENSMUSG00000005973.
CleanExiMM_RCN1.
GenevisibleiQ05186. MM.

Interactioni

Protein-protein interaction databases

BioGridi202839. 2 interactors.
IntActiQ05186. 1 interactor.
MINTiMINT-4132049.
STRINGi10090.ENSMUSP00000006128.

Structurei

3D structure databases

ProteinModelPortaliQ05186.
SMRiQ05186.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini73 – 108EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini109 – 144EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini160 – 195EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini197 – 232EF-hand 4PROSITE-ProRule annotationAdd BLAST36
Domaini238 – 273EF-hand 5PROSITE-ProRule annotationAdd BLAST36
Domaini274 – 309EF-hand 6PROSITE-ProRule annotationAdd BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi322 – 325Prevents secretion from ER4

Sequence similaritiesi

Belongs to the CREC family.Curated
Contains 6 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG4223. Eukaryota.
ENOG410XRVE. LUCA.
GeneTreeiENSGT00550000074546.
HOGENOMiHOG000230934.
HOVERGENiHBG002834.
InParanoidiQ05186.
OMAiIADMFAH.
OrthoDBiEOG091G0GUL.
PhylomeDBiQ05186.
TreeFamiTF314849.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR027241. Rcn1.
[Graphical view]
PANTHERiPTHR10827:SF17. PTHR10827:SF17. 1 hit.
PfamiPF13202. EF-hand_5. 3 hits.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 6 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05186-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGGRLGLA LGLLLALVLA LRAKPTVRKE RVVRPDSELG ERPPEDNQSF
60 70 80 90 100
QYDHEAFLGK EDSKTFDQLS PDESKERLGK IVDRIDSDGD GLVTTEELKL
110 120 130 140 150
WIKRVQKRYI YDNVAKVWKD YDRDKDEKIS WEEYKQATYG YYLGNPAEFH
160 170 180 190 200
DSSDHHTFKK MLPRDERRFK ASDLDGDLTA TREEFTAFLH PEEFEHMKEI
210 220 230 240 250
VVLETLEDID KNGDGFVDQD EYIADMFSHE DNGPEPDWVL SEREQFNDFR
260 270 280 290 300
DLNKDGKLDK DEIRHWILPQ DYDHAQAEAR HLVYESDKNK DEMLTKEEIL
310 320
DNWNMFVGSQ ATNYGEDLTK NHDEL
Length:325
Mass (Da):38,113
Last modified:June 1, 1994 - v1
Checksum:i0470B10B5A8BC76D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24K → G AA sequence (PubMed:7523108).Curated1
Sequence conflicti34R → I AA sequence (PubMed:7523108).Curated1
Sequence conflicti37 – 39SEL → DEE AA sequence (PubMed:7523108).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13003 mRNA. Translation: BAA02366.1.
D43956 Genomic DNA. Translation: BAA07896.1.
BC049108 mRNA. Translation: AAH49108.1.
AK017494 mRNA. Translation: BAB30773.1.
AK133971 mRNA. Translation: BAE21962.1.
AK159973 mRNA. Translation: BAE35525.1.
CCDSiCCDS16498.1.
PIRiA45337.
RefSeqiNP_033063.1. NM_009037.2.
UniGeneiMm.4876.

Genome annotation databases

EnsembliENSMUST00000006128; ENSMUSP00000006128; ENSMUSG00000005973.
GeneIDi19672.
KEGGimmu:19672.
UCSCiuc008lks.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13003 mRNA. Translation: BAA02366.1.
D43956 Genomic DNA. Translation: BAA07896.1.
BC049108 mRNA. Translation: AAH49108.1.
AK017494 mRNA. Translation: BAB30773.1.
AK133971 mRNA. Translation: BAE21962.1.
AK159973 mRNA. Translation: BAE35525.1.
CCDSiCCDS16498.1.
PIRiA45337.
RefSeqiNP_033063.1. NM_009037.2.
UniGeneiMm.4876.

3D structure databases

ProteinModelPortaliQ05186.
SMRiQ05186.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202839. 2 interactors.
IntActiQ05186. 1 interactor.
MINTiMINT-4132049.
STRINGi10090.ENSMUSP00000006128.

PTM databases

iPTMnetiQ05186.
PhosphoSitePlusiQ05186.

2D gel databases

REPRODUCTION-2DPAGEIPI00137831.

Proteomic databases

EPDiQ05186.
MaxQBiQ05186.
PaxDbiQ05186.
PeptideAtlasiQ05186.
PRIDEiQ05186.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006128; ENSMUSP00000006128; ENSMUSG00000005973.
GeneIDi19672.
KEGGimmu:19672.
UCSCiuc008lks.1. mouse.

Organism-specific databases

CTDi5954.
MGIiMGI:104559. Rcn1.

Phylogenomic databases

eggNOGiKOG4223. Eukaryota.
ENOG410XRVE. LUCA.
GeneTreeiENSGT00550000074546.
HOGENOMiHOG000230934.
HOVERGENiHBG002834.
InParanoidiQ05186.
OMAiIADMFAH.
OrthoDBiEOG091G0GUL.
PhylomeDBiQ05186.
TreeFamiTF314849.

Miscellaneous databases

ChiTaRSiRcn1. mouse.
PROiQ05186.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005973.
CleanExiMM_RCN1.
GenevisibleiQ05186. MM.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR027241. Rcn1.
[Graphical view]
PANTHERiPTHR10827:SF17. PTHR10827:SF17. 1 hit.
PfamiPF13202. EF-hand_5. 3 hits.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 6 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRCN1_MOUSE
AccessioniPrimary (citable) accession number: Q05186
Secondary accession number(s): Q3TVU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 30, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein has four functional calcium-binding sites; potential sites II and VI have lost affinity for calcium.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.