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Protein

L-lysine-epsilon aminotransferase

Gene

lat

Organism
Amycolatopsis lactamdurans (Nocardia lactamdurans)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-lysine + 2-oxoglutarate = (S)-2-amino-6-oxohexanoate + L-glutamate.

Cofactori

Pathwayi: cephamycin C biosynthesis

This protein is involved in the pathway cephamycin C biosynthesis, which is part of Antibiotic biosynthesis.
View all proteins of this organism that are known to be involved in the pathway cephamycin C biosynthesis and in Antibiotic biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
Biological processAntibiotic biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00183.

Names & Taxonomyi

Protein namesi
Recommended name:
L-lysine-epsilon aminotransferase (EC:2.6.1.36)
Short name:
L-lysine aminotransferase
Alternative name(s):
Lysine 6-aminotransferase
Gene namesi
Name:lat
OrganismiAmycolatopsis lactamdurans (Nocardia lactamdurans)
Taxonomic identifieri1913 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPseudonocardialesPseudonocardiaceaeAmycolatopsis

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001205101 – 450L-lysine-epsilon aminotransferaseAdd BLAST450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei300N6-(pyridoxal phosphate)lysineSequence analysis1

Interactioni

Subunit structurei

Active as either a monomer or a homopolymer.

Structurei

3D structure databases

ProteinModelPortaliQ05174.
SMRiQ05174.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

CDDicd00610. OAT_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiView protein in InterPro
IPR005814. Aminotrans_3.
IPR017657. L-lysine_6-transaminase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_sub2.
PfamiView protein in Pfam
PF00202. Aminotran_3. 1 hit.
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR03251. LAT_fam. 1 hit.
PROSITEiView protein in PROSITE
PS00600. AA_TRANSFER_CLASS_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q05174-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLEMPAARV PAGPDARDVR QALARHVLTD GYDLVLDLEA SAGPWLVDAV
60 70 80 90 100
TGTRYLDLFS FFASAPLGIN PSCIVDDPAF VGELAAAAVN KPSNPDVYTV
110 120 130 140 150
PYAKFVTTFA RVLGDPLLPH LFFVDGGALA VENALKAAFD WKAQKLGLDD
160 170 180 190 200
RAVNRLQVLH LERSFHGRSG YTMSLTNTDP SKTARYPKFD WPRIPAPALE
210 220 230 240 250
HPLTTHAEAN REAERRALEA AEEAFRAADG MIACFLAEPI QGEGGDNHFS
260 270 280 290 300
AEFLQAMQDL CHRHDALFVL DEVQSGCGLT GTAWAYQQLG LRPDLVAFGK
310 320 330 340 350
KTQVCGVMGG GRIGEVESNV FAVSSRISST WGGNLADMVR ATRVLETIER
360 370 380 390 400
TDLLDSVVQR GKYLRDGLEA LAERHPGVVT NARGRGLMCA VDLPDTEQRD
410 420 430 440 450
AVLRRMYTGH QVIALPCGTR GLRFRPPLTV TESELDQGLE ALAASLASRG
Length:450
Mass (Da):48,806
Last modified:February 1, 1994 - v1
Checksum:iC24915CAF2E93EE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21681 Genomic DNA. Translation: CAA79796.1.
PIRiA38171.

Similar proteinsi

Entry informationi

Entry nameiLAT_AMYLA
AccessioniPrimary (citable) accession number: Q05174
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 12, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families