Q050C7 (UPPP_LEPBL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Synonyms:	bacA
Ordered Locus Names:	LBL_1883

Organism

Leptospira borgpetersenii serovar Hardjo-bovis (strain L550) [Complete proteome] [HAMAP]

Taxonomic identifier

355276 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Spirochaetes › Spirochaetia › Spirochaetales › Leptospiraceae › Leptospira › Leptospira borgpetersenii › Leptospira borgpetersenii serovar Hardjo-bovis

Protein attributes

Sequence length	280 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 280	280	Undecaprenyl-diphosphatase HAMAP-Rule MF_01006		PRO_0000290721
Regions
	Transmembrane	19 – 39	21	Helical; Potential
	Transmembrane	44 – 64	21	Helical; Potential
	Transmembrane	89 – 109	21	Helical; Potential
	Transmembrane	125 – 145	21	Helical; Potential
	Transmembrane	156 – 176	21	Helical; Potential
	Transmembrane	197 – 217	21	Helical; Potential
	Transmembrane	226 – 246	21	Helical; Potential
	Transmembrane	259 – 279	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q050C7 [UniParc]. Last modified November 14, 2006. Version 1. Checksum: 9CFC103092914341	FASTA	280	31,527
	10 20 30 40 50 60 MNHYLNAFLR SIIEAVTEFL PVSSTGHLFL FSSFFPFSGE SLEFDDLFDI FIQSGAILSV 70 80 90 100 110 120 LFLYREKFGS QMLSSFQYLT KRNSDSQGFY FLVQIVIGAF PILVVGFIAK KFLDTIKARP 130 140 150 160 170 180 DLLDILASAW IFGGVLILIA EWFFQKRQGT EEKKTVGFRD AILIGIFQCV ALIPGVSRSA 190 200 210 220 230 240 ATIVTARFLG KDTKSSAEFS FFLAVPVLLA AGIYKLIKHR SILNEVTIPI LAFGFLISFL 250 260 270 280 LCTLVIRLFL RYLQKHSFGV FGIYRILLGV GVLVFTKFIR

References

[1]

"Genome reduction in Leptospira borgpetersenii reflects limited transmission potential." Bulach D.M., Zuerner R.L., Wilson P., Seemann T., McGrath A., Cullen P.A., Davis J., Johnson M., Kuczek E., Alt D.P., Peterson-Burch B., Coppel R.L., Rood J.I., Davies J.K., Adler B. Proc. Natl. Acad. Sci. U.S.A. 103:14560-14565(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: L550.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000348 Genomic DNA. Translation: ABJ79318.1.
RefSeq	YP_798251.1. NC_008508.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	355276.LBL_1883.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABJ79318; ABJ79318; LBL_1883.
GeneID	4406603.
KEGG	lbl:LBL_1883.
PATRIC	22367894. VBILepBor75619_2402.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HOG000218356.
KO	K06153.
OMA	TGHQLLI.
ProtClustDB	CLSK574452.
Enzyme and pathway databases
BioCyc	LBOR355276:GHUQ-2143-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UPPP_LEPBL

Accession

Primary (citable) accession number: Q050C7

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 12, 2007
Last sequence update:	November 14, 2006
Last modified:	May 1, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program