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Q05143

- COX1_PROWI

UniProt

Q05143 - COX1_PROWI

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Protein
Cytochrome c oxidase subunit 1
Gene
COX1, COXI
Organism
Prototheca wickerhamii
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi62 – 621Iron (heme A axial ligand) Inferred
Metal bindingi240 – 2401Copper B Inferred
Metal bindingi244 – 2441Copper B Inferred
Metal bindingi289 – 2891Copper B Inferred
Metal bindingi290 – 2901Copper B Inferred
Metal bindingi375 – 3751Iron (heme A3 axial ligand) Inferred
Metal bindingi377 – 3771Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. electron transport chain Source: InterPro
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COX1
Synonyms:COXI
Encoded oniMitochondrion
OrganismiPrototheca wickerhamii
Taxonomic identifieri3111 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeChlorophytaTrebouxiophyceaeChlorellalesChlorellaceaePrototheca

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621Helical; Reviewed prediction
Add
BLAST
Transmembranei57 – 7721Helical; Reviewed prediction
Add
BLAST
Transmembranei78 – 9821Helical; Reviewed prediction
Add
BLAST
Transmembranei101 – 12121Helical; Reviewed prediction
Add
BLAST
Transmembranei146 – 16621Helical; Reviewed prediction
Add
BLAST
Transmembranei182 – 20221Helical; Reviewed prediction
Add
BLAST
Transmembranei234 – 25421Helical; Reviewed prediction
Add
BLAST
Transmembranei266 – 28621Helical; Reviewed prediction
Add
BLAST
Transmembranei309 – 32921Helical; Reviewed prediction
Add
BLAST
Transmembranei337 – 35721Helical; Reviewed prediction
Add
BLAST
Transmembranei376 – 39621Helical; Reviewed prediction
Add
BLAST
Transmembranei413 – 43321Helical; Reviewed prediction
Add
BLAST
Transmembranei451 – 47121Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. plasma membrane Source: InterPro
  4. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 514514Cytochrome c oxidase subunit 1
PRO_0000183403Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki240 ↔ 2441'-histidyl-3'-tyrosine (His-Tyr) By similarity

Structurei

3D structure databases

ProteinModelPortaliQ05143.
SMRiQ05143. Positions 2-511.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05143-1 [UniParc]FASTAAdd to Basket

« Hide

MVTRWLYSTN HKDIGTMYLI FGAFSGVLGT VFSLLIRMEL AQPGNQILNG    50
NHQLYNVIIT AHAFLMIFFM LMPALMGGFG NWFLPILIGA PDMAFPRLNN 100
ISFWLLPPSL LLLVSSALVE VGAGTGWTVY PPLASIASHS GGSVDLAIFS 150
LHLAGVSSIL GAINFICTVF NMRAPGMSML DLLFVWAVFI TAWLLLLCLP 200
VLAGGITMLL TDRNFNTSFF DPAGGGDPIL YQHLFWFFGH PEVYILIIPG 250
FGIISHVIAT FSKKPIFGYL GMVYAMCSIG ILGFIVWAHH MYVVGLDIDT 300
RAYFTAATMI IAVPTGIKIF SWVATMWGGS IELRTPMLFA VGFLFLFTVG 350
GLTGVVLANS GLDVAFHDTY YVVAHFHYVL SMGAVFALFS GFYYWIGKIT 400
GLQYPETLGQ IHFWLMFLGV NITFFPMHFL GLAGMPRRIP DYPDCYAGWN 450
AVASYGSYLS ITAVLFFFYV VYKTLTSNEV CPRNPWETTP GVSPTLEWML 500
PSPPAFHTFE EIQV 514
Length:514
Mass (Da):56,874
Last modified:June 1, 1994 - v1
Checksum:iC5219A94E8F1BF22
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X68721 Genomic DNA. Translation: CAA48661.1.
PIRiS30291.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X68721 Genomic DNA. Translation: CAA48661.1 .
PIRi S30291.

3D structure databases

ProteinModelPortali Q05143.
SMRi Q05143. Positions 2-511.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mitochondrial genes in the colourless alga Prototheca wickerhamii resemble plant genes in their exons but fungal genes in their introns."
    Wolff G., Burger G., Lang B.F., Kueck U.
    Nucleic Acids Res. 21:719-726(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCOX1_PROWI
AccessioniPrimary (citable) accession number: Q05143
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: September 3, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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