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Protein

Ras-related C3 botulinum toxin substrate 2

Gene

Rac2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase.

Enzyme regulationi

Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 17GTPBy similarity8
Nucleotide bindingi57 – 61GTPBy similarity5
Nucleotide bindingi115 – 118GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: MGI
  • GTP binding Source: MGI
  • protein kinase regulator activity Source: CACAO

GO - Biological processi

  • actin cytoskeleton organization Source: MGI
  • actin filament organization Source: MGI
  • bone resorption Source: Ensembl
  • cell projection assembly Source: MGI
  • chemotaxis Source: MGI
  • G-protein coupled receptor signaling pathway Source: MGI
  • lymphocyte aggregation Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of lamellipodium assembly Source: UniProtKB
  • positive regulation of neutrophil chemotaxis Source: UniProtKB
  • positive regulation of protein targeting to mitochondrion Source: MGI
  • regulation of cell-substrate adhesion Source: MGI
  • regulation of mast cell chemotaxis Source: CACAO
  • regulation of mast cell degranulation Source: CACAO
  • regulation of neutrophil migration Source: MGI
  • regulation of respiratory burst Source: MGI
  • regulation of T cell proliferation Source: CACAO
  • small GTPase mediated signal transduction Source: InterPro

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-114604 GPVI-mediated activation cascade
R-MMU-194840 Rho GTPase cycle
R-MMU-4086400 PCP/CE pathway
R-MMU-416482 G alpha (12/13) signalling events
R-MMU-5668599 RHO GTPases Activate NADPH Oxidases

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related C3 botulinum toxin substrate 2
Alternative name(s):
Protein EN-7
p21-Rac2
Gene namesi
Name:Rac2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:97846 Rac2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000420481 – 189Ras-related C3 botulinum toxin substrate 2Add BLAST189
PropeptideiPRO_0000042049190 – 192Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei147N6-acetyllysineBy similarity1
Modified residuei189Cysteine methyl esterBy similarity1
Lipidationi189S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiQ05144
MaxQBiQ05144
PaxDbiQ05144
PeptideAtlasiQ05144
PRIDEiQ05144

PTM databases

iPTMnetiQ05144
PhosphoSitePlusiQ05144
SwissPalmiQ05144

Expressioni

Gene expression databases

BgeeiENSMUSG00000033220
CleanExiMM_RAC2
GenevisibleiQ05144 MM

Interactioni

Subunit structurei

Interacts with DOCK2, which may activate it. Interacts with S100A8 and calprotectin (S100A8/9).By similarity

Protein-protein interaction databases

BioGridi202557, 5 interactors
DIPiDIP-41834N
IntActiQ05144, 3 interactors
MINTiQ05144
STRINGi10090.ENSMUSP00000036384

Structurei

3D structure databases

ProteinModelPortaliQ05144
SMRiQ05144
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi32 – 40Effector regionSequence analysis9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Phylogenomic databases

eggNOGiKOG0393 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00760000118978
HOGENOMiHOG000233974
HOVERGENiHBG009351
InParanoidiQ05144
KOiK07860
OMAiLICYSIM
OrthoDBiEOG091G0KCM
PhylomeDBiQ05144
TreeFamiTF101109

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR003578 Small_GTPase_Rho
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51420 RHO, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05144-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDSKP
60 70 80 90 100
VNLGLWDTAG QEDYDRLRPL SYPQTDVFLI CFSLVSPASY ENVRAKWFPE
110 120 130 140 150
VRHHCPSTPI ILVGTKLDLR DDKDTIEKLK EKKLAPITYP QGLALAKDID
160 170 180 190
SVKYLECSAL TQRGLKTVFD EAIRAVLCPQ PTRQQKRPCS LL
Length:192
Mass (Da):21,441
Last modified:February 1, 1994 - v1
Checksum:i2A1F1266AB9D7705
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti60G → V in BAB25109 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53247 mRNA Translation: CAA37337.1
AK007561 mRNA Translation: BAB25109.1
AK144136 mRNA Translation: BAE25721.1
AK171321 mRNA Translation: BAE42390.1
BC005455 mRNA Translation: AAH05455.1
CCDSiCCDS27619.1
PIRiA60194
RefSeqiNP_033034.1, NM_009008.3
UniGeneiMm.1972

Genome annotation databases

EnsembliENSMUST00000043214; ENSMUSP00000036384; ENSMUSG00000033220
GeneIDi19354
KEGGimmu:19354
UCSCiuc007wpp.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRAC2_MOUSE
AccessioniPrimary (citable) accession number: Q05144
Secondary accession number(s): Q3TBC4, Q9D8X9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: March 28, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health