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Protein

Reticulocalbin-1

Gene

Rcn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment.

Miscellaneous

This protein has four functional calcium-binding sites; potential sites II and VI have lost affinity for calcium.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi86 – 971Add BLAST12
Calcium bindingi122 – 1332; possibly ancestralAdd BLAST12
Calcium bindingi173 – 1843Add BLAST12
Calcium bindingi210 – 2214Add BLAST12
Calcium bindingi251 – 2625Add BLAST12
Calcium bindingi287 – 2986; possibly ancestralAdd BLAST12

GO - Molecular functioni

GO - Biological processi

  • camera-type eye development Source: MGI
  • in utero embryonic development Source: MGI

Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulocalbin-1
Gene namesi
Name:Rcn1
Synonyms:Rca1, Rcn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:104559 Rcn1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000000414624 – 325Reticulocalbin-1Add BLAST302

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi47N-linked (GlcNAc...) asparagine; partial1
Modified residuei49PhosphoserineBy similarity1
Modified residuei74PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ05186
MaxQBiQ05186
PaxDbiQ05186
PeptideAtlasiQ05186
PRIDEiQ05186

2D gel databases

REPRODUCTION-2DPAGEiIPI00137831

PTM databases

iPTMnetiQ05186
PhosphoSitePlusiQ05186

Expressioni

Gene expression databases

BgeeiENSMUSG00000005973
CleanExiMM_RCN1
GenevisibleiQ05186 MM

Interactioni

Protein-protein interaction databases

BioGridi202839, 2 interactors
IntActiQ05186, 1 interactor
MINTiQ05186
STRINGi10090.ENSMUSP00000006128

Structurei

3D structure databases

ProteinModelPortaliQ05186
SMRiQ05186
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini73 – 108EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini109 – 144EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini160 – 195EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini197 – 232EF-hand 4PROSITE-ProRule annotationAdd BLAST36
Domaini238 – 273EF-hand 5PROSITE-ProRule annotationAdd BLAST36
Domaini274 – 309EF-hand 6PROSITE-ProRule annotationAdd BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi322 – 325Prevents secretion from ER4

Sequence similaritiesi

Belongs to the CREC family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG4223 Eukaryota
ENOG410XRVE LUCA
GeneTreeiENSGT00550000074546
HOGENOMiHOG000230934
HOVERGENiHBG002834
InParanoidiQ05186
OMAiRTEYGCF
OrthoDBiEOG091G0GUL
PhylomeDBiQ05186
TreeFamiTF314849

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR027241 Rcn1
PANTHERiPTHR10827:SF17 PTHR10827:SF17, 1 hit
PfamiView protein in Pfam
PF13202 EF-hand_5, 3 hits
SMARTiView protein in SMART
SM00054 EFh, 3 hits
SUPFAMiSSF47473 SSF47473, 2 hits
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 3 hits
PS50222 EF_HAND_2, 6 hits
PS00014 ER_TARGET, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05186-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGGRLGLA LGLLLALVLA LRAKPTVRKE RVVRPDSELG ERPPEDNQSF
60 70 80 90 100
QYDHEAFLGK EDSKTFDQLS PDESKERLGK IVDRIDSDGD GLVTTEELKL
110 120 130 140 150
WIKRVQKRYI YDNVAKVWKD YDRDKDEKIS WEEYKQATYG YYLGNPAEFH
160 170 180 190 200
DSSDHHTFKK MLPRDERRFK ASDLDGDLTA TREEFTAFLH PEEFEHMKEI
210 220 230 240 250
VVLETLEDID KNGDGFVDQD EYIADMFSHE DNGPEPDWVL SEREQFNDFR
260 270 280 290 300
DLNKDGKLDK DEIRHWILPQ DYDHAQAEAR HLVYESDKNK DEMLTKEEIL
310 320
DNWNMFVGSQ ATNYGEDLTK NHDEL
Length:325
Mass (Da):38,113
Last modified:June 1, 1994 - v1
Checksum:i0470B10B5A8BC76D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24K → G AA sequence (PubMed:7523108).Curated1
Sequence conflicti34R → I AA sequence (PubMed:7523108).Curated1
Sequence conflicti37 – 39SEL → DEE AA sequence (PubMed:7523108).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13003 mRNA Translation: BAA02366.1
D43956 Genomic DNA Translation: BAA07896.1
BC049108 mRNA Translation: AAH49108.1
AK017494 mRNA Translation: BAB30773.1
AK133971 mRNA Translation: BAE21962.1
AK159973 mRNA Translation: BAE35525.1
CCDSiCCDS16498.1
PIRiA45337
RefSeqiNP_033063.1, NM_009037.2
UniGeneiMm.4876

Genome annotation databases

EnsembliENSMUST00000006128; ENSMUSP00000006128; ENSMUSG00000005973
GeneIDi19672
KEGGimmu:19672
UCSCiuc008lks.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRCN1_MOUSE
AccessioniPrimary (citable) accession number: Q05186
Secondary accession number(s): Q3TVU3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: February 28, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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