ID   PPA5_MOUSE              Reviewed;         327 AA.
AC   Q05117;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 2.
DT   16-JUN-2009, entry version 77.
DE   RecName: Full=Tartrate-resistant acid phosphatase type 5;
DE            Short=TR-AP;
DE            EC=3.1.3.2;
DE   AltName: Full=Tartrate-resistant acid ATPase;
DE            Short=TrATPase;
DE   AltName: Full=Acid phosphatase 5, tartrate resistant;
DE   Flags: Precursor;
GN   Name=Acp5; Synonyms=T5ap, Trap;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=93366175; PubMed=8359686; DOI=10.1016/0378-1119(93)90420-8;
RA   Cassady A.I., King A.G., Cross N.C.P., Hume D.A.;
RT   "Isolation and characterization of the genes encoding mouse and human
RT   type-5 acid phosphatase.";
RL   Gene 130:201-207(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Czech II; TISSUE=Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-48.
RC   TISSUE=Spleen;
RX   MEDLINE=94078828; PubMed=8256664;
RA   Reddy S.V., Scarcez T., Windle J.J., Leach R.J., Hundley J.E.,
RA   Chirgwin J.M., Chou J.Y., Roodman G.D.;
RT   "Cloning and characterization of the 5'-flanking region of the mouse
RT   tartrate-resistant acid phosphatase gene.";
RL   J. Bone Miner. Res. 8:1263-1270(1993).
CC   -!- FUNCTION: May play a role in the process of bone resorption. The
CC       osteoclastic trap acts on nucleotide tri- and diphosphates with
CC       higher affinity, compared with other substrates.
CC   -!- CATALYTIC ACTIVITY: A phosphate monoester + H(2)O = an alcohol +
CC       phosphate.
CC   -!- COFACTOR: Binds 2 iron ions per subunit.
CC   -!- SUBUNIT: Exists either as monomer or, after proteolytic
CC       processing, as a dimer of two chains linked by disulfide bond(s).
CC   -!- SUBCELLULAR LOCATION: Lysosome.
CC   -!- TISSUE SPECIFICITY: Characteristic constituent of osteoclasts.
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DR   EMBL; M99054; AAA37245.1; -; Genomic_DNA.
DR   EMBL; BC012911; AAH12911.1; -; mRNA.
DR   EMBL; BC019160; AAH19160.1; -; mRNA.
DR   EMBL; BC029644; AAH29644.1; -; mRNA.
DR   EMBL; M85212; AAA40479.1; -; Genomic_DNA.
DR   IPI; IPI00137491; -.
DR   PIR; JN0787; JN0787.
DR   RefSeq; NP_001095874.1; -.
DR   RefSeq; NP_001095875.1; -.
DR   RefSeq; NP_031414.1; -.
DR   UniGene; Mm.46354; -.
DR   HSSP; P29288; 1QHW.
DR   SMR; Q05117; 27-325.
DR   Ensembl; ENSMUSG00000001348; Mus musculus.
DR   GeneID; 11433; -.
DR   KEGG; mmu:11433; -.
DR   MGI; MGI:87883; Acp5.
DR   HOGENOM; Q05117; -.
DR   HOVERGEN; Q05117; -.
DR   OMA; Q05117; HDHAGNV.
DR   BRENDA; 3.1.3.2; 244.
DR   NextBio; 278720; -.
DR   ArrayExpress; Q05117; -.
DR   Bgee; Q05117; -.
DR   CleanEx; MM_ACP5; -.
DR   GermOnline; ENSMUSG00000001348; Mus musculus.
DR   GO; GO:0005764; C:lysosome; IMP:MGI.
DR   GO; GO:0003993; F:acid phosphatase activity; IDA:MGI.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0060349; P:bone morphogenesis; IMP:MGI.
DR   GO; GO:0045453; P:bone resorption; IMP:MGI.
DR   GO; GO:0016311; P:dephosphorylation; IDA:MGI.
DR   GO; GO:0006955; P:immune response; IMP:MGI.
DR   GO; GO:0034097; P:response to cytokine stimulus; IDA:MGI.
DR   InterPro; IPR004843; M-pesterase.
DR   Pfam; PF00149; Metallophos; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hydrolase; Iron; Lysosome;
KW   Metal-binding; Signal.
FT   SIGNAL        1     22       By similarity.
FT   CHAIN        23    327       Tartrate-resistant acid phosphatase type
FT                                5.
FT                                /FTId=PRO_0000023982.
FT   METAL        35     35       Iron 1 (By similarity).
FT   METAL        73     73       Iron 1 (By similarity).
FT   METAL        73     73       Iron 2 (By similarity).
FT   METAL        76     76       Iron 1 (By similarity).
FT   METAL       112    112       Iron 2 (By similarity).
FT   METAL       207    207       Iron 2 (By similarity).
FT   METAL       242    242       Iron 2 (By similarity).
FT   METAL       244    244       Iron 1 (By similarity).
FT   CARBOHYD    118    118       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    149    149       N-linked (GlcNAc...) (Potential).
FT   DISULFID    163    221       By similarity.
SQ   SEQUENCE   327 AA;  36807 MW;  6D3975C4EF714C56 CRC64;
     MDSWVVLLGL QIIWLPLLTH GTAPTPTLRF VAVGDWGGVP NAPFHTAREM ANAKEIARTV
     QTMGADFIMS LGDNFYFTGV HDASDKRFQE TFEDVFSDRA LRNIPWYVLA GNHDHLGNVS
     AQIAYSKISK RWNFPSPYYR LRFKIPRTNI TVAIFMLDTV MLCGNSDDFA SQQPKMPRDL
     GVARTQLSWL KKQLAAAKED YVLVAGHYPI WSIAEHGPTR CLVKNLRPLL ATYGVTAYLC
     GHDHNLQYLQ DENGVGYVLS GAGNFMDPSV RHQRKVPNGY LRFHYGSEDS LGGFTHVEIS
     PKEMTIIYVE ASGKSLFKTS LPRRPRP
//