Q05118 (PO23_POPJA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Retrovirus-related Pol polyprotein from type-1 retrotransposable element R2 Alternative name(s): Retrovirus-related Pol polyprotein from type I retrotransposable element R2 Including the following 2 domains: Reverse transcriptase EC=2.7.7.49 Endonuclease
Organism	Popillia japonica (Japanese beetle)
Taxonomic identifier	7064 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Coleoptera › Polyphaga › Scarabaeiformia › Scarabaeidae › Rutelinae › Popillia

Protein attributes

Sequence length	606 AA.
Sequence status	Fragment.
Protein existence	Predicted

General annotation (Comments)

Catalytic activity	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
Sequence similarities	Contains 1 reverse transcriptase domain.

Ontologies

Keywords
Molecular function	Endonuclease Hydrolase Nuclease Nucleotidyltransferase RNA-directed DNA polymerase Transferase
Technical term	Transposable element
Gene Ontology (GO)
Biological process	RNA-dependent DNA replication Inferred from electronic annotation. Source: InterPro
Molecular function	RNA binding Inferred from electronic annotation. Source: InterPro RNA-directed DNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW endonuclease activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 606	›606	Retrovirus-related Pol polyprotein from type-1 retrotransposable element R2		PRO_0000058501
Regions
	Domain	‹1 – 208	›208	Reverse transcriptase
	Region	331 – 606	276	Nucleic acid-binding endonuclease
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	Q05118 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: B70DB4D5B099069C	FASTA	606	68,368
	10 20 30 40 50 60 GTLANIIMLE HYIKLRRLKG KTYNVVSLDI RKAFDTVSHP AILRAMRAFG IDDGMQDFIM 70 80 90 100 110 120 STITDAYTNI VVGGRTTNKI YIRNGVKQGD PLSPVLFNIV LDELVTRLND EQPGASMTPA 130 140 150 160 170 180 CKIASLAFAD DLLLLEDRDI DVPNSLATTC AYFRTRGMTL NPEKCASISA ATVSGRSVPR 190 200 210 220 230 240 SKPSFTIDGR YIKPLGGINT FKYLGLTFSS TGVAKPTVYN LTRWLRNLEK APLKPNQKFY 250 260 270 280 290 300 ILKTHLLPRL FYGLQSPGVT AGILQECDRL ARRTTRKIFH LNVHTGSQFL HARIRDGGLG 310 320 330 340 350 360 LVQMRYRIPC ILSKRLGSLK QGNDTTNWSD IFNIEGPARS FYFRIRFLSS KGDPDPYWRE 370 380 390 400 410 420 EIRTRPLSSG LQDAADDASS RSWLNTIPRG WTGRDFVRAV QLRTGNLATQ GLPYMAPEHR 430 440 450 460 470 480 GCRNGCPRTE SLSHVLQGCP LTHHERIKRH NELVAKVAKH ARKKGWTTEV EPYVYHQDGQ 490 500 510 520 530 540 LYKPDLAIHQ PDNTLVICDV QVCWEGPRPL ATSWDNKRLV YDNPRFREAA VRRWGDKSLV 550 560 570 580 590 600 FSPLLLGARG IWPRANVPTC NILSIPTTLR ASCVHTCLKW GSTIHRHFMA GVWRRRPPDP PRPVPP

References

[1]	"Sequence relationship of retrotransposable elements R1 and R2 within and between divergent insect species." Burke W.D., Eickbush D.G., Xiong Y., Jakubczak J.L., Eickbush T.H. Mol. Biol. Evol. 10:163-185(1993) [PubMed: 8383793] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Retrotransposable elements R1 and R2 interrupt the rRNA genes of most insects." Jakubczak J.L., Burke W.D., Eickbush T.H. Proc. Natl. Acad. Sci. U.S.A. 88:3295-3299(1991) [PubMed: 1849649] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 422-439.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L00948 Genomic DNA. Translation: AAA29786.1.
PIR	A47757.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR000477. RVT. [Graphical view]
Pfam	PF00078. RVT_1. 1 hit. [Graphical view]
PROSITE	PS50878. RT_POL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PO23_POPJA

Accession

Primary (citable) accession number: Q05118

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	May 31, 2011
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)