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Q050C7 (UPPP_LEPBL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA
Ordered Locus Names:LBL_1883
OrganismLeptospira borgpetersenii serovar Hardjo-bovis (strain L550) [Complete proteome] [HAMAP]
Taxonomic identifier355276 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira

Protein attributes

Sequence length280 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 280280Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000290721

Regions

Transmembrane19 – 3921Helical; Potential
Transmembrane44 – 6421Helical; Potential
Transmembrane89 – 10921Helical; Potential
Transmembrane125 – 14521Helical; Potential
Transmembrane156 – 17621Helical; Potential
Transmembrane197 – 21721Helical; Potential
Transmembrane226 – 24621Helical; Potential
Transmembrane259 – 27921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q050C7 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: 9CFC103092914341

FASTA28031,527
        10         20         30         40         50         60 
MNHYLNAFLR SIIEAVTEFL PVSSTGHLFL FSSFFPFSGE SLEFDDLFDI FIQSGAILSV 

        70         80         90        100        110        120 
LFLYREKFGS QMLSSFQYLT KRNSDSQGFY FLVQIVIGAF PILVVGFIAK KFLDTIKARP 

       130        140        150        160        170        180 
DLLDILASAW IFGGVLILIA EWFFQKRQGT EEKKTVGFRD AILIGIFQCV ALIPGVSRSA 

       190        200        210        220        230        240 
ATIVTARFLG KDTKSSAEFS FFLAVPVLLA AGIYKLIKHR SILNEVTIPI LAFGFLISFL 

       250        260        270        280 
LCTLVIRLFL RYLQKHSFGV FGIYRILLGV GVLVFTKFIR 

« Hide

References

[1]"Genome reduction in Leptospira borgpetersenii reflects limited transmission potential."
Bulach D.M., Zuerner R.L., Wilson P., Seemann T., McGrath A., Cullen P.A., Davis J., Johnson M., Kuczek E., Alt D.P., Peterson-Burch B., Coppel R.L., Rood J.I., Davies J.K., Adler B.
Proc. Natl. Acad. Sci. U.S.A. 103:14560-14565(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: L550.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000348 Genomic DNA. Translation: ABJ79318.1.
RefSeqYP_798251.1. NC_008508.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING355276.LBL_1883.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ79318; ABJ79318; LBL_1883.
GeneID4406603.
KEGGlbl:LBL_1883.
PATRIC22367894. VBILepBor75619_2402.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAAQCFALI.
OrthoDBEOG6QP13M.
ProtClustDBCLSK574452.

Enzyme and pathway databases

BioCycLBOR355276:GHUQ-1863-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_LEPBL
AccessionPrimary (citable) accession number: Q050C7
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: November 14, 2006
Last modified: February 19, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families