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Q05117

- PPA5_MOUSE

UniProt

Q05117 - PPA5_MOUSE

Protein

Tartrate-resistant acid phosphatase type 5

Gene

Acp5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 2 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    May play a role in the process of bone resorption. The osteoclastic trap acts on nucleotide tri- and diphosphates with higher affinity, compared with other substrates.

    Catalytic activityi

    A phosphate monoester + H2O = an alcohol + phosphate.

    Cofactori

    Binds 2 iron ions per subunit.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi35 – 351Iron 1By similarity
    Metal bindingi73 – 731Iron 1By similarity
    Metal bindingi73 – 731Iron 2By similarity
    Metal bindingi76 – 761Iron 1By similarity
    Metal bindingi112 – 1121Iron 2By similarity
    Metal bindingi207 – 2071Iron 2By similarity
    Metal bindingi242 – 2421Iron 2By similarity
    Metal bindingi244 – 2441Iron 1By similarity

    GO - Molecular functioni

    1. acid phosphatase activity Source: MGI
    2. ferric iron binding Source: UniProtKB
    3. ferrous iron binding Source: UniProtKB

    GO - Biological processi

    1. bone morphogenesis Source: MGI
    2. bone resorption Source: MGI
    3. defense response to Gram-positive bacterium Source: MGI
    4. dephosphorylation Source: MGI
    5. negative regulation of inflammatory response Source: MGI
    6. negative regulation of interleukin-12 production Source: MGI
    7. negative regulation of interleukin-1 beta production Source: MGI
    8. negative regulation of nitric oxide biosynthetic process Source: MGI
    9. negative regulation of superoxide anion generation Source: MGI
    10. negative regulation of tumor necrosis factor production Source: MGI
    11. response to cytokine Source: MGI
    12. response to lipopolysaccharide Source: MGI

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_216155. Vitamin B2 (riboflavin) metabolism.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tartrate-resistant acid phosphatase type 5 (EC:3.1.3.2)
    Short name:
    TR-AP
    Alternative name(s):
    Tartrate-resistant acid ATPase
    Short name:
    TrATPase
    Type 5 acid phosphatase
    Gene namesi
    Name:Acp5
    Synonyms:T5ap, Trap
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:87883. Acp5.

    Subcellular locationi

    GO - Cellular componenti

    1. lysosome Source: MGI

    Keywords - Cellular componenti

    Lysosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222By similarityAdd
    BLAST
    Chaini23 – 327305Tartrate-resistant acid phosphatase type 5PRO_0000023982Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi149 – 1491N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi163 ↔ 221By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ05117.
    PaxDbiQ05117.
    PRIDEiQ05117.

    PTM databases

    PhosphoSiteiQ05117.

    Expressioni

    Tissue specificityi

    Characteristic constituent of osteoclasts.

    Gene expression databases

    ArrayExpressiQ05117.
    BgeeiQ05117.
    CleanExiMM_ACP5.
    GenevestigatoriQ05117.

    Interactioni

    Subunit structurei

    Exists either as monomer or, after proteolytic processing, as a dimer of two chains linked by disulfide bond(s).

    Protein-protein interaction databases

    IntActiQ05117. 2 interactions.
    MINTiMINT-1851665.
    STRINGi10090.ENSMUSP00000065425.

    Structurei

    3D structure databases

    ProteinModelPortaliQ05117.
    SMRiQ05117. Positions 27-325.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG1409.
    GeneTreeiENSGT00390000016735.
    HOGENOMiHOG000007592.
    HOVERGENiHBG000433.
    InParanoidiQ05117.
    KOiK14379.
    OMAiFYFSGVQ.
    OrthoDBiEOG7WHH9R.
    PhylomeDBiQ05117.
    TreeFamiTF313175.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR024927. Acid_Pase_5.
    IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000898. Acid_Ptase_5. 1 hit.
    SUPFAMiSSF56300. SSF56300. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q05117-1 [UniParc]FASTAAdd to Basket

