ID   PO23_POPJA              Reviewed;         606 AA.
AC   Q05118;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   16-JUN-2009, entry version 43.
DE   RecName: Full=Retrovirus-related Pol polyprotein from type-1 retrotransposable element R2;
DE   AltName: Full=Retrovirus-related Pol polyprotein from type I retrotransposable element R2;
DE   Includes:
DE     RecName: Full=Reverse transcriptase;
DE              EC=2.7.7.49;
DE   Includes:
DE     RecName: Full=Endonuclease;
DE   Flags: Fragment;
OS   Popillia japonica (Japanese beetle).
OC   Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Scarabaeiformia;
OC   Scarabaeidae; Rutelinae; Popillia.
OX   NCBI_TaxID=7064;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=93196484; PubMed=8383793;
RA   Burke W.D., Eickbush D.G., Xiong Y., Jakubczak J.L., Eickbush T.H.;
RT   "Sequence relationship of retrotransposable elements R1 and R2 within
RT   and between divergent insect species.";
RL   Mol. Biol. Evol. 10:163-185(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 422-439.
RX   PubMed=1849649; DOI=10.1073/pnas.88.8.3295;
RA   Jakubczak J.L., Burke W.D., Eickbush T.H.;
RT   "Retrotransposable elements R1 and R2 interrupt the rRNA genes of most
RT   insects.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:3295-3299(1991).
CC   -!- CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) =
CC       diphosphate + DNA(n+1).
CC   -!- SIMILARITY: Contains 1 reverse transcriptase domain.
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DR   EMBL; L00948; AAA29786.1; -; Genomic_DNA.
DR   PIR; A47757; A47757.
DR   BRENDA; 2.7.7.49; 295234.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006278; P:RNA-dependent DNA replication; IEA:InterPro.
DR   GO; GO:0032196; P:transposition; IEA:UniProtKB-KW.
DR   InterPro; IPR000477; DNA_pol_RVTase.
DR   InterPro; IPR015706; Reverse_transcriptase-related.
DR   PANTHER; PTHR19446; Rev_txptase; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Endonuclease; Hydrolase; Nuclease; Nucleotidyltransferase;
KW   RNA-directed DNA polymerase; Transferase; Transposable element.
FT   CHAIN        <1    606       Retrovirus-related Pol polyprotein from
FT                                type-1 retrotransposable element R2.
FT                                /FTId=PRO_0000058501.
FT   DOMAIN       <1    208       Reverse transcriptase.
FT   REGION      331    606       Nucleic acid-binding endonuclease.
FT   NON_TER       1      1
SQ   SEQUENCE   606 AA;  68368 MW;  B70DB4D5B099069C CRC64;
     GTLANIIMLE HYIKLRRLKG KTYNVVSLDI RKAFDTVSHP AILRAMRAFG IDDGMQDFIM
     STITDAYTNI VVGGRTTNKI YIRNGVKQGD PLSPVLFNIV LDELVTRLND EQPGASMTPA
     CKIASLAFAD DLLLLEDRDI DVPNSLATTC AYFRTRGMTL NPEKCASISA ATVSGRSVPR
     SKPSFTIDGR YIKPLGGINT FKYLGLTFSS TGVAKPTVYN LTRWLRNLEK APLKPNQKFY
     ILKTHLLPRL FYGLQSPGVT AGILQECDRL ARRTTRKIFH LNVHTGSQFL HARIRDGGLG
     LVQMRYRIPC ILSKRLGSLK QGNDTTNWSD IFNIEGPARS FYFRIRFLSS KGDPDPYWRE
     EIRTRPLSSG LQDAADDASS RSWLNTIPRG WTGRDFVRAV QLRTGNLATQ GLPYMAPEHR
     GCRNGCPRTE SLSHVLQGCP LTHHERIKRH NELVAKVAKH ARKKGWTTEV EPYVYHQDGQ
     LYKPDLAIHQ PDNTLVICDV QVCWEGPRPL ATSWDNKRLV YDNPRFREAA VRRWGDKSLV
     FSPLLLGARG IWPRANVPTC NILSIPTTLR ASCVHTCLKW GSTIHRHFMA GVWRRRPPDP
     PRPVPP
//