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Protein

Tartrate-resistant acid phosphatase type 5

Gene

Acp5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the process of bone resorption. The osteoclastic trap acts on nucleotide tri- and diphosphates with higher affinity, compared with other substrates.

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Cofactori

Fe cationNote: Binds 2 iron ions per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi35Iron 1By similarity1
Metal bindingi73Iron 1By similarity1
Metal bindingi73Iron 2By similarity1
Metal bindingi76Iron 1By similarity1
Metal bindingi112Iron 2By similarity1
Metal bindingi207Iron 2By similarity1
Metal bindingi242Iron 2By similarity1
Metal bindingi244Iron 1By similarity1

GO - Molecular functioni

  • acid phosphatase activity Source: MGI
  • ferric iron binding Source: UniProtKB
  • ferrous iron binding Source: UniProtKB

GO - Biological processi

  • bone morphogenesis Source: MGI
  • bone resorption Source: MGI
  • defense response to Gram-positive bacterium Source: MGI
  • dephosphorylation Source: MGI
  • negative regulation of inflammatory response Source: MGI
  • negative regulation of interleukin-12 production Source: MGI
  • negative regulation of interleukin-1 beta production Source: MGI
  • negative regulation of nitric oxide biosynthetic process Source: MGI
  • negative regulation of superoxide anion generation Source: MGI
  • negative regulation of tumor necrosis factor production Source: MGI
  • response to cytokine Source: MGI
  • response to lipopolysaccharide Source: MGI

Keywordsi

Molecular functionHydrolase
LigandIron, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.3.2 3474
ReactomeiR-MMU-196843 Vitamin B2 (riboflavin) metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Tartrate-resistant acid phosphatase type 5 (EC:3.1.3.2)
Short name:
TR-AP
Alternative name(s):
Tartrate-resistant acid ATPase
Short name:
TrATPase
Type 5 acid phosphatase
Gene namesi
Name:Acp5
Synonyms:T5ap, Trap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:87883 Acp5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3120042

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000002398223 – 327Tartrate-resistant acid phosphatase type 5Add BLAST305

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi149N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi163 ↔ 221By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ05117
MaxQBiQ05117
PaxDbiQ05117
PeptideAtlasiQ05117
PRIDEiQ05117

PTM databases

iPTMnetiQ05117
PhosphoSitePlusiQ05117

Expressioni

Tissue specificityi

Characteristic constituent of osteoclasts.

Gene expression databases

BgeeiENSMUSG00000001348
CleanExiMM_ACP5
GenevisibleiQ05117 MM

Interactioni

Subunit structurei

Exists either as monomer or, after proteolytic processing, as a dimer of two chains linked by disulfide bond(s).

Protein-protein interaction databases

IntActiQ05117, 2 interactors
MINTiQ05117
STRINGi10090.ENSMUSP00000065425

Structurei

3D structure databases

ProteinModelPortaliQ05117
SMRiQ05117
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2679 Eukaryota
COG1409 LUCA
GeneTreeiENSGT00390000016735
HOGENOMiHOG000007592
HOVERGENiHBG000433
InParanoidiQ05117
KOiK14379
OMAiWNFPSPY
OrthoDBiEOG091G0J5W
PhylomeDBiQ05117
TreeFamiTF313175

Family and domain databases

CDDicd07378 MPP_ACP5, 1 hit
Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR024927 Acid_Pase_5
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PIRSFiPIRSF000898 Acid_Ptase_5, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05117-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSWVVLLGL QIIWLPLLTH GTAPTPTLRF VAVGDWGGVP NAPFHTAREM
60 70 80 90 100
ANAKEIARTV QTMGADFIMS LGDNFYFTGV HDASDKRFQE TFEDVFSDRA
110 120 130 140 150
LRNIPWYVLA GNHDHLGNVS AQIAYSKISK RWNFPSPYYR LRFKIPRTNI
160 170 180 190 200
TVAIFMLDTV MLCGNSDDFA SQQPKMPRDL GVARTQLSWL KKQLAAAKED
210 220 230 240 250
YVLVAGHYPI WSIAEHGPTR CLVKNLRPLL ATYGVTAYLC GHDHNLQYLQ
260 270 280 290 300
DENGVGYVLS GAGNFMDPSV RHQRKVPNGY LRFHYGSEDS LGGFTHVEIS
310 320
PKEMTIIYVE ASGKSLFKTS LPRRPRP
Length:327
Mass (Da):36,807
Last modified:February 1, 1995 - v2
Checksum:i6D3975C4EF714C56
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M99054 Genomic DNA Translation: AAA37245.1
BC012911 mRNA Translation: AAH12911.1
BC019160 mRNA Translation: AAH19160.1
BC029644 mRNA Translation: AAH29644.1
M85212 Genomic DNA Translation: AAA40479.1
CCDSiCCDS22923.1
PIRiJN0787
RefSeqiNP_001095874.1, NM_001102404.1
NP_001095875.1, NM_001102405.1
NP_031414.1, NM_007388.3
XP_006510007.1, XM_006509944.3
XP_006510008.1, XM_006509945.2
XP_006510009.1, XM_006509946.1
XP_011240686.1, XM_011242384.2
UniGeneiMm.46354

Genome annotation databases

EnsembliENSMUST00000069330; ENSMUSP00000065425; ENSMUSG00000001348
ENSMUST00000115315; ENSMUSP00000110970; ENSMUSG00000001348
ENSMUST00000165735; ENSMUSP00000127128; ENSMUSG00000001348
ENSMUST00000213815; ENSMUSP00000149597; ENSMUSG00000001348
ENSMUST00000217643; ENSMUSP00000150903; ENSMUSG00000001348
GeneIDi11433
KEGGimmu:11433
UCSCiuc009onz.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPPA5_MOUSE
AccessioniPrimary (citable) accession number: Q05117
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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