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Protein

Venom allergen 5

Gene
N/A
Organism
Vespula vulgaris (Yellow jacket) (Wasp)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Venom allergen 5
Alternative name(s):
Allergen Ves v V
Antigen 5
Short name:
Ag5
Cysteine-rich venom protein
Short name:
CRVP
Allergen: Ves v 5
OrganismiVespula vulgaris (Yellow jacket) (Wasp)
Taxonomic identifieri7454 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaeVespinaeVespula

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3523. Ves v 5.0101.
670. Ves v 5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Add BLAST23
ChainiPRO_000000629724 – 227Venom allergen 5Add BLAST204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 401 Publication
Disulfide bondi31 ↔ 1241 Publication
Disulfide bondi49 ↔ 1171 Publication
Disulfide bondi193 ↔ 2101 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

Secondary structure

1227
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi26 – 28Combined sources3
Helixi38 – 41Combined sources4
Beta strandi53 – 58Combined sources6
Helixi61 – 79Combined sources19
Beta strandi94 – 96Combined sources3
Helixi104 – 114Combined sources11
Beta strandi128 – 130Combined sources3
Beta strandi133 – 144Combined sources12
Helixi149 – 157Combined sources9
Helixi158 – 162Combined sources5
Helixi169 – 171Combined sources3
Helixi174 – 183Combined sources10
Beta strandi190 – 200Combined sources11
Beta strandi203 – 214Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QNXX-ray1.90A24-227[»]
ProteinModelPortaliQ05110.
SMRiQ05110.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ05110.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 212SCPAdd BLAST145

Sequence similaritiesi

Belongs to the CRISP family.Curated
Contains 1 SCP domain.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR002413. V5_allergen.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
[Graphical view]
PRINTSiPR00838. V5ALLERGEN.
PR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05110-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEISGLVYLI IIVTIIDLPY GKANNYCKIK CLKGGVHTAC KYGSLKPNCG
60 70 80 90 100
NKVVVSYGLT KQEKQDILKE HNDFRQKIAR GLETRGNPGP QPPAKNMKNL
110 120 130 140 150
VWNDELAYVA QVWANQCQYG HDTCRDVAKY QVGQNVALTG STAAKYDDPV
160 170 180 190 200
KLVKMWEDEV KDYNPKKKFS GNDFLKTGHY TQMVWANTKE VGCGSIKYIQ
210 220
EKWHKHYLVC NYGPSGNFMN EELYQTK
Length:227
Mass (Da):25,798
Last modified:February 1, 1994 - v1
Checksum:i99E9813740A66F55
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti109V → I in CAB42887 (Ref. 2) Curated1
Sequence conflicti118Q → E in CAB42887 (Ref. 2) Curated1
Sequence conflicti173D → N in CAB42887 (Ref. 2) Curated1
Sequence conflicti219M → K in CAB42887 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M98858 mRNA. Translation: AAA30333.1.
AJ238849 Genomic DNA. Translation: CAB42887.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M98858 mRNA. Translation: AAA30333.1.
AJ238849 Genomic DNA. Translation: CAB42887.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QNXX-ray1.90A24-227[»]
ProteinModelPortaliQ05110.
SMRiQ05110.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei3523. Ves v 5.0101.
670. Ves v 5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ05110.

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR002413. V5_allergen.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
[Graphical view]
PRINTSiPR00838. V5ALLERGEN.
PR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVA5_VESVU
AccessioniPrimary (citable) accession number: Q05110
Secondary accession number(s): Q9UB91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 2, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.