Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tartrate-resistant acid phosphatase type 5

Gene

Acp5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the process of bone resorption. The osteoclastic trap acts on nucleotide tri- and diphosphates with higher affinity, compared with other substrates.

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Cofactori

Fe cationNote: Binds 2 iron ions per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi35Iron 1By similarity1
Metal bindingi73Iron 1By similarity1
Metal bindingi73Iron 2By similarity1
Metal bindingi76Iron 1By similarity1
Metal bindingi112Iron 2By similarity1
Metal bindingi207Iron 2By similarity1
Metal bindingi242Iron 2By similarity1
Metal bindingi244Iron 1By similarity1

GO - Molecular functioni

  • acid phosphatase activity Source: MGI
  • ferric iron binding Source: UniProtKB
  • ferrous iron binding Source: UniProtKB

GO - Biological processi

  • bone morphogenesis Source: MGI
  • bone resorption Source: MGI
  • defense response to Gram-positive bacterium Source: MGI
  • dephosphorylation Source: MGI
  • negative regulation of inflammatory response Source: MGI
  • negative regulation of interleukin-12 production Source: MGI
  • negative regulation of interleukin-1 beta production Source: MGI
  • negative regulation of nitric oxide biosynthetic process Source: MGI
  • negative regulation of superoxide anion generation Source: MGI
  • negative regulation of tumor necrosis factor production Source: MGI
  • response to cytokine Source: MGI
  • response to lipopolysaccharide Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.3.2. 3474.
ReactomeiR-MMU-196843. Vitamin B2 (riboflavin) metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Tartrate-resistant acid phosphatase type 5 (EC:3.1.3.2)
Short name:
TR-AP
Alternative name(s):
Tartrate-resistant acid ATPase
Short name:
TrATPase
Type 5 acid phosphatase
Gene namesi
Name:Acp5
Synonyms:T5ap, Trap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:87883. Acp5.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: Ensembl
  • lysosome Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3120042.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000002398223 – 327Tartrate-resistant acid phosphatase type 5Add BLAST305

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi118N-linked (GlcNAc...)Sequence analysis1
Glycosylationi149N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi163 ↔ 221By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ05117.
MaxQBiQ05117.
PaxDbiQ05117.
PeptideAtlasiQ05117.
PRIDEiQ05117.

PTM databases

iPTMnetiQ05117.
PhosphoSitePlusiQ05117.

Expressioni

Tissue specificityi

Characteristic constituent of osteoclasts.

Gene expression databases

BgeeiENSMUSG00000001348.
CleanExiMM_ACP5.
GenevisibleiQ05117. MM.

Interactioni

Subunit structurei

Exists either as monomer or, after proteolytic processing, as a dimer of two chains linked by disulfide bond(s).

Protein-protein interaction databases

IntActiQ05117. 2 interactors.
MINTiMINT-1851665.
STRINGi10090.ENSMUSP00000065425.

Structurei

3D structure databases

ProteinModelPortaliQ05117.
SMRiQ05117.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2679. Eukaryota.
COG1409. LUCA.
GeneTreeiENSGT00390000016735.
HOGENOMiHOG000007592.
HOVERGENiHBG000433.
InParanoidiQ05117.
KOiK14379.
OMAiAYSRISK.
OrthoDBiEOG091G0J5W.
PhylomeDBiQ05117.
TreeFamiTF313175.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR024927. Acid_Pase_5.
IPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000898. Acid_Ptase_5. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05117-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSWVVLLGL QIIWLPLLTH GTAPTPTLRF VAVGDWGGVP NAPFHTAREM
60 70 80 90 100
ANAKEIARTV QTMGADFIMS LGDNFYFTGV HDASDKRFQE TFEDVFSDRA
110 120 130 140 150
LRNIPWYVLA GNHDHLGNVS AQIAYSKISK RWNFPSPYYR LRFKIPRTNI
160 170 180 190 200
TVAIFMLDTV MLCGNSDDFA SQQPKMPRDL GVARTQLSWL KKQLAAAKED
210 220 230 240 250
YVLVAGHYPI WSIAEHGPTR CLVKNLRPLL ATYGVTAYLC GHDHNLQYLQ
260 270 280 290 300
DENGVGYVLS GAGNFMDPSV RHQRKVPNGY LRFHYGSEDS LGGFTHVEIS
310 320
PKEMTIIYVE ASGKSLFKTS LPRRPRP
Length:327
Mass (Da):36,807
Last modified:February 1, 1995 - v2
Checksum:i6D3975C4EF714C56
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M99054 Genomic DNA. Translation: AAA37245.1.
BC012911 mRNA. Translation: AAH12911.1.
BC019160 mRNA. Translation: AAH19160.1.
BC029644 mRNA. Translation: AAH29644.1.
M85212 Genomic DNA. Translation: AAA40479.1.
CCDSiCCDS22923.1.
PIRiJN0787.
RefSeqiNP_001095874.1. NM_001102404.1.
NP_001095875.1. NM_001102405.1.
NP_031414.1. NM_007388.3.
XP_006510007.1. XM_006509944.3.
XP_006510008.1. XM_006509945.2.
XP_006510009.1. XM_006509946.1.
XP_011240686.1. XM_011242384.2.
UniGeneiMm.46354.

