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Protein

Venom allergen 5

Gene
N/A
Organism
Vespula vulgaris (Yellow jacket) (Wasp)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Venom allergen 5
Alternative name(s):
Allergen Ves v V
Antigen 5
Short name:
Ag5
Cysteine-rich venom protein
Short name:
CRVP
Allergen: Ves v 5
OrganismiVespula vulgaris (Yellow jacket) (Wasp)
Taxonomic identifieri7454 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaeVespinaeVespula

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3523. Ves v 5.0101.
670. Ves v 5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Add
BLAST
Chaini24 – 227204Venom allergen 5PRO_0000006297Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 401 Publication
Disulfide bondi31 ↔ 1241 Publication
Disulfide bondi49 ↔ 1171 Publication
Disulfide bondi193 ↔ 2101 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

Secondary structure

1
227
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi26 – 283Combined sources
Helixi38 – 414Combined sources
Beta strandi53 – 586Combined sources
Helixi61 – 7919Combined sources
Beta strandi94 – 963Combined sources
Helixi104 – 11411Combined sources
Beta strandi128 – 1303Combined sources
Beta strandi133 – 14412Combined sources
Helixi149 – 1579Combined sources
Helixi158 – 1625Combined sources
Helixi169 – 1713Combined sources
Helixi174 – 18310Combined sources
Beta strandi190 – 20011Combined sources
Beta strandi203 – 21412Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1QNXX-ray1.90A24-227[»]
ProteinModelPortaliQ05110.
SMRiQ05110. Positions 24-227.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ05110.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 212145SCPAdd
BLAST

Sequence similaritiesi

Belongs to the CRISP family.Curated
Contains 1 SCP domain.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR002413. V5_allergen.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
[Graphical view]
PRINTSiPR00838. V5ALLERGEN.
PR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05110-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEISGLVYLI IIVTIIDLPY GKANNYCKIK CLKGGVHTAC KYGSLKPNCG
60 70 80 90 100
NKVVVSYGLT KQEKQDILKE HNDFRQKIAR GLETRGNPGP QPPAKNMKNL
110 120 130 140 150
VWNDELAYVA QVWANQCQYG HDTCRDVAKY QVGQNVALTG STAAKYDDPV
160 170 180 190 200
KLVKMWEDEV KDYNPKKKFS GNDFLKTGHY TQMVWANTKE VGCGSIKYIQ
210 220
EKWHKHYLVC NYGPSGNFMN EELYQTK
Length:227
Mass (Da):25,798
Last modified:February 1, 1994 - v1
Checksum:i99E9813740A66F55
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti109 – 1091V → I in CAB42887 (Ref. 2) Curated
Sequence conflicti118 – 1181Q → E in CAB42887 (Ref. 2) Curated
Sequence conflicti173 – 1731D → N in CAB42887 (Ref. 2) Curated
Sequence conflicti219 – 2191M → K in CAB42887 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M98858 mRNA. Translation: AAA30333.1.
AJ238849 Genomic DNA. Translation: CAB42887.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M98858 mRNA. Translation: AAA30333.1.
AJ238849 Genomic DNA. Translation: CAB42887.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1QNXX-ray1.90A24-227[»]
ProteinModelPortaliQ05110.
SMRiQ05110. Positions 24-227.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei3523. Ves v 5.0101.
670. Ves v 5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ05110.

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR002413. V5_allergen.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
[Graphical view]
PRINTSiPR00838. V5ALLERGEN.
PR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence analysis and antigenic cross-reactivity of a venom allergen, antigen 5, from hornets, wasps, and yellow jackets."
    Lu G., Villalba M., Coscia M.R., Hoffman D.R., King T.P.
    J. Immunol. 150:2823-2830(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Venom and Venom gland.
  2. "Molecular cloning of a genomic sequence from the venom allergen antigen 5 from Vespula vulgaris."
    Suck R., Hagen S., Fiebig H.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-227.
    Tissue: Venom gland.
  3. "Major venom allergen of yellow jackets, Ves v 5: structural characterization of a pathogenesis-related protein superfamily."
    Henriksen A., King T.P., Mirza O., Monsalve R.I., Meno K., Ipsen H., Larsen J.N., Gajhede M., Spangfort M.D.
    Proteins 45:438-448(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 24-227, DISULFIDE BONDS.

Entry informationi

Entry nameiVA5_VESVU
AccessioniPrimary (citable) accession number: Q05110
Secondary accession number(s): Q9UB91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: October 14, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.