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    MDSWVVLLGL QIIWLPLLTH GTAPTPTLRF VAVGDWGGVP NAPFHTAREM    50
    ANAKEIARTV QTMGADFIMS LGDNFYFTGV HDASDKRFQE TFEDVFSDRA 100
    LRNIPWYVLA GNHDHLGNVS AQIAYSKISK RWNFPSPYYR LRFKIPRTNI 150
    TVAIFMLDTV MLCGNSDDFA SQQPKMPRDL GVARTQLSWL KKQLAAAKED 200
    YVLVAGHYPI WSIAEHGPTR CLVKNLRPLL ATYGVTAYLC GHDHNLQYLQ 250
    DENGVGYVLS GAGNFMDPSV RHQRKVPNGY LRFHYGSEDS LGGFTHVEIS 300
    PKEMTIIYVE ASGKSLFKTS LPRRPRP 327
    Length:327
    Mass (Da):36,807
    Last modified:February 1, 1995 - v2
    Checksum:i6D3975C4EF714C56
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M99054 Genomic DNA. Translation: AAA37245.1.
    BC012911 mRNA. Translation: AAH12911.1.
    BC019160 mRNA. Translation: AAH19160.1.
    BC029644 mRNA. Translation: AAH29644.1.
    M85212 Genomic DNA. Translation: AAA40479.1.
    CCDSiCCDS22923.1.
    PIRiJN0787.
    RefSeqiNP_001095874.1. NM_001102404.1.
    NP_001095875.1. NM_001102405.1.
    NP_031414.1. NM_007388.3.
    XP_006510007.1. XM_006509944.1.
    XP_006510008.1. XM_006509945.1.
    XP_006510009.1. XM_006509946.1.
    UniGeneiMm.46354.

    Genome annotation databases

    EnsembliENSMUST00000069330; ENSMUSP00000065425; ENSMUSG00000001348.
    ENSMUST00000115315; ENSMUSP00000110970; ENSMUSG00000001348.
    ENSMUST00000165735; ENSMUSP00000127128; ENSMUSG00000001348.
    GeneIDi11433.
    KEGGimmu:11433.
    UCSCiuc009onz.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M99054 Genomic DNA. Translation: AAA37245.1 .
    BC012911 mRNA. Translation: AAH12911.1 .
    BC019160 mRNA. Translation: AAH19160.1 .
    BC029644 mRNA. Translation: AAH29644.1 .
    M85212 Genomic DNA. Translation: AAA40479.1 .
    CCDSi CCDS22923.1.
    PIRi JN0787.
    RefSeqi NP_001095874.1. NM_001102404.1.
    NP_001095875.1. NM_001102405.1.
    NP_031414.1. NM_007388.3.
    XP_006510007.1. XM_006509944.1.
    XP_006510008.1. XM_006509945.1.
    XP_006510009.1. XM_006509946.1.
    UniGenei Mm.46354.

    3D structure databases

    ProteinModelPortali Q05117.
    SMRi Q05117. Positions 27-325.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q05117. 2 interactions.
    MINTi MINT-1851665.
    STRINGi 10090.ENSMUSP00000065425.

    PTM databases

    PhosphoSitei Q05117.

    Proteomic databases

    MaxQBi Q05117.
    PaxDbi Q05117.
    PRIDEi Q05117.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000069330 ; ENSMUSP00000065425 ; ENSMUSG00000001348 .
    ENSMUST00000115315 ; ENSMUSP00000110970 ; ENSMUSG00000001348 .
    ENSMUST00000165735 ; ENSMUSP00000127128 ; ENSMUSG00000001348 .
    GeneIDi 11433.
    KEGGi mmu:11433.
    UCSCi uc009onz.1. mouse.

    Organism-specific databases

    CTDi 54.
    MGIi MGI:87883. Acp5.

    Phylogenomic databases

    eggNOGi COG1409.
    GeneTreei ENSGT00390000016735.
    HOGENOMi HOG000007592.
    HOVERGENi HBG000433.
    InParanoidi Q05117.
    KOi K14379.
    OMAi FYFSGVQ.
    OrthoDBi EOG7WHH9R.
    PhylomeDBi Q05117.
    TreeFami TF313175.

    Enzyme and pathway databases

    Reactomei REACT_216155. Vitamin B2 (riboflavin) metabolism.

    Miscellaneous databases

    NextBioi 278720.
    PROi Q05117.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q05117.
    Bgeei Q05117.
    CleanExi MM_ACP5.
    Genevestigatori Q05117.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR024927. Acid_Pase_5.
    IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000898. Acid_Ptase_5. 1 hit.
    SUPFAMi SSF56300. SSF56300. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of the genes encoding mouse and human type-5 acid phosphatase."
      Cassady A.I., King A.G., Cross N.C.P., Hume D.A.
      Gene 130:201-207(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II.
      Tissue: Mammary gland.
    3. "Cloning and characterization of the 5'-flanking region of the mouse tartrate-resistant acid phosphatase gene."
      Reddy S.V., Scarcez T., Windle J.J., Leach R.J., Hundley J.E., Chirgwin J.M., Chou J.Y., Roodman G.D.
      J. Bone Miner. Res. 8:1263-1270(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-48.
      Tissue: Spleen.

    Entry informationi

    Entry nameiPPA5_MOUSE
    AccessioniPrimary (citable) accession number: Q05117
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 122 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3