Genome annotation databases

EnsembliENSMUST00000069330; ENSMUSP00000065425; ENSMUSG00000001348.
ENSMUST00000115315; ENSMUSP00000110970; ENSMUSG00000001348.
ENSMUST00000165735; ENSMUSP00000127128; ENSMUSG00000001348.
GeneIDi11433.
KEGGimmu:11433.
UCSCiuc009onz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M99054 Genomic DNA. Translation: AAA37245.1.
BC012911 mRNA. Translation: AAH12911.1.
BC019160 mRNA. Translation: AAH19160.1.
BC029644 mRNA. Translation: AAH29644.1.
M85212 Genomic DNA. Translation: AAA40479.1.
CCDSiCCDS22923.1.
PIRiJN0787.
RefSeqiNP_001095874.1. NM_001102404.1.
NP_001095875.1. NM_001102405.1.
NP_031414.1. NM_007388.3.
XP_006510007.1. XM_006509944.3.
XP_006510008.1. XM_006509945.2.
XP_006510009.1. XM_006509946.1.
XP_011240686.1. XM_011242384.2.
UniGeneiMm.46354.

3D structure databases

ProteinModelPortaliQ05117.
SMRiQ05117.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ05117. 2 interactors.
MINTiMINT-1851665.
STRINGi10090.ENSMUSP00000065425.

Chemistry databases

ChEMBLiCHEMBL3120042.

PTM databases

iPTMnetiQ05117.
PhosphoSitePlusiQ05117.

Proteomic databases

EPDiQ05117.
MaxQBiQ05117.
PaxDbiQ05117.
PeptideAtlasiQ05117.
PRIDEiQ05117.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000069330; ENSMUSP00000065425; ENSMUSG00000001348.
ENSMUST00000115315; ENSMUSP00000110970; ENSMUSG00000001348.
ENSMUST00000165735; ENSMUSP00000127128; ENSMUSG00000001348.
GeneIDi11433.
KEGGimmu:11433.
UCSCiuc009onz.1. mouse.

Organism-specific databases

CTDi54.
MGIiMGI:87883. Acp5.

Phylogenomic databases

eggNOGiKOG2679. Eukaryota.
COG1409. LUCA.
GeneTreeiENSGT00390000016735.
HOGENOMiHOG000007592.
HOVERGENiHBG000433.
InParanoidiQ05117.
KOiK14379.
OMAiAYSRISK.
OrthoDBiEOG091G0J5W.
PhylomeDBiQ05117.
TreeFamiTF313175.

Enzyme and pathway databases

BRENDAi3.1.3.2. 3474.
ReactomeiR-MMU-196843. Vitamin B2 (riboflavin) metabolism.

Miscellaneous databases

PROiQ05117.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001348.
CleanExiMM_ACP5.
GenevisibleiQ05117. MM.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR024927. Acid_Pase_5.
IPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000898. Acid_Ptase_5. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPPA5_MOUSE
AccessioniPrimary (citable) accession number: Q05117
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1995
Last modified: November 30, 2016
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.