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Q05156

- GUN1_STRRE

UniProt

Q05156 - GUN1_STRRE

Protein

Cellulase 1

Gene

cel1

Organism
Streptomyces reticuli
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    This endoglucanase acts only on crystalline cellulose.

    Catalytic activityi

    Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei669 – 6691PROSITE-ProRule annotation
    Active sitei717 – 7171PROSITE-ProRule annotation
    Active sitei726 – 7261PROSITE-ProRule annotation

    GO - Molecular functioni

    1. cellulase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellulose catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

    Protein family/group databases

    CAZyiCBM4. Carbohydrate-Binding Module Family 4.
    GH9. Glycoside Hydrolase Family 9.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cellulase 1 (EC:3.2.1.4)
    Alternative name(s):
    Avicelase
    Endo-1,4-beta-glucanase
    Endoglucanase
    Gene namesi
    Name:cel1
    OrganismiStreptomyces reticuli
    Taxonomic identifieri1926 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

    Subcellular locationi


    Note: Exists in both mycelium-associated and extracellular forms.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 29291 PublicationAdd
    BLAST
    Chaini30 – 746717Cellulase 1PRO_0000007958Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ05156.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini45 – 170126CBM-cenCAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni171 – 21141LinkerAdd
    BLAST
    Regioni212 – 746535CatalyticAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di1.50.10.10. 1 hit.
    2.60.120.260. 1 hit.
    2.60.40.10. 1 hit.
    InterProiIPR008928. 6-hairpin_glycosidase-like.
    IPR012341. 6hp_glycosidase.
    IPR003305. CenC_carb-bd.
    IPR008979. Galactose-bd-like.
    IPR001701. Glyco_hydro_9.
    IPR018221. Glyco_hydro_9_AS.
    IPR004197. Glyco_hydro_9_Ig-like.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    [Graphical view]
    PfamiPF02018. CBM_4_9. 1 hit.
    PF02927. CelD_N. 1 hit.
    PF00759. Glyco_hydro_9. 1 hit.
    [Graphical view]
    SUPFAMiSSF48208. SSF48208. 1 hit.
    SSF49785. SSF49785. 1 hit.
    SSF81296. SSF81296. 1 hit.
    PROSITEiPS00698. GLYCOSYL_HYDROL_F9_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q05156-1 [UniParc]FASTAAdd to Basket

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    MKRRTTAVLT LTALLGTALT ALPVQQAGAE EVEQVRNGTF DTTTDPWWTS    50
    NVTAGLSDGR LCADVPGGTT NRWDSAIGQN DITLVKGETY RFSFHASGIP 100
    EGHVVRAVVG LAVSPYDTWQ EASPVLTEAD GSYSYTFTAP VDTTQGQVAF 150
    QVGGSTDAWR FCVDDVSLLG GVPPEVYEPD TGPRVRVNQV AYLPAGPKNA 200
    TLVTDATARL PWQLRNAQGT TVARGLTVPR GVDASSGQNV HSIDFGSYRG 250
    RGTGYTLVAD GETSHPFDID AAAYRPLRLD SVKYYYTQRS GIAIRDDLRP 300
    GYGRAAGHLN VAPNQGDANV PCQPGVCDYT LDVTGGWYDA GDHGKYVVNG 350
    GIATWELLST YERSLTARTG HPAALGDGTL ALPESGNKVP DVLDEARWEL 400
    EFLLKMQVPA GQPLAGMAHH KLHDEQWTGL PLLPDQDPQK RELHPPTTAA 450
    TLNLAATAAQ AARLYRPFDK AFAARALTAA RTAWQAALAH PDLLADPNDG 500
    TGGGAYNDDD VTDEFYWAAA ELYLTTGERQ FADHVLDSPV HTADIFGPTG 550
    FDWGHTAAAG RLDLALVPSR LPGRDQVRRS VIKAADTYLA TLTAHPYGMP 600
    YAPAGNRYDW GSSHQVLNNG VVLASAYDLT GAAKYRDGAL QGMDYVLGRN 650
    ALNMSYVTGY GEVSSHNQHS RWYAHQLDPT LPNPPSGTLA GGPNSSIQDP 700
    YAQSKLTGCV GQFCYIDDIQ SWSTNETAIN WNAALARMAS FAADQG 746
    Length:746
    Mass (Da):80,000
    Last modified:June 1, 1994 - v1
    Checksum:iFDF1ADB4714A35FD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X65616 Genomic DNA. Translation: CAA46570.1.
    PIRiS27985.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X65616 Genomic DNA. Translation: CAA46570.1 .
    PIRi S27985.

    3D structure databases

    ProteinModelPortali Q05156.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi CBM4. Carbohydrate-Binding Module Family 4.
    GH9. Glycoside Hydrolase Family 9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.50.10.10. 1 hit.
    2.60.120.260. 1 hit.
    2.60.40.10. 1 hit.
    InterProi IPR008928. 6-hairpin_glycosidase-like.
    IPR012341. 6hp_glycosidase.
    IPR003305. CenC_carb-bd.
    IPR008979. Galactose-bd-like.
    IPR001701. Glyco_hydro_9.
    IPR018221. Glyco_hydro_9_AS.
    IPR004197. Glyco_hydro_9_Ig-like.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    [Graphical view ]
    Pfami PF02018. CBM_4_9. 1 hit.
    PF02927. CelD_N. 1 hit.
    PF00759. Glyco_hydro_9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48208. SSF48208. 1 hit.
    SSF49785. SSF49785. 1 hit.
    SSF81296. SSF81296. 1 hit.
    PROSITEi PS00698. GLYCOSYL_HYDROL_F9_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The gene encoding the cellulase (Avicelase) Cel1 from Streptomyces reticuli and analysis of protein domains."
      Schlochtermeier A., Walter S., Schroeder J., Moorman M., Schrempf H.
      Mol. Microbiol. 6:3611-3621(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 30-41 AND 379-391.
      Strain: Tu45.

    Entry informationi

    Entry nameiGUN1_STRRE
    AccessioniPrimary (citable) accession number: Q05156
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3