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Protein

Alcohol dehydrogenase

Gene

Adh

Organism
Drosophila willistoni (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei138SubstrateBy similarity1
Active sitei151Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 32NADBy similarityAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase (EC:1.1.1.1)
Gene namesi
Name:Adh
ORF Names:GK18290
OrganismiDrosophila willistoni (Fruit fly)
Taxonomic identifieri7260 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000007798 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0013152. Dwil\Adh.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000545001 – 254Alcohol dehydrogenaseAdd BLAST254

Proteomic databases

PRIDEiQ05114.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi7260.FBpp0247433.

Structurei

3D structure databases

ProteinModelPortaliQ05114.
SMRiQ05114.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4169. Eukaryota.
COG1028. LUCA.
InParanoidiQ05114.
KOiK00001.
OMAiWSKHWDS.
OrthoDBiEOG091G0OC9.
PhylomeDBiQ05114.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiView protein in InterPro
IPR002425. ADH_Drosophila-type.
IPR002424. ADH_insect.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PRINTSiPR01168. ALCDHDRGNASE.
PR01167. INSADHFAMILY.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.

Sequencei

Sequence statusi: Complete.

Q05114-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALTNKNIIF VAGLGGIGLD TSRELVKRDL KNLVILDRID NPAAIAELKA
60 70 80 90 100
INPKVTVTFY PYDVTTPLTE TTKLLKTIFA QLKTVDVLIN GAGILDDHQI
110 120 130 140 150
ERTIAVNFTG LVNTTTAILD FWDKRKGGPG GVICNIGSVT GFNAIYQVPV
160 170 180 190 200
YSASKAAVVS FTQSIAKLAN VTGVTAFTVN PGITKTTLVH KFNSWLDVET
210 220 230 240 250
RVAEKLLEHP TQTTLACAQN FVKAIELNKN GAIWKLDLGT LEPIEWTKHW

DSGI
Length:254
Mass (Da):27,620
Last modified:October 1, 1996 - v2
Checksum:iC20FDF95E89D6E16
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41N → K in AAF72724 (Ref. 6) Curated1
Sequence conflicti73K → N in AAF72724 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti57V → I in strain: 0811.4. 2 Publications1
Natural varianti77T → A in strain: 0811.0 and Lima. 2 Publications1
Natural varianti138S → P in strain: Manaus I. 2 Publications1
Natural varianti194S → P in strain: Manaus III. 2 Publications1
Natural varianti213T → A in strain: Cano Mora and Atlixco. 2 Publications1
Natural varianti225I → T in strain: A57. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08648 Genomic DNA. Translation: AAA91100.1.
U95251 Genomic DNA. Translation: AAD00777.1.
U95252 Genomic DNA. Translation: AAD00778.1.
U95253 Genomic DNA. Translation: AAD00779.1.
U95254 Genomic DNA. Translation: AAD00780.1.
U95255 Genomic DNA. Translation: AAD00781.1.
U95256 Genomic DNA. Translation: AAD00782.1.
U95257 Genomic DNA. Translation: AAD00783.1.
U95258 Genomic DNA. Translation: AAD00784.1.
U95259 Genomic DNA. Translation: AAD00785.1.
U95260 Genomic DNA. Translation: AAD00786.1.
U95261 Genomic DNA. Translation: AAD00787.1.
U95262 Genomic DNA. Translation: AAD00788.1.
U95263 Genomic DNA. Translation: AAD00789.1.
U95264 Genomic DNA. Translation: AAD00790.1.
U95265 Genomic DNA. Translation: AAD00791.1.
U95266 Genomic DNA. Translation: AAD00792.1.
U95267 Genomic DNA. Translation: AAD00793.1.
CH963913 Genomic DNA. Translation: EDW77442.1.
AF264082 Genomic DNA. Translation: AAF72724.1.
RefSeqiXP_002066456.1. XM_002066420.2.
XP_015033661.1. XM_015178175.1.

Genome annotation databases

EnsemblMetazoaiFBtr0248941; FBpp0247433; FBgn0013152.
GeneIDi6643501.
KEGGidwi:Dwil_GK18290.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08648 Genomic DNA. Translation: AAA91100.1.
U95251 Genomic DNA. Translation: AAD00777.1.
U95252 Genomic DNA. Translation: AAD00778.1.
U95253 Genomic DNA. Translation: AAD00779.1.
U95254 Genomic DNA. Translation: AAD00780.1.
U95255 Genomic DNA. Translation: AAD00781.1.
U95256 Genomic DNA. Translation: AAD00782.1.
U95257 Genomic DNA. Translation: AAD00783.1.
U95258 Genomic DNA. Translation: AAD00784.1.
U95259 Genomic DNA. Translation: AAD00785.1.
U95260 Genomic DNA. Translation: AAD00786.1.
U95261 Genomic DNA. Translation: AAD00787.1.
U95262 Genomic DNA. Translation: AAD00788.1.
U95263 Genomic DNA. Translation: AAD00789.1.
U95264 Genomic DNA. Translation: AAD00790.1.
U95265 Genomic DNA. Translation: AAD00791.1.
U95266 Genomic DNA. Translation: AAD00792.1.
U95267 Genomic DNA. Translation: AAD00793.1.
CH963913 Genomic DNA. Translation: EDW77442.1.
AF264082 Genomic DNA. Translation: AAF72724.1.
RefSeqiXP_002066456.1. XM_002066420.2.
XP_015033661.1. XM_015178175.1.

3D structure databases

ProteinModelPortaliQ05114.
SMRiQ05114.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7260.FBpp0247433.

Proteomic databases

PRIDEiQ05114.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0248941; FBpp0247433; FBgn0013152.
GeneIDi6643501.
KEGGidwi:Dwil_GK18290.

Organism-specific databases

FlyBaseiFBgn0013152. Dwil\Adh.

Phylogenomic databases

eggNOGiKOG4169. Eukaryota.
COG1028. LUCA.
InParanoidiQ05114.
KOiK00001.
OMAiWSKHWDS.
OrthoDBiEOG091G0OC9.
PhylomeDBiQ05114.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiView protein in InterPro
IPR002425. ADH_Drosophila-type.
IPR002424. ADH_insect.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PRINTSiPR01168. ALCDHDRGNASE.
PR01167. INSADHFAMILY.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADH_DROWI
AccessioniPrimary (citable) accession number: Q05114
Secondary accession number(s): B4MZ46
, Q9NG34, Q9TVL4, Q9TW33, Q9TY28, Q9TY29, Q9TY30, Q9TY31
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: October 1, 1996
Last modified: March 15, 2017
This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.