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Q05117

- PPA5_MOUSE

UniProt

Q05117 - PPA5_MOUSE

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Protein

Tartrate-resistant acid phosphatase type 5

Gene

Acp5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

May play a role in the process of bone resorption. The osteoclastic trap acts on nucleotide tri- and diphosphates with higher affinity, compared with other substrates.

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Cofactori

Fe cationNote: Binds 2 iron ions per subunit.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi35 – 351Iron 1By similarity
Metal bindingi73 – 731Iron 1By similarity
Metal bindingi73 – 731Iron 2By similarity
Metal bindingi76 – 761Iron 1By similarity
Metal bindingi112 – 1121Iron 2By similarity
Metal bindingi207 – 2071Iron 2By similarity
Metal bindingi242 – 2421Iron 2By similarity
Metal bindingi244 – 2441Iron 1By similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: MGI
  2. ferric iron binding Source: UniProtKB
  3. ferrous iron binding Source: UniProtKB

GO - Biological processi

  1. bone morphogenesis Source: MGI
  2. bone resorption Source: MGI
  3. defense response to Gram-positive bacterium Source: MGI
  4. dephosphorylation Source: MGI
  5. negative regulation of inflammatory response Source: MGI
  6. negative regulation of interleukin-12 production Source: MGI
  7. negative regulation of interleukin-1 beta production Source: MGI
  8. negative regulation of nitric oxide biosynthetic process Source: MGI
  9. negative regulation of superoxide anion generation Source: MGI
  10. negative regulation of tumor necrosis factor production Source: MGI
  11. response to cytokine Source: MGI
  12. response to lipopolysaccharide Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_216155. Vitamin B2 (riboflavin) metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Tartrate-resistant acid phosphatase type 5 (EC:3.1.3.2)
Short name:
TR-AP
Alternative name(s):
Tartrate-resistant acid ATPase
Short name:
TrATPase
Type 5 acid phosphatase
Gene namesi
Name:Acp5
Synonyms:T5ap, Trap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:87883. Acp5.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. lysosome Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222By similarityAdd
BLAST
Chaini23 – 327305Tartrate-resistant acid phosphatase type 5PRO_0000023982Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi149 – 1491N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi163 ↔ 221By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ05117.
PaxDbiQ05117.
PRIDEiQ05117.

PTM databases

PhosphoSiteiQ05117.

Expressioni

Tissue specificityi

Characteristic constituent of osteoclasts.

Gene expression databases

BgeeiQ05117.
CleanExiMM_ACP5.
ExpressionAtlasiQ05117. baseline and differential.
GenevestigatoriQ05117.

Interactioni

Subunit structurei

Exists either as monomer or, after proteolytic processing, as a dimer of two chains linked by disulfide bond(s).

Protein-protein interaction databases

IntActiQ05117. 2 interactions.
MINTiMINT-1851665.
STRINGi10090.ENSMUSP00000065425.

Structurei

3D structure databases

ProteinModelPortaliQ05117.
SMRiQ05117. Positions 27-325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1409.
GeneTreeiENSGT00390000016735.
HOGENOMiHOG000007592.
HOVERGENiHBG000433.
InParanoidiQ05117.
KOiK14379.
OMAiFYFSGVQ.
OrthoDBiEOG7WHH9R.
PhylomeDBiQ05117.
TreeFamiTF313175.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR024927. Acid_Pase_5.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000898. Acid_Ptase_5. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05117-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDSWVVLLGL QIIWLPLLTH GTAPTPTLRF VAVGDWGGVP NAPFHTAREM
60 70 80 90 100
ANAKEIARTV QTMGADFIMS LGDNFYFTGV HDASDKRFQE TFEDVFSDRA
110 120 130 140 150
LRNIPWYVLA GNHDHLGNVS AQIAYSKISK RWNFPSPYYR LRFKIPRTNI
160 170 180 190 200
TVAIFMLDTV MLCGNSDDFA SQQPKMPRDL GVARTQLSWL KKQLAAAKED
210 220 230 240 250
YVLVAGHYPI WSIAEHGPTR CLVKNLRPLL ATYGVTAYLC GHDHNLQYLQ
260 270 280 290 300
DENGVGYVLS GAGNFMDPSV RHQRKVPNGY LRFHYGSEDS LGGFTHVEIS
310 320
PKEMTIIYVE ASGKSLFKTS LPRRPRP
Length:327
Mass (Da):36,807
Last modified:February 1, 1995 - v2
Checksum:i6D3975C4EF714C56
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M99054 Genomic DNA. Translation: AAA37245.1.
BC012911 mRNA. Translation: AAH12911.1.
BC019160 mRNA. Translation: AAH19160.1.
BC029644 mRNA. Translation: AAH29644.1.
M85212 Genomic DNA. Translation: AAA40479.1.
CCDSiCCDS22923.1.
PIRiJN0787.
RefSeqiNP_001095874.1. NM_001102404.1.
NP_001095875.1. NM_001102405.1.
NP_031414.1. NM_007388.3.
XP_006510007.1. XM_006509944.1.
XP_006510008.1. XM_006509945.1.
XP_006510009.1. XM_006509946.1.
UniGeneiMm.46354.

