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Reviewed, UniProtKB/Swiss-Prot Q05117 (PPA5_MOUSE)

Last modified June 16, 2009. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Tartrate-resistant acid phosphatase type 5
      Short name=TR-AP
    EC=3.1.3.2
Alternative name(s):
    Tartrate-resistant acid ATPase
      Short name=TrATPase
    Acid phosphatase 5, tartrate resistant
Gene names
Name: Acp5
Synonyms: T5ap, Trap
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length327 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

May play a role in the process of bone resorption. The osteoclastic trap acts on nucleotide tri- and diphosphates with higher affinity, compared with other substrates.

Catalytic activity

A phosphate monoester + H2O = an alcohol + phosphate.

Cofactor

Binds 2 iron ions per subunit.

Subunit structure

Exists either as monomer or, after proteolytic processing, as a dimer of two chains linked by disulfide bond(s).

Subcellular location

Lysosome.

Tissue specificity

Characteristic constituent of osteoclasts.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 By similarity
Chain23 – 327305Tartrate-resistant acid phosphatase type 5
PRO_0000023982

Sites

Metal binding351Iron 1 By similarity
Metal binding731Iron 1 By similarity
Metal binding731Iron 2 By similarity
Metal binding761Iron 1 By similarity
Metal binding1121Iron 2 By similarity
Metal binding2071Iron 2 By similarity
Metal binding2421Iron 2 By similarity
Metal binding2441Iron 1 By similarity

Amino acid modifications

Glycosylation1181N-linked (GlcNAc...) Potential
Glycosylation1491N-linked (GlcNAc...) Potential
Disulfide bond163 ↔ 221 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q05117-1 [UniParc].

Last modified February 1, 1995. Version 2.
Checksum: 6D3975C4EF714C56

FASTA32736,807
        10         20         30         40         50         60 
MDSWVVLLGL QIIWLPLLTH GTAPTPTLRF VAVGDWGGVP NAPFHTAREM ANAKEIARTV 

        70         80         90        100        110        120 
QTMGADFIMS LGDNFYFTGV HDASDKRFQE TFEDVFSDRA LRNIPWYVLA GNHDHLGNVS 

       130        140        150        160        170        180 
AQIAYSKISK RWNFPSPYYR LRFKIPRTNI TVAIFMLDTV MLCGNSDDFA SQQPKMPRDL 

       190        200        210        220        230        240 
GVARTQLSWL KKQLAAAKED YVLVAGHYPI WSIAEHGPTR CLVKNLRPLL ATYGVTAYLC 

       250        260        270        280        290        300 
GHDHNLQYLQ DENGVGYVLS GAGNFMDPSV RHQRKVPNGY LRFHYGSEDS LGGFTHVEIS 

       310        320 
PKEMTIIYVE ASGKSLFKTS LPRRPRP 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and characterization of the genes encoding mouse and human type-5 acid phosphatase."
Cassady A.I., King A.G., Cross N.C.P., Hume D.A.
Gene 130:201-207(1993) [PubMed: 8359686] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Czech II.
Tissue: Mammary gland.
[3]"Cloning and characterization of the 5'-flanking region of the mouse tartrate-resistant acid phosphatase gene."
Reddy S.V., Scarcez T., Windle J.J., Leach R.J., Hundley J.E., Chirgwin J.M., Chou J.Y., Roodman G.D.
J. Bone Miner. Res. 8:1263-1270(1993) [PubMed: 8256664] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-48.
Tissue: Spleen.
+Additional computationally mapped references.

Cross-references

Sequence databases

M99054 Genomic DNA. Translation: AAA37245.1.
BC012911 mRNA. Translation: AAH12911.1.
BC019160 mRNA. Translation: AAH19160.1.
BC029644 mRNA. Translation: AAH29644.1.
M85212 Genomic DNA. Translation: AAA40479.1.
IPIIPI00137491.
PIRJN0787.
RefSeqNP_001095874.1.
NP_001095875.1.
NP_031414.1.
UniGeneMm.46354

3D structure databases

HSSPHSSP built from PDB template 1QHW based on UniProtKB P29288.
SMRQ05117. Positions 27-325.
ModBaseSearch...

Genome annotation databases

EnsemblENSMUSG00000001348. Mus musculus. [Contig view]
GeneID11433.
KEGGmmu:11433.

Organism-specific databases

MGIMGI:87883. Acp5.

Phylogenomic databases

HOGENOMQ05117.
HOVERGENQ05117.
OMAQ05117. HDHAGNV.

Enzyme and pathway databases

BRENDA3.1.3.2. 244.

Gene expression databases

ArrayExpressQ05117.
BgeeQ05117.
CleanExMM_ACP5.
GermOnlineENSMUSG00000001348. Mus musculus.

Family and domain databases

InterProIPR004843. M-pesterase.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio278720.
SOURCESearch...

Entry information

Entry namePPA5_MOUSE
AccessionPrimary (citable) accession number: Q05117
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1995
Last modified: June 16, 2009
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents