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Q050C4

- PANC_LEPBL

UniProt

Q050C4 - PANC_LEPBL

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Protein

Pantothenate synthetase

Gene

panC

Organism
Leptospira borgpetersenii serovar Hardjo-bovis (strain L550)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei37 – 371Proton donorUniRule annotation
Binding sitei61 – 611Beta-alanineUniRule annotation
Binding sitei61 – 611PantoateUniRule annotation
Binding sitei154 – 1541PantoateUniRule annotation
Binding sitei177 – 1771ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi30 – 378ATPUniRule annotation
Nucleotide bindingi148 – 1514ATPUniRule annotation
Nucleotide bindingi185 – 1884ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLBOR355276:GHUQ-1866-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Gene namesi
Name:panCUniRule annotation
Ordered Locus Names:LBL_1886
OrganismiLeptospira borgpetersenii serovar Hardjo-bovis (strain L550)
Taxonomic identifieri355276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira
ProteomesiUP000000655: Chromosome 1

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 285285Pantothenate synthetasePRO_0000305473Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi355276.LBL_1886.

Structurei

3D structure databases

ProteinModelPortaliQ050C4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175517.
KOiK01918.
OMAiECPIVRE.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR004821. Cyt_trans-like.
IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q050C4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIICRTPEEI SVQVRRWKAE DKKVGFVPTM GYLHEGHASL FRECLSKADK
60 70 80 90 100
TVVSIFVNPA QFNDPEDYAK YPINTDGDLK ICESGKVDLV FLPEKETIYP
110 120 130 140 150
EGIPNVVLQV PHLMRNLCAV SRPGHFEGVL LVISRLFHFV KPDFAFFGKK
160 170 180 190 200
DYQQYLLVKE FCKILAFPVE VIGCETIRSD KGLALSSRNS RLSEDEKEES
210 220 230 240 250
LLISRALKLG EAQILSGIKD PVVVRDIMKD VLDSSPKIRL DYLEVLNADT
260 270 280
LESLEILEGN ILLAAAVFIG SVRLIDNRTL RVASV
Length:285
Mass (Da):32,038
Last modified:November 14, 2006 - v1
Checksum:i83414C3FD0AD15EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000348 Genomic DNA. Translation: ABJ79321.1.
RefSeqiYP_798254.1. NC_008508.1.

Genome annotation databases

EnsemblBacteriaiABJ79321; ABJ79321; LBL_1886.
GeneIDi4406606.
KEGGilbl:LBL_1886.
PATRICi22367900. VBILepBor75619_2405.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000348 Genomic DNA. Translation: ABJ79321.1 .
RefSeqi YP_798254.1. NC_008508.1.

3D structure databases

ProteinModelPortali Q050C4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 355276.LBL_1886.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ79321 ; ABJ79321 ; LBL_1886 .
GeneIDi 4406606.
KEGGi lbl:LBL_1886.
PATRICi 22367900. VBILepBor75619_2405.

Phylogenomic databases

eggNOGi COG0414.
HOGENOMi HOG000175517.
KOi K01918.
OMAi ECPIVRE.
OrthoDBi EOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci LBOR355276:GHUQ-1866-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR004821. Cyt_trans-like.
IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
Pfami PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: L550.

Entry informationi

Entry nameiPANC_LEPBL
AccessioniPrimary (citable) accession number: Q050C4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: November 14, 2006
Last modified: October 29, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3