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Q05156

- GUN1_STRRE

UniProt

Q05156 - GUN1_STRRE

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Protein
Cellulase 1
Gene
cel1
Organism
Streptomyces reticuli
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

This endoglucanase acts only on crystalline cellulose.

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei669 – 6691 By similarity
Active sitei717 – 7171 By similarity
Active sitei726 – 7261 By similarity

GO - Molecular functioni

  1. cellulase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Protein family/group databases

CAZyiCBM4. Carbohydrate-Binding Module Family 4.
GH9. Glycoside Hydrolase Family 9.

Names & Taxonomyi

Protein namesi
Recommended name:
Cellulase 1 (EC:3.2.1.4)
Alternative name(s):
Avicelase
Endo-1,4-beta-glucanase
Endoglucanase
Gene namesi
Name:cel1
OrganismiStreptomyces reticuli
Taxonomic identifieri1926 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 29291 Publication
Add
BLAST
Chaini30 – 746717Cellulase 1
PRO_0000007958Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ05156.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 170126CBM-cenC
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni171 – 21141Linker
Add
BLAST
Regioni212 – 746535Catalytic
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di1.50.10.10. 1 hit.
2.60.120.260. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR012341. 6hp_glycosidase.
IPR003305. CenC_carb-bd.
IPR008979. Galactose-bd-like.
IPR001701. Glyco_hydro_9.
IPR018221. Glyco_hydro_9_AS.
IPR004197. Glyco_hydro_9_Ig-like.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
[Graphical view]
PfamiPF02018. CBM_4_9. 1 hit.
PF02927. CelD_N. 1 hit.
PF00759. Glyco_hydro_9. 1 hit.
[Graphical view]
SUPFAMiSSF48208. SSF48208. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00698. GLYCOSYL_HYDROL_F9_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05156-1 [UniParc]FASTAAdd to Basket

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MKRRTTAVLT LTALLGTALT ALPVQQAGAE EVEQVRNGTF DTTTDPWWTS    50
NVTAGLSDGR LCADVPGGTT NRWDSAIGQN DITLVKGETY RFSFHASGIP 100
EGHVVRAVVG LAVSPYDTWQ EASPVLTEAD GSYSYTFTAP VDTTQGQVAF 150
QVGGSTDAWR FCVDDVSLLG GVPPEVYEPD TGPRVRVNQV AYLPAGPKNA 200
TLVTDATARL PWQLRNAQGT TVARGLTVPR GVDASSGQNV HSIDFGSYRG 250
RGTGYTLVAD GETSHPFDID AAAYRPLRLD SVKYYYTQRS GIAIRDDLRP 300
GYGRAAGHLN VAPNQGDANV PCQPGVCDYT LDVTGGWYDA GDHGKYVVNG 350
GIATWELLST YERSLTARTG HPAALGDGTL ALPESGNKVP DVLDEARWEL 400
EFLLKMQVPA GQPLAGMAHH KLHDEQWTGL PLLPDQDPQK RELHPPTTAA 450
TLNLAATAAQ AARLYRPFDK AFAARALTAA RTAWQAALAH PDLLADPNDG 500
TGGGAYNDDD VTDEFYWAAA ELYLTTGERQ FADHVLDSPV HTADIFGPTG 550
FDWGHTAAAG RLDLALVPSR LPGRDQVRRS VIKAADTYLA TLTAHPYGMP 600
YAPAGNRYDW GSSHQVLNNG VVLASAYDLT GAAKYRDGAL QGMDYVLGRN 650
ALNMSYVTGY GEVSSHNQHS RWYAHQLDPT LPNPPSGTLA GGPNSSIQDP 700
YAQSKLTGCV GQFCYIDDIQ SWSTNETAIN WNAALARMAS FAADQG 746
Length:746
Mass (Da):80,000
Last modified:June 1, 1994 - v1
Checksum:iFDF1ADB4714A35FD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X65616 Genomic DNA. Translation: CAA46570.1.
PIRiS27985.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X65616 Genomic DNA. Translation: CAA46570.1 .
PIRi S27985.

3D structure databases

ProteinModelPortali Q05156.
ModBasei Search...

Protein family/group databases

CAZyi CBM4. Carbohydrate-Binding Module Family 4.
GH9. Glycoside Hydrolase Family 9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.50.10.10. 1 hit.
2.60.120.260. 1 hit.
2.60.40.10. 1 hit.
InterProi IPR008928. 6-hairpin_glycosidase-like.
IPR012341. 6hp_glycosidase.
IPR003305. CenC_carb-bd.
IPR008979. Galactose-bd-like.
IPR001701. Glyco_hydro_9.
IPR018221. Glyco_hydro_9_AS.
IPR004197. Glyco_hydro_9_Ig-like.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
[Graphical view ]
Pfami PF02018. CBM_4_9. 1 hit.
PF02927. CelD_N. 1 hit.
PF00759. Glyco_hydro_9. 1 hit.
[Graphical view ]
SUPFAMi SSF48208. SSF48208. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEi PS00698. GLYCOSYL_HYDROL_F9_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The gene encoding the cellulase (Avicelase) Cel1 from Streptomyces reticuli and analysis of protein domains."
    Schlochtermeier A., Walter S., Schroeder J., Moorman M., Schrempf H.
    Mol. Microbiol. 6:3611-3621(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 30-41 AND 379-391.
    Strain: Tu45.

Entry informationi

Entry nameiGUN1_STRRE
AccessioniPrimary (citable) accession number: Q05156
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: February 19, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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