Genome annotation databases

EnsembliENSMUST00000069330; ENSMUSP00000065425; ENSMUSG00000001348.
ENSMUST00000115315; ENSMUSP00000110970; ENSMUSG00000001348.
ENSMUST00000165735; ENSMUSP00000127128; ENSMUSG00000001348.
GeneIDi11433.
KEGGimmu:11433.
UCSCiuc009onz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M99054 Genomic DNA. Translation: AAA37245.1 .
BC012911 mRNA. Translation: AAH12911.1 .
BC019160 mRNA. Translation: AAH19160.1 .
BC029644 mRNA. Translation: AAH29644.1 .
M85212 Genomic DNA. Translation: AAA40479.1 .
CCDSi CCDS22923.1.
PIRi JN0787.
RefSeqi NP_001095874.1. NM_001102404.1.
NP_001095875.1. NM_001102405.1.
NP_031414.1. NM_007388.3.
XP_006510007.1. XM_006509944.1.
XP_006510008.1. XM_006509945.1.
XP_006510009.1. XM_006509946.1.
UniGenei Mm.46354.

3D structure databases

ProteinModelPortali Q05117.
SMRi Q05117. Positions 27-325.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q05117. 2 interactions.
MINTi MINT-1851665.
STRINGi 10090.ENSMUSP00000065425.

Chemistry

ChEMBLi CHEMBL3120042.

PTM databases

PhosphoSitei Q05117.

Proteomic databases

MaxQBi Q05117.
PaxDbi Q05117.
PRIDEi Q05117.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000069330 ; ENSMUSP00000065425 ; ENSMUSG00000001348 .
ENSMUST00000115315 ; ENSMUSP00000110970 ; ENSMUSG00000001348 .
ENSMUST00000165735 ; ENSMUSP00000127128 ; ENSMUSG00000001348 .
GeneIDi 11433.
KEGGi mmu:11433.
UCSCi uc009onz.1. mouse.

Organism-specific databases

CTDi 54.
MGIi MGI:87883. Acp5.

Phylogenomic databases

eggNOGi COG1409.
GeneTreei ENSGT00390000016735.
HOGENOMi HOG000007592.
HOVERGENi HBG000433.
InParanoidi Q05117.
KOi K14379.
OMAi FYFSGVQ.
OrthoDBi EOG7WHH9R.
PhylomeDBi Q05117.
TreeFami TF313175.

Enzyme and pathway databases

Reactomei REACT_216155. Vitamin B2 (riboflavin) metabolism.

Miscellaneous databases

NextBioi 278720.
PROi Q05117.
SOURCEi Search...

Gene expression databases

Bgeei Q05117.
CleanExi MM_ACP5.
ExpressionAtlasi Q05117. baseline and differential.
Genevestigatori Q05117.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR024927. Acid_Pase_5.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PIRSFi PIRSF000898. Acid_Ptase_5. 1 hit.
SUPFAMi SSF56300. SSF56300. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of the genes encoding mouse and human type-5 acid phosphatase."
    Cassady A.I., King A.G., Cross N.C.P., Hume D.A.
    Gene 130:201-207(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary gland.
  3. "Cloning and characterization of the 5'-flanking region of the mouse tartrate-resistant acid phosphatase gene."
    Reddy S.V., Scarcez T., Windle J.J., Leach R.J., Hundley J.E., Chirgwin J.M., Chou J.Y., Roodman G.D.
    J. Bone Miner. Res. 8:1263-1270(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-48.
    Tissue: Spleen.

Entry informationi

Entry nameiPPA5_MOUSE
AccessioniPrimary (citable) accession number: Q05117
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1995
Last modified: November 26, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3